Foxp2 regulates gene networks implicated in neurite outgrowth in the developing brain. by Sonja C Vernes, Peter L Oliver, Elizabeth Spiteri, Helen E Lockstone, Rathi Puliyadi, Jennifer M Taylor, Joses Ho, Cedric Mombereau, Ariel Brewer, Ernesto Lowy, Jérôme Nicod, Matthias Groszer, Dilair Baban, Natasha Sahgal, Jean-Baptiste Cazier, Jiannis Ragoussis, Kay E Davies, Daniel H Geschwind, Simon E Fisher

“…We used an integrated functional genomics strategy to robustly define Foxp2-dependent pathways, both direct and indirect targets, in the embryonic brain. …”
Get full text

A dictionary learning approach with overlap for the low dose computed tomography reconstruction and its vectorial application to differential phase tomography. by Alessandro Mirone, Emmanuel Brun, Paola Coan

“…The functional depends on two free regularization parameters: a coefficient multiplying the sparsity-inducing L1 norm of the patch basis functions coefficients, and a coefficient multiplying the L2 norm of the differences between patches in the overlapping regions. …”
Get full text

The ISWI chromatin remodeler organizes the hsrω ncRNA-containing omega speckle nuclear compartments. by Maria C Onorati, Sandra Lazzaro, Moushami Mallik, Antonia M R Ingrassia, Anna P Carreca, Anand K Singh, Deo Prakash Chaturvedi, Subhash C Lakhotia, Davide F V Corona

“…Remarkably, we found that the organization of nucleoplasmic omega speckles depends on ISWI function. Our findings highlight a novel role for chromatin remodelers in organization of nucleoplasmic compartments, providing the first example of interaction between an ATP-dependent chromatin remodeler and a large ncRNA.…”
Get full text

Exploring Two Modified Ali-Mikhail-Haq Copulas and New Bivariate Logistic Distributions by Christophe Chesneau

“…This research paper proposes two modifications of the Ali-Mikhail-Haq copula that overcome these limitations, but at the price of the loss of the positive dependence nature. Contrary to the common approach that focuses on modifying the corresponding generator function, we apply direct functional changes to the Ali-Mikhail-Haq copula. …”
Get full text

Measurement properties of the Swedish version of the Knee Self‐Efficacy Scale: A Rasch analysis by Ramana Piussi, Roland Thomeé, Kristian Samuelsson, Eric Hamrin Senorski

“…The RMT analysis assessed targeting aspects of reliability, response category thresholds, item hierarchy, overall and individual item fit, local dependency, differential item functioning (DIF) and unidimensionality. …”
Get full text

A neuronal acetylcholine receptor regulates the balance of muscle excitation and inhibition in Caenorhabditis elegans. by Maelle Jospin, Yingchuan B Qi, Tamara M Stawicki, Thomas Boulin, Kim R Schuske, H Robert Horvitz, Jean-Louis Bessereau, Erik M Jorgensen, Yishi Jin

“…We identified a gain-of-function mutation that leads to spontaneous muscle convulsions. …”
Get full text

Domain Switching Dynamics in Relaxor PNN–PZT Ceramics With Nano‐Domain Morphology by Xudong Qi, Lang Bian, Da Huo, Kai Li, Huashan Zheng, Jinpeng Ma, Limei Zheng

“…The findings suggest that the dispersed nano‐domain morphology within PNN–PZT ceramics results in a flatter relaxation function distribution, thereby enhancing domain switching response concerning f. …”
Get full text

ATM knock out alters calcium signalling and augments contraction in skeletal muscle cells differentiated from human urine-derived stem cells by Giulia Dematteis, Giulia Lecchi, Giulia Boni, Diana Pendin, Carla Distasi, Mariagrazia Grilli, Dmitry Lim, Luigia Grazia Fresu, Maria Talmon

“…These results highlight the relevant function of ATM in skeletal muscle, which is not only dependent on a non-functional neuronal communication, paving the way for future studies on a muscular interpretation of A-T ataxia.…”
Get full text

Combined lipid lowering therapy, including ezetimibe, in the post-infarction period by V. E. Oleynikov, L. I. Salyamova, A. A. Chernova, A. A. Tonkoglaz, O. D. Vershinina, I. A. Babkina, N. S. Plaksin

“…When analyzing endothelial function, there was an increase in flow-dependent vasodilation only in group 2 from 9,1 (5,6; 11,8)% to 14,3±6,8% after 48 weeks (p<0,001). …”
Get full text

Optimal frequency of platelet-rich plasma injections for managing osteoarthritis: A longitudinal study by Masahiko Kemmochi

“…Conclusions: PRP injections administered at specific intervals can significantly reduce pain and improve function in patients with OA, with the required frequency depending on disease severity. …”
Get full text

