Does Incretin Agonism Have Sustainable Efficacy? by Sok-Ja Janket, Miyo K. Chatanaka, Dorsa Sohaei, Faleh Tamimi, Jukka H. Meurman, Eleftherios P. Diamandis

“…Amylin is co-expressed with insulin from the pancreas β-cells but does not have insulinotropic function. Amylin suppresses glucagon secretion, slowing gastric emptying and suppressing the reward center in the central nervous system, leading to weight loss. …”
Get full text

Rehabilitation of patients after surgical treatment of pulmonary tuberculosis in a specialized sanatorium by R. V. Tarasov, E. V. Krasnikova, D. F. Gorlov, M. I. Chushkin, M. A. Bagirov

“…Surgery for patients with pulmonary tuberculosis should be accompanied by a complex of rehabilitation measures with an algorithm for the formation of rehabilitation programs depending of the patients functional state and of volume of surgical intervention.Aim: to study the effectiveness of rehabilitation measures depending on the degree of functional impairments considering the volume of surgical interventions in patients operated on for advanced destructive pulmonary tuberculosis.Object and methods. …”
Get full text

Advancements in artificial synapses: The role of fluorite–structured ferroelectrics by P.R. Sekhar Reddy

“…Artificial synapses (ASs) in neuromorphic systems replicate synaptic functions like potentiation/depression, short-/long-term plasticity, and spike-time-dependent plasticity. …”
Get full text

Unitary and entangling solutions to the parametric Yang–Baxter equation in all dimensions by Arash Pourkia

“…A key feature of R(u) is its composition from four monomial-based layers: R(u)=Ra(u)+Rb(u)+Rx(u)+Ry(u),where a(u), b(u), x(u) and y(u) are four sets of monomial complex functions of the form, auna, bunb, xunx and yuny, respectively. …”
Get full text

Malvidin-3-glucoside induces insulin secretion by activating the PLC/IP3 pathway and enhancing Ca2+ influx in INS-1 pancreatic β-cells by Pilailak Channuwong, Yuanying Yuan, Shaomian Yao, Fernando Vicosa Bauermann, Henrique Cheng, Tanyawan Suantawee, Sirichai Adisakwattana

“…M3G holds promise as a natural anti-diabetic agent by enhancing insulin secretion and supporting β-cell function.…”
Get full text

Twenty-Week Dietary Supplementation with Beeswax Alcohol (BWA; Raydel^®) Ameliorates High-Cholesterol-Induced Long-Term Dyslipidemia and Organ Damage in Hyperlipidemic Ze... by Kyung-Hyun Cho, Ashutosh Bahuguna, Yunki Lee, Sang Hyuk Lee, Ji-Eun Kim

“…Background/Objectives: Beeswax alcohol (BWA; Raydel^®) is a blend of six long-chain aliphatic alcohols extracted from honeybee wax and is well known for its diverse functionality and health benefits. Herein, the efficacy of a BWA dietary intervention for 20 weeks was assessed to ameliorate high-cholesterol diet (HCD)-induced dyslipidemia and adverse effects on the vital organs of adult zebrafish. …”
Get full text

Rapid and cumulative adult plasticity in the mouse visual cortex by Hiroyuki Miyamoto, Emi Mazaki, Yuichi Makino, Qi Fang, Tomohito Hamada, Youichi Handa, Takao K. Hensch, Takao K. Hensch, Takao K. Hensch

“…Experience-dependent neural plasticity enables the brain to adapt to diverse and dynamic environments by reshaping circuits. …”
Get full text

Mitochonic acid 5 mitigates age-related hearing loss progression by targeting defective 2-methylthiolation in mitochondrial transfer RNAs by Teppei Kouga, Toru Miwa, Toru Miwa, Fan-yan Wei, Kishiko Sunami, Kazuhito Tomizawa

“…Mitochonic acid 5 (MA-5) has shown promise as a therapeutic candidate by improving mitochondrial function, reducing oxidative stress, and stabilizing membrane potential.MethodsIn this study, we investigated the effects of MA-5 on ARHL in cyclin-dependent kinase 5 regulatory subunit-associated protein 1 (Cdk5rap1) knockout (KO) mice, which exhibit early-onset ARHL due to abnormalities in mitochondrial transfer RNA (mt-tRNA) modifications.ResultsMA-5 treatment effectively attenuated ARHL progression in Cdk5rap1-KO mice by improving auditory brainstem response thresholds and distortion product otoacoustic emissions. …”
Get full text

Serum-Free Medium Supplemented with <i>Haematococcus pluvialis</i> Extracts for the Growth of Human MRC-5 Fibroblasts by Eun-Jeong Koh, Seong-Yeong Heo, Areumi Park, Yeon-Ji Lee, Woon-Yong Choi, Soo-Jin Heo

