Targeting PRMT1-mediated methylation of TAF15 to protect against myocardial infarction by inhibiting ferroptosis via the GPX4/NRF2 pathway by Guanshen Huang, Liwei He, Bishan Liang, Mingjian Gao, Jianming Huang, Hao Xia, Xinyu Li, Hai Li, Yunjun Ruan

“…Results TAF15 was significantly downregulated in AMI, as observed in patient samples and experimental models. Functionally, TAF15 overexpression significantly improved myocardial function by inhibiting ferroptosis. …”
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INFECTION AND IMMUNITY: CURRENT ISSUES IN PEDIATRIC PRACTICE by O. V. Zaytseva

“…The article contains current data on the age-dependent physiological features of children’s immunity. …”
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Prognostic value of advanced lung cancer inflammation index in heart failure patients: A comprehensive analysis by Wentao Chen, Guihua Zhang, Qiao Lei, Huixia Lu

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Spontaneous water dissociation on intermetallic electride LaCu0.67Si1.33 enhances electrochemical methanization of CO2 by Luming Zhang, Huan Ma, Yongfang Sun, Yilin Zhao, Huiying Deng, Yuhang Wang, Fei Wang, Xiao-Dong Wen, Mingchuan Luo

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Optimizing therapeutic outcomes of immune checkpoint blockade by a microbial tryptophan metabolite by Giorgia Renga, Emilia Nunzi, Marilena Pariano, Matteo Puccetti, Marina Maria Bellet, Giuseppe Pieraccini, Fiorella D’Onofrio, Ilaria Santarelli, Claudia Stincardini, Franco Aversa, Francesca Riuzzi, Cinzia Antognelli, Marco Gargaro, Oxana Bereshchenko, Maurizio Ricci, Stefano Giovagnoli, Luigina Romani, Claudio Costantini

“…Indeed, paralleling the activation of the host AhR/IL-22-dependent pathway, 3-IAld also affected the composition and function of the microbiota such that FMT from 3-IAld-treated mice protected against ICI-induced colitis with the contribution of butyrate-producing bacteria. …”
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ФУНКЦИОНАЛЬНАЯ АКТИВНОСТЬ ТРОМБОЦИТОВ У БОЛЬНЫХ АСТРАХАНСКОЙ РИККЕТСИОЗНОЙ ЛИХОРАДКОЙ С СОПУТСТВУЮЩЕЙ ГИПЕРТОНИЧЕСКОЙ БОЛЕЗНЬЮ... by Н. Р. Бедлинская, Х. М. Галимзянов, Е. Н. Лазарева

“…The analysis of functional activity of platelets at patients with middle severity of illness of Astrakhan rickettsial fever with accompanying hypertensive illness depending on age was carried out. …”
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EFFICACY AND SAFETY OF AMLODIPINE MALEATE IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE AND BRONCHIAL ASTHMA WITH CONCOMITANT ARTERIAL HYPERTENSION by N. A. Karoli, A. P. Rebrov, A. A. Roshchina, V. A. Sergeeva, E. E. Arkhangelskaya

“…The high efficacy of amlodipine maleate as antihypertensive drug was found in patients with COPD or BA and hypertension without dependence on bronchial obstruction severity. The positive influence of amlodipine on endothelial function and vascular rigidity was also observed.Conclusion: study results confirm the rationales of amlodipine use in patients with COPD or BA and hypertension.…”
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Anatomical and morphological features of the heart of a domestic dog (Canis Lupus Familiaris L., 1758) by M. R. Ragulya, L. P. Goralskyi, I. M. Sokulskyi, N. L. Kolesnik, B. V. Gutyj

“…The cardiovascular system in mammals performs vital functions, ensuring the vital activity of the animal and human body. …”
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A phosphoswitch at acinus-serine437 controls autophagic responses to cadmium exposure and neurodegenerative stress by Nilay Nandi, Zuhair Zaidi, Charles Tracy, Helmut Krämer

“…Neuronal health depends on quality control functions of autophagy, but mechanisms regulating neuronal autophagy are poorly understood. …”
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Quinoa Protein/Sodium Alginate Complex-Stabilized Pickering Emulsion for Sustained Release of Curcumin and Enhanced Anticancer Activity Against HeLa Cells by Yiqun Zhu, Jianan Li, Shuhong Liu, Hongli Yang, Fei Lu, Minpeng Zhu

“…Cytotoxicity assays using HeLa cells confirmed the biocompatibility of QPI/SA complexes (≤500 μg/mL), while curcumin-loaded emulsions exhibited dose-dependent anticancer activity. These findings suggest that QPI/SA holds significant potential for applications in functional foods and oral delivery systems.…”
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Theoretical studies on benzonitrile-carbazole-based pure organic molecules with room-temperature phosphorescence by Wen-Kai Chen, Jing-Yao Kang, Yan-Jiang Wang, Yuan-Jun Gao, Yanli Zeng

