High mtDNA content identifies oxidative phosphorylation-driven acute myeloid leukemias and represents a therapeutic vulnerability by Diego A. Pereira-Martins, Isabel Weinhäuser, Emmanuel Griessinger, Juan L. Coelho-Silva, Douglas R. Silveira, Dominique Sternadt, Ayşegül Erdem, Bruno Kosa L. Duarte, Prodromos Chatzikyriakou, Lynn Quek, Antonio Bruno Alves-Silva, Fabiola Traina, Sara T. Olalla Saad, Jacobien R. Hilberink, Amanda Moreira-Aguiar, Maria L. Salustiano-Bandeira, Marinus M. Lima, Pedro L. Franca-Neto, Marcos A. Bezerra, Nisha K. van der Meer, Emanuele Ammatuna, Eduardo M. Rego, Gerwin Huls, Jan Jacob Schuringa, Antonio R. Lucena-Araujo

“…Abstract Metabolic reprogramming is a hallmark of cancer, with acute myeloid leukemia (AML) being no exception. Mitochondrial function, particularly its role in protecting tumor cells against chemotherapy, is of significant interest in AML chemoresistance. …”
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Directed evolution and modular integration of a high-affinity ICOS-L variant for potent T cell–mediated tumor elimination by Ji Yeon Ha, Tae Wook Song, Petrina Jebamani, Sun-Gu Lee, Sang Taek Jung

“…The Inducible T-cell Co-Stimulator (ICOS) is a clinically validated co-stimulatory receptor whose engagement enhances T-cell function. However, the development of ICOS-targeting biologics has been hindered by limited receptor affinity and format-dependent agonist activity. …”
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Information and measuring system on the basis of strain sensors based on silicon microcrystals by A. O. Druzhinin, O. P. Kutrakov, S. I. Nichkalo, V. M. Stasiv

“…One of the promising directions of development of information and measuring systems for monitoring and diagnostics is the use of intelligent sensors of various physical quantities, in particular pressure, temperature, deformation, acceleration, etc. The main functional feature that distinguishes such sensors is the possibility of signal processing directly in the measuring zone, which involves the temperature compensation of the output signal, linearization of the transformation function. …”
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Health Status After Total Hip Arthroplasty: A Literature Review by Mădălin Bulzan, Florica Voiță-Mekeres, Simona Cavalu, Gheorghe Szilagyi, Gabriel Mihai Mekeres, Lavinia Davidescu, Călin Tudor Hozan

“…Total hip arthroplasty (THA) is the definitive treatment for end-stage hip osteoarthritis, reliably relieving pain and restoring joint function. However, patient-reported quality of life (QoL) after THA remains heterogeneous, with recovery trajectories influenced by a range of biological, psychological, and social factors. …”
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Surgery versus non-operative treatment for ER-stress unstable Weber-B unimalleolar fractures: a study protocol for a prospective randomized non-inferiority (Super-Fin) trial by Pasi Ohtonen, Tero Kortekangas, Harri Pakarinen, Simo Taimela, Teppo Jarvinen, Ristomatti Lehtola, Hannu-Ville Leskelä, Olli Savola

“…We hypothesize that non-operative treatment yields non-inferior functional outcome to surgery, the current standard treatment, with no increased risk of harms.…”
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Systematic Construction and Validation of a Novel Ferroptosis-Related Gene Model for Predicting Prognosis in Cervical Cancer by Wentao Qin, Can He, Daqiong Jiang, Yang Gao, Yu Chen, Min Su, Yuanjun Yang, Zhao Yang, Hongbing Cai, Hua Wang

“…Nevertheless, the specific function that ferroptosis plays in the onset and progression of cervical cancer (CC) is yet uncertain. …”
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Potentials of Ultrahigh-Field MRI for the Study of Somatosensory Reorganization in Congenital Hemiplegia by Simona Fiori, Laura Biagi, Paolo Cecchi, Giovanni Cioni, Elena Beani, Michela Tosetti, Mirco Cosottini, Andrea Guzzetta

“…Reorganization of somatosensory function influences the clinical recovery of subjects with congenital unilateral brain lesions. …”
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Dupuytren’s contracture of hand and its medical and social review by V. O. Vishnevskiy

“…For the expert diagnosis, the most important are functional disorders such as the capture and retention of items. …”
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A Highly Charged Positive Cage Causes Simultaneous Enhancement of Type‐II and O2‐Independent‐Type‐I Photodynamic Therapy via One‐/Two‐Photon Stimulation and Tumor Immunotherapy via... by Xiao‐Dong Zhang, Hui‐Juan Yu, Shao‐Qi Guan, Yu‐Lin Lu, Yu Zhang, Yin‐Hui Huang, Ya‐Ping Wang, Chen‐Hui Liu, Zhong‐Min Cao, Yu‐Han Qin, Mei Pan, Jun Shen, Cheng‐Yong Su

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The Laplace Virtual Fields Method for the direct extraction of viscoelastic properties of materials by Marcot, Quentin, Fourest, Thomas, Langrand, Bertrand, Pierron, Fabrice

