<i>α</i>-Fluctuating Nakagami-<i>m</i> Fading Model for Wireless Communications by Aleksey S. Gvozdarev

“…For the assumed channel model, the research presents a complete first-order statistical description (including the probability density function (PDF), cumulative distribution function (CDF), moment generating function (MGF), and raw moments) and provides closed-form results for system performance (assessed in terms of outage probability, average bit error rate (ABER), and channel capacity). …”
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Histone methyltransferases MES-4 and MET-1 promote meiotic checkpoint activation in Caenorhabditis elegans. by Piero Lamelza, Needhi Bhalla

“…The synapsis checkpoint signal is dependent on cis-acting loci called Pairing Centers (PCs). …”
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Singular Points of Curves by Artem D. Uvarov

“…In this part, the author introduces a function that achieves a global minimum only at singular points of the intersection curves and solves the problem of minimizing this function. …”
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Enhanced antigen cross-presentation in human colorectal cancer-associated fibroblasts through upregulation of the lysosomal protease cathepsin S by Peter A van Veelen, Jacques Neefjes, Sjoerd H van der Burg, Thorbald van Hall, Marten Visser, Linda de Bruin, Lukas JAC Hawinkels, James CH Hardwick, Saskia J Santegoets, Tom J Harryvan, Léonie Plug, Lisa Griffioen, Arend Mulder, Gerbrand J van der Heden van Noort, Marlieke LM Jongsma, Miranda H Meeuwsen, Emmanuel JHJ Wiertz, Els ME Verdegaal

“…Cognate interaction between CD8+ T cells and cross-presenting CAFs suppressed T cell function, reflected by decreased cytotoxicity, reduced activation (CD137) and increased exhaustion (TIM3, LAG3 and CD39) marker expression.Conclusion These data indicate that CAFs may directly suppress tumor-specific T cell function in an antigen-dependent fashion in human CRC.…”
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Sulforaphane attenuates aldose reductase-mediated platelet dysfunction in high glucose-stimulated human platelets via downregulation of the Src/ROS/p53 signaling pathway by Xiaoyan Bi, Xinhui Huang, Chunmei Zhang, Xin Zhao, Junyu Ma, Mengyao Li, Xuexun Li, Bangzhao Zeng, Rong Li, Xian Zhang, Fuli Ya

“…Pharmacological inhibition revealed that the beneficial effects of SFN on platelet function were mediated mechanistically through AR downregulation, which attenuated p53 phosphorylation via Src-dependent ROS generation.ConclusionThese findings suggest that by inhibiting the Src/ROS/p53 signaling pathway and mitigating AR-mediated platelet dysfunction, SFN may confer significant protection against atherothrombosis during hyperglycemia.…”
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Diets shape thermal responses in Chinese giant salamanders by altering liver metabolism by Runliang Zhai, Runliang Zhai, Chunlin Zhao, Liming Chang, Liming Chang, Jiongyu Liu, Tian Zhao, Jianping Jiang, Jianping Jiang, Wei Zhu, Wei Zhu

“…While both temperature and diet shape microbiota composition, functional shifts occur only in response to temperature, indicating that the microbiota is not a major link between diet and liver metabolism. …”
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Retinoic acid differently modulates NOD1/NOD2-mediated inflammatory responses in human macrophage subsets by Hala Ahmad, Hala Ahmad, Ahmad Alatshan, Ahmad Alatshan, Eduárd Bíró, Eduárd Bíró, Szilvia Benkő, Szilvia Benkő

“…In conclusion, these results show that NOD1/NOD2-induced cytokine secretion by macrophage subsets is highly context-dependent and our results highlight the importance of the retinoic acid content of the local tissue environment in shaping macrophage function in health and disease.…”
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Efficacy of the Baseline Complex Treatment in Achieving the Target Blood Pressure Values, Dynamics of Brachial Artery Remodeling and Endothelial Dysfunction in Patients with Acute... by Denesyuk О.

“…An individual analysis of the extent of disturbances in the brachial artery remodeling indices, despite the small number of individuals examined, showed a tendency to decrease the number of patients with II (moderate) thickness of the intima­media complex and III (significant) degree of endothelium­dependent vasodilatation as a result of a transition to a less pronounced degree, which testifies to the positive dynamics of the brachial artery remodeling, endothelial function and the efficacy of the treatment.…”
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Gradient method for designing cascaded DOEs focusing radiation of different wavelengths by G.A. Motz, D.V. Soshikov, L.L. Doskolovich, E.V. Byzov, E.A. Bezus, D.A. Bykov

“…The problem of designing a cascaded DOE is formulated as that of minimizing a functional that depends on the height functions of the diffractive microrelief of the cascaded DOEs and represents the error in the generation of specified intensity distributions at the operating wavelengths. …”
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STUDY OF APPROACHES TO IMPROVING DENTAL HEALTH OF DONETSK REGION RESIDENTS ON THE BASIS OF SELECTIVE ANALYSIS OF ORAL CAVITY DISEASES by S.O. Turchenenko, S.P. Yarova, O.P. Reva, Yu. Yu. Yarov, A. A. Komlev

