Therapeutic potential of cedrol in alleviating cognitive impairments in aluminum chloride-induced Alzheimer's disease: A biomarker-based approach by Mohd Sajad, Rafat Ali, Rajesh Kumar, Nida Jamil Khan, Shadma Wahab, Saad Ali Alshehri, Sonu Chand Thakur

“…Key findings: The study found that Cedrol improved cognitive impairment in a dose-dependent manner by reducing oxidative stress and enhancing cholinergic function. …”
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Sulforaphane Wrapped in Self-Assembled Nanomicelle Enhances the Effect of Sonodynamic Therapy on Glioma by Yihong Li, Xuejie Yang, Zhen Wei, Heng Niu, Liyang Wu, Caijing Chen, Huina Liu, Ting Cai, Huadong Fan

“…<b>Results/Conclusions:</b> SFN@RB@SPM can be internalized by the glioma cells through the tumor-targeting motif RGDS (abbreviated for the peptide sequence composed of arginine, glycine, aspartic acid, and serine), and further executes antitumor function during SDT. Also, SFN@RB@SPM could be easily taken up by U87-MG cells and cross the BBB in glioma-bearing mice during SDT. …”
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Impact of vitamin D on hyperoxic acute lung injury in neonatal mice by Thu T. Tran, Jonathan Davies, Richard A. Johnston, Harry Karmouty-Quintana, Huiling Li, Caroline E. Crocker, Amir M. Khan, Joseph L. Alcorn

“…Our objective was to determine if VitD provides a dose-dependent protective effect against HALI by reducing inflammatory cytokine expression and improving alveolarization and lung function in neonatal mice. …”
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NFATc1 deficiency in B cells ameliorates atopic dermatitis by Hidaya Abdul Kader, Syed Sabih Ur Rehman, Dhanya Saraswathiamma, Sadiya Sadiq Shiek, Antonio A. Bencomo-Hernández, Ubaid Rahman Moorakkan, Muhammad Touseef Haider, Nayla Munawar, Rabah Iratni, Edgar Serfling, Mohammad Tauqeer Alam, Khalid Muhammad

“…NFATc1, a transcription factor, operates through a calcium-dependent calcineurin/calmodulin pathway to regulate target genes and is vital in immune system development and function. …”
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Transgenerational epigenetic self-memory of Dio3 dosage is associated with Meg3 methylation and altered growth trajectories and neonatal hormones by M. Elena Martinez, Aldona Karaczyn, Zhaofei Wu, Christian A. Bennett, Kassey L. Matoin, Heather M. Daigle, Arturo Hernandez

“…Previous studies in rodent and human models have shown that abnormal developmental exposure to thyroid hormone affects endocrine function and thyroid hormone sensitivity in later generations. …”
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Atrium Design in Hot and Dry Climates: Understanding the Influence of Achitectural Form Variation on Indoor Thermal Conditions by Khalida Boussebci, Noureddine Zemmouri, Chafik Mahaya

“… The atrium is becoming more prevalent in desert regions as a key architectural and functional element in the urban landscape. In southern Algerian cities, we are observing an increasing integration of centralized atriums in public buildings. …”
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Tumor-associated neutrophil precursors impair homologous DNA repair and promote sensitivity to PARP inhibition by Siddhartha Mukherjee, Cindy Garda, Letizia Boffa, Angela Rita Elia, Matteo Massara, Maria Teresa Balia, Daniela Brina, Simone Mosole, Anna Campagnari, Giada Andrea Cassanmagnago, Andrea Rinaldi, Giacomo Lazzaroni, David Jarrossay, Diego Morone, Ilaria Ceppi, Riccardo De Sillo, Isabella Giacomini, Ilaria Craparotta, Laura Di Rito, Simon Barry, Endre Laczko, Sebastian Streb, Francesco Meani, Simona Di Lascio, Nancy Hynes, Enrico Lugli, Simone Puccio, Stephen-John Sammut, Ulrike Perriard, Yves Harder, Lorenzo Rossi, Maria Luisa Gasparri, Marco Bolis, Petr Cejka, Arianna Calcinotto

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Radioactive Imagine Agents: 99mTc-Toxicological Study by Kafa Khalaf Hammud

“…Many biomolecules labeled with Technetium-99 in relationship to toxicity issues can be transported, distributed, and detected with the computerized algorithm detector depending upon chemical, biological, metabolic, and functional properties of tissue or organ (bone, liver, heart, kidney, and others). …”
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Non-parametric Kernel Estimation of Weighted Dynamic Cumulative Past Inaccuracy Measure Based on Censored Data by K.V. Viswakala, E.I. Abdul Sathar

“…When the observations generated by a stochastic process are recorded using a weight function, weighted distributions are established. Based on right-censored dependent data, we provide a nonparametric estimate for the weighted dynamic cumulative past inaccuracy measure in this study. …”
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Anomalous Long-Ranged Influence of an Inclusion in Momentum-Conserving Active Fluids by Thibaut Arnoulx de Pirey, Yariv Kafri, Sriram Ramaswamy

