Neurorehabilitation and white matter repair in traumatic spinal cord injury: a dialogue between clinical and preclinical studies by Vito Antonio Baldassarro, Ilaria Baroncini, Laura Calzà, Francesca Ciardulli, Luca Lorenzini, Francesco Giuseppe Materazzi, Francesca Merighi, Corinne Quadalti, Lucia Ricci, Francesca Serafino, Laura Simoncini

“…The central nervous system (CNS) has very limited repair capabilities, and the functional adaptation/compensation after acute injuries is attributed to the significant plasticity of neural circuits, in particular at the synaptic level. …”
Get full text

The interplay of RecA-related proteins and the MND1-HOP2 complex during meiosis in Arabidopsis thaliana. by Julien Vignard, Tanja Siwiec, Liudmila Chelysheva, Nathalie Vrielynck, Florine Gonord, Susan J Armstrong, Peter Schlögelhofer, Raphael Mercier

“…However, little is known about the functional interplay between these proteins during meiosis. …”
Get full text

A Syntenic Cross Species Aneuploidy Genetic Screen Links RCAN1 Expression to β-Cell Mitochondrial Dysfunction in Type 2 Diabetes. by Heshan Peiris, Michael D Duffield, Joao Fadista, Claire F Jessup, Vinder Kashmir, Amanda J Genders, Sean L McGee, Alyce M Martin, Madiha Saiedi, Nicholas Morton, Roderick Carter, Michael A Cousin, Alexandros C Kokotos, Nikolay Oskolkov, Petr Volkov, Tertius A Hough, Elizabeth M C Fisher, Victor L J Tybulewicz, Jorge Busciglio, Pinar E Coskun, Ann Becker, Pavel V Belichenko, William C Mobley, Michael T Ryan, Jeng Yie Chan, D Ross Laybutt, P Toby Coates, Sijun Yang, Charlotte Ling, Leif Groop, Melanie A Pritchard, Damien J Keating

“…This lack of β-cell ATP had functional consequences by negatively affecting both glucose-stimulated membrane depolarisation and ATP-dependent insulin granule exocytosis. …”
Get full text

The glycosaminoglycan chains of perlecan regulate the perivascular fluid transport by Abhishek Singh, Mika Kaakinen, Harri Elamaa, Vesa Kiviniemi, Lauri Eklund

“…The purpose of this study was the functional characterization of perivascular fluid transport and brain clearance in mice lacking perlecan GAG chains. …”
Get full text

Intelligent assistance system for people with visual impairments by Олеся Барковська, Віталій Сердечний

“…Tasks: To achieve the set objective, the following tasks were accomplished: a generalized functional model of the proposed intelligent assistance system for people with visual impairments was created; the functional dependencies of the components of the developed model were substantiated; a review of the basic modules of the proposed system model was conducted. …”
Get full text

Dragonfly‐Inspired Compound Eye Lens with Biomimetic Structural Design by Kenshin Takemura, Taisei Motomura, Wataru Iwasaki, Nobutomo Morita, Kazuya Kikunaga

“…Abstract Compound eye biomimetics are extensively studied owing to their high level of functionality. However, optimizing material‐dependent parameters, such as refractive index, is essential for maximizing lens function. …”
Get full text

Butterfat recovery from waste ice cream via churning and clarification – Proof of concept by Rafael A. Garcia, Lorelie P. Bumanlag, Faith Olszewski, Farah Huynh, Changhoon Lee, Benjamin M. Plumier, John A. Renye, Peggy M. Tomasula

Get full text

Constraints on the Electron Acceleration Process in Solar Flare: A Case Study by G. Li, X. Wu, F. Effenberger, L. Zhao, S. Lesage, N. Bian, L. Wang

“…We further find that the release time of in situ electrons is a function of electron energy. Under the assumption that the acceleration mechanism for the upward propagating electrons is of Fermi‐type and is controlled by an energy‐dependent diffusion coefficient, we fit these release times by a simple functional form, related to the turbulence spectral index. …”
Get full text

Oxidized protein aggregate lipofuscin impairs cardiomyocyte contractility via late-stage autophagy inhibition by Sophia Walter, Steffen P. Häseli, Patricia Baumgarten, Stefanie Deubel, Tobias Jung, Annika Höhn, Christiane Ott, Tilman Grune

“…Induction of autophagy with rapamycin mitigated contractile dysfunction in lipofuscin-treated cardiomyocytes, whereas inhibition of autophagic flux revealed stage-dependent effects. Late-stage autophagy inhibition using chloroquine or concanamycin A reduced cardiomyocyte contraction amplitude, whereas early-stage autophagy inhibition via 3-methyladenine did not affect contraction within 24 h.In conclusion, our results indicate that lipofuscin directly impairs cardiomyocyte function by diminishing late-stage autophagic flux. …”
Get full text

RyRCa2+ leak limits cardiac Ca2+ window current overcoming the tonic effect of calmodulinin mice. by María Fernández-Velasco, Gema Ruiz-Hurtado, Angélica Rueda, Patricia Neco, Martha Mercado-Morales, Carmen Delgado, Carlo Napolitano, Silvia G Priori, Sylvain Richard, Ana María Gómez, Jean-Pierre Benitah