“…To achieve this goal, the data of the annual reports of municipal dental services of Donetsk region were analyzed and a survey with additional functional (electromyography and digital analysis of occlusion) examination of the dental status of 200 people was conducted. …”
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An economic evaluation of sensor-assisted health monitoring in dairy farming using the example of a rumen bolus by J. Pfrombeck, M. Gandorfer, E. Zeiler, J. Ettema

“…For a full economic evaluation of the sensor system, other functions (estrus detection, calving detection) and functional extensions (e.g., monitoring rumination) have to be considered.…”
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Role of Pharmacogenetic Testing in the Risk and Safety Assessment of Valproates: The Ethnic Aspect (Review) by N. A. Shnayder, V. V. Grechkina, V. V. Arkhipov, R. F. Nasyrova

“…The authors reviewed the results of population studies concerning the frequency of non-functional and low-function alleles of genes encoding isoenzymes that play key roles in VPA P-oxidation in the liver. …”
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Pyrolysis temperature optimization of biochar from tobacco stalk and its physicochemical characterization by YANG Xing, HUANG Huagang, WANG Ling, SHEN Yan, LU Kouping, HAN Xuebo, WANG Hailong

“…It can be used as soil amendment due to its favorable properties, such as high pH value, cation exchange capacity, oxygen-containing function groups, as well as microporous structures. …”
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Evolution of PqsE as a Pseudomonas aeruginosa-specific regulator of LuxR-type receptors: insights from Pseudomonas and Burkholderia by Caleb P. Mallery, Kayla A. Simanek, Autumn N. Pope, Jon E. Paczkowski

“…This study explored the conservation of PqsE and examined PqsE ortholog structure-function across different species. Our results show that PqsE in Pseudomonas retains their functional interactions with RhlR homologs, unlike PqsE orthologs in Burkholderia spp., which do not interact with their respective LuxR-type receptors. …”
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Unraveling the pathogenicity role of the novel compound heterozygous mutations of MED25 gene in a Chinese patient with BVSYS by Linbing Zou, Ruikang Qiu, Zhijun Dai, Yulei Li, Yunjiao Liao, Yan Zhou

“…However, bioinformatics analysis suggested that the mutation c.670C&gt;G (p.R224G) may affect gene function by altering the structure of the MED25 protein.ConculsionThese findings demonstrated that two mutation sites identified in the MED25 gene in this case are pathogenic or likely pathogenic and may be associated with the clinical phenotype of the proband in this study.…”
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Comparative analysis of anthocyanin content in various tomato samples in connection with breeding by E. A. Dzhos, M. I. Mamedov, O. N. Pyshnaya, N. A. Golubkina, O. V. Verba, A. A. Matyukina

“…Vegetable products containing antioxidant substances belong to the functional products and conform to the concept of a healthy diet. …”
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Gut microbiome features associate with immune checkpoint inhibitor response in individuals with non-melanoma skin cancers: an exploratory study by Yujie Zhao, Jacqueline T. Ferri, James R. White, Megan D. Schollenberger, Kim Peloza, Cynthia L. Sears, Evan J. Lipson, Fyza Y. Shaikh

“…To examine the association of gut microbiota structure and function with non-melanoma skin cancer ICI outcomes, we performed 16S rRNA V1-V2 gene amplicon sequencing of 68 fecal samples collected longitudinally from individuals with basal cell carcinoma (n = 5), Merkel cell carcinoma (n = 5), or cutaneous squamous cell carcinoma (CSCC, n = 11), followed by tumor-dependent differential analyses of bacterial composition and fecal sample analysis by untargeted metabolomics. …”
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FOXP2 suppresses gastric cancer progression by transcriptionally repressing FBXW2 via WASL degradation by Sihan Lin, Wencheng Kong, Xinchun Liu, Guang Yin, Kangwen Cheng, Zonglei Mao, Yuqiang Shan, Xinger Lv

“…Here, we integrated transcriptomic analyses using the TNMplot database and clinical specimens to demonstrate that FBXW2 expression was significantly downregulated in GC tissues, with low FBXW2 levels correlating closely with poor survival in GC patients. Functional characterization via gain- and loss-of-function strategies revealed that FBXW2 overexpression potently inhibited proliferation, cancer stem cell phenotype, migratory capacity, and invasive potential in human GC cell lines. …”
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Lungs volume status and oxygen transport in patients with coronary artery disease with various types of comorbidity before and after coronary artery bypass grafting by B. I. Geltser, E. A. Sergeev, V. N. Kotelnikov, K. A. Fogelevich, A. A. Silaev

“…Volume and hemodynamic monitoring was carried out by transpulmonary thermodilution using the Pulsion PiCCO Plus (Germany) technology and the following indices: cardiac function index (CFI), extravascular lung water (EVLW), pulmonary vascular permeability index (PVPI). …”
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Metagenomic and phylogenetic analyses reveal gene-level selection constrained by bacterial phylogeny, surrounding oxalate metabolism in the gut microbiota by Sromona D. Mukherjee, Mangesh Suryavanshi, John Knight, Dirk Lange, Aaron W. Miller

“…In conservative genome-based estimates, over 30% of gut microbial species harbored at least one oxalate-handling gene, with the specific pathways used dependent on bacterial phylum. Co-occurrence analyses revealed interactions between specialist genes that can metabolize oxalate or its by-products, but not multi-functional genes that can act in more than one oxalate-related pathway. …”
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