Disruption of glutamine transport uncouples the NUPR1 stress-adaptation program and induces prostate cancer radiosensitivity by Uğur Kahya, Vasyl Lukiyanchuk, Ielizaveta Gorodetska, Matthias M. Weigel, Ayşe Sedef Köseer, Berke Alkan, Dragana Savic, Annett Linge, Steffen Löck, Mirko Peitzsch, Ira-Ida Skvortsova, Mechthild Krause, Anna Dubrovska

“…This effect is more pronounced in PCa cells with high dependency on OXPHOS for energy production. Conclusions Our work underscores the role of Gln transporters and the NUPR1-mediated stress response in PCa cell survival, oxidative stress, mitochondrial functions, and radioresistance. …”
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Systematic identification of post-transcriptional regulatory modules by Matvei Khoroshkin, Andrey Buyan, Martin Dodel, Albertas Navickas, Johnny Yu, Fathima Trejo, Anthony Doty, Rithvik Baratam, Shaopu Zhou, Sean B. Lee, Tanvi Joshi, Kristle Garcia, Benedict Choi, Sohit Miglani, Vishvak Subramanyam, Hailey Modi, Christopher Carpenter, Daniel Markett, M. Ryan Corces, Faraz K. Mardakheh, Ivan V. Kulakovskiy, Hani Goodarzi

“…We then use this map to match RBPs to their context-specific functions and validate the predicted functions biochemically for four RBPs. …”
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Properties of the diffusion and drift kinetic coefficients in momentum space for a cold Fermi system by S. V. Lukyanov

“…Using the methods of kinetic theory, expressions for the diffusion and drift coefficients for a cold Fermi system are obtained. Their dependencies on the momentum are calculated for the step distribution function as well as in the case of excitation of a particle-hole pair.…”
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Prediction and analysis of toxic and side effects of tigecycline based on deep learning by Yin Xiong, Guoxin Liu, Xin Tang, Boyang Xia, Yalian Yu, Guangjun Fan

“…The median hospitalization days of patients in the non-hepatotoxicity group, liver function injury group and hepatotoxicity group were 20, 23, and 30 days, respectively. …”
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Improvement of ultrasonic inspection of wheelset axles of railway rolling stock by A. N. Kireev, V. A. Vitrenko

“…To automate the calculation when setting up the time function to adjust the sensitivity of the ultrasonic flaw detector the software “NDTRT-18” was designed (Unit 5). …”
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Pyruvate kinase M2 activation maintains mitochondrial metabolism by regulating the interaction between HIF-1α and PGC-1α in diabetic kidney disease by Jimin Park, Young Su Joo, Bo Young Nam, Gyuri Kim, Jung Tak Park, Tae-Hyun Yoo, Shin-Wook Kang, Seung Hyeok Han

“…Conclusion Our study highlights the role of PKM2 activation in restoring impaired mitochondrial metabolism and function by modulating HIF-1α and PGC-1α interactions in DKD.…”
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The relationship between ferrokinetic parameters and the state of cardiac remodeling in patients with coronary artery disease with concomitant iron deficiency by M. O. Konovalova, N. S. Mykhailovska

“…All patients were divided into 4 clinical groups depending on the parameters of iron metabolism and hemogram: I (n = 16) – patients with absolute ID; II (n = 15) – with latent ID; III (n = 14) – with functional ID; IV (n = 45) – patients with CAD without iron metabolism disorders. …”
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Urbanization enhances body condition, but not innate immune defences, in a common waterbird by Amelia Chyb, Kevin D. Matson, Radosław Włodarczyk, Joanna Drzewińska-Chańko, Piotr Minias

“…Thus, our study offers no support for condition-dependent immune function. Our analyses also revealed significant differences between male and female coots in both condition and immune defences; however, we found no evidence for sex-specific responses to urbanization. …”
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Diagnostic Instruments and Therapeutic Decisions in Velopharyngeal Dysfunction of Pediatric Patients by Maja Solarz, Barbara Jarzemska, Dorota Gabrowska, Józef Mierzwiński

“…Velopharyngeal dysfunction (VPD) is a disorder of the function of the velopharyngeal valve, whose task is to separate the nasal cavity from the oral cavity during the act of speech, blowing, sucking or vomiting. …”
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Overexpression of luxS Cannot Increase Autoinducer-2 Production, Only Affect the Growth and Biofilm Formation in Streptococcus suis by Yang Wang, Li Yi, Zhicheng Zhang, Hongjie Fan, Xiangchao Cheng, Chengping Lu