“…The inverse Laplace transform is then applied to these functions in order to obtain the temporal evolution of the material properties. …”
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FGF21 inhibits ferroptosis caused by mitochondrial damage to promote the repair of peripheral nerve injury by Yao Yan, Yao Yan, Yao Yan, Xinyu Ran, Xinyu Ran, Zihan Zhou, Zihan Zhou, Yuting Gu, Yuting Gu, Yuting Gu, Rendu Wang, Rendu Wang, Chuanqi Qiu, Chuanqi Qiu, Yinuo Sun, Yinuo Sun, Jifeng Wang, Jifeng Wang, Jian Xiao, Jian Xiao, Jian Xiao, Yingfeng Lu, Yingfeng Lu, Jian Wang, Jian Wang, Jian Wang

“…Introduction Ferroptosis is a new type of cell death characterized by lipid peroxidation and iron dependency, representing an emerging disease regulation mechanism. …”
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[Translated article] The influence of socioeconomic status and psychological factors on surgical outcomes of the carpometacarpal osteoarthritis of the thumb by A.M. Martín-Fuentes, C. Ojeda-Thies, M. Campoy-Serón, C. Ortega-Romero, L.R. Ramos-Pascua, D. Cecilia López

“…Lower socio-economic class significantly influences levels of depression and anxiety but did not affect functional outcome. Surgical treatment of carpometacarpal thumb osteoarthritis achieved better self-perceived hand function (QDASH, VAS, Kapandji) than conservative treatment. …”
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Improving Anxiety Related to Chronic Pain Through a Sleep Circadian Intervention Program: A Pilot Study by Sonia López-Monzoni, Gloria Hernando Benito, Sofía Romero-Peralta, Laura Silgado-Martínez, Maria Esther Viejo-Ayuso, Leticia Álvarez-Balado, Enrique Rodríguez Matarranz, Carles Forné Izquierdo, Manuel Sánchez-de-la-Torre, Juan Fernando Masa, Ferrán Barbé, Francisco García-Río, Antonio Martínez-Nicolás, Belén García-Mediano, Esther Solano-Pérez, Olga Mediano

“…Outcomes were evaluated after 6 months through self-reported questionnaires (pain intensity, physical function, depression/anxiety, and quality of life (QoL)). …”
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GLDC interacts with VPS34 to inhibit tumorigenesis and epithelial-mesenchymal transition in hepatocellular carcinoma by Zan Song, Hao Dong, Kailing Zhang, Bingke Qiao, Leilei Li, Zhicheng Zhang, Zhili Fan, Jing Li, Yu Li, Mengfei Liu, Ying Liu, Xinyu Gu, Tao Zhang

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Distribution and diversity of classical deacylases in bacteria by Leonie G. Graf, Carlos Moreno-Yruela, Chuan Qin, Sabrina Schulze, Gottfried J. Palm, Ole Schmöker, Nancy Wang, Dianna M. Hocking, Leila Jebeli, Britta Girbardt, Leona Berndt, Babett Dörre, Daniel M. Weis, Markus Janetzky, Dirk Albrecht, Daniela Zühlke, Susanne Sievers, Richard A. Strugnell, Christian A. Olsen, Kay Hofmann, Michael Lammers

“…Systematic structural and functional characterization of representative enzymes from each cluster reveal high functional diversity, including polyamine deacylases and protein deacylases with various acyl-chain type preferences. …”
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An innovative thermal simulation study of microstructure improvement by delay forging during solidification by Jiongshen Chen, Li Rong, Chenxi Ma, Wu Wei, Shengping Wen, Kunyuan Gao, Hui Huang, Zuoren Nie

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The Study of Fractional Quadratic Integral Equations Involves General Fractional Integrals by Mi Zhou, Hengtai Wang, Zhenghua Xu, Lu Zhang

“…This paper investigates the well-posedness of analytical solutions to fractional quadratic differential equations, which involve generalized fractional integrals with respect to other functions. The nonlinear components <i>f</i> and <i>h</i> depend on spatial variables and the general fractional integral, respectively. …”
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Direct and indirect pathways linking the Lon protease to motility behaviors in the pathogen Pseudomonas aeruginosa. by Aswathy Kallazhi, Anamika Rahman, Ute Römling, Kristina Jonas

“…The ATP-dependent cytoplasmic protease Lon has critical functions in protein quality control and cellular regulation in organisms across the three domains of life. …”
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The pattern of the NOS isoforms expression in arcuate nucleus of hypothalamus in experimental hypertension by Yu. M. Kolesnyk, O. V. Gancheva, S. V. Tishchenko

“…One of the main conditions of the proper neuronal function is combination of their functional stability and plasticity, which is strictly dependable on adequate blood supply, metabolic and trophic processes. …”
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Therapeutic management for patients with trunk and extremities integumentary tissues defects of traumatic genesis by O. V. Ponomarenko

“…Objective: To improve the results of treating patients with wounds, functional and aesthetic defects of mechanical origin by developing a comprehensive program of surgery to restore the form and function of trunk and limbs. …”
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