CONVENTIONAL APPROACHES TO THE THERAPY OF HEREDITARY MYOPATHIES by M. V. Pokrovsky, M. V. Korokin, A. M. Krayushkina, N. S. Zhunusov, K. N. Lapin, M. O. Soldatova, E. A. Kuzmin, O. S. Gudyrev, I. S. Kochkarova, A. V. Deikin

“…At the same time, treatment approaches vary significantly depending on the type of myopathy and can be based on 1) substitution of the mutant protein; 2) an increase in its expression; 3) stimulation of the internal compensatory pathways expression; 4) restoration of the compounds balance associated with the mutant protein function (for enzymes); 5) impact on the mitochondrial function (with metabolic and mitochondrial myopathies); 6) reduction of inflammation and fibrosis (with muscular dystrophies); as well as 7) an increase in muscle mass and strength. …”
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Changes in glomerular filtration rate in liver recipients after reduced exposure to calcineurin inhibitors with concomitant everolimus administration within the first year after im... by V. E. Syutkin, A. A. Salienko, S. V. Zhuravel, M. S. Novruzbekov

“…At the time of ISxC, 32 (15%) of 215 recipients had normal renal function. Chronic kidney disease (CKD) increased in 60% of the recipients with normal eGFR by the end of the first year following ISxC; the fall in eGFR was particularly pronounced in older recipients. …”
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Cadaveric kidney allotransplantation at Krasnoyarsk Regional Clinical Hospital by V. S. Arutyunyan, A. V. Keosyan, M. A. Firsov, D. P. Evdokimov, M. R. Tsokaev, O. S. Amelchugova, E. V. Lukicheva

“…Hospitalization lasted for an average of 34.05 ± 9.56 days. Primary function was observed in 32 (45.08%) patients, while 39 (54.92%) cases had delayed function. …”
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Reconstruction of the temperature in the active layer of the glacier on the Western plateau of Elbrus for 1930–2008 by S. A. Tyuflin, O. V. Nagornov, G. A. Chernyakov, V. N. Mikhalenko, P. A. Toropov, S. S. Kutuzov

“…The boundary condition on the surface (the restored function of the temperature changes) was found as a finite sum of harmonics with indeterminate coefficients. …”
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Optimization method for main parameters of vibration protection system in motor grader seat with quasi-zero static characteristic by M. S. Korytov, I. E. Kashapova, V. S. Shcherbakov

“…RMS vertical acceleration of a seat in a stationary coordinate system was taken as the target function for optimizing the design parameters of the vibration protection system of a seat. …”
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Expression of early biomarkers in gentamicin-induced nephrotoxicity in rats by Chen Menglu, Luo Qihui, Sun Fengjiao, Chen Zhengli, Li Mingyang, Zeng Wen, Gong Li, Cheng Anchun, Peng Xi, Fang Jing, Tang Li, Geng Yi, Chen Xiaolu

“…Rapid diagnosis is vital to preserve renal function and to slow down renal injury. Owing to the poor sensitivity and specificity of serum creatinine (SCr) and blood urea nitrogen (BUN), there is a strong need for the identification and validation of more sensitive and reliable biomarkers. …”
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KIR and HLA-C interactions promote differential dendritic cell maturation and is a major determinant of graft failure following kidney transplantation. by Raj Hanvesakul, Chandrashekhar Kubal, Jason Moore, Desley Neil, Mark Cook, Simon Ball, David Briggs, Paul Moss, Paul Cockwell

“…<h4>Background</h4>HLA-C is an important ligand for killer immunoglobulin like receptors (KIR) that regulate natural killer (NK) cell function. Based on KIR specificity HLA-C molecules are allocated into two groups, HLA-C1 or HLA-C2; HLA-C2 is more inhibiting to NK cell function than HLA-C1. …”
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Exploiting mitochondrial dysfunction to overcome BRAF inhibitor resistance in advanced melanoma: the role of disulfiram as a copper ionophore by Bolun Zhao, Fazhan Ban, Yuehua Li, Qiong Shi, Sen Guo, Xiuli Yi, Huina Wang, Tianwen Gao, Chunying Li, Guannan Zhu

“…We provided evidence that DSF induced cell death in BRAFi-resistant melanoma in a copper-dependent manner, severely impairing mitochondrial structure and function through increased oxidative stress. …”
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Assessing sexual dysfunction in patients with external genital endometriosis by E. Begovich, A. G. Solopova, S. V. Khlopkova, E. A. Son, J. Yu. Ungiadze, L. E. Idrisova

“…External genital endometriosis (EGE) is a chronic, relapsing disease that affects various aspects of sexual function, the quality of sexual and interpersonal relationships, physical and psycho-emotional health and leads to social maladjustment and anxiety-depressive disorders, resulting in progressively decreased quality of life (QoL).Aim: to analyze an impact of sexual disorders on QoL of women with painful and painless EGEs.Materials and Methods. …”
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Simulación numérica de un nuevo sensor de anisotropía magnética//Numeric Simulation of a new magnetic anisotropy sensor by Gustavo Eugenio Carro-Hernández, Carlos Manuel Cruz-Inclán, Josué Arteche-Díaz, Antonio Leyva-Fabelo

