Docking Simulations of G-Protein Coupled Receptors Uncover Crossover Binding Patterns of Diverse Ligands to Angiotensin, Alpha-Adrenergic and Opioid Receptors: Implications for Car... by Harry Ridgway, Graham J. Moore, Laura Kate Gadanec, John M. Matsoukas

“…Ligands specific to each GPCR category showed considerable cross-binding with alternative GPCRs, with small-molecule medications appearing less selective than their peptide or ARB functional equivalents. ARBs that exhibit higher affinities for AT₁R also demonstrate higher affinities for µORs and ժORs than opiate ligands, such as fentanyl and naltrexone. …”
Get full text

Antigen 43 associated with Escherichia coli membrane vesicles contributes to bacterial cell association and biofilm formation by Lauren Zavan, Lilian Hor, Ella L. Johnston, Jason Paxman, Begoña Heras, Maria Kaparakis‑Liaskos

“…ABSTRACT Bacterial membrane vesicles (MVs) are produced by all bacteria and contribute to numerous bacterial functions due to their ability to package and transfer bacterial cargo. …”
Get full text

Hemodynamics and Gas Exchange Effects of Inhaled Nitrous Oxide in Patients with Acute Respiratory Distress Syndrome by V. N. Poptsov

“…The study has demonstrated that in 48.3% of cases, the early stage of ARDS is attended by the increased tone pulmonary vessels due to impaired NO-dependent vasodilatation. In these patients, iNO therapy is an effective therapeutic method for correcting hemodynamic disorders and lung oxygenizing function.…”
Get full text

Chaotic Watermarking for Authentication by Melad Saeed

“…The work has two phases in each of which the chaotic function has been used twice. In the first phase it is used to generate the watermark from the same cover picture then embedding it in another level of the cover depending on the chaotic positions in order to increase authenticity and fortification against attacks. …”
Get full text

Modified Firefly Algorithm by Surafel Luleseged Tilahun, Hong Choon Ong

“…In the algorithm, randomly generated solutions will be considered as fireflies, and brightness is assigned depending on their performance on the objective function. …”
Get full text

X-Ray Diffraction Line Broadening of Irradiated Zr-2.5Nb Alloys by Malcolm Griffiths

“…Empirical models for the integral breadth of the diffraction peaks as a function of operating conditions have been developed to predict the mechanical properties of CANDU reactor pressure tubes as a function of fast neutron flux, time and temperature. …”
Get full text

NEW SOWING SYSTEM FOR VARIABLE RATE INTRA SOIL APPLICATION OF MINERAL FERTILIZERS by Е. A. Zolotukhin, G. I. Lichman, S. O. Nukeshev

“…Researches were carried out both in laboratory and field conditions. Functional dependence of flow rate of SS on number of turns of coils is received. …”
Get full text

A Proposed Stochastic Finite Difference Approach Based on Homogenous Chaos Expansion by O. H. Galal

“…In this approach, included stochastic parameters are modeled as second-order stochastic processes and are expanded using Karhunen-Loève expansion, while the response function is approximated using homogenous chaos expansion. …”
Get full text

Reduction of friction by normal oscillations. I. Influence of contact stiffness by M. Popov, V. L. Popov, N. V. Popov

“…This function in turn depends on the shape of the contacting bodies. …”
Get full text

Quantum “contact” friction: The contribution of kinetic friction coefficient from thermal fluctuations by Rasoul Kheiri

“…Further, we consider acoustic dispersion relation and evaluate the friction coefficient from the force autocorrelation function. While the sliding particle remains classical describing a nano-particle or a tip with negligible quantum effects like tunneling or delocalization in the wave function, the quantized model of the surface fluctuations results in the temperature dependence of the kinetic friction coefficient. …”
Get full text

Referring to women using feminine and neuter gender by Simone Busley, Damaris Nübling

“… In German, gender is a strongly grammaticalized category and has the function of indicating grammatical agreement between syntactic units. …”
Get full text

Phase-Change Materials, 1/f Noise, and Phase Synchrony by J. C. Martinez, R. E. Simpson

“…Electron conduction is envisaged in terms of an envelope function and a field-dependent Bloch wave function; the electron transport across the structure is modeled as driven phase oscillators under a weak field and obeys a Kuramoto-type equation. …”
Get full text

Gut reactions: harnessing microbial metabolism to fuel next-generation cancer immunotherapy by Laurence Zitvogel, Andrew A. Almonte

