FIBCD1 is an endocytic GAG receptor associated with a novel neurodevelopmental disorder by Christopher W Fell, Astrid Hagelkruys, Ana Cicvaric, Marion Horrer, Lucy Liu, Joshua Shing Shun Li, Johannes Stadlmann, Anton A Polyansky, Stefan Mereiter, Miguel Angel Tejada, Tomislav Kokotović, Venkat Swaroop Achuta, Angelica Scaramuzza, Kimberly A Twyman, Michelle M Morrow, Jane Juusola, Huifang Yan, Jingmin Wang, Margit Burmeister, Biswa Choudhury, Thomas Levin Andersen, Gerald Wirnsberger, Uffe Holmskov, Norbert Perrimon, Bojan Žagrović, Francisco J Monje, Jesper Bonnet Moeller, Josef M Penninger, Vanja Nagy

“…Together, we identified FIBCD1 as an endocytic receptor for GAGs in the brain ECM and a novel gene associated with an NDD, revealing a critical role in nervous system structure, function and plasticity.…”
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Skin Homeostasis is Impaired in Hidradenitis Suppurativa Lesions: A Comparative Study by A. Soto-Moreno, N. Delgado-Moya, M. Sánchez-Díaz, S. Arias-Santiago, A. Molina-Leyva

“…A trend of increasing TEWL values was observed as a function of Hurley stage. Conclusion: HS lesions exhibit epidermal barrier dysfunction that depends on the severity of inflammatory activity. …”
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[Artículo traducido] Alteración de la homeostasis cutánea en lesiones de hidradenitis supurativa, un estudio comparativo by A. Soto-Moreno, N. Delgado-Moya, M. Sánchez-Díaz, S. Arias-Santiago, A. Molina-Leyva

“…A trend of increasing TEWL values was observed as a function of Hurley stage. Conclusion: HS lesions exhibit epidermal barrier dysfunction that depends on the severity of inflammatory activity. …”
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Profiling of pathogenic variants in Japanese patients with sarcoglycanopathy by Rui Shimazaki, Yoshihiko Saito, Tomonari Awaya, Narihiro Minami, Ryo Kurosawa, Motoyasu Hosokawa, Hiroaki Ohara, Shinichiro Hayashi, Akihide Takeuchi, Masatoshi Hagiwara, Yukiko K. Hayashi, Satoru Noguchi, Ichizo Nishino

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Among Independence, Sovereignty and Autonomy: The Dutch Caribbean by Mine Kojima

“…This paper critiques the structure and functionality of the 21st century nation-state through analysis of emancipatory decisions in the former Dutch Caribbean colonies of Aruba, Curaçao, and Suriname.Suriname, the most culturally Dutch of the Caribbean territories, was the first of the former colonies to secede from the Netherlands. …”
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Mathematical modeling of technological parameters of laser powder surfacing based on approximation of the deposition track profile by Mikhail E. Soloviev, Denis V. Malyshev, Sergey L. Baldaev, Lev Kh. Baldaev

“…A nonlinear two-parameter function was selected from three options for approximating functions of the section profile of a surfacing track. …”
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WNK2 variants associated with familial osteoarthritis alter the chondrocyte response to hyperosmotic stress by Chris Stubben, Gregory J Stoddard, Michael J Jurynec, Matthew Honeggar, Shivakumar R Veerabhadraiah, Nikolas H Kazmers, David J Grunwald, Derek J Matheson, Collin Aslor, Antonio C Zelada

“…Transcriptomic analyses were used to identify genes and pathways dependent on WNK2 function and hyperosmotic stress.Results We identified novel coding variants of WNK2 associated with familial erosive hand OA and foot OA. …”
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Chromatin remodeling protein BPTF mediates chromatin accessibility at gene promoters in planarian stem cells by Prince Verma, John M. Allen, Alejandro Sánchez Alvarado, Elizabeth M. Duncan

“…However, we found that genes marked by Set1-dependent H3K4me3, but not MLL1/2-dependent H3K4me3, showed increased sensitivity to the loss of BPTF-dependent accessibility. …”
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Surgical treatment of primary and recurrent pterygium by I. A. Filatova, J. P. Kondratyeva, Yu. I. Borodin

“…It was shown that primary pterygium of the I degree should best be operated according to McReynolds method, pterygium of the II degree or higher should optimally be removed with conjunctival plastics by a free flap grafting, while for recurrent pterygium of the III degree or higher, combined treatment is recommended: removal of the pterygium using brachytherapy.Conclusion. For an adequate functional result of surgery, an individual approach is required for each case depending on pterygium proliferation stage.…”
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Global stability of a network-based SIS epidemic model with a general nonlinear incidence rate by Shouying Huang, Jifa Jiang

