Landscape analysis of m5C modification regulators unveils DNMT1-mediated dysregulated pyrimidine metabolism in hepatocellular carcinoma by Xuhui Zhao, Shengwei Mao, Yuan Fang, Jiafeng Chen, Lifu Bi, Jie Li, Jinglei Wu, Jun Gao, Shiguang Yang, Jialu Fu, Xiaoling Wu, Guiqi Zhu, Zheng Tang, Yinghong Shi, Jian Zhou, Jia Fan, Xingxing Zhang, Jinling Jiang, Weiren Liu

“…However, its specific functions and their underlying mechanisms are poorly understood in hepatocellular carcinoma (HCC). …”
Get full text

Exploring the microbiota of grapevines: Tools and perspectives for sustainable agriculture by María Paz Villanueva-Llanes, María Carbú, Jesús Manuel Cantoral, Gustavo Cordero-Bueso

“…Understanding microbial diversity is crucial for optimizing plant health, enhancing disease resistance, improving nutrient availability, and supporting vital physiological functions.Research has identified a wide range of endophytic microorganisms, including fungi, bacteria, viruses, and yeasts, across different Vitis vinifera cultivars and Vitis species. …”
Get full text

Interleukin-27-polarized HIV-resistant M2 macrophages are a novel subtype of macrophages that express distinct antiviral gene profiles in individual cells: implication for the anti... by Tomozumi Imamichi, Jun Yang, Qian Chen, Suranjana Goswami, Mayra Marquez, Udeshika Kariyawasam, Homa Nath Sharma, Rosana Wiscovitch-Russo, Xuan Li, Akihiro Aioi, Joseph W. Adelsberger, Weizhong Chang, Jeanette Higgins, Hongyan Sui

Get full text

Practical Recommendations of Scientific Society for the Study of Human Microbiome and Russian Gastroenterological Association (RGA) for Probiotics in Treatment and Prevention of Ga... by V. T. Ivashkin, I. V. Mayev, D. I. Abdulganieva, S. A. Alekseenko, N. Yu. Ivashkina, N. V. Korochanskaya, S. N. Mammaev, E. A. Poluektova, A. S. Trukhmanov, Yu. P. Uspensky, V. V. Tsukanov, O. S. Shifrin, O. Yu. Zolnikova, K. V. Ivashkin, T. L. Lapina, R. V. Maslennikov, A. I. Ulyanin

“…Some probiotics registered in the Russian Federation include probiotic strains that have proved to be effective for the prevention and treatment of antibiotic-associated diarrhea, the prevention of C. difficile-associated disease, the eradication of H. pylori infection, as well as for the treatment of irritable bowel syndrome and functional constipation.Conclusions. The clinical efficacy of probiotics depends on the probiotic strains included in their composition and is confirmed by a comparative analysis of the results of appropriate clinical studies. …”
Get full text

Cognitive and emotional changes in patients with juvenile myoclonic epilepsy by R. V. Magzhanov, D. V. Anisimova, P. N. Vlasov, V. A. Petrukhin, E. B. Tsevtsivadze, S. R. Nurmukhametova

“…BDI scores indicated that there were minimal, mild, moderate, and severe manifestations in 6 (20%), 3 (10%), 2 (6.7%), and 1 patients, respectively. Cognitive functions and the level of anxiety and depression did not depend on the patients’ age at disease onset and at the time of investigation, disease duration, menstrual cycle regularity, therapy regimen, and hormonal status. …”
Get full text

Symbiotic Learning Grey Wolf Optimizer for Engineering and Power Flow Optimization Problems by Aala Kalananda Vamsi Krishna Reddy, Komanapalli Venkata Lakshmi Narayana

Get full text

THE SYSTEM OF MOTIVES OF EDUCATIONAL ACTIVITY AS A PROGNOSTIC SYSTEM SUCCESS FACTORS IN LEARNING: VIEW THROUGH THE PRISM OF UNIFICATIONNOW APPROACH by A. Egorova, S. Bobryshov

Get full text

Two-Dimensional Probability Models for the Weighted Discretized Fréchet–Weibull Random Variable with Min–Max Operators: Mathematical Theory and Statistical Goodness-of-Fit Analysis... by Sofian T. Obeidat, Diksha Das, Mohamed S. Eliwa, Bhanita Das, Partha Jyoti Hazarika, Wael W. Mohammed

“…A rigorous mathematical formulation is presented, encompassing the joint cumulative distribution function, joint probability mass function, and joint (reversed) hazard rate function. …”
Get full text

Thermal behavior of the Klein Gordon oscillator in a dynamical noncommutative space by Ilyas Haouam

Get full text

M6A-METTL3-dependent nuclear PANC754/PSPC1/H3K4me1 repression complex regulate immune evasive LGALS7 signal to enhance immunotherapy against colorectal cancer by Jianfeng Zhang, Guilian Cao, Feng Li, Siyu Tang, Chenxi Wu, Min Jiang, Jingxin Ye, Shaoqing Ju, Fei Qian, Weifeng Ding

“…Abstract Non-coding RNAs (ncRNAs) have important regulatory functions similar to traditional oncogenes or tumor suppressor genes. …”
Get full text

Random dynamics of fractional stochastic retarded FitzHugh–Nagumo systems on unbounded domains by Dongjie Gao

“…More precisely, we use the method of backward uniform tail-estimates of solutions to resolve the first difficulty, and we introduce an inverse function to solve the second difficulty.…”
Get full text

Nonlinear Rayleigh wave propagation in a three-layer sandwich structure in dual-phase-lag by A. A. Youssef, N. K. Amein, F. A. Salama, A. F. Ghaleb, Ethar A. A. Ahmed

Get full text

A novel strategy for the management of non-productive cough: mechanisms, efficacy, safety. A review by Oleg V. Kalyuzhin, Andrey G. Malyavin

“…Modern therapeutic approaches often focus solely on symptomatic cough suppression, while targeting its pathogenetic mechanisms, including MCP-dependent inflammation, remains understudied. The article examines the innovative antitussive drug Eladis®, designed to target chemokine-dependent mechanisms involved in the development of cough sensitization. …”
Get full text

Depth-Induced Intra-to-Inter Transformer network for stereoscopic image retargeting by Xiaoting Fan, Long Sun, Zhong Zhang

“…Finally, a hybrid loss function is applied to improve the stereoscopic image retargeting quality. …”
Get full text

Experimental Study of the Reactions of Br Atoms with Thiirane and Nitrosyl Chloride by Yuri Bedjanian

Get full text

Endothelial dysfuncton and 2 type diabetes: novel markers for earlier diagnostics by I. A. Khripun, M. N. Morgunov, S. V. Vorobyov, V. P. Terentiev, M. I. Kogan

Get full text

Inline Waveguide Sharp-Rejection Bandpass Filters With Transmission Zeros Using Resonant Coupling Slots by Lubina Iram, Muhammad Yameen Sandhu, Adam Lamecki, Roberto Gomez-Garcia, Michal Mrozowski

Get full text

Long-Term Persistence in Observed Temperature and Precipitation Series by Huayu Zhong, Yiping Guo

Get full text

A Study on Factors Influencing Nonunion Tibia with Failed Fixation and Its Management Outcome by S Vijaya Anand, Rex Chandrabose, Prem Anand

Get full text

Unified pre- and postsynaptic long-term plasticity enables reliable and flexible learning by Rui Ponte Costa, Robert C Froemke, P Jesper Sjöström, Mark CW van Rossum

“…Although it is well known that long-term synaptic plasticity can be expressed both pre- and postsynaptically, the functional consequences of this arrangement have remained elusive. …”
Get full text