Structure of the human transcobalamin beta domain in four distinct states. by Joël S Bloch, Markus Ruetz, Bernhard Kräutler, Kaspar P Locher

“…We used this structure to model the binding of anti-B12 into full-length holo-TC and could rule out that the inhibitory function of anti-B12 was based on an inability to form a functional complex with TC.…”
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Ready...go: Amplitude of the FMRI signal encodes expectation of cue arrival time. by Xu Cui, Chess Stetson, P Read Montague, David M Eagleman

“…Specifically, the amplitude of the fMRI signal appears to encode a cumulative conditional probability, also known as the cumulative hazard function. The fMRI signal loses its dependence on waiting time in a "countdown" condition in which the arrival time of the go cue is known in advance, suggesting that the signal encodes temporal probabilities rather than simply elapsed time. …”
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Predicting Thermochemical Equilibria with Interacting Defects: Sr_{1−x}Ce_{x}MnO_{3−δ} Alloys for Water Splitting by Anuj Goyal, Michael D. Sanders, Ryan P. O’Hayre, Stephan Lany

“…To account for such repulsive defect interactions, we introduce a statistical mechanics approach, defining an expression for the free energy of defect interaction based on limited sampling of defect configurations in density functional theory supercell calculations. The parameterization of this energy contribution as a function of defect concentration and temperature allows on-the-fly simulation of thermochemical equilibria. …”
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The ClpXP protease and the ClpX unfoldase control virulence, cell division, and autolysis in Streptococcus pneumoniae by Viktor H. Mebus, Supradipta De, Larissa M. Busch, Manuela Gesell Salazar, Rabea Schlüter, Uwe Völker, Sven Hammerschmidt, Dorte Frees

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Mitochondrial dysfunction in oocytes: implications for fertility and ageing by Tong Wang, Peixin Xu, Jianlong Yuan, Hong Chen, Xin Guo, Jing Gao, Yurong Wang, Dongmei Yao, Xin Li, Bingchun Liu, Yang Liu

“…Maturation, fertilisation, and embryonic development of oocytes depend on the energy provided by mitochondria; however, with increased environmental pollution and ageing, mitochondrial dysfunction and its subsequent functional and metabolic abnormalities have become leading causes of female fertility decline. …”
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Mechanisms of natural killer cell-mediated clearance of senescent renal tubular epithelial cells by Nils David Funk, Julius Sinning, Patrick Schaser, Patrick Schaser, Inga Soerensen-Zender, Vera Christine Wulfmeyer, Kai Schmidt-Ott, Korbinian Brand, Stephan Halle, Stephan Halle, Roland Schmitt, Roland Schmitt

“…IntroductionIntact kidney function is essential for fluid and electrolyte homeostasis, with renal tubular epithelial cells providing critical functions in the reabsorption or secretion of numerous metabolites. …”
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A New Arbiter PUF for Enhancing Unpredictability on FPGA by Takanori Machida, Dai Yamamoto, Mitsugu Iwamoto, Kazuo Sakiyama

“…In general, conventional Arbiter-based Physically Unclonable Functions (PUFs) generate responses with low unpredictability. …”
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Effects of board gender and foreign directorship on the financial sustainability of Saudi listed firms: Does family ownership matter? by Mohammed Naif Alshareef, Hamid Ghazi H Sulimany

“…This positive moderating result supports the agency theory's argument that robust and stringent monitoring of corporate ownership may complement boards' functions and boost organizational efficiency. The policy decision of the findings is that setting corporate boards with a considerable ratio of foreign directors may lead to sustainable performance. …”
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A Copula-Driven CNN-LSTM Framework for Estimating Heterogeneous Treatment Effects in Multivariate Outcomes by Jong-Min Kim

“…Our framework accommodates continuous, count, and censored survival outcomes simultaneously through a multitask learning setup with customized loss functions, including Cox partial likelihood for survival data. …”
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Regulating addictive algorithms and designs: protecting older adults from digital exploitation beyond a youth-centric approach by Yu Yao

“…These designs, which exploit features like infinite scrolling, are associated with higher risk of compulsive use and may correlate with long-term impacts on cognitive health, social functioning, and quality of life for certain subgroups of older adults. …”
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Energy factors affecting environmental pollution for sustainable development goals: The case of India by Vu Ngoc Xuan

