Transcription factors bind thousands of active and inactive regions in the Drosophila blastoderm. by Xiao-yong Li, Stewart MacArthur, Richard Bourgon, David Nix, Daniel A Pollard, Venky N Iyer, Aaron Hechmer, Lisa Simirenko, Mark Stapleton, Cris L Luengo Hendriks, Hou Cheng Chu, Nobuo Ogawa, William Inwood, Victor Sementchenko, Amy Beaton, Richard Weiszmann, Susan E Celniker, David W Knowles, Tom Gingeras, Terence P Speed, Michael B Eisen, Mark D Biggin

“…Surprisingly, for five of the six factors, their recognition sites are not unambiguously more constrained evolutionarily than the immediate flanking DNA, even in more highly bound and presumably functional regions, indicating that comparative DNA sequence analysis is limited in its ability to identify functional transcription factor targets.…”
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Development of Food Hydrogels with Andean Purple Corn (<i>Zea mays</i> L.) Extracts and Cushuro (<i>Nostoc sphaericum</i>) Polysaccharide: Rheological Characterization by Cecilia A. Arenas, Nancy A. Chasquibol

“…The objective of this research was to characterize the rheological and functional properties of food hydrogels developed with purple corn extracts, red prickly pear fruit pulp, and cushuro polysaccharide (CP). …”
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A Conserved Interaction between a C-Terminal Motif in Norovirus VPg and the HEAT-1 Domain of eIF4G Is Essential for Translation Initiation. by Eoin N Leen, Frédéric Sorgeloos, Samantha Correia, Yasmin Chaudhry, Fabien Cannac, Chiara Pastore, Yingqi Xu, Stephen C Graham, Stephen J Matthews, Ian G Goodfellow, Stephen Curry

“…We have found that this site is non-overlapping with the binding site for eIF4A on eIF4G HEAT-1 by demonstrating that norovirus VPg can form ternary VPg-eIF4G-eIF4A complexes. The functional significance of the VPg-eIF4G interaction was shown by the ability of fusion proteins containing the C-terminal peptide of MNV VPg to inhibit in vitro translation of norovirus RNA but not cap- or IRES-dependent translation. …”
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Compositional factors driving antibacterial efficacy in healthcare wet wipe products by Carolina Angulo-Pineda, Jian Ren Lu, Sarah Cartmell, Andrew J. McBain

“…Antibacterial wet wipes are widely used in public health service settings, but their effectiveness varies depending on their composition and design. Evaluating existing products based on objective criteria provides a valuable foundation for enhancing future functional wet wipe formulations. …”
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Principles of physical factor selection in the early postoperative period of breast cancer treatment: a randomized controlled study by Inna S. Evstigneeva

“…To develop algorithms for selecting physical factors depending on the clinical and functional state of patients after radical surgical treatment of breast cancer (BC) in the early postoperative period. …”
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Gross Tonnage-Based Statistical Modeling and Calculation of Shipping Emissions for the Bosphorus Strait by Kaan Ünlügençoğlu

“…These EPA-estimated values served as dependent variables in the modeling process. The modeling framework followed a three-step strategy: (1) outlier detection using Rosner’s test to reduce the influence of outliers on model accuracy, (2) curve fitting with 12 regression models representing four curve types—polynomial (e.g., linear, quadratic), concave/convex (e.g., exponential, logarithmic), sigmoidal (e.g., logistic, Gompertz, Weibull), and spline-based (e.g., cubic spline, natural spline)—to capture diverse functional relationships between GT and emissions, and (3) model comparison using difference performance metrics to ensure a comprehensive assessment of predictive accuracy, consistency, and bias. …”
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Extrachromosomal circular DNAs in the differentiation of human bone marrow mesenchymal stem cells by Yuxi Gu, Yidan Song, Shuhua Wang, Jun Liu

“…Finally, we demonstrated eccDNA as functional enhancers to regulate BMSC differentiation in a dose-dependent manner. …”
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Application of the original method of intra-operative electrophysiological stimulation of recurrent laryngeal nerve with surgical interventions on the neck organs by Yu. V. Kovalenko, A. S. Tolstokorov, S. N. Kotov, G. A. Manakhov, E. N. Kurochkina

“…The OBJECTIVE was the reduction in the frequency of specific complications of surgical treatment of patients with pathology of the thyroid and parathyroid glands using the original method of monitoring the neuro-functional activity of the recurrent laryngeal nerve.METHODS AND MATERIALS. …”
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Computational evaluation of triphenylimidazole-coumarin-3-carboxylic acid derivatives as potential sensitizers for dye sensitized solar cells by Idayat Sulaiman, Richard K. Adeleke, Bolatito E. Olanipekun, Olusola O. James

