Mapping the hippocampal spatial proteomic signature in male and female mice of an early Alzheimer’s disease model by Ana Contreras, Raquel Jiménez-Herrera, Souhail Djebari, Juan D. Navarro-López, Lydia Jiménez-Díaz

“…Abstract Background Hippocampal dysfunction induced by soluble amyloid-β oligomers (oAβ) is an early neuropathological hallmark of Alzheimer’s disease (AD). oAβ shifts hippocampal synaptic-plasticity induction threshold facilitating long-term depression (LTD) instead of long-term potentiation (LTP, the functional basis of memory), thereby leading to memory deficits in early AD-like amyloidosis mouse models. …”
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Quality of life and associated factors among patients with cancer receiving chemotherapy at Dessie Comprehensive Specialized Hospital, North-East Ethiopia: a cross-sectional study by Ewunetie Mekashaw Bayked, Mekdes Getachew Yimam, Zemen Mengesha Yalew, Husien Nurahmed Toleha, Segenet Zewdie

“…About 54.8% and 31.7% reported good overall health status and good overall QoL, respectively. The most impacted functional domain was social functioning, affecting 64.5% of participants. …”
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Direct effects of prolonged TNF-α and IL-6 exposure on neural activity in human iPSC-derived neuron-astrocyte co-cultures by Noah Goshi, Doris Lam, Chandrakumar Bogguri, Vivek Kurien George, Aimy Sebastian, Jose Cadena, Nicole F. Leon, Nicholas R. Hum, Dina R. Weilhammer, Nicholas O. Fischer, Heather A. Enright

“…In this study, we characterized the changes in neural functionality, secreted cytokine profiles, and gene expression in co-cultures of human iPSC-derived neurons and primary astrocytes in response to prolonged exposure to TNF-α and IL-6. …”
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A genome-wide shRNA screen uncovers a novel potential ligand for NK cell activating receptors by Paolo Romania, Loredana Cifaldi, Loredana Cifaldi, Paula Gragera, Valerio D’Alicandro, Matteo Caforio, Valentina Folgiero, Valeria Lucarini, Ombretta Melaiu, Ombretta Melaiu, Roberto Bei, Franco Locatelli, Franco Locatelli, Doriana Fruci

“…IntroductionNatural Killer (NK) cells play a key role in both innate and adaptive immune responses against viruses and tumor cells. Their function relies on the dynamic balance between activating and inhibitory signals, which are mediated by receptors that bind ligands expressed on target cells. …”
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The Invertebrate-Derived Antimicrobial Peptide Cm-p5 Induces Cell Death and ROS Production in Melanoma Cells by Ernesto M. Martell-Huguet, Daniel Alpízar-Pedraza, Armando Rodriguez, Marc Zumwinkel, Mark Grieshober, Fidel Morales-Vicente, Ann-Kathrin Kissmann, Markus Krämer, Steffen Stenger, Octavio L. Franco, Ludger Ständker, Anselmo J. Otero-Gonzalez, Frank Rosenau

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Ambient low-level benzene, genetic factors, and heart failure incidence among urban adults by Yongxuan Li, Yujia Bao, Jiawei Gu, Zheshen Han, Xiaobei Deng, Wei Mu, Hui Wang, Hongchao Qi, Lefei Han, Jinjun Ran

“…Furthermore, the effect of ambient benzene on cardiac functional parameters was estimated using multiple linear regression models. …”
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Receptor interacting protein kinase 1 activation and triggering mesangial cells necroptosis in MRL/lpr mice model of lupus nephritis by Lin Peng, Xiaodong Xu, Pengcheng Wang, Fan Yang, Xiaodong Zhu, Shuying Yang, Hongguang Xia, Zhihong Liu, Weisong Qin

“…Firstly, the involvement of RIPK1/RIPK3/MLKL-dependent necroptosis was shown in the mesangial cells of MRL/lpr mice. …”
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Alteration in ATR protein level does not account for the inherent radiosensitivity of HPV-positive head and neck squamous cell carcinoma by Sibylla Kohl, Florentine S.B. Subtil, Vanessa Climenti, Houmam Anees, Ann C. Parplys, Rita Engenhart-Cabillic, Sebastian Adeberg, Ekkehard Dikomey, Ulrike Theiß

“…Protein level was almost two-fold lower in HPV-positive compared to HPV-negative cells, but fully functional as observed by active phosphorylation in response towards irradiation. …”
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Application of Deep Learning Techniques in Uranium Microparticle Fission Track Detection by ZHAO Xiong, REN Fangda, SHEN Yan

