NPC1L1 Drives Osteoporosis by Activating the C/EBPα/Cyp27a1/27‐Hydroxycholesterol Axis: A Novel Therapeutic Target for Bone Loss by Bohao Li, Wuling Zhou, Yueming Yu, Boyu Chen, Zhicheng Lv, Jiarui Zhang, Tieqi Zhang, Shiwei Sun, Lei Zhou, Minghai Wang

“…ABSTRACT This study investigated how NPC1L1, a cholesterol transporter, regulates osteogenic differentiation through cholesterol metabolism independently of its transport function. We also explored the role of NPC1L1 in osteoporosis (OP), focusing on the downstream C/EBPα/Cyp27a1/27‐hydroxycholesterol (27‐OHC) axis. …”
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INTERDISCIPLINARY APPROACH IN TREATMENT OF PATIENTS WITH DENTAL ANOMALIES by l.V. Smahlyuk, N.V. Kulish, O. M. Nesterenko

“…After creating the maximum occlusal contact, the patient regained chewing function. Thus, the treatment of mesial occlusion and its prognosis largely depends on etiological factors and the possibility of their elimination, as well as the severity of morphological and functional disorders, the difficulty of eliminating them during permanent occlusion. …”
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Galacto-oligosaccharide production by Lactobacillus delbrueckii ssp. bulgaricus whole cells and lysates by Giselle K.P. Guron, Arland T. Hotchkiss, Jr., John A. Renye, Jr., Adam M. Oest, Michael J. McAnulty

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CHEMICAL AND QUALITATIVE CHARACTERISTIC OF BREAD AND CRACKERS INNOVATIVE ENRICHES WITH PUREE OF RUCOLA CARACTERISTIQUE CHIMIQUE ET QUALITATIVE DE PAIN ET CRAQUELINS INNOVATIFS ENRI... by ROSEN CHOCHKOV, SILVIYA TOPLEVA, VALENTINA CHONOVA, TZVETANA GOGOVA, MILENA NIKOLOVA, TSVETKO PROKOPOV

“…The industrial production and the market realization of innovative, functional foods are highly dependent on the phenomenon of information asymmetry between the producer and the consumer. …”
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Music-induced cognitive change and whole-brain network flexibility: a pilot study by E. Lydia Wu-Chung, Melia E. Bonomo, Anthony K. Brandt, Bryan T. Denny, Christof Karmonik, Christof Karmonik, J. Todd Frazier, Karl Blench, Christopher P. Fagundes, Christopher P. Fagundes, Christopher P. Fagundes, Christopher P. Fagundes

“…However, the relationship between group assignment and change in global cognitive function depended on baseline flexibility: music creativity improved global cognition more than the control condition, only among individuals who had higher than average network flexibility.DiscussionFindings suggest that having a dynamic brain network, which has previously been linked to better executive functioning performance, may be necessary for music-related benefits on cognition. …”
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Pharmacokinetic, pharmacodynamic, and transcriptomic analysis of chronic levetiracetam treatment in 5XFAD mice: A MODEL‐AD preclinical testing core study by Kristen D. Onos, Sara K. Quinney, David R. Jones, Andrea R. Masters, Ravi Pandey, Kelly J. Keezer, Carla Biesdorf, Ingrid F. Metzger, Jill A. Meyers, Johnathon Peters, Scott C. Persohn, Brian P. McCarthy, Amanda A. Bedwell, Lucas L. Figueiredo, Zackary A. Cope, Michael Sasner, Gareth R. Howell, Harriet M. Williams, Adrian L. Oblak, Bruce T. Lamb, Gregory W. Carter, Stacey J. Sukoff Rizzo, Paul R. Territo

“…Abstract Introduction Hyperexcitability and epileptiform activity are commonplace in Alzheimer's disease (AD) patients and associated with impaired cognitive function. The anti‐seizure drug levetiracetam (LEV) is currently being evaluated in clinical trials for ability to reduce epileptiform activity and improve cognitive function in AD. …”
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The impact of point mutations in the human androgen receptor: classification of mutations on the basis of transcriptional activity. by Colin W Hay, Iain J McEwan

“…Therefore, the widely accepted supposition that androgen receptor mutations in prostate cancer result in gain of function is appealing, but mistaken. In addition, the transcriptional outcome of some mutations is dependent upon the androgen receptor responsive element. …”
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Selecting of statins optimum dosage regimen in patients with acute Q-wave myocardial infarction after thrombolytic therapy by V. D. Syvolap, S. M. Kyselov, A. A. Alferov

“…In group of high-doses of statins in the subacute period of Q-wave myocardial infarction observed higher exercise tolerance against the backdrop of increasing the power of global LV systolic function. 4. The use of low-dose statin regimens accompanied by more severe violations of diastolic LV function. …”
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Passive Wireless Body Joint‐Monitoring Networks with Textile‐Integrated, Strongly Coupled Magnetic Resonators by Fan Ye, Amirhossein Hajiaghajani, Amir Zargari, Alberto Escobar, Huiting Qin, Lei Li, Chengyang Qian, Kazi Khurshidi Haque Dia, Md Abeed Hasan, Manik Dautta, Fadi Kurdahi, Michelle Khine, Peter Tseng

