An amphioxus Gli gene reveals conservation of midline patterning and the evolution of hedgehog signalling diversity in chordates. by Sebastian M Shimeld, Marcel van den Heuvel, Rebecca Dawber, James Briscoe

“…Many aspects of the signalling pathway are conserved between these lineages, however vertebrates have diverged in at least one key aspect: they have evolved multiple Gli genes encoding functionally-distinct proteins, increasing the complexity of the hedgehog-dependent transcriptional response. …”
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NSUN5 promotes cholangiocarcinoma progression by enhancing GLS mRNA stabilization by Ming Shu, Kunpeng Guo, Yikai Huang, Weishan Wang

“…Methods Human tissue samples were collected to assess the expression levels of NSUN5 in CCA. In vitro functional assays were conducted to evaluate the biological function of NSUN5. …”
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Nanobodies targeting the tumor microenvironment and their formulation as nanomedicines by Liudmyla Maksymova, Yannick A. Pilger, Lutz Nuhn, Jo A. Van Ginderachter

“…Hence, effective therapeutic targeting of the tumor microenvironment requires modulation of immune cell function, overcoming resistance mechanisms associated with stromal components or the extracellular matrix, and/or direct elimination of cancer cells. …”
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Palmitate enhances MSC immunomodulation of human macrophages via the ceramide/CCL2 axis in vitro by Courteney Tunstead, Laura M. Bitterlich, James A. Ankrum, Andrew E. Hogan, Karen English

“…Abstract Background The immunomodulatory function of human mesenchymal stromal cells (MSCs) strongly depends on external factors; such as cytokines and other signalling molecules encountered in the disease microenvironment. …”
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Small modifier, big decision: switching to SUMO mode adds weight to cancer stemness in mammary tumors by Veronika Yevdokimova, Yannick D. Benoit

“…Li et al. applied genetically engineered models of mammary gland tumorigenesis to demonstrate that SUMOylation of the transcription factor Etv1 is essential for maintaining cancer stem cell functions. Moreover, SUMO conjugation of Etv1 acts as a switch between stem and nonstem cancer cell states. …”
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A Rare Case of Dermatomyositis Sine Dermatitis in an Indian Geriatric Patient by Saumyarup Pal, Akshata Rao, Abhijith R. Rao, Bhabhor Kaminiben Narsinhbhai, Mujtaba Waris, Saumya Sahu, Avinash Chakrawarty

“…Pulse steroid therapy followed by gradual tapering, methotrexate, and regular physiotherapy significantly improved functionality.…”
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Un exemple de charpente à double croupe du début du xiiie s. : la porterie du prieuré de Courtozé à Azé (Loir-et-Cher) by Franck Tournadre

“…The uncommon organization of this rural establishment in the Middle Ages also prompts us to question the functions of this dependency of the Abbey of the Trinity of Vendôme.…”
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Quasi-Analytical Least-Squares Generative Adversarial Networks: Further 1-D Results and Extension to Two Data Dimensions by Graham W. Pulford

“…Visualisation strategies are given for the cost function and parameter trajectories during training. …”
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Pseudouridine synthases are proviral factors for Sindbis virus in insect and mammalian cells by Nicole Stark, Ram Podicheti, Lauren Garcia, Adela Krenz, Douglas B. Rusch, Irene L. G. Newton, Richard W. Hardy

“…Furthermore, ectopic expression of Nop60B in cell culture increased SINV infectivity and intracellular RNA levels, which is dependent on the catalytic function of Nop60B. We found that this proviral function is conserved as the human ortholog, dyskerin, increases SINV replication. …”
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Non-pharmacological interventions for patients with axial spondyloarthritis: a meta-analysis by Lidong Hu, Xingkang Liu, Xiaojian Ji, Yiwen Wang, Jiaxin Zhang, Lulu Zeng, Yangqin Xun, Jianglin Zhang, Jian Zhu, Feng Huang

“…Both supervised combined exercises and neuromuscular training showed a significant reduction in disease activity (Bath Ankylosing Spondylitis Disease Activity Index (BASDAI): 1.13 lower, 1.17 lower, respectively), physical function (Bath Ankylosing Spondylitis Functional Index (BASFI): 1.0 lower, 0.88 lower, respectively), and spinal mobility (Bath Ankylosing Spondylitis Metrology Index (BASMI): 0.7 lower, 1.35 lower, respectively), compared to standard care. …”
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Exploring the Neuroplastic Effects of Biofeedback Training on Smokers by Niki Pandria, Alkinoos Athanasiou, Nikos Terzopoulos, Evangelos Paraskevopoulos, Maria Karagianni, Charis Styliadis, Chrysoula Kourtidou-Papadeli, Athanasia Pataka, Evgenia Lymperaki, Panagiotis D. Bamidis