“…It is found that the integrated network alters the performance of the loss functions, with the DIOU loss function being most compatible with the YOLOv5-ST network. …”
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Analysis and Calculation of DC-link Ripple for the Inverter in Electric Vehicle by WU Chundong, LI Yun, JIAO Mingliang, ZHU Shiwu

“…Based on the SVPWM modulation mode and its latent modulation wave function, the calculation formulas of ripple current and ripple voltage of DC-link capacitor were deduced and analyzed under different operation conditions.…”
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ONE-DIMENSIONAL TREATMENT OF HYDROGEN BOND PART1 THE CASE OF THE LINEAR HYDROGENBOND

“…The possibility of obtaining the semi-empircal parameters in the Lippincott and Schroeder potential function from OH Stretchihg frequeficies , hydrogen bond energy and geometrical parameters has been discussed…”
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Parameter Estimation in Mean Reversion Processes with Deterministic Long-Term Trend by Freddy H. Marín Sánchez, Verónica M. Gallego

“…This paper describes a procedure based on maximum likelihood technique in two phases for estimating the parameters in mean reversion processes when the long-term trend is defined by a continued deterministic function. Closed formulas for the estimators that depend on observations of discrete paths and an estimation of the expected value of the process are obtained in the first phase. …”
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Determination of possibilities of the use of high-intensive trainings facilities on lessons health aerobics by N.A. Bryukhanova, O.V. Bulgakova, T.I. Mokrova, Y.A. Bogashchenko

“…Also appeared, that 14 from 89 students have weak functional preparedness: already at the rate of music of 138-142 shots in a minute and height of step platform 15 centimetre, heart rate for them attained an age-dependent maximum (on the average 207 shots in a minute). …”
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Role of lactic acid bacterial enzymes in forming antioxidant potential of fermented milk products by Bychkova T. S., Krutina E. M., Diaghileva Yu. A.

“…Lactobacillus acidophilus and other probiotic microorganisms have high enzymatic activity, improving the bioavailability of nutrients and contributing to the formation of functional products. The antioxidant potential of fermented dairy products depends on the type of microorganisms, fermentation conditions, and milk composition.…”
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Utility of Botulinum Injections in Stiff-Person Syndrome by L. M. Conners, A. Betcher, A. Shahinian, P. Janda

“…Furthermore, a wide-based gait with functional impairment is generally seen. High-dose benzodiazepines or baclofen are widely considered the optimal initial therapy; however, major adverse effects often preclude adequate dosing. …”
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Optimal estimates of trace distance between bosonic Gaussian states and applications to learning by Lennart Bittel, Francesco Anna Mele, Antonio Anna Mele, Salvatore Tirone, Ludovico Lami

“…In this work, we fully resolve this question by demonstrating that if the first and second moments are known up to an error $\varepsilon$, the trace distance error on the state also scales as $\varepsilon$, and this functional dependence is optimal. To prove this, we establish tight bounds on the trace distance between two Gaussian states in terms of the norm distance of their first and second moments. …”
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Reconstruction of the Tongue after Hemiglossectomy Using Serratus Anterior Muscle Free Flap by Petr Šín, Alica Hokynková, Pavel Rotschein, Radek Pejčoch, Lucie Nártová

“…There was not a single case of flap failure observed and the donor site healed completely in all cases. The functional outcome (tongue mobility, phonation, and deglutition) depended on the severity of the primary oncological disease and health status of the patient. …”
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Impact of the Allee Effect on the Dynamics of a Predator–Prey Model Exhibiting Group Defense by Manoj Kumar Singh, Arushi Sharma, Luis M. Sánchez-Ruiz

“…This research paper examines the impact of integrating the Allee effect on the dynamics of a predator–prey model, including a density-dependent functional response that reflects the defensive strategies of the prey population. …”
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Acute Blood Loss: Regional Blood Flow and Microcirculation (Review, Part II) by V. V. Moroz, I. A. Ryzhkov

“…It was shown that microcirculatory alterations in a particular organ are largely determined by the structural and functional features of its blood supply, as well as by the role of this organ in the pathogenesis of acute blood loss. …”
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Modeling of Wastewater Sludge Dewatering Kinetics Using the Method of Linear Proportionalities by Orest Verbovskyi, Vadym Orel, Volodymyr Femiak

“…Modeling was carried out using the method of linear proportions, which allowed the derivation of a uniform functional dependence under different combinations of similarity numbers.…”
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