“…Abstract Triphenylimidazole derivatives linked with coumarin-carboxylic acid were evaluated as sensitizers for DSSC applications through density functional theory (DFT) and time-dependent density functional theory (TD-DFT) calculations. …”
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Impact of Varicocele on The Expression of Testicular Enzymes Involved in The Transsulfuration Pathway by Azam Shiasi, Marziyeh Tavalaee, Ramesh Monajemi, Dattilo M, Mohammad Hossein Nasr-Esfahani

“…We evaluated sperm parameters and functional tests,as well as the expression of CBS, CSE, and HO-1 proteins using Western blot analysis. …”
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Teredinibacter turnerae secretome highlights key enzymes for plant cell wall degradation by Lyle Ijssel P. De Guzman, Renato C. Carpina, Joan Catherine A. Chua, Eizadora T. Yu

“…Our results show that T. turnerae E7MBN exhibits minimal enzyme secretion across various carbon sources, where secretomes mostly display similar functional profiles. Enzymatic complexity varied with the substrate, with cellulose-grown secretome being the most complex and comprising the majority of secreted CAZymes. …”
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Current Applications of Chatbots Powered by Large Language Models in Oral and Maxillofacial Surgery: A Systematic Review by Vincenzo Ronsivalle, Simona Santonocito, Umberto Cammarata, Eleonora Lo Muzio, Marco Cicciù

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Phytochemical characterization of ethanolic and ethyl acetate extracts of avocado Persea americana leaves by FT-IR and GC-MS reveals potential bioactive compounds by Mary Olaoluwa Agunloye, Daniel. U. Owu, Olufunke Onaadepo, Felix Nnaemeka Ugwu, Oludare Michael Ogunyemi

“…Phytochemical characterization was conducted using Fourier-transform infrared spectroscopy (FT-IR) to identify functional groups and gas chromatography-mass spectrometry (GC-MS) to detect bioactive constituents. …”
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Modulation of Hypoxia-Inducible Factors and Vascular Endothelial Growth Factor Expressions by Superfood Camu-Camu (Myrciaria dubia) Treatment in ARPE-19 and Fetal Human RPE Cells by Ayaka Nakai, Deokho Lee, Chiho Shoda, Kazuno Negishi, Hiroyuki Nakashizuka, Satoru Yamagami, Toshihide Kurihara

“…The demand for disease prevention or treatment using functional foods such as superfoods has increased in recent years. …”
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The correlation between facial and eyelid demodicosis. Complex therapeutic approaches by D. Yu. Maychuk, M. M. Shokirova, T. A. Simonova, Z. G. Malysheva

“…Anti-parasitic therapy with preceding anti-inflammatory treatment, eyelid hygiene and massage improved functional state of meibomian glands and objective signs of posterior meibomian blepharitis. …”
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Retrospective analysis of vitreoretinal surgery outcomes in diabetic retinopathy by A. P. Goydin

“…To analyze the clinical and functional results of vitreoretinal operations in patients with type II diabetes mellitus and diabetic retinopathy (DR).Materials and methods. …”
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Long-Term Results of Surgical Treatment of Pulmonary Embolism (PE) by Balloon Angioplasty (BAP) in Combination with Thrombolytic Therapy by M. V. Davydenko, N. A. Trofimov, A. G. Dragunov, I. P. Efimova, N. I. Kiseleva, N. A. Shatilova, O. A. Shipunova, A. A. Sibirtsev

“…Positive dynamics of ECG indicators — in particular, pulmonary hypertension, RV KDR, functional class of heart failure NYHA as well as the reduction of right ventricular overload according to the ECG — indicates that the BAP LA method for the surgical treatment of pulmonary embolism, in combination with thrombolytic therapy, is effective and safe.Conclusions. …”
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Insulin-like Growth Factor-1 and Myocardial Remodeling in Patients with Chronic Heart Failure of Ischemic Origin by A. N. Zakirova, N. E. Zakirova, D. F. Nizamova

“…Assessment of left ventricular (LV) structural-functional state was carried out by echocardiography. …”
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Evolution of melanopsin photoreceptors: discovery and characterization of a new melanopsin in nonmammalian vertebrates. by James Bellingham, Shyam S Chaurasia, Zara Melyan, Cuimei Liu, Morven A Cameron, Emma E Tarttelin, P Michael Iuvone, Mark W Hankins, Gianluca Tosini, Robert J Lucas

“…Here, we describe the discovery and functional characterisation of a new melanopsin gene in fish, bird, and amphibian genomes, demonstrating that, in fact, the vertebrates have evolved two quite separate melanopsins. …”
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In vitro anticancer and antifungal effects of Lactobacillus paracasei supernatants: a step toward sustainable food systems by Berna Erdal, Bahar Yilmaz, Esra Bozgeyik, Seydi Yıkmış, Isam A. Mohamed Ahmed, Moneera O. Aljobair, Monica Trif

“…These findings represent a promising strategy for integrating probiotic-derived bioactives into sustainable food systems and functional food development.…”
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