Distinct roles of non-canonical poly(A) polymerases in RNA metabolism. by Salvatore San Paolo, Stepanka Vanacova, Luca Schenk, Tanja Scherrer, Diana Blank, Walter Keller, André P Gerber

“…To assess the level of functional redundancy between the paralogous Trf4 and Trf5 proteins and to investigate the role of the Trf4-dependent polyadenylation in vivo, we used DNA microarrays to compare gene expression of the wild-type yeast strain of S. cerevisiae with either that of trf4Delta or trf5Delta mutant strains or the trf4Delta mutant expressing the polyadenylation-defective Trf4(DADA) protein. …”
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Role of sirtuins in epigenetic regulation and aging control by E. M. Samoilova, S. E. Romanov, D.  A. Chudakova, P. P. Laktionov

“…This multifactorial regulatory system affects many processes: cellular metabolism, mitochondrial functions, epigenetic regulation, DNA repair and more. …”
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The impact of overall obesity on serotonin level in the acute phase of coronavirus infection and post-coronavirus sequelae: aspects of neuropsychological and cognitive impairments by O. V. Zinych, N. M. Kushnarova, A. A. Shuprovych, O. M. Trofymenko

“…Parameters of quality of life (QL), psycho-emotional state, and cognitive function were studied by a questionnaire method 6 months after recovery. …”
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Modular mimicry and engagement of the Hippo pathway by Marburg virus VP40: Implications for filovirus biology and budding. by Ziying Han, Shantoshini Dash, Cari A Sagum, Gordon Ruthel, Chaitanya K Jaladanki, Corbett T Berry, Michael P Schwoerer, Nina M Harty, Bruce D Freedman, Mark T Bedford, Hao Fan, Sachdev S Sidhu, Marius Sudol, Olena Shtanko, Ronald N Harty

“…A key regulator of YAP nuclear/cytoplasmic localization and function is angiomotin (Amot); a multi-PPxY containing protein that strongly interacts with YAP WW-domains. …”
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An Erg11 lanosterol 14-α-demethylase-Arv1 complex is required for Candida albicans virulence. by Michelle L Villasmil, Antonio Daniel Barbosa, Jessie Lee Cunningham, Symeon Siniossoglou, Joseph T Nickels

“…To define the relationship between Arv1 function and azole susceptibility, we undertook a structure/function analysis of ScArv1. …”
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The impact of pulmonary hypertension on the risk of early graft dysfunction in related kidney transplantation by R. A. Ibadov, D. A. Chernov, S. Kh. Ibragimov, Z. T. Matkarimov

“…The study was based on the analysis of treatment results in 650 patients who underwent kidney transplantation from a living related donor. Depending on the graft function, 2 groups of patients were identified: group I consisting of patients with early renal graft dysfunction (n=82); group II (n=79) that included the patients with a primary graft function who were selected by demographic and clinical laboratory data statistically comparable to patients of group I (p>0.5). …”
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The microcephaly gene Donson is essential for progenitors of cortical glutamatergic and GABAergic neurons. by Sathish Venkataramanappa, Dagmar Schütz, Friederike Saaber, Praveen Ashok Kumar, Philipp Abe, Stefan Schulz, Ralf Stumm

“…Thus, the early telencephalic neuroepithelium depends critically on Donson function. Our findings help explain why the neocortex is most severely affected in individuals with DONSON mutations and suggest that DONSON-dependent microcephaly might be associated with so far unrecognized defects in cortical GABAergic neurons. …”
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THE USE OF THE FINITE DIFFERENCE METHOD FOR CALCULATION OF ELECTRONIC STATES IN MIS-STRUCTURE WITH SINGLE DONOR 1 by E. A. Levchuk, S. V. Lemeshevskii, L. F. Makarenko

“…Using the developed difference schemes, the dependences of the energy spectrum of the bound electron on the gate potential are calculated, and the values of critical potential at which the wave function of the electron is relocated are determined. …”
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Sensory Cortical Plasticity Participates in the Epigenetic Regulation of Robust Memory Formation by Mimi L. Phan, Kasia M. Bieszczad

“…Neuroplasticity remodels sensory cortex across the lifespan. A function of adult sensory cortical plasticity may be capturing available information during perception for memory formation. …”
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Inhomogeneous abelian Chern-Simons Higgs model with new inhomogeneous BPS vacuum and solitons by Yoonbai Kim, O-Kab Kwon, Hanwool Song, Chanju Kim

“…We also discuss the case of a delta-function impurity as the infinitely thin limit of the Gaussian impurity which shows some nontrivial feature of BPS Chern-Simons Higgs theory.…”
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PUMPING PRESSURE AND FLOW RATE RELATIONSHIP TO REDUCE ENERGY CONSUMPTION IN IRRIGATION SYSTEMS by Esmeralda CHIORESCU

“…Since the PPS serving the irrigation plots must work mainly on demand, the required flow rate in the network can vary widely even during each day of the irrigation period. Also, due to the dependence of the pressure loss on the flow carried in the pipe network, this dependence is usually represented by an increasing quadratic function, and the variation of the required flow also leads to a variation, generally significant, of the pressure required from the PPS. …”
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The RNA export factor, Nxt1, is required for tissue specific transcriptional regulation. by Simona Caporilli, Yachuan Yu, Jianqiao Jiang, Helen White-Cooper

“…Nxt1 is essential for viability; using a partial loss of function allele, we reveal a role for this gene in tissue specific transcription. …”
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Development of a New Approach to the Problem of Detecting the Integrity Violations of a Digital Image by Bobok I., Kobozeva A.

