Amlodipine improves symmetric dimethylarginine in dogs with chronic kidney disease by Shohei Morita, Youhei Mochizuki, Takahiro Kondo, Yasuyoshi Matsuda, Takahiro Ohmori, Aritada Yoshimura, Ryuji Fukushima

“…Amlodipine is used to treat hypertension in dogs, and we anticipated that amlodipine administration might improve renal function in dogs. However, the effect of amlodipine on canine renal function is unknown. …”
Get full text

Scaling of fractured rock flow. Proposition of indicators for selection of DFN based flow models by Davy, Philippe, Le Goc, Romain, Darcel, Caroline, Selroos, Jan-Olof

“…We first studied what the inflow distribution tells us about the permeability structure from a series of analyses: distribution of transmissivities as a function of depth, proportion of flowing sections as a function of section scale, and scaling of the arithmetically-averaged and geometrically-averaged permeability. …”
Get full text

Pin1 promotes human CaV2.1 channel polyubiquitination by RNF138: pathophysiological implication for episodic ataxia type 2 by Ssu-Ju Fu, Kai-Min Cheng, Cheng-Tsung Hsiao, Ya-Ching Fang, Chung-Jiuan Jeng, Chih-Yung Tang

“…Our data are consistent with the idea that CaV2.1 proteostasis at the ER, as well as dominant-negative suppression of disease-causing loss-of-function mutants on CaV2.1 WT, entail both Pin1/RNF138-dependent and -independent mechanisms.…”
Get full text

Arterial hypertension and stiffness in women of different age groups and reproductive status by O. S. Ivanova, E. Y. Maychuk, I. V. Voevodina, I. A. Makarova, E. V. Akatova, A. I. Zavyalova, O. P. Nikolin

“…Objective:  study of the relationship between  arterial hypertension  and arterial stiffness  in women  to identify potential markers of target organ damage and therapeutic targets of antihypertensive therapy.Materials  and methods: the study involved 161 women who were divided into three groups depending on age and reproductive function. Group 1 consisted of 52 women  aged 18 to 30; group 2 – 54 women  aged 31 years before menopause; 3rd group – 55 women in the postmenopausal period. …”
Get full text

Viral-mediated knockdown of Atxn2 attenuates TDP-43 pathology and muscle dysfunction in the PFN1C71G ALS mouse model by Zachary C. E. Hawley, Xueying Li, Dora Bodnar, Yuanzheng Gu, Yi Luo, Daniel Ferretti, Adam Sheehy, Rachelle Driscoll, Maria I. Zavodszky, Shaolong Cao, Isabel Isaza, Luke Jandreski, Yuqing Liu, Thomas Carlile, Shih-Ching Lo, Anna Grimard, Shawn Bourque, Aditya Utturkar, Samantha Desmarais, H. Moore Arnold, Dann Huh, Edward Guilmette, Deborah Y. Kwon

“…Lastly, we find significant gene co-expression network homology between PFN1C71G mice and human ALS, with shared dysregulation of modules related to neuroinflammation and neuronal function and uncover novel hub genes that provide biological insight into ALS and potential drug targets that can be further investigated in this mouse model.…”
Get full text

Systematic analysis of the pharmacology of myoinositol and D-chiroinositola by T. E. Bogacheva, O. A. Gromova, I. Yu. Torshin

“…(Myoinositol is the basis for the synthesis of an important group of signaling molecules, inositol phosphates, which mediate signal transmission from growth factor receptors and neurotransmitters). Most inositol-dependent proteins with known functions are necessary for the vital functions of the cardiovascular, immune system, and connective tissue structure. …”
Get full text

Astrocytic BDNF Modulates Sensitivity to Stress-Induced Anxiety-Like Behaviors by Wei-Peng Li, Gui-Yu Liu, Shi-Yun Wang, Jiao Hu, Wen-Juan Ji, Jun-Ming Zhu, Qing-Yu Chang, Tian-Yi Li, Guo-Rong Wei, Jian-Qing Shang, Hong-Zhan Li, Fu-Hua Peng, Yun-Yan Zhao, Xiao-Hong Su, Wei Xie

“…Chronic restraint stress induces anxiety-like behaviors and disrupts presynaptic glutamatergic transmission in hippocampal CA1 neurons, with astrocytes potentially playing a central regulatory role in a Ca2+-dependent manner. Pharmacological manipulation confirms the involvement of BDNF/TrkB signaling, while knockdown of astrocytic BDNF further impairs synaptic function and exacerbates stress-induced anxiety. …”
Get full text

Influence of oxidative stress on cardiovascular parameters in patients with combined flow of chronic obstructive pulmonary disease and arterial hypertension by V. G. Deinega, V. V. Kryvenko

“…The higher levels of iron induced fraction show decreased function of antioxidant system in patients with combined flow of COPD and AH. …”
Get full text

Coronary heart disease and the course of newly detected prostate cancer by E. V. Pomeshkin, S. V. Popov, I. N. Orlov, A. I. Bragin-Maltsev, S. A. Pomeshkina, O. L. Barbarash

“…All patients had the level of prostate-specific antigen, pelvic MRI, prostate biopsy with determination of Gleason score, all patients filled out the questionnaire of the International Index of Erectile Function (IIEF-5). Depending on the presence of coronary heart disease (CHD), all patients were divided into two groups: Group 1 — 94 (67%) PCa patients without CHD; Group 2 — 46 (33%) PCa patients with CHDResults. …”
Get full text

