Attenuation of hedgehog acyltransferase-catalyzed sonic Hedgehog palmitoylation causes reduced signaling, proliferation and invasiveness of human carcinoma cells. by Antonios D Konitsiotis, Shu-Chun Chang, Biljana Jovanović, Paulina Ciepla, Naoko Masumoto, Christopher P Palmer, Edward W Tate, John R Couchman, Anthony I Magee

“…Our data identify Hhat as a key player in Hh-dependent signaling and tumour cell transformed behaviour.…”
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Magazine Cover as Multimodal Text by O. A. Blinova

“…The expediency of applying system-functional and sociocognitive approaches to the analysis of the material is substantiated. …”
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Introduction to trophology of walleye pollock by Anatoly F. Volkov

“…Various aspects of walleye pollock feeding at different stages of its ontogenesis are reviewed and discussed. Structure and functional features of its mouth organs are considered with meristic and quantitative description of the filter one. …”
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Hydrazones derivatives from halo-pyridinol: Synthesis and DFT-based theoretical exploration

“…Various properties of the synthesized compounds were explored using density functional theory (DFT) calculations, including NBO (natural bond orbital), NLO (non-linear optical properties), NPA (natural population analysis), and FMO (frontier molecular orbital) analyses. …”
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Therapeutic Potential of Human Amniotic Membrane-Derived Mesenchymal Stem Cell Conditioned Medium in Combating Oxidative Stress and Age-Related Female Infertility by Kihae Ra

“…Oxidative stress is a crucial factor accelerating the age-related functional deterioration of reproductive organs and fertility. …”
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The Concept of Tawaqquf in Grammatical Analysis In the Context of Ibn Hishām’s Idea of Murāʻāt al-Maʻnā by Bünyamin Aydın

“…Accordingly, the context, with its internal and external elements, can determine not only the lexical meaning of the word, but also its functional meaning. From the interpreter’s point of view, the effects of contextual elements on grammatical analysis can be seen in the following ways: by not analyzing unknown words, by listing the possibilities in meaningful words or by making a choice based on contextual factors. …”
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Pain syndrome in rheumatoid arthritis by Ekaterina Sergeyevna Filatova, V V Alekseyev, Sh F Erdes

“…The patients with NCP were ascertained to be older, they were longer ill with RA, had higher clinical, X-ray stages and functional class, as well as higher pain intensity. …”
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Low-Noise Dynamic Reconstruction for X-Ray Tomographic Perfusion Studies Using Low Sampling Rates by Pau Montes, Günter Lauritsch

“…Functional imaging based on tomographic X-ray imaging relies on the reconstruction of a temporal sequence of images which accurately reproduces the time attenuation curves of the tissue. …”
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Expo ’58 and “the car as king” by Michel Hubert

“…As we approach a new bend in the technological road, only a massive investment plan in Brussels’s mass transport and the latter’s integration in a management and information system on the appropriate functional scale (the REN area) could offset the road network development plans that marked the three decades that began with Expo ’58. …”
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PECULIARITIES OF INHERITANCE AND TRANSGRESSIVE VARIABILITY OF GRAIN NUMBER IN INTRASPECIFIC HYBRIDISATION OF WINTER BREAD WHEAT by Halyna USTYNOVA, Mykola LOZINSKYI, Mykola GRABOVSKYI, Igor POKOTYLO, Yurii FEDORUK, Valerii KHAKHULA, Oksana LUPITKO, Taras PANCHENKO, Anatolii ALDOSH

“…Positive correlations (r = 0.932; r = 0.977) between the positive degree and the frequency of transgressive recombinants were found to be very strong and close to functional correlations (r = 0.932; r = 0.977). The inclusion of varieties of different vegetation periods in hybridisation contributes to the formation of F2 populations with the possibility of selecting economically valuable recombinants by the number of grains per main ear.…”
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Obesity Related Coronary Microvascular Dysfunction: From Basic to Clinical Practice by K. Selthofer-Relatić, I. Bošnjak, A. Kibel

“…The pathophysiological basis of coronary microcirculatory dysfunction consists of a heterogeneous group of disorders with individual morphologic/functional/clinical presentation and prognosis. Coronary microcirculatory changes include mechanisms connected with vascular dysfunction, as well as extravascular and vasostructural changes in responses to neural, mechanical, and metabolic factors. …”
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An arginine switch drives the stepwise activation of β-arrestin by CXCR7. by Jeong Seok Ji, Yaejin Yun, Tomasz Maciej Stepniewski, Hye-Jin Yoon, Kyungjin Min, Ji Young Park, Chiwoon Chung, Miguel Dieguez Eceolaza, Ka Young Chung, Jana Selent, Hyung Ho Lee

“…Canonically, interactions of βarr with the phosphorylated intracellular GPCR-tail induce a multi-step conformational transition that results in the activation of βarr. Depending on the specific interaction pattern with the receptor, βarrs adopt multiple conformational states, each tightly linked to a specific functional outcome of βarr recruitment. …”
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Identifying species traits that predict vulnerability to climate change by Damien A. Fordham

“…Accurately predicting the vulnerabilities of species to climate change requires a more detailed understanding of the functional and life-history traits that make some species more susceptible to declines and extinctions in shifting climates. …”
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VITAMINS WITH ANTIOXIDANT EFFECTS IN PROPHYLAXIS AND TREATMENT OF ACUTE RESPIRATORY INFECTIONS IN CHILDREN by E. V. Shikh

“…The presented analysis of clinical trials showed, that usage of antioxidant complex led to health and functional state improvement, appetite and sleep normalization. …”
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Key Trends in Upgrading Finance Accounting of Public Sector in View of Using Ipsas Standards by L. B. Trofimova

“…In the process of research the author specified characteristis of models for drawing up the report on results of finance operations by nature of costs and by their functional purpose depending on national specific features of conducting budget accounting in the concrete country.…”
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Industry Specifics and Consumers’ Reactions to Business Crises by Kazlauskienė Asta

“…Experimental research design, including online experiment with tobacco, beer and functional soft drinks consumers (in total 306 respondents), was chosen for competing research hypotheses testing. …”
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Scenario Approach to the Planning of the Production Activities of the Enterprise with a Discrete Type of Production (for Example, Electrical Engineering Industry) by Krylova E.V.

“…In conditions of global economic instability the success of electromechanical enterprises depends on their ability to react quickly to challenges of external environment. …”
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Effect of Coated Silver Nanoparticles on Cancerous vs. Healthy Cells by Liubov Artiukh, Olga Povnitsa, Svitlana Zahorodnia, Calin V. Pop, Nodari Rizun

“…The influence of silver nanoparticles coated with natural resin (Ag NPs) on the morphological and functional features of healthy BHK-21 and cancerous Hep-2 cells were studied using fluorescence microscopy, MTT, and neutral red assays. …”
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Proteoglycans in normal physiology and carcinogenesis by A. V. Suhovskih, E. V. Grigorieva

“…At present, many key PG are identified as possible diagnostic and prognostic molecular markers and target molecules for the creation of new antitumor drugs.The review describes the main PG types, their structure, localisation, functional role in normal cell and tissue physiology and participation in molecular mechanisms of carcinogenesis.…”
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Pain at chronic pancreatitis: origin and treatment options by V. T. Ivashkin, K. V. Ivashkin, A. V. Okhlobystin

“…Treatment efficacy in each given case depends on duly establishment and adequate treatment of complications, motivation for abstain of alcohol intake and smoking; strict diet restriction for relapse period, and functional rest for the pancreas.…”
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