An anticipatory mechanism enhances the cooperative behaviors of quorum sensing mutants in Pseudomonas aeruginosa. by Min Yuan, Huifang Qiu, Xiaoqing Zhou, Weijun Dai

“…We found that a LasR228 variant strain, bearing a non-conserved substitution in LasR, exhibited minimal LasR-dependent phenotypes. However, the function of this LasR228 variant strain was restored by inactivation of the transcriptional repressor PsdR, and the phenotypes of this variant strain were similar to the parental strain. …”
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Evaluation of the Physicochemical and Micromeritic Properties of Exudate Gum of Cussonia arborea Stem Bark in Conventional Tablet Formulation by Samuel Lugrie Kipo, Noble Kuntworbe, Mariam El Boakye-Gyasi, Yaa Asantewaa Osei, Frederick William Akuffo Owusu, Raphael Johnson, Kwabena Ofori-Kwakye, Marcel Tunkumgnen Bayor

“…However, functionality evaluations, procedures, and related acceptance criteria for excipients tend to depend on the dosage form, and assessment is usually done on a case-by-case basis. …”
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Cystic fibrosis treatment; small molecule modulators vs genetic therapy by Salma Aly Elmallah, Raafat Soliman

“…Small molecule therapy depends on the development of small pharmacological agents that can bind to the mutated CFTR protein restoring its function. …”
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Improving viral annotation with artificial intelligence by Zachary N. Flamholz, Charlotte Li, Libusha Kelly

“…ABSTRACT Viruses of bacteria, “phages,” are fundamental, poorly understood components of microbial community structure and function. Additionally, their dependence on hosts for replication positions phages as unique sensors of ecosystem features and environmental pressures. …”
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Monopolin subunit Csm1 associates with MIND complex to establish monopolar attachment of sister kinetochores at meiosis I. by Sourav Sarkar, Rajesh T Shenoy, Jacob Z Dalgaard, Louise Newnham, Eva Hoffmann, Jonathan B A Millar, Prakash Arumugam

“…In budding yeast, mono-orientation depends on a four component protein complex referred to as monopolin which consists of two nucleolar proteins Csm1 and Lrs4, meiosis-specific protein Mam1 of unknown function and casein kinase Hrr25. …”
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Angiotensin 1-7 Protects against Angiotensin II-Induced Endoplasmic Reticulum Stress and Endothelial Dysfunction via Mas Receptor. by Dharmani Murugan, Yeh Siang Lau, Chi Wai Lau, Mohd Rais Mustafa, Yu Huang

“…The present study provides new evidence for functional antagonism between the two arms of the renin-angiotensin system in endothelial cells by demonstrating that Ang 1-7 ameliorates Ang II-stimulated ER stress to raise NO bioavailability, and subsequently preserves endothelial function.…”
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Perineuronal Nets in Syrian Hamsters: Anatomical Localization, Sex Differences, Diurnal Variation, and Response to Social Stress by Emma K. Shaughnessy, Benjamin W. Horne, Kim L. Huhman

“…Finally, we also demonstrated that there are sex differences in PNN expression in the somatosensory cortex and the basolateral amygdala in hamsters, suggesting that sex as a biological variable should be considered in studies of PNN function. Conclusion Together, the data from the current study suggest that a comparative approach will be necessary to fully elucidate the functional role of PNNs and, further, that Syrian hamsters are a valuable model in this endeavor.…”
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Brain deletion of insulin receptor substrate 2 disrupts hippocampal synaptic plasticity and metaplasticity. by Derek A Costello, Marc Claret, Hind Al-Qassab, Florian Plattner, Elaine E Irvine, Agharul I Choudhury, K Peter Giese, Dominic J Withers, Paola Pedarzani

“…These deficits and the corresponding neurophysiological structural and functional alterations are linked to both metabolic and vascular changes, related to chronic hyperglycaemia, but probably also defects in insulin action in the brain. …”
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Ventilation in the obese: physiological insights and management by Claudio Rabec, Jean-Paul Janssens, Patrick B. Murphy

“…Obesity can have profound adverse effects on the respiratory system, including an impact on pulmonary function, respiratory mechanics, respiratory muscle strength and endurance, gas exchange, control of breathing, and exercise capacity. …”
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Current concepts in managing fractures of metacarpal and phalangess by Jagannath B. Kamath, Deepak M. Naik, Ankush Bansal

“…No where in the body, the form and function are so closely related to each other than in hand. …”
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Molecular remodeling of tip links underlies mechanosensory regeneration in auditory hair cells. by Artur A Indzhykulian, Ruben Stepanyan, Anastasiia Nelina, Kateri J Spinelli, Zubair M Ahmed, Inna A Belyantseva, Thomas B Friedman, Peter G Barr-Gillespie, Gregory I Frolenkov