“…When the inclusion is held in place, the far-field fluid flow is a Stokeslet, while the microswimmer density decays as 1/r^{2+ε}, with r the distance from the inclusion and ε an anomalous exponent which depends on the symmetry of the inclusion and varies continuously as a function of a dimensionless number characterizing the relative amplitudes of the convective and diffusive effects. …”
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Design and application of synthetic 17B-HSD13 substrates reveals preserved catalytic activity of protective human variants by Michelle R. Garnsey, Yang Wang, David J. Edmonds, Matthew F. Sammons, Benjamin Reidich, Youngwook Ahn, Yotam Ashkenazi, Anthony Carlo, Matthew A. Cerny, Karen J. Coffman, Jeffrey A. Culver, Anne-Marie Dechert Schmitt, Heather Eng, Ethan L. Fisher, Jemy A. Gutierrez, Larry James, Samantha Jordan, Jeffrey T. Kohrt, Melissa Kramer, Erik A. LaChapelle, Jack C. Lee, Jisun Lee, Dongmei Li, Zhenhong Li, Shenping Liu, Jianhua Liu, Thomas V. Magee, Melissa R. Miller, Michael Moran, Deane M. Nason, Nicole L. Nedoma, Steven V. O’Neil, Mary A. Piotrowski, Jillian Racich, Ruth F. Sommese, Lucy M. Stevens, Ann S. Wright, Jun Xiao, Liying Zhang, Dahui Zhou, Ornella Barrandon, Michelle F. Clasquin

“…Application to multiple cellular systems expressing the protective human variants reveals that the most prevalent IsoD variant maintains NAD-dependent catalytic activity towards some but not all substrates, contradicting reports that the truncation results in loss-of-function.…”
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Malvidin-3-galactoside from blueberry suppresses the growth and metastasis potential of hepatocellular carcinoma cell Huh-7 by regulating apoptosis and metastases pathways by Jie Lin, Jinlong Tian, Chi Shu, Zhen Cheng, Yunen Liu, Weisheng Wang, Ruihai Liu, Bin Li, Yuehua Wang

“…The compound is well-characterized by its anti-oncogenesis function in multiple organs including liver. In the current study, the mechanism driving the anti-hepatocellular carcinoma (HCC) function of Mv-3-gal was further explored by focusing on apoptosis and metastases pathways. …”
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Jump around: Selecting Markov Chain Monte Carlo parameters and diagnostics for improved food web model quality and ecosystem representation by Gemma Gerber, Ursula M. Scharler

“…We analysed ensembles with Ecological Network Analysis (ENA) to calculate indicators describing system function. Results show that LIM-MCMC algorithm parameters, in particular the jump size, affect ensemble flow values, which propagate to ecological indicators describing different ecosystem function of the same model. …”
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Male Akita diabetic mice develop underactive bladder independent of NLRP3 that can be prevented with blood glucose control by Austin J. Livingston, J. Todd Purves, Michael R. Odom, Huixia Jin, Francis M. Hughes, Jr.

“…Mice were assessed at 15 weeks for blood glucose, HbA1c, Evans blue dye extravasation (a marker of capillary permeability/inflammation) and bladder function. Results:: Blood glucose was elevated in diabetics, reduced in an insulin dose-dependent manner, and not affected by NLRP3 deletion. …”
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Method of Estimating the Equivalence of Dissolution Profiles: a Modern View (Review) by I. E. Shohin, N. S. Bagaeva, E. A. Malashenko, V. N. Kuzina

“…If f2 is not used, it is necessary to use model-dependent and model-independent methods that are statistically correct, and their use is sufficiently justified (difference factor f1, Weibull distribution function, comparison of release degrees at different time points (according to the student's t-criterion). …”
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Herpes Zoster Reactivation Following COVID-19 and the Risk of Renal, Infectious, and Autoimmune Complications: A Global Propensity-Matched Cohort Study by Ming-Hung Chien, Joshua Wang, Kuo-Cheng Lu, Chien-Lin Lu

“…Time-to-event analyses over a three-year follow-up period were conducted to estimate the risks of major adverse kidney events (MAKE; defined as acute kidney injury, dialysis dependence, or severely reduced kidney function with eGFR <30 mL/min/1.73 m²), sepsis, systemic lupus erythematosus (SLE), and rheumatoid arthritis (RA), using Kaplan–Meier survival curves and Cox proportional hazards models. …”
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Enhanced Conformer-Based Speech Recognition via Model Fusion and Adaptive Decoding with Dynamic Rescoring by Junhao Geng, Dongyao Jia, Zihao He, Nengkai Wu, Ziqi Li

“…Additionally, to further optimize the decoding process, we introduce a penalty function mechanism as a regularization technique to reduce the model’s dependence on a single decoding approach. …”
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Open-label randomised clinical trial investigating whether robot-assisted kidney transplantation can reduce surgical complications compared to open kidney transplantation (ORAKTx):... by Milla Ortved, Julia Dagnæs-Hansen, Hein V. Stroomberg, Thomas Kistorp, Malene Rohrsted, Søren Schwartz Sørensen, Andreas Røder

“…Abstract Background Kidney transplantation is the ultimate treatment for end-stage kidney disease. Function of the kidney graft is not only dependent on medical factors but also on a complication-free surgical procedure. …”
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Asterias amurensis lipids enhance the immunity of immunosuppressed mice as sustainable marine-eco materials by Ju Hyun Nam, JeongUn Choi, Weerawan Rod-in, A-yeong Jang, Jun Jae Jung, Sang-min Lee, Woo Jung Park

“…Results revealed that AA-PEG at 150 mg/kg BW promoted the recovery of cellular immune function in both splenocytes from the spleen and peritoneal macrophages, similar to the normal group. …”
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Continuous Estimation of Swallowing Motion With EMG and MMG Signals by Zhenhui Guo, Ziyang Wang, Yue Wang, Weiguang Huo, Jianda Han

“…Assessment of swallow function is crucial for managing OD, yet depends on devices for long-term monitoring during daily life and relevant methods for accurately assessing swallow function. …”
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