Brain tumors induce immunoregulatory dendritic cells in draining lymph nodes that can be targeted by OX40 agonist treatment by Shokoufeh Karimi, Mats Hellström, Oscar Badillo-Godinez, Jenni Niemi, Liam Helfridsson, Mohanraj Ramachandran, Hitesh Bhagavanbhai Mangukiya, Sven Nelander

“…Furthermore, we identified OX40 (Tnfrsf4) as a modulator of immunoregulatory DC-c function and found that its antitumor effect depended on lymphocyte trafficking and the DC transcription factor Batf3. …”
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RNAi dynamics in Juvenile Fasciola spp. Liver flukes reveals the persistence of gene silencing in vitro. by Paul McVeigh, Erin M McCammick, Paul McCusker, Russell M Morphew, Angela Mousley, Abbas Abidi, Khalid M Saifullah, Raman Muthusamy, Ravikumar Gopalakrishnan, Terry W Spithill, John P Dalton, Peter M Brophy, Nikki J Marks, Aaron G Maule

“…Whilst current control is unsustainable due to anthelmintic resistance, gene silencing (RNA interference, RNAi) has the potential to contribute to functional validation of new therapeutic targets. The susceptibility of juvenile Fasciola hepatica to double stranded (ds)RNA-induced RNAi has been reported. …”
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Molecular Genetic Analysis of a DMD Frameshift Mutation in a Boy with Duchenne Muscular Dystrophy by MLPA and Sanger Sequencing by Chen Q, Zhang W, Zha L

“…The deletion of those four nucleotides resulted in a frameshift mutation and a premature nonsense codon, which resulted in a truncated dystrophin that lost its most critical function and underwent post-transcriptional degradation. …”
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Assessing the Efficiency and Role of Eivan Based on Users’ Perception: A Semi-open Space in Rural Vernacular Houses of Mazandaran by Majid Yousefniapash, Maria Barzegar

“…Given that the lifestyle is enmeshed with the nature and because of the special characteristics of the environment of this region, semi-open spaces generally, and loggia particularly, play various functional, aesthetical, climatic, cultural, and social roles within vernacular houses. …”
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Genetic Polymorphism of beta1-adrenergic Receptors and the Effect on the Clinical Efficacy of beta-adrenoblockers by V. N. Larina, M. V. Leonova

“…The variant Gly389 allele has reduced functional activity and carriers have a weak response to the use of beta-blockers. …”
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Association of multidimensional frailty and dynapenia with fall risk in older adults by Maryam Ghorbanzadeh, Afsaneh Bakhtiari, Karimollah Hajian-Tilaki, Maryam Abbaszadeh-Amirdehi

“…Abstract Background Dynapenia and frailty are known to be strong predictors of decreased function and increased mortality in the older adults. …”
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RISK FACTORS FOR IRREVERSIBLE VISION LOSS IN TUMORS OF THE SELLAR REGION by Kateryna S. Iegorova, Mykola O. Guk, Maria A. Znamenska, Valeriia V. Musulevska

“…The results of diagnosis and treatment of 300 patients (600 eyes) with skull base tumors, who were treated at the National Academy of Medical Sciences of Ukraine Romodanov Neurosurgery Institute from 2017 to 2023. Depending on the ophthalmological result after the removal of the skull base tumors and decompression of the chiasm, the patients were divided into 2 subgroups: I – recovery of visual functions (100 patients, 33.3%, 200 eyes), II – without recovery of visual functions (200 patients, 66.7 %, 400 eyes). …”
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Chronic benzodiazepine treatment triggers gephyrin scaffold destabilization and GABAAR subsynaptic reorganization by Caitlyn A. Chapman, Nadya Povysheva, Tyler B. Tarr, Jessica L. Nuwer, Stephen D. Meriney, Jon W. Johnson, Tija C. Jacob

“…An identified rise in extrasynaptically-localized gephyrin cleavage fragments may function to confine receptors away from the synapse, as supported by a decrease in extrasynaptic γ2-GABAAR mobility. …”
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CircSmox knockdown alleviates PC12 cell apoptosis and inflammation in spinal cord injury by miR‐340‐5p/Smurf1 axis by Ziyin Han, Zufang Mou, Yulong Jing, Rong Jiang, Tao Sun

“…Results LPS elevated the levels of circSmox and Smurf1, but decreased the levels of miR‐340‐5p in PC12 cells in a dose‐dependent manner. Functionally, circSmox silencing alleviated LPS‐induced apoptosis and inflammation in PC12 cells in vitro. …”
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Strain Engineering of Anisotropic Electronic, Transport, and Photoelectric Properties in Monolayer Sn₂Se₂P₄ by Haowen Xu, Yuehua Xu

“…In this study, we demonstrate that the Sn₂Se₂P₄ monolayer exhibits intrinsic anisotropic electronic characteristics with the strain-synergistic modulation of carrier transport and optoelectronic properties, as revealed by various levels of density functional theory calculations combined with the non-equilibrium Green’s function method. …”
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Standard mouse diets lead to differences in severity in infectious and non-infectious colitis by Joshua E. Denny, Julia N. Flores, Nontokozo V. Mdluli, Michael C. Abt

