Exon Sequencing of HNF1β in Chinese Patients with Early-Onset Diabetes by Siqian Gong, Hong Lian, Yating Li, Xiaoling Cai, Wei Liu, Yingying Luo, Meng Li, Si-min Zhang, Rui Zhang, Lingli Zhou, Yu Zhu, Qian Ren, Xiuying Zhang, Jing Chen, Jing Wu, Xianghai Zhou, Xirui Wang, Xueyao Han, Linong Ji

“…Methods Among 679 EOD patients clinically diagnosed with type 2 diabetes mellitus (age at diagnosis ≤40 years), the exons of HNF1β were sequenced. Functional impact of rare variants was evaluated using a dual-luciferase reporter system. …”
Get full text

ER-Associated Degradation of Membrane Proteins in Yeast by Cédric Pety de Thozée, Michel Ghislain

“…Recent studies in yeast have highlighted the possible function of the Sar1p/COPII machinery in ER-associated degradation of some lumenal and membrane proteins.…”
Get full text

Analysis of Mechanical and Thermal Material Characteristics of GPL-Reinforced Double-FG Composite Nanoplates under Temperature Load by Kerim Gökhan Aktaş

“…This article analyzes the variation in the mechanical and thermal material characteristics of graphene platelets (GPLs)-reinforced double-functionally graded (FG) composite nanoplates subjected to thermal load. …”
Get full text

Proteomic approach for evaluating cryoprotectant formulations for enhanced post-cryopreservation recovery of yeast by Thiruganesh Ramasamy, Rahul Tevatia, Shahin Ali, Anthony Muhle, Victoria Knight-Connoni, Nilay Chakraborty

“…Spot assays were performed to study the recovery response of each formulation. Functional proteomic and KEGG pathway analyses were used to investigate the molecular mechanism of cold-stress response in S. cerevisiae. …”
Get full text

Dopaminergic system and its relationship with the hypothalamic-pituitary-gonadal and hypothalamic-pituitary-thyroid systems (review) by I. N. Molodovskaya

“…Most studies focus on the functions of dopamine in the central nervous system. …”
Get full text

Predicting neuronal firing from calcium imaging using a control theoretic approach. by Nicholas A Rondoni, Fan Lu, Daniel B Turner-Evans, Marcella Gomez

“…Calcium imaging techniques, such as two-photon imaging, have become a powerful tool to explore the functions of neurons and the connectivity of their circuitry. …”
Get full text

Expanding the Role of FurA as Essential Global Regulator in Cyanobacteria. by Andrés González, M Teresa Bes, M Luisa Peleato, María F Fillat

“…The results of such approaches led us to identify 15 novel direct iron-dependent transcriptional targets belonging to different functional categories including detoxification and defences against oxidative stress, phycobilisome degradation, chlorophyll catabolism and programmed cell death, light sensing and response, heterocyst differentiation, exopolysaccharide biosynthesis, among others. …”
Get full text

Correlation of PROMIS Scores with the Various Classes of the New Classification System of Progressive Collapsing Foot Deformity by Seif El Masry, Grace DiGiovanni BS, Brittany M. Ammerman MD, Allison L. Boden MD, Jonathan Day MD, Joseph T. Nguyen MPH, Cesar de Cesar Netto MD, PhD, Scott J. Ellis MD

“…Conclusion: Patients with more severe PCFD had clinically significant improvement in physical function at both 1- and 2-years post-operatively, but had worse outcomes compared to those with less severe deformity. …”
Get full text

Closed-Form Solution for CFAR Detection Threshold in G⁰ Distributed SAR Clutter by Dheeren Ku Mahapatra, Sourabh Paul, Biswajit Dwivedy, Alejandro C. Frery

“…Exploiting the dependencies between hypergeometric functions and the Fisher-Snedecor distribution function, we formulate a closed-form solution for the CFAR detection threshold. …”
Get full text

Optimum Arrangement of Reactive Power Sources While Using Genetic Algori by A. M. Gashimov, R. N. Rakhmanov, S. T. Rakhmanov

“…Total expenses for installation of capacitor banks, their operation and also expenses related to electric power losses are considered as an efficiency function which is used for determination of places with optimum values of capacitor bank power. …”
Get full text