Pond water microbiome antibiotic resistance genes vary seasonally with environmental pH and tannins by Maya Vaccaro, Andrew M. Pilat, Logan Gusmano, Minh T. N. Pham, Daniel Barich, Audrey Gibson, Mwï Epalle, Dominick J. Frost, Elianajoy Volin, Zachary C. Slimak, Chelsea C. Menke, M. Siobhan Fennessy, Joan L. Slonczewski

“…Acidity amplifies the transmembrane pH difference component of the proton-motive force, thus increasing the cell’s energy available for pump function and ARG expression. Association with microbial taxa was tested by the Kraken2/Bracken predictor of taxa profiles. …”
Get full text

Nephrotic Syndrome Secondary to Proliferative Glomerulonephritis with Monoclonal Immunoglobulin Deposits of Lambda Light Chain by Seongseok Yun, Beth L. Braunhut, Courtney N. Walker, Waheed Bhati, Amy N. Sussman, Faiz Anwer

“…We describe a rare case of a 46-year-old woman with history of refractory nephrotic syndrome and hypertension who presented with worsening proteinuria and kidney function. Work-up for both autoimmune and infectious diseases and hematologic malignancies including multiple myeloma were negative. …”
Get full text

Role of NMDA Receptor-Mediated Glutamatergic Signaling in Chronic and Acute Neuropathologies by Francisco J. Carvajal, Hayley A. Mattison, Waldo Cerpa

“…Here, we will review some of the current evidence of how traumatic brain injury can hasten the onset of several neurological conditions, focusing on the role of NMDAR distribution and the functional consequences in calcium homeostasis associated with synaptic dysfunction and neuronal death present in this group of chronic diseases.…”
Get full text

Successful Selective Embolization for Recurrent Hemarthrosis after Knee Arthroplasty by Cristian Barrientos, Maximiliano Barahona, Tomas Cermenati, Rodrigo Wulf, Jaime Hinzpeter

“…After two years, the patients report 92 points in the Forgotten joint score, 0 in Womac pain, 1 in Womac stiffness, and 3 in Womac functional score.…”
Get full text

Robust Nonfragile H∞ Filtering for Uncertain T-S Fuzzy Systems with Interval Delay: A New Delay Partitioning Approach by Xianzhong Xia, Renfa Li, Jiyao An

“…By developing a delay decomposition approach, both lower and upper bound information of the delayed plant states can be taken into full consideration; the proposed delay-fractional-dependent stability condition for the filter error systems is obtained based on the direct Lyapunov method allied with an appropriate and variable Lyapunov-Krasovskii functional choice and with tighter upper bound of some integral terms in the derivation process. …”
Get full text

RELATIONSHIPS BETWEEN LIPID AND IMMUNE DISORDERS AT VARIOUS STAGES OF DEVELOPING EXPERIMENTAL DYSLIPIDEMIA by E. G. Lobanova, Yu. K. Karaman

“…It was found that development of lipid disorders in rats is accompanied by increased levels  of  tumor  necrosis  factor  alpha  (TNFα)  in  blood  and  liver,  decreased  cytokine  regulation  index,  thus  suggesting  arising  inflammatory  reaction  at  the  organ  and  systemic  levels,  exhaustion  of  functional  reserve  and  diminished  response of immunocompetent cells. …”
Get full text

Rapid high resolution T1 mapping as a marker of brain development: Normative ranges in key regions of interest. by Sylvain Eminian, Steven David Hajdu, Reto Antoine Meuli, Philippe Maeder, Patric Hagmann

“…<h4>Results</h4>In the basal ganglia, there was a small, yet significant, decrease in T1 relaxation time (-0.45 ≤R≤-0.59, p<10-2) and ADC (-0.60≤R≤-0.65, p<10-4) as a function of age. In the frontal and parietal white matter, there was a significant decrease in T1 relaxation time (-0.62≤R≤-0.68, p<10-4) and ADC (-0.81≤R≤-0.85, p<10-4) as a function of age. …”
Get full text

Research Institute of Pediatrics and Children’s Health in “Central Clinical Hospital of the Russian Academy of Sciences” by Nikolay N. Murashkin, Roman V. Epishev, Alexander I. Materikin, Eduard T. Ambarchian, Leonid A. Opryatin, Roman A. Ivanov

“…Federation Skin lesions with development of erosive-ulcerative defects and impaired skin barrier function are common for large number of diseases. Successful epithelization of skin defects depends on the wound process, body’s compensatory functions, environmental factors and correctly selected treatment. …”
Get full text

Quantitative Estimates for Positive Linear Operators in terms of the Usual Second Modulus by José A. Adell, A. Lekuona

“…We show that the size of the constants Cn(A(I),x) mainly depends on the degree of smoothness of the functions in the set A(I) and on the distance from the point x to the boundary of I. …”
Get full text

Human formin FHOD3-mediated actin elongation is required for sarcomere integrity in cardiomyocytes by Dylan A Valencia, Angela N Koeberlein, Haruko Nakano, Akos Rudas, Aanand A Patel, Airi Harui, Cassandra Spencer, Atsushi Nakano, Margot E Quinlan

“…Contractility and cell motility depend on accurately controlled assembly of the actin cytoskeleton. …”
Get full text

Experimental research of technological elastic deformations of the central holes of gears by A. S. Serkov, V. V. Derkach, S. V. Mikhailenko, L. B. Serkova

“…The least squares method was used to confirm the assumed linear dependence of the graphs of hole shape distortion from roundness as a function of the tightening torque applied to the wrench handle. …”
Get full text