“…Dysbiosis, or an imbalance in gut microbial composition and function, can diminish immunotherapy responses by altering immune cell trafficking and metabolic output. …”
Get full text

Time and temperature effects on Poisson’s ratio of poly(butylene terephthalate)

“…The viscoelastic nature of the Poisson’s ratio of a semicrystalline poly (butylene terephthalate) is highlighted by investigating its dependence on time, temperature and strain rate, under two types of loading conditions: i) constant deformation rate tests, in which the transverse strain is measured in tensile ramps at various temperatures and at two strain rates; and ii) constant deformation tests, in which, under a constant axial deformation, the transverse strain is measured as a function of time in isothermal experiments performed at various temperatures. …”
Get full text

Herpes simplex virus 1 glycoprotein C promotes virus penetration from endosomes during entry, independent of interaction with heparan sulfate by Seth M. Schneider, Seth M. Schneider, Giulia Tebaldi, Katrina A. Gianopulos, Katrina A. Gianopulos, Darin J. Weed, Suzanne M. Pritchard, Chloe Leach, Anthony V. Nicola, Anthony V. Nicola

“…Herpes simplex virus 1 (HSV-1) gC is a multi-functional glycoprotein present in the viral envelope and on the surface of infected cells. …”
Get full text

Understanding the Role of Alcohol in Metabolic Dysfunction and Male Infertility by Valentina Annamaria Genchi, Angelo Cignarelli, Andrea Sansone, Dimitri Yannas, Leonardo Dalla Valentina, Daniele Renda Livraghi, Giorgia Spaggiari, Daniele Santi

“…This increase in alcohol intake is a major public health concern due to its far-reaching effects on human health, particularly on metabolic processes and male reproductive function. This narrative review focuses on the role of alcohol consumption in altering metabolism and impairing testicular function, emphasizing the potential damage associated with both acute and chronic alcohol intake. …”
Get full text

Effects of a 6-Week Concurrent Training Program Combining Resistance and Various Modalities of Aerobic Exercise in Obese Women with Prehypertension: A Randomized Controlled Trial by Jinhyuk Yu, Eunjoo Lee, Jae-Ho Choi, Yerin Sun, Seungyeon Woo, Sohyang Cho, Deunsol Hwang, Sung-Woo Kim, Jisu Kim, Kiwon Lim, Hun-Young Park

“…<b>Background/Objectives</b>: Our study aimed to verify the effects of 6 weeks of concurrent training composed of resistance training (RT) and different modalities of aerobic exercise (moderate-intensity continuous training (MICT) or high-intensity interval training (HIIT)) on body composition, blood pressure, vascular function, autonomic nervous system (ANS) function, blood lipid levels, cardiometabolic index (CMI), and health-related fitness in obese middle-aged women with prehypertension. …”
Get full text

ESTIMATION OF ENERGY SECURITY OF AZERBAIJAN REPUBLIC WITH DUE ACCOUNT OF TENDENCY INFLUENCE ON INDICATORS’ CHANGES by V. Kh. Nasibov

“…It is shown that, instead of the eigenvalues of the diagonal indicators can use these indicators, the functional dependence on the time.…”
Get full text

Environmental enrichment in middle age rats improves spatial and object memory discrimination deficits by Magdalena Miranda, Maria Carla Navas, Maria Belen Zanoni Saad, Dinka Piromalli Girado, Noelia Weisstaub, Pedro Bekinschtein

“…In conclusion, these results suggest that memory is differentially affected by aging in the object and spatial domains, but that BPS function is responsive to an EE intervention in a multidomain manner.…”
Get full text

Cysteine-10 on 17β-Hydroxysteroid Dehydrogenase 1 Has Stabilizing Interactions in the Cofactor Binding Region and Renders Sensitivity to Sulfhydryl Modifying Chemicals by Lyubomir G. Nashev, Atanas G. Atanasov, Michael E. Baker, Alex Odermatt

“…For the development of novel inhibitors, an improved understanding of the structure-function relationships is essential. In the present study, we examined the role of a cysteine residue, Cys10, in the Rossmann-fold NADPH binding region, for 17β-HSD1 function and tested the sensitivity towards sulfhydryl modifying chemicals. 3D structure modeling revealed important interactions of Cys10 with residues involved in the stabilization of amino acids of the NADPH binding pocket. …”
Get full text