Loss of correlated proteasomal subunit expression selectively promotes the 20SHigh state which underlies luminal breast tumorigenicity by Rangapriya Sundararajan, Shubhada R. Hegde, Ashish Kumar Panda, Joel Christie, Nikhil Gadewal, Prasanna Venkatraman

“…By retaining connectivity with key tumor 19S:20S interface nodes, the PSMD9 19S subunit chaperone emerges as a crucial regulator of 26S/30S:20S ratios sustaining tumor cell proteasome function. Disrupting this connectivity by depleting PSMD9 in MCF7 cells introduces structural anomalies in the proteasome, and shifts dependence from 20SHigh to a deregulated 26SHigh state invoking anti-tumor responses which opens up clinically-relevant therapeutic possibilities.…”
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Self-powered triboelectric-responsive microneedles with controllable release of optogenetically engineered extracellular vesicles for intervertebral disc degeneration repair by Weifeng Zhang, Xuan Qin, Gaocai Li, Xingyu Zhou, Hongyang Li, Di Wu, Yu Song, Kangcheng Zhao, Kun Wang, Xiaobo Feng, Lei Tan, Bingjin Wang, Xuhui Sun, Zhen Wen, Cao Yang

“…Optogenetically engineered EVs deliver TRAM1 protein into senescent NP cells, which effectively reconstructs the elimination function of TREX1. Triboelectric nanogenerator (TENG) harvests mechanical energy and triggers the controllable release of engineered EVs. …”
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CHANGES AND TRENDS IN WINE PRODUCTION AND CONSUMPTION IN THE WORLD AND ROMANIA DURING THE PERIOD 2007-2018 by Agatha POPESCU

“…The paper analyzed the evolution of wine production and consumption in Romania and at the world level in order to identify the main changes and trends in the period 2007-2018 using official data which have been processed using fixed and variable indices, correlation coefficients, regression functions, consumption/production rate, export/consumption rate, self sufficiency rate and import dependency rate. …”
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Mechanobiological Assessment of TMJ Disc Surfaces: Nanoindentation and Transmission Electron Microscopy by Cassandra M. Juran, M. Franklin Dolwick, Peter S. McFetridge

“…Conclusions: These are the first works that demonstrate that the superior central surface of the he temporomandibular disc is structured in depth-dependent isometric layers, each of which provides different mechanical function supporting the bulk tissue’s properties. …”
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Assessing spatial variability of soil macro fauna and tree canopy using fractal theory (Case study: Riparian Forest of Maroon River) by Shaieste Gholami, ehsan sayad, Hamid Taleshi

“…1-Introduction Sustainability and maintenance of riparian vegetation or restoring of degraded sites is critical to sustain inherent ecosystem function and values. There is an increasing recognition of fundamental role of space in population. …”
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PROVISION OF RELIABILITY OF HOMOGENEOUS REGISTER MEDIA WITH PROGRAMMED SLIDING REDUNDANCY STRUCTURE by S. A. Ibragimov, P. A. Kadiev

“…It is proposed that functional models of media elements be oriented towards the presence of their internal redunant elements; on the basis of the established functional dependence of the number of external redundant elements with the number of internal redundant elements, we calculated the reliability of redundant media, thus confirming reliability improvement. …”
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Clinico-expert diagnostics of gastrointestinal form of diabetic neuropathy by Irina Alekseevna Kurnikova, Tatiana Evgen'evna Chernyshova, Irina Vladimirovna Gur'eva, Guzyal' Ilgisovna Kliment'eva

“…Functional changes in the gastrointestinal tract of DM1 patients do not depend on the quality of compensation ofmetabolic disorders but correlate (r=-0.39) with DM duration. …”
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Unusual case of cleft hand by Sahasrabudhe Parag, Kulkarni Madhuri

“…Depending upon the function of the thumb tendon transfers can be planned to augment thumb function at a later date along with correction of rotational deformities of the index and middle finger.…”
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Unusual case of cleft hand by B Parag Sahasrabudhe, D Madhuri Kulkarni

“…we present a case of a six-year-old male child with cleft hand deformity involving the dominant right hand. it was a rare case of atypical cleft hand with no missing tissue but cleft extending to metacarpal level and associated hypoplasia of thumb and index finger. as per manske′s classification of cleft hand our patient belongs to the class iii variety. there was associated malposition of the index finger with absence of first web space and syndactly of thumb and index finger at the metacarpal level. a modified snow-littler procedure was planned. the surgical plan involved closure of cleft, release of thumb and index finger syndactly and reconstruction of the first web space. the functional outcome was good considering hypoplasia of the index finger and thumb. depending upon the function of the thumb tendon transfers can be planned to augment thumb function at a later date along with correction of rotational deformities of the index and middle finger.…”
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Metabolic phenotype of bovine blood-derived neutrophils is altered in milk by Heidi C. Duda, Carolin J. Sprenzel, Andrea Didier, Armin M. Scholz, Cornelia A. Deeg, Roxane L. Degroote

