The Fanconi Anemia Pathway Protects Genome Integrity from R-loops. by María L García-Rubio, Carmen Pérez-Calero, Sonia I Barroso, Emanuela Tumini, Emilia Herrera-Moyano, Iván V Rosado, Andrés Aguilera

“…Importantly, FANCD2 foci in untreated and MMC-treated cells are largely R loop dependent, suggesting that the FA functions at R loop-containing sites. …”
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The GPI sidechain of Toxoplasma gondii inhibits parasite pathogenesis by Julia A. Alvarez, Elisabet Gas-Pascual, Sahil Malhi, Juan C. Sánchez-Arcila, Ferdinand Ngale Njume, Hanke van der Wel, Yanlin Zhao, Laura García-López, Gabriella Ceron, Jasmine Posada, Scott P. Souza, George S. Yap, Christopher M. West, Kirk D. C. Jensen

“…While the glycan portion is conserved, species differ in sidechains added to the triple mannose core. The functional significance of the Glcα1,4GalNAcβ1- sidechain reported in Toxoplasma gondii has remained largely unknown without understanding its biosynthesis. …”
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Interlayer interaction and Davydov splitting in antiferromagnetic few-layer NiPS3 by Manh Hong Nguyen, Giung Park, Je-Geun Park, Hyeonsik Cheong

“…Abstract Interlayer interactions in few-layer NiPS3 were investigated by analyzing low-frequency interlayer vibration modes and Davydov splitting of an intralayer, A1g vibration mode at ~255 cm–1 by Raman spectroscopy as a function of temperature. The interlayer force constants were estimated from the low-frequency Raman spectra by using the linear chain model. …”
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An Advanced Understanding of Uterine Microbial Ecology Associated with Metritis in Dairy Cows by Soo Jin Jeon, Klibs N. Galvão

“…Although affected cows are treated with broad-spectrum antibiotics such as ceftiofur, endometrial and ovarian function are not fully recovered, which results in subfertility and infertility. …”
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Fly Ash/Blast Furnace Slag-Based Geopolymer as a Potential Binder for Mine Backfilling: Effect of Binder Type and Activator Concentration by Jingping Qiu, Yingliang Zhao, Jun Xing, Xiaogang Sun

“…Slump, final setting time, and setting ratio increased as a function of FA content. However, the increase in FA content reduced the compressive strength and microstructure of the backfilling material (BM) due to the lower reactivity than BFS. …”
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The current treatment strategy for gouty arthritis by M. S. Petrova, М. M. Musiychuk, V. I. Mazurov

“…A number of studies are being conducted to further evaluate the cardiovascular safety of febuxostat and its possible positive effects in preserving renal function. Of importance is the fact that febuxostat does not require dose adjustment in elderly patients.…”
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Effect of π Orbital on I/V Characteristics and Transmission in Molecular Diode Structures with Au Contacts by A. Mallaiah, G.N. Swamy, K. Padmapriya

“…The electronic transport properties of electrons in a molecules are observed by using Non equilibrium Green’s function(NEGF). We present a extremely through and careful computational approach well ordered method to do a framework analysis of donor (CH3) and acceptor (CN) molecules connected between the Au(111) contacts, and also observed current progress through molecular devices depends on number of bonds or not. …”
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Regulation and mechanisms of action of RNA helicases by Nina Lang, Pravin Kumar Ankush Jagtap, Janosch Hennig

“…RNA helicases are an evolutionary conserved class of nucleoside triphosphate dependent enzymes found in all kingdoms of life. Their cellular functions range from transcription regulation up to maintaining genomic stability and viral defence. …”
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ACTUAL DISCOURE ABOUT TIPES FND DEVELOPMENT TENDENCIES NATIONAL STATE by E. G. Ponomareva

“…These include the concept of "dimensionality" based on the parameters of scale (the size of the territory) of the states and their functions in the international systems, as well as the "political order". …”
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Study of kinetic performance effect on wheel and rail wear using computer simulation by Lev I. Evelson, Evgeny A. Pamfilov, Alexander G. Tsygankov, Ludmila I. Shiryaeva

“…The work objective is to investigate the wheel and rail wear dependence on the kinetic performance parameters. The problems solved here are analysis of the earlier proposed mathematical functions describing the kinetic performance for the presence of extremes, the functional behavior (growth, decrease, monotonicity, and unimodality, etc.) in various parameter ranges; implementation of the computer simulation of the wheelpair movement by rail with the quantitative estimation of the wheel and rail wear with various kinetic performance parameters; to determine qualitative influence patterns of the kinetic wear performance. …”
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Fructose-mediated AGE-RAGE axis: approaches for mild modulation by Halyna Semchyshyn

