Impaired inhibitory reno-renal reflex responses in chronic kidney disease by Ahmed A. Rahman, Ahmed A. Rahman, Cara M. Hildreth, Phil Milliken, Sarah Hassan, Arun Sridhar, Jacqueline K. Phillips

“…We have undertaken an in-depth characterization of reno-renal reflex function in CKD using an anesthetized rodent model with concurrent physiological outflows assessed. …”
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Dual-Branch Deep Learning with Dynamic Stage Detection for CT Tube Life Prediction by Zhu Chen, Yuedan Liu, Zhibin Qin, Haojie Li, Siyuan Xie, Litian Fan, Qilin Liu, Jin Huang

“…In terms of optimization strategy, a dynamically weighted triplet mixed loss function is designed to adjust the weight ratios of different prediction tasks, effectively solving the problems of sample imbalance and uneven prediction accuracy. …”
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A Transformer-LSTM-SVR hybrid model for AI-driven emotional optimization in NEV embedded interior systems by Zongming Liu, Xuhui Chen, Xinan Liang, Zhicheng Sun, Fengqi Yang, Wenwen Ou, Linwei Li, Xiayan Qin

“…Abstract With the rapid expansion of the new energy vehicle (NEV) market, a shift from function-oriented toward emotion-oriented interior design has emerged as a key factor in enhancing user experience and brand differentiation. …”
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The systemic lupus erythematosus IRF5 risk haplotype is associated with systemic sclerosis. by F David Carmona, Jose-Ezequiel Martin, Lorenzo Beretta, Carmen P Simeón, Patricia E Carreira, José Luis Callejas, Mónica Fernández-Castro, Luis Sáez-Comet, Emma Beltrán, María Teresa Camps, María Victoria Egurbide, Spanish Scleroderma Group, Paolo Airó, Raffaella Scorza, Claudio Lunardi, Nicolas Hunzelmann, Gabriela Riemekasten, Torsten Witte, Alexander Kreuter, Jörg H W Distler, Rajan Madhok, Paul Shiels, Jacob M van Laar, Carmen Fonseca, Christopher Denton, Ariane Herrick, Jane Worthington, Annemie J Schuerwegh, Madelon C Vonk, Alexandre E Voskuyl, Timothy R D J Radstake, Javier Martín

“…In this study we aimed to evaluate whether three different haplotypic blocks within this locus, which have been shown to alter the protein function influencing systemic lupus erythematosus (SLE) susceptibility, are involved in SSc susceptibility and clinical phenotypes. …”
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Metabolic adaptation to acute metabolic stress via PFKFB3 upregulation in rodent beta cells by Koki Chiba, Hiroshi Nomoto, Hiroshi Nomoto, Rimi Izumihara, Xinxin Zhang, Hiraku Kameda, Akinobu Nakamura, Tatsuya Atsumi

“…MTT assay results showed a time-dependent reduction in metabolic activity following Pfkfb3 knockdown, suggesting compromised cell survival under acute metabolic stress.ConclusionPFKFB3 upregulation under acute metabolic stress may be an adaptive response that helps maintain beta cell function. …”
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The Influence of Remnant Preservation on the Final Outcome after Anterior Cruciate Ligament Reconstruction: A Prospective Comparative Study by Vishanth Krishna Rao, Madan Ballal

“…ACL remnants have recently been recognized for their importance in biomechanical, vascular, and proprioceptive functions. Theoretically, maintaining ACL remnants can improve knee stability and preserve proprioceptive mechanoreceptors. …”
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Technical progress of construction and safe operation of underground gas storage under complex geological conditions by Qiqi WANYAN, Yun WANG, Dongxu LI, Hongcheng XU, Chun LI, Kang LI, Jingcui LI, Lifeng LI

“…Due to the high dependency of China on imported natural gas, continuously enhancing the gas storage capacity in peak shaving and stable supply is an inevitable choice to assure natural gas security in China. …”
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Teknik Identifikasi Fitur Berdasarkan Kalimat Pernyataan Kebutuhan dalam Konteks Pengembangan Software Product Line by M Syauqi Haris, Tri Astoto Kurniawan

“…Representation of features with nouns is considered too abstract and does not represent the concept of features as capabilities or functionality of the software. In this study, the identification of features represented by combined phrases of verbs and nouns is proposed because it is considered to better explain the capabilities and functionality of software. …”
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Integrated frailty and intrinsic capacity care model for community-dwelling older adults in Singapore: a rapid qualitative study of anticipated implementation barriers and enablers... by Mimaika Luluina Ginting, Grace Sum, Sinead Zhen Wang, Yew Yoong Ding, Yew Yoong Ding, Yew Yoong Ding, Laura Tay, Laura Tay