“…Factors like diet that shape microbiota composition and function may modulate C. difficile colitis. Here, we report that mice fed two distinct standard mouse chows (LabDiet 5010 and LabDiet 5053) exhibited significantly different susceptibility to severe C. difficile infection. …”
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Monitoring of Aspirin Therapy in Patients with Cerebrovascular Pathology by M. M. Tanashyan, A. A. Raskurazhev, A. A. Kornilova, A. A. Shabalina, D. A. Abaimov, A. V. Naminov

“…The relationship between the level of ASA and SA in the blood plasma and the functional activity of platelets was confirmed. The presence of T2DM is associated with a decrease in the concentration of ASA and aspirin resistance detected in therapeutic drug monitoring.…”
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Electronic structure of (Mn_{1−x}Pb_{x})Bi_{2}Te_{4}: Experimental evidence of topological phase transition by D. A. Estyunin, T. P. Estyunina, I. I. Klimovskikh, K. A. Bokai, V. A. Golyashov, K. A. Kokh, O. E. Tereshchenko, S. Ideta, Y. Miyai, Y. Kumar, T. Iwata, T. Kosa, T. Okuda, K. Miyamoto, K. Kuroda, K. Shimada, A. M. Shikin

“…In this study, we present a detailed investigation of the electronic structure evolution in (Mn_{1−x}Pb_{x})Bi_{2}Te_{4} as a function of Pb concentration, using a variety of angle-resolved photoemission spectroscopy based techniques, including photon-energy-dependent studies, spin-resolved, and circular dichroism (CD) measurements. …”
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Oxygen determines the requirement for cobalamin but not riboflavin in the growth of Propionibacterium freudenreichii by Ruoxi Zhang, Yuandong Sha, Bhawani Chamlagain, Minnamari Edelmann, Kirsi Savijoki, Vieno Piironen, Paulina Deptula, Pekka Varmanen

“…Abstract Vitamin B12 (cobalamin, hereafter B12) is essential for human health, particularly for neural function and DNA synthesis. It is synthesized exclusively by bacteria and archaea, with animal-derived foods serving as the primary sources for humans. …”
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Optimizing Screening Performance for the Risk of Hyperoxaluria and Urolithiasis Using the Urinary Oxalate/Creatinine Ratio: A Retrospective Analysis by Pierre Letourneau, Lara Cabezas, Aurélie De Mul, Nadia Abid, Christelle Machon, Cécile Poussineau, Cécile Acquaviva, Justine Bacchetta, Laurence Derain-Dubourg, Sandrine Lemoine

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Application of Robust Approach to Capacitated Location of Collection Sites and Capacitated Vehicle-routing Problem Model in an Urban Waste Management System by Mohammad Hossein Kabgani, Hamid Shahbandarzadeh, Ebrahim Heidari, Nooraldin Amiri

“…In the present study, a model including two robust objective functions to reduce costs related to the location of waste transfer facilities in Bushehr. …”
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CD73+CD8+ T cells define a subset with anti-tumor potential in DLBCL patients by Lingyu Zhang, Rui Cheng, Zongbing Fan, Yunxiao Liu, Jie Huang, Jiabing Peng

“…Our findings deepen the understanding of CD8+ T cell heterogeneity in DLBCL and emphasize the need for mechanistic studies to explore CD73’s context-dependent functions.…”
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Negative Differential Resistance in Single‐Molecule Junctions Based on Heteroepitaxial Spherical Au/Pt Nanogap Electrodes by Dongbao Yin, Miku Furushima, Eiji Tsuchihata, Seiichiro Izawa, Tomoya Ono, Ryo Shintani, Yutaka Majima

“…This NDR feature persists in a consecutive endurance test of 180 current traces. the thermally stable NDR effects in the Si2 × 2 single‐molecule junctions between 9 and 300 K are demonstrated. The density functional theory calculations under electric fields indicate that the NDR effect can be ascribed to the bias‐dependent resonant tunneling transport via the polarized HOMO, which has asymmetrically changed electrode coupling with increased bias voltages. …”
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Mitochondrial KMT9 methylates DLAT to control pyruvate dehydrogenase activity and prostate cancer growth by Yanhan Jia, Sheng Wang, Sylvia Urban, Judith M. Müller, Manuela Sum, Qing Wang, Helena Bauer, Uwe Schulte, Heike Rampelt, Nikolaus Pfanner, Katrin M. Schüle, Axel Imhof, Ignasi Forné, Christopher Berlin, August Sigle, Christian Gratzke, Holger Greschik, Eric Metzger, Roland Schüle

“…Together, we present a mechanism of PDC regulation and an example of a histone methyltransferase with nuclear and mitochondrial functions. The dependency of PCa cells on mitochondrial KMT9 allows to develop therapeutic strategies to selectively fight PCa.…”
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hu.MAP3.0: atlas of human protein complexes by integration of >25,000 proteomic experiments by Samantha N Fischer, Erin R Claussen, Savvas Kourtis, Sara Sdelci, Sandra Orchard, Henning Hermjakob, Georg Kustatscher, Kevin Drew

“…Additionally, we use AlphaFold modeling to identify 5871 mutually exclusive proteins in hu.MAP3.0 complexes suggesting complexes serve different functional roles depending on their subunit composition. …”
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