“…It is interesting that the threshold value $R_0$ bears no relation to the functional form of the nonlinear incidence rate and degree-dependent birth. …”
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LONG-LIVED BONE MARROW PLASMA CELLS DURING IMMUNE RESPONSE TO ALPHA (1→3) DEXTRAN by I. N. Chernyshova, M. V. Gavrilova, L. V. Komarova, E. V. Sidorova

“…The in vitro experiments have shown that supplementation of bone marrow cells from immune mice with dextran did not influence their functional activity. It was previously shown for cells responding to T-dependent antigens only. …”
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Mechanisms of vaccine protection in chickens against challenge with virulent Mycoplasma synoviae by Kanishka I. Kamathewatta, Anna Kanci Condello, Pollob K. Shil, Amir H. Noormohammadi, Neil D. Young, Glenn F. Browning, Kelly A. Tivendale, Nadeeka K. Wawegama

“…In vaccinated-challenged chickens, functional categories enriched with up-regulated genes included IL4 production, TCR signalling (without T-cell co-stimulation), T-cell activation/proliferation/differentiation and B-cell activation/proliferation. …”
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Prognostic factors for work disability in patients with chronic widespread pain and fibromyalgia: protocol for a cohort study by Robin Christensen, Marius Henriksen, Eva Ejlersen Wæhrens, Henning Bliddal, Lars Erik Kristensen, Karsten Thielen, Henning Locht, Kirstine Amris, Pernille H Duhn

“…Although research support large interindividual differences in functional outcomes, limited studies are available on the socio-economic consequences of offering stratified treatment based on prognostic factors. …”
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GluA2 palmitoylation by SELENOK modulates AMPAR assembly and synaptic plasticity in Alzheimer's disease by Jiaying Peng, Zhiyu Cai, Pei Ouyang, Shujing Lin, Shurui Zhang, Danchan Liang, Ziqi Feng, Changbin Chen, Xilin Ye, Guoli Song, Zhonghao Zhang

“…Importantly, neuronal overexpression of SELENOK in the hippocampus restored synaptic plasticity and cognitive function in AD mice. Overall, this study uncovers a novel SELENOK-dependent mechanism regulating AMPAR assembly, offering experimental support for developing Se-based therapeutic strategies for AD.…”
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The DCR protein TTC3 affects differentiation and Golgi compactness in neurons through specific actin-regulating pathways. by Gaia Elena Berto, Cristina Iobbi, Paola Camera, Elena Scarpa, Corinne Iampietro, Federico Bianchi, Federico Bianchi, Marta Gai, Francesco Sgrò, Flavio Cristofani, Annette Gärtner, Carlos G Dotti, Ferdinando Di Cunto

“…However, the functional relationships between these molecules differ significantly if considering the TTC3 activity on neurite extension or on Golgi organization. …”
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CREB Activation Mediates Plasticity in Cultured Hippocampal Neurons by Menahem Segal, Diane D. Murphy

“…Such stimuli share with estradiol the same mechanism of action in that both require activity-dependent CREB phosphorylation. Our observations suggest that CREB phosphorylation is a necessary, but perhaps not sufficient, step in the process leading to the generation of new dendritic spines and perhaps to functional plasticity as well.…”
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Orthodontic Treatment of Bilateral Transposition of Maxillary Canines and Lateral Incisors by Mandla Dominic Nyakale

“…Successful treatment outcomes depend on the patient’s age, concern about facial and dental aesthetics, motivation of the patient, functional requirements, type of malocclusion, and the position of the root apices. …”
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ECOLOGICAL SAFETY OF RURAL AREAS: ECOLOGICAL AND ECONOMIC ASSESSMENT OF LAND USE EFFICIENCY by Anton TRETIAK, Nataliia TRETIAK, Yurii SKLIAR, Yuliia LOBUNKO, Andrii MELNICHUK

“…The analysis shows that the ecological balance depends on the structure of land use and the functional use of land. …”
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Rate of Return on Education in Indonesia: The Privilege of A High Economic Group and Urban Areas by Yusuf Faisal Martak, C Chotib

“…Using the Mincer equation, the results of the study show that urban types functionally and administratively have a higher average rate of return than functional and administrative rural areas of 2.9% and 1.9%, respectively. …”
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Transcription of a centromere-enriched retroelement and local retention of its RNA are significant features of the CENP-A chromatin landscape by B. J. Chabot, R. Sun, A. Amjad, S. J. Hoyt, L. Ouyang, C. Courret, R. Drennan, L. Leo, A. M. Larracuente, L. J. Core, R. J. O’Neill, B. G. Mellone

“…Abstract Background Centromeres depend on chromatin containing the conserved histone H3 variant CENP-A for function and inheritance, while the role of centromeric DNA repeats remains unclear. …”
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