“…Both increasing fast [Ca(2+)](i) buffer capacity or depleting SR Ca(2+) store blunted these changes, which could be reproduced in WT cells by RyRCa(2+) leak induced with Ryanodol and CaM inhibition.Our results unveiled a new paradigm for CaM-dependent effect on LTCC gating and further the nanodomain Ca(2+) control of LTCC, emphasizing the importance of spatio-temporal relationships between Ca(2+) signals and CaM function.…”
Get full text

Phosphorylation of Sli15 by Ipl1 is important for proper CPC localization and chromosome stability in Saccharomyces cerevisiae. by Vasso Makrantoni, Stephen J Corbishley, Najma Rachidi, Nicholas A Morrice, David A Robinson, Michael J R Stark

“…Here we have identified multiple sites of CPC autophosphorylation on yeast Sli15 that are located within its central microtubule-binding domain and examined the functional significance of their phosphorylation by Ipl1 through mutation of these sites, either to non-phosphorylatable alanine (sli15-20A) or to acidic residues to mimic constitutive phosphorylation (sli15-20D). …”
Get full text

Optical investigation of degradation of graphene oxide in alkaline environment: Evidence of two distinct photon-emitting phases in visible region. by Emiliano Burresi, Maria Lucia Protopapa

“…In this work we show a procedure of treating of the graphene oxide in alkaline environment as a function of the treatment time in order to obtain novel structures with strong luminescence properties, water-stable, useful as potential replacement for critical raw materials employed as example in optical and optoelectronic devices or for diagnostic and therapeutic technology. …”
Get full text

Evidence for a major role of antisense RNAs in cyanobacterial gene regulation by Jens Georg, Björn Voß, Ingeborg Scholz, Jan Mitschke, Annegret Wilde, Wolfgang R Hess

“…Transferring cultures to high light, carbon‐limited conditions or darkness influenced the expression levels of several asRNAs, suggesting their functional relevance. Examples include the asRNA to rpl1, which accumulates in a light‐dependent manner and may be required for processing the L11 r‐operon and the SyR7 noncoding RNA, which is antisense to the murF 5′ UTR, possibly modulating murein biosynthesis. …”
Get full text

Vector Effects of Dissipative Soliton in All-Fiber MOPA System by Xiang-Yue Li, Shi-Lin Liu, Meng Liu, Ai-Ping Luo, Zhi-Chao Luo, Wen-Cheng Xu

Get full text

Creating a Superior <i>Wx</i> Allele with Temperature-Responsive Amylose Regulation and a Novel Transcriptional Pattern in Rice via CRISPR/Cas9-Mediated Promoter Editing by Jiali Yan, Jiawen Yu, Huimin Shen, Lihui Zhou, Zhuanzhuan Chen, Xiaolei Fan, Qianfeng Li, Changquan Zhang, Qing Liu, Lichun Huang, Qiaoquan Liu

Get full text

The Geometry of Concepts: Sparse Autoencoder Feature Structure by Yuxiao Li, Eric J. Michaud, David D. Baek, Joshua Engels, Xiaoqing Sun, Max Tegmark

“…We find that the quality of such parallelograms and associated function vectors improves greatly when projecting out global distractor directions such as word length, which is efficiently performed with linear discriminant analysis. (2) The “brain” intermediate-scale structure has significant spatial modularity; for example, math and code features form a “lobe” akin to functional lobes seen in neural fMRI images. …”
Get full text

Trans-synaptic molecular context of NMDA receptor nanodomains by Michael C. Anderson, Poorna A. Dharmasri, Martina Damenti, Sarah R. Metzbower, Rozita Laghaei, Thomas A. Blanpied, Aaron D. Levy

“…These findings suggest synaptic functional architecture depends on assembly of and trans-cellular spatial relationships between multiprotein nanodomains.…”
Get full text

Morphology of Mitochondria in Syncytial Annelid Female Germ-Line Cyst Visualized by Serial Block-Face SEM by Anna Z. Urbisz, Sebastian Student, Małgorzata A. Śliwińska, Karol Małota

“…Mitochondria change their morphology and distribution depending on the metabolism and functional state of a cell. …”
Get full text

Tissue-specific control of latent CMV reactivation by regulatory T cells. by Maha Almanan, Jana Raynor, Allyson Sholl, Mei Wang, Claire Chougnet, Rhonda D Cardin, David A Hildeman

“…Combined, these data show that Treg have divergent control of MCMV infection depending upon the tissue. In the spleen, Treg antagonize CD8+ effector function and promote viral persistence while in the salivary gland Treg prevent IL-10 production and limit viral reactivation and replication. …”
Get full text

A generalized linear model for estimating spectrotemporal receptive fields from responses to natural sounds. by Ana Calabrese, Joseph W Schumacher, David M Schneider, Liam Paninski, Sarah M N Woolley

“…Several algorithms have been used to estimate STRFs from responses to natural stimuli; these algorithms differ in their functional models, cost functions, and regularization methods. …”
Get full text