“…Moreover, we observed differences in production of reactive oxygen species, deviant early and late apoptosis and functional changes in these cells, pointing to an altered metabolic phenotype in milk cells dependent on the health status of mammary gland quarters. …”
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Tenderness prediction for beef using novel data analysis methods based on system dynamic and acoustic signals by Janna Tholen, Jan Gohe, Helene Dörksen, Theo Kiesel, Matthias Upmann

“…To evaluate the mechanical properties, transfer functions were used representing the time dependency of the signal and thus the viscoelastic behaviour. …”
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A cyclophilin homology domain-independent role for Nup358 in HIV-1 infection. by Anne M Meehan, Dyana T Saenz, Rebekah Guevera, James H Morrison, Mary Peretz, Hind J Fadel, Masakazu Hamada, Jan van Deursen, Eric M Poeschla

“…Experiments with cylosporine, viruses with capsids that do not bind cyclophilins, and growth arrest did not uncover viral dependency on the C-terminal domains of Nup358. Our data reinforce the virological importance of TNPO3 and show that Nup358 supports nuclear transport functions important for cellular homeostasis and for HIV-1 nuclear import. …”
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The evolutionary dynamics of plastic foraging and its ecological consequences: a resource-consumer model by Ledru, Léo, Garnier, Jimmy, Guillot, Océane, Faou, Erwan, Noûs, Camille, Ibanez, Sébastien

“…Consumers could either forage randomly, only as a function of resources abundance, or plastically, as a function of resource abundance, suitability and consumption by competitors. …”
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Effects of combined exposure to heavy metals on lower respiratory flora and its role of lung injury in rats by Ping Ding, Xiaoxia Wang, Nan Li, Shuxia Yu, Shuxia Yu, Yiwen Zhang, Junpu Yu, Tian Tian, Rentong Chen, Bin Luo, Li Ma, Rongxuan Zhang, Rongxuan Zhang

“…Microbial community structure and function were further analyzed using LEfSe, PICRUSt2, and ecological network analysis.ResultsCompared exposure to Ni, Cu, and As induced dose-dependent lung damage, including inflammation, alveolar deformation, and bronchial thickening, accompanied by significant declines in lung function, including a 21.2% reduction in tidal volume and a 34.5% increase in airway resistance in the high-dose group (P < 0.05). …”
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Selective Retention of an Inactive Allele of the DKK2 Tumor Suppressor Gene in Hepatocellular Carcinoma. by Yung-Feng Lin, Ling-Hui Li, Chih-Hung Lin, Mei-Hua Tsou, Ming-Tai Kiffer Chuang, Keh-Ming Wu, Tsai-Lien Liao, Jian-Chiuan Li, Wei-Jie Wang, Angela Tomita, Beverly Tomita, Shiu-Feng Huang, Shih-Feng Tsai

“…In HuH-7 cells, DKK2 functioned in the Wnt/β-catenin signaling pathway, as an antagonist of Wnt3a, in a dose-dependent manner that inhibited Wnt3a-induced cell proliferation. …”
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Characterization of venturi injector using dimensional analysis by Luiz R. Sobenko, José A. Frizzone, Antonio P. de Camargo, Ezequiel Saretta, Hermes S. da Rocha

“…Four models of Venturi injectors were submitted to functional tests using clean water as motive and injected fluid. …”
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Pathophysiological Changes to the Peritoneal Membrane during PD-Related Peritonitis: The Role of Mesothelial Cells by Susan Yung, Tak Mao Chan

“…The success of peritoneal dialysis (PD) is dependent on the structural and functional integrity of the peritoneal membrane. …”
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Post occupancy evaluation of architectural design studio facilities by Mohamed Salah Ezz, Mohamed Salah Ezz, Mohamed Ahmed F. Mahdy, Mohamed Ahmed F. Mahdy, Saleh Baharetha, Mohammad A. Hassanain, Mohammad A. Hassanain, Mohammed M. Gomaa, Mohammed M. Gomaa

“…Educational architecture proves its dependency on fundamental features of comfort together with functionality based on the study outcomes. …”
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Altered cytoskeleton dynamics in patient-derived iPSC-based model of PCDH19 clustering epilepsy by Rossella Borghi, Stefania Petrini, Valentina Apollonio, Marina Trivisano, Nicola Specchio, Sandra Moreno, Enrico Bertini, Marco Tartaglia, Claudia Compagnucci

“…The mechanism by which altered PCDH19 function drive pathogenesis is not yet fully understood. …”
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Somatically mutated ABL1 is an actionable and essential NSCLC survival gene by Ewelina Testoni, Natalie L Stephenson, Pedro Torres‐Ayuso, Anna A Marusiak, Eleanor W Trotter, Andrew Hudson, Cassandra L Hodgkinson, Christopher J Morrow, Caroline Dive, John Brognard

“…Here, we identify somatically mutated ABL1 as a genetic dependency that is required to maintain NSCLC cell survival. …”
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