“…This study investigates the nexus between electricity consumption, fossil fuel dependency, renewable energy adoption, population growth, trade activities, economic growth, and environmental pollution in India. …”
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Vision-related Quality of Life (VRQOL) and its determinants among the Elderly in rural blocks of Haryana, India by Mona Duggal, Ankita Kankaria, Latika Rohilla, Harashish Jindal, Limalemla Jamir, Parul Chawla Gupta, Debarati Sarkar, Vaibhav Miglani, Akash Kumar, Drishti Sharma, Neha Dahiya, Siddhartha Sharma, Sandeep Grover

“…The study found higher VR-QOL scores in General Health, Distance activities, and Near activities, while lower scores were observed in Mental health, Dependency, Social functioning, Ocular pain, General vision, and Role difficulties. …”
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MODEL FOR THE EVALUATION OF THE AIRPORT SECURITY SYSTEM by Jacek SKORUPSKI, Piotr UCHROŃSKI

“…The paper describes a method for obtaining parameters of trapezoidal membership functions which have been adopted for the linguistic variables “Napłotowy” and “Wykrywalność materiałów”. …”
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p53 transactivation and the impact of mutations, cofactors and small molecules using a simplified yeast-based screening system. by Virginia Andreotti, Yari Ciribilli, Paola Monti, Alessandra Bisio, Mattia Lion, Jennifer Jordan, Gilberto Fronza, Paola Menichini, Michael A Resnick, Alberto Inga

“…<h4>Conclusions/significance</h4>We found that the small molecules Nutlin and RITA could both relieve the MDM2-dependent inhibition of WT p53 transactivation function, while only RITA could impact p53/53BP1 functional interactions. …”
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The human adenovirus E4-ORF1 protein subverts discs large 1 to mediate membrane recruitment and dysregulation of phosphatidylinositol 3-kinase. by Kathleen Kong, Manish Kumar, Midori Taruishi, Ronald T Javier

“…While the mechanism of activation is not understood, this function depends on a complex formed between E4-ORF1 and the membrane-associated cellular PDZ protein Discs Large 1 (Dlg1), a common viral target having both tumor suppressor and oncogenic functions. …”
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TopBP1 coordinates DNA repair synthesis in mitosis via recruitment of the nuclease scaffold SLX4 by Jonas Bagge, Kamilla Vandsø Petersen, Sinem N. Karakus, Thorbjørn M. Nielsen, Johanne Rask, Christian R. Brøgger, Jonas Jensen, Meliti Skouteri, Antony M. Carr, Ivo A. Hendriks, Vibe H. Oestergaard, Michael Lisby

“…To alleviate the consequences of replication stress, cells utilize a mechanism known as MiDAS that functions to complete synthesis of underreplicated DNA in early mitosis. …”
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CHANGE OF ORAL LIQUID PROPERTIES UNDER TREATMENTS DEVELOPED INFLAMMATION OF PERIODONTAL TISSUES IN PATIENTS CONSTRUCTIONS WITH FIXED DENTURE IN MOUTH CAVITY DYNAMICS by O. Petrushanko, S. Hermanchuk

“…In addition, an oral fluid viscosity change during treatment also depends on the age of patients. At the same time, the exchange of application offers treatments that include the use of hygienic elixir "Lisomucoid" mucosal gel "Flavogel" and iodine "Ioddicerin" in the form of oral rinses and applications, stimulate the functional activity of salivary glands and reduce the figure viscosity of 1.3 - 1.5 times, depend on the method of treatment, which greatly improves the cleansing and protective functions of oral fluid and provides a balance of physiological processes in periodontal tissues. …”
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Dec2 attenuates autophagy in inflamed periodontal tissues by Shunichi Oka, Xiaoyan Li, Fuyuki Sato, Fengzhu Zhang, Nitesh Tewari, Chongchong Chen, Liangjun Zhong, Makoto Makishima, Yi Liu, Ujjal K. Bhawal

“…Here, we provide a comprehensive functional characterization of periodontal ligament fibroblasts (PDLFs) treated with Porphyromonas gingivalis lipopolysaccharide (LPS), aiming to reveal previously unappreciated biological changes and to investigate how a transcription factor differentiated embryonic chondrocytes 2 (Dec2)‐deficient environment influences the function of autophagy in nflamed human PDLFs. …”
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Influence of Road Pavement Macrotexture on Tyre/Road Noise of Vehicles by Wladyslaw Gardziejczyk

“…The functional dependences between maximum rolling noise levels in the range of complete level and in the octave band spectra: 250 Hz, 500 Hz, 1000 Hz, 2000 Hz and 4000 Hz and between the surface macrotexture described by mean profile depth, and logarithm of vehicle speed and adequate nomograms were evaluated in the paper. …”
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