“…Clinical, behavioral, and neurophysiological (resting-state EEG) data were collected from twenty-seven subjects before and after five sessions of skin temperature training. DMN functional cortical connectivity was investigated. While clinical status remained unaltered, the degree of nicotine dependence and psychiatric symptoms were significantly improved. …”
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Low dose ribosomal DNA P-loop mutation affects development and enforces autophagy in Arabidopsis by Thiruvenkadam Shanmugam, Palak Chaturvedi, Deniz Streit, Arindam Ghatak, Thorsten Bergelt, Stefan Simm, Wolfram Weckwerth, Enrico Schleiff

“…The mutation led to allelic, dosage-dependent defects marked by lateral root inhibition, reduced size, and pointy leaves, all previously observed for defective ribosomal function. …”
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The role of the contralesional primary motor cortex in upper limb recovery after stroke: a scoping review following PRISMA-ScR guidelines by Peerapat Suputtitada, Valton Costa, Felipe Fregni

“…Animal studies provided evidence of structural and functional plasticity, including dendritic remodeling and enhanced neuronal connectivity, which paralleled improvements in motor function. …”
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Yeast Complementation Assays Demonstrating the Importance of the Affinity Tag Position in Membrane Protein Purification, as Exemplified by HpUreI, the pH‐Gated Urea Channel of Heli... by Anna Stoib, Sahar Shojaei, Christine Siligan, Andreas Horner

“…Yeast complementation assays test the pH‐dependent functionality of exogenous proteins expressed in deletion strains by observing growth. …”
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Activities of daily living limitations in relation to the presence of pain in community-dwelling older adults by Paweł Balicki, Bartłomiej Konrad Sołtysik, Ewa Borowiak, Tomasz Kostka, Joanna Kostka

“…After adjustments for age, sex, education, BMI, concomitant diseases, depressive symptoms, cognitive function, and nutritional status, pain contributed to dependence in bathing [OR = 1.64 (1.22–2.19)], continence [OR = 1.52 (1.14–2.02)], and transferring [OR = 2.01 (1.23–3.28)]. …”
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Interaction between corticotropin-releasing factor, orexin, and dynorphin in the infralimbic cortex may mediate exacerbated alcohol-seeking behavior by Francisco J. Flores-Ramirez, Jessica M. Illenberger, Rémi Martin-Fardon

“…As individuals transition to alcohol dependence, compensatory allostatic mechanisms result in insults to hypothalamic-pituitary-adrenal axis function, mediated by corticotropin-releasing factor (CRF), which is subsequently hypothesized to alter brain reward pathways, influence affect, elicit craving, and ultimately perpetuate problematic drinking and relapse vulnerability. …”
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Non-enzymatic SETD1A activity drives breast cancer cell proliferation via cyclin K by Kanako Hayashi, Takayuki Hoshii, Meng Ning, Makoto Matsumoto, Shintaro Izumi, Masaki Fukuyo, Bahityar Rahmutulla, Masahiko Tanabe, Atsushi Kaneda

“…Exogenous expression of both genes restores defective cell proliferation following SETD1A knockout. The non-catalytic function of SETD1A in breast cancer cells depends on its cyclin K-associated FLOS domain. …”
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Markers of early post-stroke cognitive impairment by A. M. Tynterova, E. R. Barantsevich

“…In order to verify the markers, anamnestic characteristics were assessed, cognitive-functional indicators (according to the scales of the National Institutes of Health, MoCA, Bartel, Rankin, IQCODE questionnaire, additional scales to assess praxis, semantic aphasia, perception and executive function), data of neuroimaging studies. …”
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ANKHD1 promotes pathogenic proliferation in Autosomal Dominant Polycystic Kidney Disease via the Cyclin D1/CDK4 pathway by Maria-Eirini Terzenidou, Foteini Patera, Fiona M Macleod, Albert C M Ong, Maria Fragiadaki

“…ANKHD1-mediated enhancement of Cyclin D1/CDK4 activity leads to increased retinoblastoma phosphorylation and proliferation, a mechanism that is p19-dependent but p21 independent. Conclusions We report a functional role for ANKHD1 in driving pathogenic proliferation in ADPKD via the Cyclin D1/CDK4 axis.…”
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REMODELING OF THE HEART AND VESSELS IN ATRIAL FIBRILLATION PATIENTS WITH CHRONIC HEART FAILURE ACCORDING TO CYSTATIN C-RELATED GLOMERULAR FILTRATION RATE by S. V. Mironova, E. A. Polyanskaya, M. V. Surovtseva

“…To investigate on structural and functional specifics of the left cardiac chambers and arteries in patients with permanent atrial fibrillation (AF) comorbid with chronic heart failure (CHF) of ischemic origin, with relation to cystatin C-dependent glomerular filtration rate (GFR).Material  and  methods. …”
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