“…Additionally, the interaction between growth factor cocktails and HE significantly improved cell viability, promoted cell cycle progression, and activated key cell cycle regulators, such as cyclin A and cyclin-dependent kinases 1 (CDK1). Our findings suggest that HE have considerable potential to substitute FBS in MRC-5 cell cultures and have functional and ethical advantages.…”
Get full text

Brown and Levy Steady-State Motions by Iddo Eliazar

“…The motions have two parameters: a critical exponent which determines the Noah effect and the memory structure; and a clock function which determines the Joseph effect and the correlation structure. …”
Get full text

Investigating SMYD3 role during oocyte maturation in a 3D follicle-enclosed oocyte in vitro model in sheep by Chiara Camerano Spelta Rapini, Alessia Peserico, Chiara Di Berardino, Giulia Capacchietti, Camila Rojo-Fleming, Andrada-Ioana Damian-Buda, Irem Unalan, Aldo Roberto Boccaccini, Valentina Grossi, Mauro Mattioli, Barbara Barboni

Get full text

Chromatin remodelling factor BAF155 protects hepatitis B virus X protein (HBx) from ubiquitin-independent proteasomal degradation by Huijing Chen, Yi Zhang, Shuangshuang Ye, Qiong Wu, Youfen Lin, Kaiqin Sheng, Wannan Chen, Xinjian Lin, Xu Lin

“…Consequently, overexpression of BAF155 enhanced the transcriptional transactivation function of HBx, activated protooncogene expression and inhibited hepatoma cell clonogenicity. …”
Get full text

Heterogeneity of autoimmune diabetes mellitus in adults: real-world clinical practice by N. V. Rusyaeva, I. V. Kononenko, O. K. Vikulova, O. M. Smirnova, M. V. Shestakova

“…Autoimmune DM in adults demonstrates heterogeneity in the rate of β-cell function decline and the development of insulin dependence. …”
Get full text

Riemann-Liouville fractional-order pantograph differential equation constrained by nonlocal and weighted pantograph integral equations by Ahmed M. A. El-Sayed, Wagdy G. El-Sayed, Kheria M. O. Msaik, Hanaa R. Ebead

“…Moreover, we analyzed the continuous dependence of the solution on some functions and parameters. …”
Get full text

PEDAGOGICAL MODELLING AS METHOD AND TECHNOLOGY OF PRODUCTIVE INNOVATIVE SOLUTION OF PROBLEMS OF PROFESSIONAL AND PEDAGOGICAL ACTIVITY by O. Gutak, N. Kozyrev, O. Kozyreva

“…Concepts are specified, the principles, functions, constructs of optimization of quality of use of pedagogical modeling in work of the teacher and scientific and pedagogical workers in the SPO, VO, DPO system are marked out. …”
Get full text

Unveiling CKS2: A Key Player in Aggressive B‐Cell Lymphoma Progression and a Target for Synergistic Therapy by Fenling Zhou, Lu Chen, Zhen Liu, Yuli Cao, Cuilan Deng, Gexiu Liu, Chengcheng Liu

Get full text

Targeting CDK4/6 suppresses colorectal cancer by destabilizing YAP1 by Yalei Wen, Xiao Yang, Shengrong Li, Lei Huang, Jiayi Chen, Lirong Tan, Xiuqing Ma, Yingjie Zhu, Zhengqiu Li, Changliang Shan, Chunze Zhang, Qiushi Zhang, Mingchao Liang, Haoxing Zhang, Tongzheng Liu

“…Collectively, our study uncovers a novel oncogenic role of the CDK4/6‐DUB3 pathway, which promotes YAP1 stabilization and tumor‐promoting function, highlighting that targeting CDK4/6 offers a potential therapeutic strategy for CRC with aberrantly upregulated DUB3 and YAP1.…”
Get full text

Robust stability and memory feedback control for uncertain switched TS fuzzy systems with multiple time-varying delays by Marwen Kermani, Anis Sakly

“…This paper focuses on the robust stability and the memory feedback control problems of uncertain switched fuzzy systems with mode-dependent multiple time-varying delays. Thus, by constructing a novel Lyapunov functional, the aggregation techniques, and the Borne and Gentina criterion, new algebraic robust stability and stabilization conditions under arbitrary switching have been established. …”
Get full text

APPLICATION OF LINEAR AND NONLINEAR EXTRAPOLATIONS IN ANALYZING THE TRENDS OF CHANGES IN FINANCIAL STABILITY by EVGENY Negashev

Get full text

The impact of man-made virtual reality: from impressions to a person's worldview / Воздействие техногенной виртуальной реальности: от впечатлений к мировоззрению личности... by Olga Moskvitina / Ольга Александровна Москвитина

“…Possible distortions of the main aspects of a person's worldview are given: substantive, value, structural and functional in nature. As conditions for the occurrence of these distortions, the originality of the impressions received from the impact of TVR and the peculiarities of the work of the brain are put forward. …”
Get full text