“…Abstract Current joint angle monitoring techniques—essential for evaluating biomechanical functions and rehabilitation outcomes—face significant challenges. …”
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Bivariate Epanechnikov-exponential distribution: statistical properties, reliability measures, and applications to computer science data by H. M. Barakat, M. A. Alawady, I. A. Husseiny, M. Nagy, A. H. Mansi, M. O. Mohamed

“…In addition, we calculated reliability and information measures including the hazard function, reversed hazard function, positive quadrant dependence feature, bivariate extropy, bivariate weighted extropy, and bivariate cumulative residual extropy. …”
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Fructose promotes ampicillin killing of antibiotic-resistant Streptococcus agalactiae by Xuan-Wei Chen, Jia-Han Wu, Ying-Li Liu, Hetron Mweemba Munang’andu, Bo Peng

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Conformational Locking of the Geometry in Photoluminescent Cyclometalated N^C^N Ni(II) Complexes by Maryam Niazi, Iván Maisuls, Lukas A. Mai, Sascha A. Schäfer, Alex Oster, Lukas Santiago Diaz, Dirk M. Guldi, Nikos L. Doltsinis, Cristian A. Strassert, Axel Klein

“…The complexes exhibit long-wavelength absorption bands at approximately 425 nm in solution, with the experimental spectra being accurately reproduced through time-dependent density functional theory (TD-DFT) calculations. …”
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RELATIONSHIP OF THE IMMUNOLOGICAL PARAMETRES WITH NEOADJUVANT CHEMOTHERAPY EFFECTIVENESS IN BREAST CANCER PATIENTS by Y. V. Kukharev, M. N. Stakheeva, A. V. Doroshenko, N. V. Litvyakov, N. N. Babyshkina, E. M. Slonimskaya, N. V. Cherdyntseva

“…The estimation of the subpopulation composition of blood mononuclear cells, their functional activity, apoptosis markers, allelic polymorphism of cytokine genes, depending on the presence or absence of clinical response to NAC was done. …”
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CARDIOPROTECTIVE EFFECT OF PHYSICAL REHABILITATION IN PATIENTS WITH ISCHEMIC-ORIGIN DIASTOLIC DYSFUNCTION AFTER PERCUTANEOUS CORONARY INTERVENTION by N. P. Lyamina, A. N. Nosenko, I. B. Razborova, O. V. Orlikova, E. V. Kotel'nikova, E. S. Karpova

“…To study effect of long-term controlled physical training (CPT) of moderate intensity on diastolic function, depending on the degree of recanalization, in patients with ischemic heart disease (ICD) with left ventricle diastolic dysfunction (DD) who underwent percutaneous coronary intervention (PCI). …”
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STABILITY IN PRODUCTION PROCESS OF TRANSPORT MACHINERY by T. I. Chepeleva

“…Number of constructive characteristics are determined by functional structure and depend on an abstraction rate, revealing ratio of complete description of the production system.…”
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Unveiling Wolbachia transcriptomic signature in the arboviral vector Aedes aegypti by Sebastián Mejías, Sebastián Mejías, Natalia E. Jiménez, Natalia E. Jiménez, Natalia E. Jiménez, Carlos Conca, Carlos Conca, J. Cristian Salgado, J. Cristian Salgado, Ziomara P. Gerdtzen, Ziomara P. Gerdtzen, Ziomara P. Gerdtzen, Ziomara P. Gerdtzen

“…By identifying differences between Wolbachia-infected and uninfected A. aegypti, previous transcriptomic studies proposed a wide range of symbiotic interactions, but a systematic identification of consistent effects across datasets is still missing.MethodsTo identify A. aegypti genes and functions consistently affected by Wolbachia, we performed differential expression and functional enrichment analysis on published transcriptomic datasets, followed by a meta-analysis of the obtained p-values using the maxP method. …”
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THE STUDY OF CHEMICAL ASSEMBLY OF MACROMOLECULES IN POLYCONDENSATION OF DIFUNCTIONAL DIMETHYLSILANES by Е. М. Tarasova, A. V. Butuzov, A. A. Cherkasova, P. V. Ivanov

“…The effect of the molar ratio of components on the composition of products of partial hydrolysis of the functional dimethylsilanes and dependence of the monomer conversion degree (Xm) vs. conversion of functional groups (Xf) are presented. …”
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Primate lentiviruses use at least three alternative strategies to suppress NF-κB-mediated immune activation. by Dominik Hotter, Teresa Krabbe, Elisabeth Reith, Ali Gawanbacht, Nadia Rahm, Ahidjo Ayouba, Benoît Van Driessche, Carine Van Lint, Martine Peeters, Frank Kirchhoff, Daniel Sauter

“…Thus, primate lentiviruses have evolved at least three alternative strategies to inhibit NF-κB-dependent immune activation. Functional analyses showed that the inhibitory activity of SIVolc and SIVcol Vprs is independent of DCAF1 and the induction of cell cycle arrest. …”
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Ginsenoside Rg1 controls CKLF1-mediated apoptosis to reduce hypoxic/reoxygenation injury in HT22 cells by Jinping Liang, Xuan Zhu, Feng Li, Yan Yang, Yuchen Zhu, Shasha Liu, Yang Sun, Boyu Kuang, Junpeng Long, Qian Yan, Yuting Lin, Qidi Ai, Yantao Yang

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Mechanisms and active substances of targeting lipid peroxidation in ferroptosis regulation by Hui Chen, Lingli Chen, Wenjun Wang

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