“…Optimizing the intrinsic capacity and functional ability of individuals is important to enable healthy aging. …”
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Age-related hearing loss associated with cognitive impairment in the Polish cohort of the PURE study by Katarzyna Połtyn-Zaradna, Katarzyna Pazdro-Zastawny, Katarzyna Pazdro-Zastawny, Dorota Szcześniak, Alicja Basiak-Rasała, Maria Wołyniec, Katarzyna Zatońska, Tomasz Zatoński

“…BackgroundCurrently, dementia is estimated to be the seventh most common cause of death and one of the leading causes of disability and dependency among older people worldwide. The main aim of this study is to analyze the association of presbycusis and cognitive impairment in the study population. …”
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Factors Related to Pain and Disability Outcomes After an Internet-Delivered or Physiotherapist-Led Exercise Program for Individuals With Chronic Whiplash Symptoms: Secondary Analys... by Gunnel Peterson, Stefan Ljunggren, Anneli Peolsson

“…Multivariate data analyses and orthogonal partial least squares (OPLS) models were used to investigate change in psychological and physiological factors (independent factors) related to change in the dependent factors: neck-related disability measured with the Neck Disability Index (NDI), neck pain intensity measured with a visual analogue scale, and physical function measured with the Patient-Specific Functional Scale (PSFS). …”
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Unveiling new phases of the Standard Model Higgs potential by Florian Goertz, Álvaro Pastor-Gutiérrez

“…We study the Standard Model physical trajectory accounting for the Higgs curvature mass with the mass-dependent functional renormalisation group. New unstable and non-trivially stable phases are found at energies above the Planck scale and below the Abelian Landau pole. …”
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Dual effects of GABAAR agonist anesthetics in neurodevelopment and vulnerable brains: From neurotoxic to therapeutic effects by Dihan Lu, Wen Zhang, Keyu Chen, Xia Feng

“…These effects range from neuroprotection to neurotoxicity, depending on different brain functional states. However, the exact values of the specific thresholds for different drugs in various brain states, as well as the underlying mechanisms explaining why these thresholds exist, remain unclear. …”
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Prevalence, correlative and statistical relationships of renal dysfunction in patients with chronic ischemic heart failure by D. A. Lashkul

“…The perspective is to further explore the prognostic significance of the detected change, the possibility of pharmacological correction in patients with ischemic chronic heart failure, depending on age, sex, functional class, left ventricular contractile ability.…”
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From aspectual to degree quantifiers: Context expansion of por completo and completamente in Spanish and Portuguese by Katharina Gerhalter, Stefan Koch

“… This paper examines four adverbial cognates in Spanish and Portuguese, Sp. por completo, Pt. por completo, Sp. completamente, and Pt. completamente, from a historical and functional point of view. Our analysis is based on three major corpora of Spanish and Portuguese (CDH, CdP, and CORPES XXI). …”
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Androgen receptor-mediated downregulation of microRNA-221 and -222 in castration-resistant prostate cancer. by Bin Gui, Chen-Lin Hsieh, Philip W Kantoff, Adam S Kibel, Li Jia

“…MicroRNAs (miRNAs) play important roles in cancer formation and progression by suppressing the production of key functional proteins at the post-transcriptional level in a sequence-specific manner. …”
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TET3 is a positive regulator of mitochondrial respiration in Neuro2A cells. by Valeria Leon Kropf, Caraugh J Albany, Anna Zoccarato, Hannah L H Green, Youwen Yang, Alison C Brewer

“…This is particularly important in post-mitotic neurons where changes in DNA methylation are known to associate with changes in neural function. TET3, specifically, is a critical regulator of both neuronal differentiation in development and mediates dynamic changes in the methylome of adult neurons associated with cognitive function. …”
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High efficiency focusing vortex generation and multichannel multiplexing based on terahertz metasurfaces by Wenyu Li, Tianhua Meng, Lijuan Dong, Lixiang Liu, Jingyu Liu, Guozhong Zhao

“…Abstract Single-function metasurfaces can only perform one task and thus cannot satisfy the demands of many advanced applications. …”
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Royal Jelly Attenuates LPS-Induced Inflammation in BV-2 Microglial Cells through Modulating NF-κB and p38/JNK Signaling Pathways by Meng-Meng You, Yi-Fan Chen, Yong-Ming Pan, Yi-Chen Liu, Jue Tu, Kai Wang, Fu-Liang Hu

“…Royal jelly (RJ), a hive product with versatile pharmacological activities, has been used as a traditional functional food to prevent or treat inflammatory diseases. …”
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Unveiling Tissue‐Specific RNA Landscapes in Mouse Organs During Fasting and Feeding Using Nanopore Direct RNA Sequencing by Chengfei Jiang, Ping Li, Haiming Cao

“…Abstract Understanding tissue‐specific RNA landscapes is essential for uncovering the functional mechanisms of key organs in mammals. However, current knowledge remains limited, as short‐read RNA sequencing—the predominant method for assessing gene expression—depends on incomplete gene annotations and struggles to resolve the diverse transcripts produced by genes. …”
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