“…Thus, our findings provide a molecular mechanism for regeneration and maintenance of mechanosensory function in postmitotic auditory hair cells and could help identify elusive components of the mechanotransduction machinery.…”
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Exploring the Neural Correlates of Metal Exposure in Motor Areas by Daniele Corbo, Roberto Gasparotti, Stefano Renzetti

“…Some studies exhibit structural or functional reductions in these areas that correlate with increased levels of metal exposure, suggesting a dose-dependent neurotoxic effect. …”
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The role of the matrix-edge dynamics of amphibian conservation in tropical montane fragmented landscapes by Georgina Santos-Barrera, Nicolás Urbina-Cardona

“…Edge effects play a key role in forest dynamics in which the context of the anthropogenic matrix has a great influence on fragment connectivity and function. The study of the interaction between edge and matrix effects in nature is essential to understand and promote the colonization of some functional groups in managed ecosystems. …”
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Construction of a theoretical framework for the downstream effects of social alienation in young-onset dementia patients based on grounded theory by KANG Yun, SHAO Yan, PENG Guihai, ZHU Shuzhen, LI Longti

“…Data were gathered using semi-structured interviews and analyzed through procedural grounded theory methods using NVIVO 12.0 software for open, axial, and selective coding to test the saturation of the theory.Results Cognitive decline process, diminished occupational abilities, emotional isolation and psychological stress, shrinking social activities and interactions, declining life skills and quality, and increased need for medical and social support were the six main dornains of the core category "social alienation downstream effects in YOD patiens" and were categorized as the central impact, functional decrement, emotional disorder, social disconnection, life adaptation, and support dependence.Conclusion This research constructed a six-dimensional theoretical framework for the downstream effects of social alienation in YOD patients. …”
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Pulmonary hazards of nanoplastic particles: a study using polystyrene in in vitro models of the alveolar and bronchial epithelium by Sara Michelini, Safaa Mawas, Ema Kurešepi, Francesco Barbero, Katarina Šimunović, Dorian Miremont, Stéphanie Devineau, Martin Schicht, Victor Ganin, Øyvind Pernell Haugen, Anani Komlavi Afanou, Charlotte Izabelle, Shan Zienolddiny-Narui, Katharina Jüngert, Neža Repar, Ivana Fenoglio, Barbara Šetina Batić, Friedrich Paulsen, Ines Mandić-Mulec, Sonja Boland, Andreja Erman, Damjana Drobne

“…Conclusion Our results show that PS-Eu exposure does not induce acute cytotoxicity in these models, but affects cell-specific functions like surfactant, mucin, and cytokine production. …”
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Emulsifying properties of tribomechanically treated whey proteins by Suzana Rimac Brnčić, Marija Badanjak Sabolović, Vesna Lelas

“…Whey proteins are used in a wide range of food products because of their high nutritional value and the ability to contribute to the unique functional properties of the final products. The functional properties of whey proteins are affected not only by the whey origin, season dependent variations of protein and non-protein components amount, but also by the conditions of processes involved in their isolation, purification and modification (temperature, pH, pressure, chemicals). …”
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Phase and Valence State Engineering of MOFs-Derived Iron Oxide@Carbon Polyhedrons for Advanced Microwave Absorption by Xiaojiao Yang, Shuai Han, Hongna Xing, Yi Dong, Xia Deng, Yan Zong, Juan Feng, Xiuhong Zhu, Xinghua Li, Xinliang Zheng

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Correlations in Magnetic Sub‐Domains as an Unconventional Phase Diagram for van der Waals Ferromagnets by Sergey Y. Grebenchuk, Magdalena Grzeszczyk, Zhaolong Chen, Makars Šiškins, Vladislav Borisov, Manuel Pereiro, Mikhail I. Katsnelson, Olle Eriksson, Kostya S. Novoselov, Maciej Koperski

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Case report: full recovery from dialysis-requiring renal failure after surgical repair of a completely occluded renal artery in a patient with a single kidney by Marta Kantauskaite, Klaus Grabitz, Lars Christian Rump, Sebastian Alexander Potthoff

“…Abstract Introduction Renal infarction is an extremely rare condition occurring in the context of structural or functional cardiac abnormalities, renal artery injury or coagulative syndromes. …”
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A new method of surgical upper eyelid ptosis treatment by I. A. Filatova, Yu. P. Kondratyeva, S. A. Shemetov, M. S. Trefilova

“…Purpose: to develop a new method of surgical treatment of moderate upper eyelid ptosis.Material and methods. 88 patients (106 eyes) aged 5–68 years (averagely 24.9 yrs), operated for moderate or severe upper eyelid ptosis, were divided into 3 groups depending on the degree of upper eyelid prolapse and levator function. …”
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