“…The characterization of the new sensor response function was carried out using the numeric simulation. …”
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Association of abdominal aortic calcification with cognitive impairment in peritoneal dialysis patients by Conghui Liu, Yanan Shi, Jiajie Cai, Tingting Bai, Jingjing Li, Lingju Yue, Zhongxin Li

“…The purpose of this study was to determine whether abdominal aortic calcification (AAC) may have an impact on PD patients’ cognitive function. Methods In this cross-sectional study of 110 PD patients, cognitive function was assessed using the Montreal Cognitive Assessment (MoCA), and AAC severity was quantified via lateral lumbar radiography (Kauppila method). …”
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New Possibilities in Quantitative Assessment of Albuminuria in Patients with Atrial Fibrillation and Chronic Kidney Disease by A. A. Sokolova, A. I. Skripka, I. I. Ivanov, V. V. Kogay, A. I. Listratov, A. A. Gindis, D. A. Napalkov

“…When comparing the renal function of patients with and without DM after 15 months statistically significant differences were also not found (p = 0.510).Conclusion. …”
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Mathematical Model of an Antenna-Waveguide Path with Separation of Signals by Frequency–Polarization by D. D. Gabriel’ean, A. E. Korovkin, S. I. Boychuk, S. V. Dvornikov, M. R. Bibarsov, G. Sh. Bibarsova

“…This task involves the construction of an adequate mathematical model of AWP MMA both without and with the implementation of an auto-tracking function built using the "frequency separation – polarization separation" method. …”
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The small molecule LOXL2 inhibitor SNT-5382 reduces cardiac fibrosis and achieves strong clinical target engagement by Lara Perryman, Alison Findlay, Jana Baskar, Brett Charlton, Jonathan Foot, Ross Hamilton, Dieter Hamprecht, Amar Joshi, Jessica Stolp, Craig Turner, Amna Zahoor, Wenbin Zhou, Begoña López, Susana Ravassa, Arantxa González, Wolfgang Jarolimek

“…Abstract Cardiac remodeling involves myocardial hypertrophy and fibrosis which impairs cardiac function and, ultimately, contributes to heart failure (HF) and mortality. …”
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Malignant otitis externa: What is the role of surgery? by Lisa Zhang, Joseph Bonanno, Woo Yul Byun, Yin Ren

“…Patients with poor FN function at presentation were more likely to undergo surgical intervention. …”
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Cancer metabolism rewiring and chromatin methylation: a vulnerable epi-metabolic link by Sandra Atlante, Sandra Atlante, Veronica Barbi, Carlo Gaetano, Barbara Illi

“…Whereas higher levels of expression of metabolic enzymes may be considered a conceivable compensatory mechanism to satisfy the increasing request of energy of tumor cells, the detection of changes in the amount and species of intermediate metabolites (oncometabolites) and the discovery of their functional role as co-factors and structural components of chromatin modifiers tightened the link between metabolic shifts and epigenome reshaping in cancer. …”
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Pain Medication in Chronic Low Back Pain by Ali Jerjir, Frederik Nietvelt, Iris Smet, Nina D’hondt, Jean-Pierre Van Buyten

“…Chronic low back pain (CLBP) significantly impacts individuals’ quality of life and functional abilities. In non-oncological settings, CLBP is often treated for long periods using pharmacotherapy. …”
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The Nuclear Quadrupole Resonance and Sensory Properties of GaSe and InSe Layered Semiconductors by A.P. Samila, V.O. Khandozhko, Z.D. Kovalyuk

“…An experimental installation pulse NQR method based on multi-functional software-controlled digital processing core is implemented in the FPGA Altera Cyclone. …”
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Back-propagation-assisted inverse design of structured light fields for given profiles of optical force by Zhao Xiaoshu, Lin Haoze, Chen Huajin, Zheng Hongxia, Ng Jack

“…The modus operandi relies on the back-propagation algorithm, which is facilitated by the currently available machine learning framework, and, in particular, by an exact and efficient expression of OF that shows only polynomial and trigonometric functional dependence on the engineered parameters governing the structured light field. …”
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Senescence-induced p21high macrophages contributed to CD8+ T cells-related immune hyporesponsiveness in kidney transplantation via Zfp36/IL-27 axis by Tingting Zhu, Qixia Shen, Lingling Shen, Yucheng Wang, Bochen Zhu, Lifeng Ma, Shi Feng, Cuili Wang, Sijing Yan, Jingyi Li, Zhimin Chen, Jingyi Zhou, Hongfeng Huang, Bingjue Li, Zhouji Shen, Qian Wang, Jianwei Wang, Wilfried Gwinner, Irina Scheffner, Song Rong, Bing Yang, Junwen Wang, Hermann Haller, Xiaoping Han, Guoji Guo, Zhinan Yin, Jin Jin, Hui-Yao Lan, Jianghua Chen, Hong Jiang

“…Abstract Recipients’ age has emerged as a key factor that impacts on acute renal allograft rejection and graft survival. Age-related functional and structural changes in the immune system have been observed, yet the precise influence of aged immunity on kidney transplant remains unclear. …”
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