“…Maintaining an appropriate balance between various RAGE isoforms with different functions is also crucial. In this context, mild approaches related to lifestyle—such as diet optimization, consuming functional foods, intake of probiotics, and regular moderate physical activity—are valuable due to their beneficial effects and their ability to mildly modulate the fructose-mediated AGE-RAGE axis.…”
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Greener solvents in extraction of proteins and peptides by Katarína Maráková

“…Proteins, with their unique structural and functional characteristics, are utilized in several industries such as pharmaceuticals, biomedicine, cosmetics, and food. …”
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Effect of Duration of Exposure of Thumb Movements While Operating Mobile Phone on Nerve Conduction Velocity and Handgrip Strength in Undergraduate Medical Students by Jagdish C. Hundekari, Sanjay Wasnik, Manoj Paliwal, Indrajeet Yadav, Chandeep Kau, Bhumika Badjatiya, Lokendra Kot, Ranjana Sharma

“…Aims and Objective: In the present study, we investigated the handgrip strength and median motor nerve conduction velocity to assess the impact of duration of mobile usage on the functional status of the hands. Material and Method: 175 undergraduate medical students aged 18–25 years were divided into four groups depending on duration of usage: less than 1 year (N = 23), 1–2 years (N = 89), 2–4 years (N = 37), and more than 4 years (N = 26). …”
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Network and atomistic simulations unveil the structural determinants of mutations linked to retinal diseases. by Simona Mariani, Daniele Dell'Orco, Angelo Felline, Francesco Raimondi, Francesca Fanelli

“…These findings provide insights into the structural fundamentals of abnormal functioning of visual phototransduction caused by a missense mutation in one component of the signaling network. …”
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Characterization of Toll-Like Receptor-4 (TLR-4) in the Spleen and Thymus of Swiss Albino Mice and Its Modulation in Experimental Endotoxemia by Chandrayee Ghosh, Biswadev Bishayi

“…On characterization of TLR-4 in spleen and thymus of Swiss albino mice—with no reports of TLR-4 expression—induced with endotoxemia, it was found that the mode of expression varied among the organs at both mRNA and protein level in a time-dependent manner. Their functionality was verified by measuring proinflammatory and anti-inflammatory cytokines. …”
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Simulation of the Workspace and Manipulability of An Industrial Robot For Research in Robotic Milling Needs by Kijovský Ján, Križan Peter, Hanko Lukáš, Svátek Michal, Bábics Jozef

“…Goals of research activities on our institute is to determine the functional dependencies between technological parameters of robotic milling, and rigidity of robotic arm, which can be easily evaluated by final machined surface quality and precision of machined components. …”
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Multiligament Knee Injury With Common Peroneal Nerve Rupture: Single-Stage Reconstruction of the Anterior Cruciate Ligament, Posterolateral Corner, and Common Peroneal Nerve Graft by Kevin M. Lehane, Jr., D.O., Jose Perez, M.D., Taylor Bates, M.D., Dylan T. Lowe, M.D., Jacques H. Hacquebord, M.D., Michael J. Alaia, M.D.

“…Multiligament knee injuries (MLKIs) are rare injuries that can result in devastating outcomes and functional impairment, especially in the setting of concomitant peroneal nerve injuries. …”
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Silicon strip detector with a polyethylene converter as a position sensitive detector for a narrow beam of fast neutrons by I. E. Anokhin, O. S. Zinets

“…The average charge collected on strips as a function of coordinates of incident neutrons has been calculated. …”
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Research Progress on the Correlation Between Microecological Flora and Endometriosis by LI Maoping, CHANG Heng

“…Microecological flora, an important part of the human microenvironment, changes with the changes in the internal and external environments of the human body, and plays an important role in maintaining human body's normal function. Endometriosis (EMs) is a common estrogen-dependent female disease chara-cterized by the growth of endometrial glands and mesenchyme outside the uterine cavity. …”
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NC Machine Tools Fault Diagnosis Based on Kernel PCA and k-Nearest Neighbor Using Vibration Signals by Zhou Yuqing, Sun Bingtao, Li Fengping, Song Wenlei

“…This paper focuses on the fault diagnosis for NC machine tools and puts forward a fault diagnosis method based on kernel principal component analysis (KPCA) and k-nearest neighbor (kNN). A data-dependent KPCA based on covariance matrix of sample data is designed to overcome the subjectivity in parameter selection of kernel function and is used to transform original high-dimensional data into low-dimensional manifold feature space with the intrinsic dimensionality. …”
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