Ferroptosis and ageing by A. A. Garanin, T. E. Bogacheva, O. A. Gromova

“…The ageing process is characterized by a progressive decline in cellular function and increased susceptibility to oxidative damage, both of which intersect with ferroptosis pathways. …”
Get full text

Neural repair mechanisms after ischemic stroke by Koshi Irisa, Takashi Shichita

“…Understanding the molecular mechanisms involving immune cells in acute inflammation, subsequent neural repair, and neuronal circuit reorganization that compensate for the lost brain function is indispensable to establish treatment strategies for stroke patients.…”
Get full text

The Blow-Up of Solutions to the Cauchy Problem of Semilinear Tricomi Equations with Damping and Mass Terms by Sen Ming, Xiongmei Fan, Xiao Wu

“…The upper bound estimate for the lifespan of the solution to the problem with a power-type nonlinear term is obtained by applying the test function method. The lifespan estimates of solutions to the coupled system with power nonlinearities and combined nonlinearities are derived using the iteration method. …”
Get full text

THE STUDY OF THE INFLUENCE OF THE FLAVONOIDS ON ENERGY EXCHANGE MITOHONDRIALNYE PROTSESSY AND MICROSOMAL SYSTEMS IN THE LIVER IN ACUTE CCL4 - STEATOSIS IN RATS by Elena Olegovna Sergeeva, Elena Grigorievna Dorkina, Lubov Anatolievna Sadjaia

“…Disturbed detoxification function of the liver, a reduction in the activity of glutathione-S-transferase and NADPH-dependent microsomal monooxygenase system, accompanied by compensatory increased activity of NADH is microsomal chain oxidation. …”
Get full text

Photoeffect Peculiarities in Macroporous Silicon Structures by L. A. Karachevtseva, V. F. Onyshchenko, A. V. Sachenko

“…The effects of increase in photoconductivity in the macroporous silicon structures have been examined as a function of the distance between cylinder macropores. …”
Get full text

Hemodynamic Effects of Positive Airway Pressure: A Cardiologist’s Overview by Anna Di Cristo, Andrea Segreti, Nardi Tetaj, Simone Pasquale Crispino, Emiliano Guerra, Emanuele Stirpe, Gian Paolo Ussia, Francesco Grigioni

“…However, the role of PAP in right ventricular function and its effects on venous return and cardiac output are critical in the cardiac intensive care setting. …”
Get full text

Targeting the gut microbiota-bile acid axis: Therapeutic strategies for cholestatic liver disease and metabolic dysfunction-associated steatotic liver disease by Xingtao Zhao, Ruolan Li, Ruiqi Sun, Qiong Pan, Hongyan Lu, Jin Chai

“…Conversely, the composition and function of BAs, including their reabsorption and excretion, are regulated by gut microbiota. …”
Get full text

Temporal network analysis of gut microbiota unveils aging trajectories associated with colon cancer by Ziqi Chen, Zhipeng Zhang, Bei Ning Nie, Wei Huang, Ying Zhu, Long Zhang, Meng Xu, Mengfei Wang, Chenyue Yuan, Ningning Liu, Xinyi Wang, Jianhui Tian, Qian Ba, Ziliang Wang

“…Extensive metagenomic sequencing of fecal samples allowed for the exploration of both the structural and functional profiles of the microbiome, with findings validated in an independent cohort to ensure robustness. …”
Get full text

Fluctuation scaling in neural spike trains by Shinsuke Koyama, Ryota Kobayashi

“…In time series that describe sequences of events, fluctuation scaling is expressed as power function relationships between the mean and variance of either inter-event intervals or counting statistics, depending on measurement variables. …”
Get full text

The role of crystal orientation in attosecond photoinjection dynamics in germanium by Talarico Matteo, Di Palo Nicola, Adamska Lyudmyla, Bonetti Simone, Inzani Giacomo, Arias Velasco Marta, Dolso Gian Luca, Borrego-Varillas Rocío, Nisoli Mauro, Pittalis Stefano, Rozzi Carlo Andrea, Lucchini Matteo

“…To this end, we investigated the effects of crystal orientation on ultrafast photoinjection dynamics in germanium using attosecond transient reflectance spectroscopy (ATRS) aided by time-dependent density functional theory (TD-DFT) calculations. …”
Get full text