Telomere length sensitive regulation of interleukin receptor 1 type 1 (IL1R1) by the shelterin protein TRF2 modulates immune signalling in the tumour microenvironment by Ananda Kishore Mukherjee, Subhajit Dutta, Ankita Singh, Shalu Sharma, Shuvra Shekhar Roy, Antara Sengupta, Megha Chatterjee, Soujanya Vinayagamurthy, Sulochana Bagri, Divya Khanna, Meenakshi Verma, Dristhi Soni, Anshul Budharaja, Sagar Kailasrao Bhisade, Vivek Anand, Ahmad Perwez, Nija George, Mohammed Faruq, Ishaan Gupta, Radhakrishnan Sabarinathan, Shantanu Chowdhury

“…In summary, using TNBC cancer tissue (>90 patients), tumour-derived organoids, cancer cells, and xenograft tumours with either long or short telomeres, we uncovered a heretofore undeciphered function of telomeres in modulating IL1 signalling and tumour immunity.…”
Get full text

Positive and negative regulation of Gli activity by Kif7 in the zebrafish embryo. by Ashish Kumar Maurya, Jin Ben, Zhonghua Zhao, Raymond Teck Ho Lee, Weixin Niah, Ashley Shu Mei Ng, Audrey Iyu, Weimiao Yu, Stone Elworthy, Fredericus J M van Eeden, Philip William Ingham

“…Loss of function mutations of Kif7, the vertebrate orthologue of the Drosophila Hh pathway component Costal2, cause defects in the limbs and neural tubes of mice, attributable to ectopic expression of Hh target genes. …”
Get full text

Microglial clock dysfunction during neuroinflammation impairs oligodendrocyte progenitor cell recruitment and disrupts neuroimmune homeostasis by Qingqing Lu, Qingqing Lu, Jin Young Kim, Jin Young Kim

“…Although time-of-day–dependent variation in microglial immune activity has been reported, how intrinsic microglial clocks respond to neuroinflammatory stimuli and influence microglial function remains unclear.MethodsWe induced neuroinflammation via intraperitoneal injection of lipopolysaccharide (LPS) and isolated microglia from control and LPS-treated mouse brains. …”
Get full text

Cognitive impairment mediates the association between sarcopenic obesity and daily living ability in the frail older population by Hang Li, Haifei Shen, Lei Yu, Yao Wen, Dan Ren, Cong Ding, Xiaobo Wang, Wanjun Xie, Yongwang Miao, Wenxu Zheng

“…We used correlation analysis, multiple logistic regression analysis, and mediation analysis to assess the associations between sarcopenic obesity, cognitive function and daily living ability. Results: The SO group had the highest prevalence of cognitive impairment and life activity dependency. …”
Get full text

SYSTEM ANALYSIS OF LOGISTIC STREAMS by Vladimir F. Minakov, Aleksei A. Ostroumov, Mariya V. Radchenko

“…In article system approach to the analysis of logisticstreams is offered: material, fi nancial, information, manpower. For functional dependence of streams production function, model of influence of scientific and technical progress, model of infl uence of information on a consumer demand is used. …”
Get full text

Robust Control for Uncertain Switched Systems with Interval Nondifferentiable Time-Varying Delays by T. La-inchua, P. Niamsup

“…The system to be considered is autonomous and the state delay is time-varying. Using Lyapunov functional approach, restriction on the derivative of time-delay function is not required to design switching rule for the robust stabilization of switched systems with time-varying delays. …”
Get full text

Uterotubal junction prevents chlamydial ascension via innate immunity. by Yuyang Zhang, Lili Shao, Xiaodong Li, Guangming Zhong

“…These observations suggest that the uterotubal junction may function as a barrier between the uterine horn and oviduct. …”
Get full text

Hedge Euphemisms as Tools of Economic Discourse by E. L. Shubina, A. V. Sedova

“…The relevance of the study is due to the need to study the causes and situations of the appearance of hedge euphemisms in the German language, as well as their functioning in economic discourse. The definitions, classifications and functional features of euphemisms and hedging tools in linguistics are considered. …”
Get full text

Epimedin C enhances mitochondrial energy supply by regulating the interaction between MIC25 and UBC in rodent model. by Mi Huang, Lei Yu, Zhong Li, Ying Wang, Chunlin Yang

“…Using C57BL/6 mice, we demonstrate that Epimedin C enhances exercise performance through preservation of mitochondrial function. Proteomic analysis identified MIC25 as a key protein modulated by Epimedin C, whose stability is regulated via ubiquitin-dependent degradation. …”
Get full text

Simultaneous Model Change Detection in Multivariate Linear Regression With Application to Indonesian Economic Growth Data by Wayan Somayasa, Muhammad Kabil Djafar, Norma Muhtar, Desak Ketut Sutiari

“…When the assumed model is true, the limit process is given by the standard multivariate Brownian motion which does not depend on the regression functions. However, when the assumed model is not true (some models change), the limit process is represented by a vector of deterministic trend plus the standard multivariate Brownian motion. …”
Get full text