Organoid: Biomedical application, biobanking, and pathways to translation by Aprajita Sinha, Maheshree Maibam, Ronit Jain, Kalash Aggarwal, Asish Kumar Sahu, Pawan Gupta, Sayan Paul, Bharti Bisht, Manash K. Paul

“…Organoids are tiny stem cell-derived 3D in vitro cell culture systems mimicking the structural and functional aspects of the tissues in the human body and provide a means to study complex bio-physiological processes in normal and disease states (disease modeling) and also for therapeutic screening and clinical trials. …”
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Application of induced pluripotent stem cells in the conservation of endangered animals by Jiao Lou, Weina Li, Panlong Chen, Haiyan Chen, Amna Shakoor, Yunlong Chen, Jinlian Hua, Yan Wang, Shiqiang Zhang

“…We highlight breakthroughs in differentiating iPSCs into functional gametes for assisted reproduction and blastoids formation for embryonic reconstruction, circumventing donor oocyte dependency and genetic homogeneity risks. …”
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Redox Regulation of PPARγ in Polarized Macrophages by Verena Trümper, Ilka Wittig, Juliana Heidler, Florian Richter, Bernhard Brüne, Andreas von Knethen

“…Mutating these cysteines to alanine to mimic a redox modification decreased PPARγ-dependent reporter gene transactivation supporting a functional shift of PPARγ associated with the MΦ phenotype. …”
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Quercetin and Mesenchymal Stem Cell Metabolism: A Comparative Analysis of Young and Senescent States by Alexandra Ivan, Alexandra Teodora Lukinich-Gruia, Iustina-Mirabela Cristea, Maria-Alexandra Pricop, Crenguta Livia Calma, Alina-Georgiana Simina, Călin Adrian Tatu, Atena Galuscan, Virgil Păunescu

“…Conversely, in older, senescent SHEDs, quercetin supports mitochondrial function at lower concentrations but appears to inhibit respiration at higher doses. …”
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The correlation of sleep disorders with postoperative outcomes in spine surgery: A narrative review by Joseph E. Nassar, BS, Manjot Singh, BS, Ashley Knebel, BA, Mohmmad Daher, BS, Daniel Alsoof, MBBS, Bassel G. Diebo, MD, Alan H. Daniels, MD

“…Patients with untreated sleep disturbances experience higher pain levels, delayed rehabilitation and increased dependency on analgesics. Improved management of sleep disturbances has shown potential to improve clinical and functional outcomes after surgery. …”
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Structural origin of fracture-induced surface charges in piezoelectric pharmaceutical crystals for engineering bulk properties by Kaustav Das, Ishita Ghosh, Soumalya Chakraborty, Amritha G. Nambiar, Sourav Maji, Sumanta K. Karan, Dinesh Kumar, Arvind K. Bansal, C. Malla Reddy

“…Abstract Altering surface chemistry of functional materials is an attractive route to enable large property enhancements without sacrificing overall structural-order, appealing to diverse fields of application sciences; however, the same remains unexplored for organic crystalline materials. …”
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Demographic ageing and public debt in Poland. Is the public finance sector about to collapse? by Marek Piotrowski, Magdalena Antoń, Emilia Kwiatkowska

“…The paper addresses the issue of demographic ageing of the Polish population, with particular emphasis on its impact on the functioning of the national economy. Its main objective was to assess the influence of demographic changes on the public finance sector in Poland. …”
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Variation in perioperative practice in elective colorectal cancer surgery: opportunities for quality improvement by John C. Taylor, Hannah Rossington, Rina George, Sarah L. Alderson, Philip Quirke, Caroline Thomas, Simon Howell, the YCR BCIP Study Group

“…Results Information on 216 patients were collected. Functional assessment by Cardiopulmonary Exercise Testing varied across the region (performed in 100% patients at three Trusts, but not at all in six Trusts, P < 0.001). …”
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Efficacy and safety of edaravone for acute intracerebral haemorrhage: protocol for a systematic review and meta-analysis by Tingting Li, Ping Jiang, Ying Gao, Luda Feng, Ning Liang, Qinyu Yang

“…While several trials in the last 8 years have reported the favourable long-term functional outcomes, a few reports indicated edaravone to be associated with an increase in adverse events.Methods and analysis This protocol was performed in accordance with the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols. …”
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A Perspective on Software-in-the-Loop and Hardware-in-the-Loop Within Digital Twin Frameworks for Automotive Lighting Systems by George Balan, Philipp Neninger, Enrique Ruiz Zúñiga, Elena Serea, Dorin-Dumitru Lucache, Alexandru Sălceanu

“…The increasing complexity of modern automotive lighting systems requires advanced validation strategies that ensure both functional performance and regulatory compliance. This study presents a structured integration of Software-in-the-Loop (SiL) and Hardware-in-the-Loop (HiL) testing within a digital twin (DT) framework for validating headlamp systems. …”
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The envy-contempt spiral: affective self-regulation in grandiose narcissism by Alexandros Raftopoulos, Human-Friedrich Unterrainer, Human-Friedrich Unterrainer, Human-Friedrich Unterrainer

