CH25H/25-HC promotes pulmonary fibrosis via AMPK/STAT6 pathway-dependent M2 macrophage polarization in COPD by Ying Li, Guangzhi Xiao, Xianghui Fu, Xing Luo, Fengfan Yang, Yadan Li, Zhaohui Zheng

“…CH25H knockdown alleviated alveolar damage, airway remodeling, and pulmonary fibrosis in COPD mice, evidenced by reduced expression of fibrosis-related proteins, improved lung function, and attenuated inflammatory responses. Moreover, CH25H knockdown inhibited M2 macrophage polarization and decreased the proportion of M2-type macrophages. …”
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IGF2BP3 promotes autophagy-mediated TNBC metastasis via m6A-dependent, cap-independent c-Met translation by Zi-Wen Wang, Yi-Han Li, Meng-Yuan Cai, Xu Zhang, Ruo-Xi Xu, Hai-Yan Yang, Yu-Zhou Huang, Liang Shi, Ji-Fu Wei, Qiang Ding

“…Conclusions Our study expands the understanding of IGF2BP3’s role in TNBC metastasis by establishing its function in regulating autophagy. Notably, IGF2BP3 could bind to the m6A motif on the 5′ and 3′ untranslated regions (UTRs) of c-Met mRNA to facilitate its translation in a cap-independent manner.…”
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Rnd3 protects against doxorubicin-induced cardiotoxicity through inhibition of PANoptosis in a Rock1/Drp1/mitochondrial fission-dependent manner by Wen Ge, Xiaohua Zhang, Jie Lin, Yangyang Wang, Xiao Zhang, Yu Duan, Xinchun Dai, Jiye Zhang, Yan Zhang, Mengyuan Jiang, Huanhuan Qiang, Zhijing Zhao, Xuebin Zhang, Dongdong Sun

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A dataset on potentially groundwater-dependent vegetation in the Sierra Nevada Protected Area (Southern Spain) and its underlying NDVI-derived ecohydrological attributesZENODO by Javier Cabello, Montserrat Escudero-Clares, Sergio Martos-Rosillo, J. Jesús Casas, Juanma Cintas, Thomas Zakaluk, María J. Salinas-Bonillo

“…It supports comparative research across regions, facilitates the study of groundwater buffering effects on vegetation function, and offers a transferable framework for ecohydrological classification based on remote sensing. …”
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Long-Term Investigation of Marine-Derived Aspergillus Diversity in the Republic of Korea by Jun Won Lee, Wonjun Lee, Rekhani Hansika Perera, Young Woon Lim

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Suppression of the T-dependent antibody response following oral exposure to selected polycyclic aromatic compounds in B6C3F1/N mice by Victor J. Johnson, Cynthia V. Rider, Michael I. Luster, Cynthia J. Willson, Shawn Harris, Billie Stiffler, James Blake, Esra Mutlu, Veronica Godfrey, Brian Burback, Reshan Fernando, Suramya Waidyanatha, Gary R. Burleson, Dori R. Germolec

“…Antibody suppression was associated with significant immune cell loss in the spleen; however, it was clear that the suppression of the TDAR was more sensitive than cell loss indicating that cell function impairments were involved. Phenanthrene treatment also resulted in suppression of the antibody response but only at dose levels ≥50 mg/kg bodyweight/day without significant effects on other parameters, while pyrene showed no significant immune effects.ConclusionSuppression of the TDAR to SRBC immunization was the most sensitive immune endpoint being 33 times more sensitive than changes in liver weight, a commonly used outcome for risk assessment for PACs. …”
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The evolution of the therapeutic concept ‘GIP receptor antagonism’ by Frederikke Koefoed-Hansen, Frederikke Koefoed-Hansen, Mads Marstrand Helsted, Hüsün Sheyma Kizilkaya, Asger Bach Lund, Asger Bach Lund, Asger Bach Lund, Mette Marie Rosenkilde, Lærke Smidt Gasbjerg, Lærke Smidt Gasbjerg

“…Moreover, the long-term effects of therapeutic GIP receptor antagonism in humans are not fully elucidated and are thought to depend on the specific drug molecule, receptor functions, and the extent of GLP-1 receptor activation. …”
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THE WAYS OF IMPROVING METHODICAL BASIS AND INSTRUMENTAL TOOLS OF DECISION MAKING PROCESSES SUPPORT WITHIN THE NATIONAL SECURITY SYSTEM by Volodymyr Y. Bohdanovych, Andrii L. Vysidalko, Oleksandr M. Kosohov

“…Identified the main target function, list of functions of the dependence from signs, integral indexes, basic indicators and criteria of estimation of the automated modeling of scenarios of the reacting to threats of the realization of national interests (NI). …”
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Atomistic understanding of rough surface on the interfacial friction behavior during the chemical mechanical polishing process of diamond by Song Yuan, Xiaoguang Guo, Hao Wang, Renke Kang, Shang Gao

“…Herein, the rough surface with a special root mean square (RMS) value is constructed by multivariate Weierstrass–Mandelbrot (W–M) function and the rubbing process during that the chemical mechanical polishing (CMP) process of diamond is mimicked utilizing the reactive force field molecular dynamics (ReaxFF MD) simulation. …”
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Neurobehavioral features in medication-overuse headache by Franz Riederer, Roberto Pirrotta, Chantal Martin Soelch, Andreas R. Gantenbein, Adrian Scutelnic, Antonia Klein, Christoph J. Schankin, Peter S. Sándor

“…Background: Medication-overuse headache (MOH) has been related to the spectrum of dependence behavior and impaired orbitofrontal cortex function. …”
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Static and dynamic study of composite beams with a new interlaminar sliding field using different beam theories by Rachida Mohamed Krachaï, Noureddine Elmeiche, Ismail Mechab, Fabrice Bernard, Hichem Abbad

“…Methods: A new interlaminar slip field which takes into account, for each layer, the axial displacement, the rotation due to bending, and the high-order transverse shear with a new warping shape function, has been introduced in this study. The equilibrium equations were solved analytically based on the principle of Hamilton. …”
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Real-world clinical determinants of alcohol dependence in outpatients with bipolar disorder: a multicenter treatment survey for bipolar disorder in psychiatric outpatient clinics w... by Keita Tokumitsu, Norio Sugawara, Naoto Adachi, Yukihisa Kubota, Yoichiro Watanabe, Kazuhira Miki, Takaharu Azekawa, Koji Edagawa, Eiichi Katsumoto, Seiji Hongo, Eiichiro Goto, Hitoshi Ueda, Masaki Kato, Masaki Kato, Reiji Yoshimura, Reiji Yoshimura, Atsuo Nakagawa, Atsuo Nakagawa, Toshiaki Kikuchi, Toshiaki Kikuchi, Takashi Tsuboi, Takashi Tsuboi, Koichiro Watanabe, Koichiro Watanabe, Norio Yasui-Furukori, Norio Yasui-Furukori

“…BackgroundBipolar disorder is a psychiatric disorder characterized by mood swings between manic and depressed states that causes psychosocial problems. Cognitive function deteriorates with each recurrence, making it important to maintain remission through continued treatment. …”
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Targeting netrin‐1/DCC interaction in diffuse large B‐cell and mantle cell lymphomas by Laura Broutier, Marion Creveaux, Jonathan Vial, Antonin Tortereau, Jean‐Guy Delcros, Guillaume Chazot, Mark J McCarron, Sophie Léon, Céline Pangault, Nicolas Gadot, Amélie Colombe, Marie‐Laure Boulland, Jonathan Blachier, Julien C Marie, Alexandra Traverse‐Glehen, Olivier Donzé, