The small GTPase ARF6 regulates sphingolipid homeostasis and supports proliferation in acute myeloid leukemia by Helong Gary Zhao, Nataly Cruz-Rodriguez, Kent C. Johnson, Anthony D. Pomicter, Briana Bates, Benjamin Bateman, Torsten Haferlach, Tongjun Gu, Jonathan Ahmann, Dongqing Yan, Greg S. Lee, Weiquan Zhu, Jenna Bishop, Shannon J. Odelberg, Michael W. Deininger

“…Here we describe a novel function of the RAS superfamily small GTPase ARF6 in maintaining sphingolipid homeostasis in AML. …”
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Vascular dysfunction in a mouse model of Rett syndrome and effects of curcumin treatment. by Anna Panighini, Emiliano Duranti, Ferruccio Santini, Margherita Maffei, Tommaso Pizzorusso, Niccola Funel, Stefano Taddei, Nunzia Bernardini, Chiara Ippolito, Agostino Virdis, Mario Costa

“…To investigate the relationship between loss of MeCP2 and this clinical aspect, we used the MeCP2 null mouse model B6.129SF1-MeCP2tm1Jae for functional and pharmacological studies. Functional experiments were performed on isolated resistance mesenteric vessels, mounted on a pressurized myograph. …”
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Hybrid metaheuristic optimization for detecting and diagnosing noncommunicable diseases by Saleem Malik, S. Gopal Krishna Patro, Chandrakanta Mahanty, Saravanapriya Kumar, Ayodele Lasisi, Quadri Noorulhasan Naveed, Anjanabhargavi Kulkarni, Abdulrajak Buradi, Addisu Frinjo Emma, Naoufel Kraiem

“…The proposed framework introduces novel hybrid algorithms, including the Hierarchical Genetic Multiple Reduct Selection Algorithm (H-GMRA) and the Customized Function-based Particle Swarm Optimization with Rough Set Theory for NCD Feature Selection (CPSO-RST-NFS). …”
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Perioperative cytokine profile during lung surgery predicts patients at risk for postoperative complications-A prospective, clinical study. by Kai B Kaufmann, Sebastian Heinrich, Hans Felix Staehle, Lioudmila Bogatyreva, Hartmut Buerkle, Ulrich Goebel

“…<h4>Results</h4>The complication and non-complication group differed significantly according to nicotine dependency, Angiotensin-receptor-II blocker medication, rate of thoracotomy and preoperative lung function. …”
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Two-Stream Modality-Based Deep Learning Approach for Enhanced Two-Person Human Interaction Recognition in Videos by Hemel Sharker Akash, Md Abdur Rahim, Abu Saleh Musa Miah, Hyoun-Sup Lee, Si-Woong Jang, Jungpil Shin

“…Moreover, we newly created a custom filter function to enhance computational efficiency and eliminate irrelevant keypoints and mesh components from the dataset. …”
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Exploring interactions between shading and view using visual difference prediction by Stephen Wasilewski, Marilyne Andersen

“…For a given view content, how well a view can be seen through different facade layers, or ‘view visibility’, depends on both the properties of the facade and the incident lighting. …”
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Measurement report: Influence of particle density on secondary ice production by graupel and frozen drop collisions by S. Yadav, L. Metten, P. Grzegorczyk, A. Theis, S. K. Mitra, M. Szakáll

“…The number of fragments generated in the collisions was analyzed, following a theoretical framework, as a function of the collision kinetic energy. The detection limit of our experiments was 30 <span class="inline-formula">µ</span>m; thus, fragments with sizes lower than 30 <span class="inline-formula">µ</span>m could not be detected. …”
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From support to recovery: the evolving role of LVAD in reversing heart failure by Bingqi Sun, Zhigang Liu

“…Not only do they provide circulatory support for patients, but the reverse biological changes in myocardial tissue induced by LVAD have led to the recovery of heart function in some patients, allowing for the removal of the device—which termed bridge to recovery (BTR). …”
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Physical training influence on blood pressure dynamics and target organs status in arterial hypertension patients by N. I. Gromnatsky, V. A. Novikov, V. N. Shilenok

“…To study physical training (PT) antihypertensive effects and influence on left ventricular (ГУ) structure and function, cerebral blood flow, and endothelial vasokinetic function in patients with arterial hypertension (AH). …”
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INSULIN-LIKE GROWTH FACTOR-1, CYTOLYSIS AND CHOLESTASIS IN PATIENTS WITH NON-ALCOHOLIC FATTY LIVER DISEASE AND ITS COMBINATION WITH TYPE 2 DIABETES MELLITUS by L. V. Zhuravlyova, E. V. Ogneva

“…The study was designed to assess the relationship between the level of plasma concentration of insulin-like growth factor-1 (IGF-1) and indices of the functional state of the liver in patients with non-alcoholic fatty liver disease (NAFLD) and its combination with diabetes mellitus (DM) 2 types depending on the trophological status.Materials and methods. …”
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On the stable approximate solution of the ill-posed boundary value problem for the Laplace equation with homogeneous conditions of the second kind on the edges at inaccurate data o... by Evgeniy B. Laneev, Alexander V. Klimishin

“…On the basis of an idea about the source function of the original problem, the exact solution is represented as a sum of two functions, one of which depends explicitly on the Cauchy conditions, and the second one can be obtained as a solution of the Fredholm integral equation of the first kind in the form of Fourier series on the eigenfunctions of the second boundary value problem for the Laplace equation. …”
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Protein kinase C theta is dispensable for suppression mediated by CD25+CD4+ regulatory T cells. by Kerstin Siegmund, Nikolaus Thuille, Katarzyna Wachowicz, Natascha Hermann-Kleiter, Gottfried Baier

“…The activation of conventional T cells upon T cell receptor stimulation critically depends on protein kinase C theta (PKCθ). However, its role in regulatory T (Treg) cell function has yet to be fully elucidated. …”
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Association of prestroke medicine use and health outcomes after ischaemic stroke in Sweden: a registry-based cohort study by Katharina S Sunnerhagen, Lekander Ingrid, Mia von Euler

“…Patients with haemorrhagic stroke (ICD-10 I61*) were excluded.Primary outcome The primary outcome was the association, expressed in ORs, of prestroke medicine use (oral anticoagulants, statins, antihypertensives, antidepressants, non-steroidal anti-inflammatory drugs (NSAIDs) and antidiabetic drugs) and health outcomes 1 and 2 years poststroke (survival, activities of daily living dependency and modified Rankin Scale (mRS) 0–2), adjusted for patient characteristics and stroke severity at stroke onset.Results The multivariate analysis indicated that patients on drugs for hypertension, diabetes, oral anticoagulants and antidepressants prestroke had worse odds for health outcomes in both survival (OR 0.65, 95% CI 0.60 to 0.69; OR 0.77, 95% CI 0.71 to 0.83; OR 0.72, 95% CI 0.66 to 0.80; OR 0.91, 95% CI 0.84 to 0.98, respectively, for survival at 2 years) and functional outcome (OR 0.82, 95% CI 0.75 to 0.89; OR 0.61, 95% CI 0.55 to 0.68; OR 0.83, 95% CI 0.72 to 0.95; OR 0.58, 95% CI 0.52 to 0.65, respectively, for mRS 0–2 at 1 year), whereas patients on statins and NSAIDS had significantly better odds for survival (OR 1.16, 95% CI 1.08 to 1.25 and OR 1.12, 95% CI 1.00 to 1.25 for 1-year survival, respectively), compared with patients without these treatments prior to stroke.Conclusions The results indicated that there are differences in health outcomes between patients who had different common prestroke treatments, patients on drugs for hypertension, diabetes, oral anticoagulants and antidepressants had worse health outcomes, whereas patients on statins and NSAIDS had significantly better survival, compared with patients without these treatments prior to stroke.…”
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Feasibility and inter-rater reliability of physical performance measures in acutely admitted older medical patients. by Ann Christine Bodilsen, Helle Gybel Juul-Larsen, Janne Petersen, Nina Beyer, Ove Andersen, Thomas Bandholm

“…<h4>Objective</h4>Physical performance measures can be used to predict functional decline and increased dependency in older persons. …”
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Professional Barriers in Energy Efficiency Retrofits—A Solution Based on Information Flow Modeling by Xilong Liao, Chun Wang, Baiyi Li, Baizhan Li, Chenqiu Du

“…The IDEF0 model can clearly describe the interaction relationship of all expert information through functional decomposition, while the DSM can show the dependency relationship and information flow path among specialties through the matrix structure. …”
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The relevance of a multidomain geriatric assessment in older patients with heart failure by Emma E.F. Kleipool, Julia H.I. Wiersinga, Marijke C. Trappenburg, Albert C. vanRossum, Carmen S. vanDam, Su‐San Liem, Mike J.L. Peters, M. Louis Handoko, Majon Muller

“…The following geriatric domains were assessed: physical function, nutrition, polypharmacy, cognition, and dependency in activities of daily living. …”
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Exploring Interactions of Older Adults with Mild Dementia Participating in Robotherapy with Robot Cats in a Day Hospital in Spain: A Qualitative Study by Cristina Perdomo-Delgado, Minoo Dabiri-Golchin, Patricia Sánchez-Herrera-Baeza, Almudena Muñoz-Martínez, Nereida Reyes-Sosa, Marta Pérez-de-Heredia-Torres, Paula Obeso-Benítez

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QUALITY OF LIFE IN FEMALE PATIENTS WITH TUBERCULOSIS DURING HORMONE MODULATION THERAPY by A. E. Grabarnik, O. G. Zhuchenko, Z. A. Zangieva, V. M. Esikova

“…The normal function of reproductive organs should be regarded as one of the most important indicators of women’s health. …”
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A comparative approach to stabilizing mechanisms between discrete- and continuous-time consumer-resource models. by Abhyudai Singh

“…A key focus of this contribution is to systematically compare between the two modeling formalisms the stabilizing/destabilizing impacts of diverse ecological processes that result in a density-dependent consumer attack rate. Inspired by the Nicholson-Bailey/Lotka-Volterra models in discrete-time/continuous-time, respectively, we consider host-parasitoid interactions with an arbitrary parasitoid attack rate that is a function of both the host/parasitoid population densities. …”
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The Effect of Anthocyanins on Microcirculation and Retrobulbar Blood Flow in Ocular Pathology by T. N. Kiseleva, T. V. Sudovskaya, M. S. Zaitsev, K. V. Lugovkina

“…The literature review presents information on positive effects of anthocyanins on functional indices of cardiovascular system, vascular reactivity of main arteries, microcirculation and retrobulbar blood flow. …”
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