“…In our previous study, the function of LuxS in AI-2 production was verified in Streptococcus suis (SS). …”
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Capsular polysaccharide restrains type VI secretion in Acinetobacter baumannii by Nicolas Flaugnatti, Loriane Bader, Mary Croisier-Coeytaux, Melanie Blokesch

“…To function effectively, the T6SS must penetrate the membranes of both attacker and target bacteria. …”
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Novel Criteria on Global Robust Exponential Stability to a Class of Reaction-Diffusion Neural Networks with Delays by Jie Pan, Shouming Zhong

“…By employing the Lyapunov-functional method, several new sufficient conditions are obtained to ensure the global exponential robust stability of equilibrium point for the reaction diffusion CGNN with delays. …”
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Optimization of TMS target engagement: current state and future perspectives by Pantelis Lioumis, Pantelis Lioumis, Pantelis Lioumis, Timo Roine, Timo Roine, Ida Granö, Dogu Baran Aydogan, Dogu Baran Aydogan, Elena Ukharova, Victor H. Souza, Dubravko Kičić, Risto J. Ilmoniemi, Nikos Makris, Nikos Makris, Nikos Makris, Nikos Makris

“…Given the intersubject structural and functional variability, neuromodulation has a personalized effect in the brain. …”
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Slowly Rotating Black Holes with Nonlinear Electrodynamics by S. H. Hendi, M. Allahverdizadeh

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The Outcome of Cell Therapy Treating Urinary Incontinence Correlates with Precise Cell Localization in the Sphincter Complex by Niklas Harland, Liv Johnen, Kamal T. Avula, Andrea Buzanich-Ladinig, Lukas Schwarz, Jasmin Knoll, Arnulf Stenzl, Wilhelm K. Aicher

“…Sham-treated animals served as controls. Functional sphincter muscle regeneration was monitored by urodynamics over 5 weeks of follow-up. …”
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Thymic peptides in immune reconstitution and clinical outcome after allogeneic hematopoietic cell transplantation by Hannah Kunstek, Janneke Kieviet, Caroline Lindemans, Coco de Koning, Stefan Nierkens

“…However, besides its established function to produce T cells, the thymus also produces thymic peptides with hormone-like activity. …”
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Triclosan Caused Oocyte Meiotic Arrest by Modulating Oxidative Stress, Organelle Dysfunctions, Autophagy, and Apoptosis in Pigs by Ning Zhao, Anli Xu, Jingxian Yang, Jianan Zhao, Junhao Xie, Bugao Li, Jiaxin Duan, Guoqing Cao

“…Our results demonstrated that TCS significantly decreased the maturation rate of porcine oocytes in a concentration-dependent manner and impaired cumulus expansion. These detrimental effects were mediated by the disruption of mitochondrial function and distribution, leading to oxidative stress characterized by an accumulation of reactive oxygen species (ROS), a decrease in the expression of the antioxidant enzymes SOD2 and GSH, reduced ATP production, and a loss of mitochondrial membrane potential (ΔΨm). …”
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An inhibitory segment within G-patch activators tunes Prp43-ATPase activity during ribosome assembly by Daniela Portugal-Calisto, Alexander Gregor Geiger, Julius Rabl, Oscar Vadas, Michaela Oborská-Oplová, Jarosław Mazur, Federica Richina, Purnima Klingauf-Nerurkar, Erich Michel, Alexander Leitner, Daniel Boehringer, Vikram Govind Panse

“…We posit that Prp43 function at discrete locations on pre-ribosomal RNA is coordinated through toggling interactions with G-patch and I-patch segments. …”
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Androgens as the “old age stick” in skeletal muscle by Giulia Gentile, Ferdinando De Stefano, Carmela Sorrentino, Rosa D’Angiolo, Carmine Lauretta, Pia Giovannelli, Antimo Migliaccio, Gabriella Castoria, Marzia Di Donato

“…Abstract Aging is associated with a reduction in skeletal muscle fiber size and number, leading to a decline in physical function and structural integrity—a condition known as sarcopenia. …”
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Noisier2Inverse: Self-Supervised Learning for Image Reconstruction With Correlated Noise by Nadja Gruber, Johannes Schwab, Markus Haltmeier, Ander Biguri, Clemens Dlaska, Gyeongha Hwang

“…Our approach learns a reconstruction function without requiring ground truth data and is applicable in settings where measurement noise is statistically correlated. …”
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