“…In the present paper, we translate this theory to contemporary personality psychology by drawing on Affective Neuroscience and socio-functional approaches of emotion. We propose that envy and contempt interact in a self-regulating, opposing way, forming the core of the self-protective strategy seen in grandiose narcissism. …”
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Gibbs Free Energy and Enthalpy–Entropy Compensation in Protein Folding by María J. Benítez, Juan S. Jiménez

“…Our analysis suggests that EEC may be the quantum-mechanical evolutive mechanism to make functional proteins adaptative to environmental temperature and metabolite concentrations. …”
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Exercises Training Program: Its Effect on Muscle Strength and Activity of Daily Living among Elderly People by Amal M. Mohamed, Eman T. Mohamed, Jehan A. R. Mohamed

“… Context: Aging is associated with the loss of muscle strength and difficulties in functional activities. Research evidence has identified that regular exercises in the elderly have been shown to enhance gait, balance, and muscle strength, leading to a reduction in seniors’ dependency. …”
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Physiological normoxia and absence of EGF is required for the long-term propagation of anterior neural precursors from human pluripotent cells. by Bilada Bilican, Matthew R Livesey, Ghazal Haghi, Jing Qiu, Karen Burr, Rick Siller, Giles E Hardingham, David J A Wyllie, Siddharthan Chandran

“…These neurons display multiple attributes including the capability to form functional synapses and undergo activity-dependent gene regulation. …”
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Can targeted cognitive intervention improve rehabilitation outcome in hip fracture patients: a randomized controlled trial by Yedida Borow, Renata Efrati, Noa Doron, Michal Tzin, Yaara Ginsburg, Daniela Gesner, Avital Hershkovitz

“…Rehabilitation success depends on various factors, such as, age, pre-fracture function, level of cognitive function, nutritional status, comorbidity, and family support. …”
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Brain organoid maturation and implantation integration based on electrical signals input by Xiao-Hong Li, Nan Hu, Zhe-Han Chang, Jian-Xin Shi, Xiu Fan, Meng-Meng Chen, Shuang-Qing Bao, Chong Chen, Jia-Chen Zuo, Xiao-Wang Zhang, Jing-Jing Wang, Dong Ming

“…Methods: Bioelectricity was input into cortical organoids by electrical stimulation (ES) with a multi-electrode array (MEA) to obtain a better-transplanted candidate with better viability and maturity, realizing structural-functional integration with the host brain. Results: We found that electrical stimulation facilitated the differentiation and maturation of organoids, displaying well-defined cortical plates and robust functional electrophysiology, which was probably mediated via the pathway of calcium-calmodulin (CaM) dependent protein kinase II (CAMK II)-protein kinase A (PKA)-cyclic-AMP response binding protein (pCREB). …”
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TRIM24 regulates chromatin remodeling and calcium dynamics in cardiomyocytes by Marco Neu, Anushka Deshpande, Ankush Borlepawar, Elke Hammer, Ahmed Alameldeen, Phillipp Vöcking, Timon Seeger, Michael Hausmann, Norbert Frey, Ashraf Yusuf Rangrez

“…Abstract Background Cardiomyocyte proteostasis and calcium homeostasis are critical for maintaining cardiac function, with their dysregulation contributing to cardiac hypertrophy and heart failure. …”
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THE POSSIBILITY OF USAGE OF METABOLIC CORRECTION THERAPY IN PATIENTS WITH ISCHEMIC HEART DISEASE AND HEART FAILURE by I. V. Sergienko, M. E. Bugriy, T. V. Balahonova, G. A. Tkachev, V. B. Sergienko

“…The endothelium function was measured as endothelium dependent vasodilation.Results. …”
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Integrated microbiome and metabolome approaches reveal the resistant mechanisms of leaf blight resistant plum cultivar by Xinyan Zhou, Yufei Wei, Yu Zhu, Jiaoming Li, Runche Zhou, Qingju Xiao, Ruihong Luo, Shangdong Yang

“…Meanwhile, positive correlations between potential functional microorganisms, metabolites and leaf blight resistant plum cultivar also had been identified. …”
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ER stress-driven unfolded protein response fuels aging-related tumor aggressiveness in gliomas by Xiaodong Shao, Shaolei Guo, Jia Yang, Junjie Dai, Kaihua Cao, Xia Cai, Tianshi Song, Shun Yao, Umar Raza, Kun Chen

“…Differential gene and protein expression, functional annotation and pathway enrichment, gene set enrichment, network construction, CRSISPR-based functional dependency, transcription factor prediction, correlation, clinical association and survival analyses were conducted to identify, develop and validate endoplasmic reticulum (ER) stress-driven unfolded protein response (UPR) as key aging-related molecular mechanism driving tumor aggressiveness in gliomas. …”
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