“…The significance of the obtained result lies in the fact that the use of the estab-lished properties for the function of the dependence of the frequency index of singular vectors on its number makes it possible to develop universal integrity examination methods that are ef-fective regardless of the strength and type of disturbances that violated the integrity of the im-age. …”
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Free-Energy-Based Design Policy for Robust Network Control against Environmental Fluctuation by Takuya Iwai, Daichi Kominami, Masayuki Murata, Tetsuya Yomo

“…When the best solution fails due to environmental fluctuation, the system cannot keep its function until the system finds another solution again. …”
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TROLL 4.0: representing water and carbon fluxes, leaf phenology, and intraspecific trait variation in a mixed-species individual-based forest dynamics model – Part 1: Model descrip... by I. Maréchaux, F. J. Fischer, F. J. Fischer, S. Schmitt, S. Schmitt, S. Schmitt, J. Chave

“…<p>TROLL 4.0 is an individual-based forest dynamics model that is capable of jointly simulating forest structure, diversity, and ecosystem functioning, including the ecosystem water balance and productivity, leaf area dynamics, and the tree community functional and taxonomic composition. …”
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A novel fertility-sparing nanocomposite for endometriosis treatment via oxidative stress and inflammation alleviation by Wenwen Liu, Jie Shen, Jiaqi You, Tao Wang, Pusheng Yang, Yaxin Miao, Xiaotong Peng, Yimin Yu, Chengyu Liu, Ang Li, Jing Sun

“…Current therapeutic strategies primarily focus on lesion removal and pain alleviation, often at the cost of compromising ovarian function and natural conception. Herein, we engineered a nanocomposite with polydopamine and dydrogesterone for precise and gentle endometriosis treatment while protecting ovarian function and fertility. …”
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The mechanosensitive adhesion G protein-coupled receptor 133 (GPR133/ADGRD1) enhances bone formation by Juliane Lehmann, Hui Lin, Zihao Zhang, Maren Wiermann, Albert M. Ricken, Franziska Brinkmann, Jana Brendler, Christian Ullmann, Luisa Bayer, Sandra Berndt, Anja Penk, Nadine Winkler, Franz Wolfgang Hirsch, Thomas Fuhs, Josef Käs, Peng Xiao, Torsten Schöneberg, Martina Rauner, Jin-Peng Sun, Ines Liebscher

“…This osteopenic phenotype in receptor-deficient mice is caused by impaired osteoblast function, which, in turn, promotes increased osteoclast activity. …”
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APPLICATION EFFICIENCY OF MONTELUKAST AMONG CHILDREN SUFFERING FROM BRONCHIAL ASTHMA by A.K. Gevorkyan, E.A. Galeeva

“…The article provides the results of montelukast efficiency depending on bronchial asthma severity level and the duration of a disease; the assessment of functional figures dynamics, disease pattern before and after the treatment with montelukast and the possibility of its application as mono therapy to achieve long term disease remission and asthma symptoms control.Key words: bronchial asthma, montelukast, children.…”
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DFT/TDDFT and Experimental Studies of Natural Pigments Extracted from Black Tea Waste for DSSC Application by N. T. R. N. Kumara, Muhammad Raziq Rahimi Kooh, Andery Lim, Mohammad Iskandar Petra, Nyuk Yoong Voo, Chee Ming Lim, Piyasiri Ekanayake

“…Combined effect of these developments caused the enhanced efficiency of DSSC. Density functional theory (DFT) and time-dependent density functional theory (TDDFT) computational calculations were carried out to study the four theaflavin analogues which are responsible for the dark colour of BTE. …”
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Molecular basis of ligand binding and receptor activation at the human A3 adenosine receptor by Liudi Zhang, Jesse I. Mobbs, Felix M. Bennetts, Hariprasad Venugopal, Anh T. N. Nguyen, Arthur Christopoulos, Daan van der Es, Laura H. Heitman, Lauren T. May, Alisa Glukhova, David M. Thal

“…In addition, we identify a cryptic pocket that accommodates the N6-iodobenzyl group of Piclidenoson through a ligand-dependent conformational change of M1745.35. Our comprehensive structural and functional characterisation of A3AR advances our understanding of adenosine receptor pharmacology and establishes a foundation for developing more selective therapeutics for various disorders, including inflammatory diseases, cancer, and glaucoma.…”
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