“…Herein we employ density functional theory (DFT) and linear response time-dependent density functional theory (LR-TDDFT) together with our own n-layered integrated molecular orbital and molecular mechanics (ONIOM)-based quantum mechanical/molecular mechanics (QM/MM) methods to study the room-temperature phosphorescent (RTP) micro-mechanism of several benzonitrile-carbazole (CzBz-X) molecules (i.e. …”
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Activation-induced cytidine deaminase in tertiary lymphoid structures: dual roles and implications in cancer prognosis by Zhuangwei Lv, Junna Jiao, Junna Jiao, Wuyang Xue, Xiaoyu Shi, Ruihan Wang, Jinhua Wu

“…The review thereby provides a conceptual framework reconciling AID’s dual functionality with the context-dependent immunobiology of tumor-associated lymphoid structures.…”
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Disruption of <i>ABI4</i> Enhances Anthocyanin Accumulation in <i>Arabidopsis</i> Seedlings Through HY5-Mediated Light Signaling by Mingyang Zeng, Yan Wu, Shunfa Lin, Fang Zhang, Haiyan Jiang, Lixia Ma, Dong Liu

“…Interestingly, the light-hypersensitive phenotype of <i>abi4</i> mutants was partially rescued by the loss of HY5 function. Taken together, these findings demonstrate that <i>ABI4</i> negatively regulates anthocyanin accumulation in <i>Arabidopsis</i> seedlings through a HY5-dependent light signaling pathway.…”
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Order-to-Disorder and Disorder-to-Order Transitions of Proteins upon Binding to Phospholipid Membranes: Common Ground and Dissimilarities by Reinhard Schweitzer-Stenner

“…Cytochrome <i>c</i> is one of the most prominent representatives of peripheral membrane proteins. Besides functioning as an electron transfer carrier in the mitochondrial respiratory chain, it can acquire peroxidase capability, promote the self-assembly of α-synuclein, and function as a scavenger of superoxide. …”
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The choice of surgical treatment method of perforated pyloroduodenal ulcer by D. V. Maksymchuk, V. I. Mamchich, V. D. Maksymchuk

“…To develop a method of organ-saving operation aimed at preservation of the physiological function of the pylorus and the normal physiological functioning of the pyloroduodenal area in patients with combined perforated, stenotic pyloroduodenal ulcers. …”
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Extracellular and Intracellular Regulation of Calcium Homeostasis by Felix Bronner

“…All cells have a calcium-sensing receptor that modulates cell function via its response to extracellular calcium. …”
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Dissecting the enhancer gene regulatory network in early Drosophila spermatogenesis by Patrick van Nierop y Sanchez, Pallavi Santhi Sekhar, Kerem Yildirim, Tim Lange, Laura Zoe Kreplin, Vigneshwarr Muruga Boopathy, Stephanie Rosswag de Souza, Kim Dammer, David Ibberson, Qian Wang, Katrin Domsch, Anniek Stokkermans, Shubhanshu Pandey, Petra Kaspar, Rafael Martinez-Gallegos, Xuefan Gao, Aakriti Singh, Natalja Engel, Fillip Port, Michael Boutros, Josephine Bageritz, Ingrid Lohmann

“…This enables inference of 147 cell type-specific enhancer-gene regulons using SCENIC + . We functionally validate key transcription factors, including ovo and klumpfuss, known from other stem cell systems but not previously linked to spermatogenesis. …”
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Assessment of the Applicability of Coconut and Skim Milk Powder as a Carrier for Lactic Acid Bacteria on Their Performance During Production of Ting by Nontobeko Xolisiwe Zulu, Angela Parry-Hanson Kunadu, Eugenie Kayitesi, Bhekisisa Dlamini

“…FTIR showed similar functional groups corresponding to O–H and phenolic compounds for both SM and CCN ting. …”
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Comparative Clinical and Laboratory Assessment of the Effectiveness of Rehabilitation Therapy in Patients with Osteoarthritis of the Knee Joints by O. A. Rechkunova, T. V. Chernysheva, I. A. Krivotulova, N. V. Sharapova

“…In all patients, before and after rehabilitation treatment (after 14 days and 3 months), the clinico-functional status was assessed using the Western Ontario and McMaster Universities Osteoarthritis Index scale and the indicators of the intensity of the free radical oxidation processes and the activity of antioxidant protection were studied.Results. …”
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The features of the first trimester of pregnancy course in first-time mothers over 40 years old by Т. V. Lescheva

“…There are no clear data on the peculiarities of the fetoplacental complex formation and functional state and of a fetus and a newborn state depending on the endocrinological and immunological features. …”
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