A kinetic model for USP14 regulated substrate degradation in 26S proteasome. by Di Wu, Qi Ouyang, Hongli Wang, Youdong Mao

“…The model elucidates that USP14 typically reduces the substrate degradation rate and reveals the functional dependence of this rate on the concentrations of substrate and adenosine triphosphate (ATP). …”
Get full text

Future Roadmaps for Precision Medicine Applied to Diabetes: Rising to the Challenge of Heterogeneity by P. Bowman, S. E. Flanagan, A. T. Hattersley

“…Advances in molecular genetics and functional laboratory techniques and availability and sharing of large population data provide exciting opportunities for human studies. …”
Get full text

Cytotoxic activity of peripheral blood lymphocytes in children with infectious mononucleosis by N. R. Slepicheva, O. I. Urazova, V. V. Novitsky, A. P. Pomogayeva

“…The present study is aimed at investigating the functional activity of cytotoxic lymphocytes in children with IM during clinical and hematological manifestation of the disease and early reconvalescence phase. …”
Get full text

Metagenomics approaches for studying the human microbiome by Biniam Moges, Degisew Yinur Mengistu

“…Hence, metagenomics analysis is a powerful advanced technology for comprehensively studying human microbial composition and diversity, exploring novel and antibiotic resistance genes, microbial metabolic pathways, functional dysbiosis, and co-evolution of the microbiome with the host. …”
Get full text

Evidence for a push-pull interaction between superior colliculi in monocular dynamic vision mode by Rita Gil, Mafalda Valente, Francisca F. Fernandes, Noam Shemesh

“…However, the associated pathway-wide mechanisms remain poorly understood, especially in terms of corticotectal and tectotectal feedback upon encoding the continuity illusion during the dynamic vision mode. Here, we harness functional MRI combined with rat brain lesions to investigate whole-pathway neural interactions in the dynamic vision mode. …”
Get full text

Morphology and electric potential-induced mechanical behavior of metallic porous nanostructures by Sunghan Kim, Andreas A. Polycarpou, Hong Liang

“…We suggest that the relation between electric potential and the mechanical behaviors of metallic porous nanostructures can be crucial for building mechanically robust functional devices, which are influenced by electric potential. …”
Get full text

MANAGEMENT AND VALORIZATION OF AGRICULTURAL WASTES FROM WINE PRODUCTION USING STATISTICAL ANALYSIS TO OBTAIN NOVEL FOOD by Gjore NAKOV, Zlatin ZLATEV, Iliana LAZOVA-BORISOVA, Jasmina LUKINAC

“…With proper treatment, this waste can be used to produce new functional foods. The aim of the article is to determine the exact amount of grape pomace powder (GPP) in cakes using statistical data processing using the "Correspondence Analysis" method and using an initial model (second-order polynomial). …”
Get full text

Modification of surface layers by high energy treatment by M. N. Vereschagin, S. N. Tselueva, M. Yu. Tseluev

“…The nature of heating, which is determined by the rate of change of temperature, temperature gradients, the time to reach the temperatures of structural and phase transitions, is different depending on the properties of the material being processed and the processing conditions.When modifying the surface layers by high-energy processing by changing the power and time of exposure to laser radiation, you can get a wide range of structural states of the treated surface areas of the material.It is shown that the shape of TVP diagrams and cooling curves of precision alloys on the surface of a two-layer metal system after heating them with laser radiation are determined by the competition of two processes acting in opposite directions: an increase in the driving force of the crystallization process with an increase in supercooling and a decrease in the surface of atoms.The method of surface modification by moving laser radiation allows to obtain amorphous functional layers of precision alloys on the surface of metal products.…”
Get full text

Visual BOLD Response in Late Blind Subjects with Argus II Retinal Prosthesis. by E Castaldi, G M Cicchini, L Cinelli, L Biagi, S Rizzo, M C Morrone

“…We studied the capability of plastic remodeling in late blind subjects implanted with the Argus II Retinal Prosthesis with psychophysics and functional MRI (fMRI). After surgery, six out of seven retinitis pigmentosa (RP) blind subjects were able to detect high-contrast stimuli using the prosthetic implant. …”
Get full text

CHARACTERISTICS OF MOTIVATION AND ITS RELATIONSHIP TO RESILIENCE IN KAZAKHSTANI PARALYMPIC ATHLETES by Yuliya Krasmik, Tatiana Iancheva, Bolat Rahmalin

“…Paralympic sport enables people with disabilities to significantly develop their functional abilities, improving their opportunities for full personal development and social integration. …”
Get full text

Designing of hydroxyapatite-gelatin based porous matrix as bone substitute: Correlation with biocompatibility aspects

“…The prepared composites were characterized by Fourier transform spectroscopy (FTIR) which revealed the presence of functional groups in the composite. The X-ray diffraction (XRD) studies indicated that HA powder was present in nano size. …”
Get full text

Interplay of gene expression noise and ultrasensitive dynamics affects bacterial operon organization. by J Christian J Ray, Oleg A Igoshin

“…We hypothesized that operons alter gene expression noise characteristics, resulting in selection for or against maintaining operons depending on network architecture. Mathematical models for 6 functional classes of network modules showed that three classes exhibited decreased noise and 3 exhibited increased noise with same-operon cotranscription of interacting proteins. …”
Get full text

DOLOMITE THERMAL-DECOMPOSITION MACROKINETIC MODELS FOR EVALUATION OF THE GASGENERATORS SORBENT SYSTEMS by K. V. Dobrego

“…Such technics can be founded on thermogravimetric data and standard approximation error minimizing algorithms.The author assumes that CO2  evacuation from the reaction zone within the particle may proceed by diffusion mechanism and/or by the Darcy filtration and indicates that functional dependence of the thermal-decomposition rate from the particle sizes and the temperature differs for the specified mechanisms. …”
Get full text

Vascularized Palmaris Longus Tendon Graft in Delayed Tendon Injuries of Hand by Yog Raj Handoo

“…Delayed tendon injuries of the hand often require auto tendon grafts, the success depending largely on tendon type, its own synovial cover or provided by tendon bed, and tendon bed vascularity. …”
Get full text

<b>Nitric oxide and exercise: a review</b> - doi: 10.4025/reveducfis.v23i3.11738 by Tácito Pessoa Souza Junior, Ricardo Yukio Asano, Jonato Prestes, Marcelo Magalhães Sales, João Maurício Coelho, Herbert Gustavo Simões

“…Studies have demonstrated the role of NO in preserving the functional capacity of the endothelium, preventing atherosclerosis, vascular injury, hypertension and others. …”
Get full text

Thio-NHS esters are non-innocent protein acylating reagents by Weibing Liu, Aziz Khan, Yana Demyanenko, Shabaz Mohammed, Benjamin G. Davis

“…The resulting formation of bioconjugates with unintended, unstable linkages and modifications suggests the re-evaluation of: (i) known commercial reagents; and (ii) functional conclusions previously drawn using NHS esters in areas as diverse as antibody-drug biotherapy, vaccination and cross-link-enabled structural analyses.…”
Get full text

Delayed Station Blackout Event and Nuclear Safety by Andrija Volkanovski, Andrej Prošek

“…The reduction of the CDF depends on the time delay of the SBO after the LOOP event. …”
Get full text

Ligand-Free Polymeric Catalysts for Suzuki, Sonogashira and Heck Cross-Coupling Reactions: Influence of Support Hydrophobicity. by Elena S. Bakhvalova, Nadezhda A. Mavrenkova, Alexey V. Bykov, Linda Zh. Nikoshvili

“…In this study, new data are presented on the behavior of Pd nanoparticles (NPs) stabilized in naphthalene-based polymers containing different functional groups (hydroxyl, sulfonate, and nitro groups) in cross-coupling reactions (Suzuki, Sonogashira, and Heck). …”
Get full text

ADAM9 Genetic Variants and Their Role in Modulating Enzyme Activity in Diabetes and Metabolic Traits by Hana Drobiova, Fahd Al-Mulla, Rabeah Al-Temaimi

“…A disintegrin and metalloproteinase Domain 9 (ADAM9) is a zinc-dependent proteinase involved in various biological processes. …”
Get full text

Structure and properties of resole resin crosslinked vulcanizates of natural rubber grafted with polymethylmethacrylate by Nabil Hayeemasae, Siriwat Soontaranon, Abdulhakim Masa

“…Moreover, the thermal stability of the graft copolymers was also improved over that of the plain NR at least 23 °C, depending on MMA contents. These improvements are tentatively attributed to the strong adhesion between NR and PMMA phases, based on interactions between the functional groups of PMMA and hydrogen bonding between phenolic resin crosslinker and PMMA. …”
Get full text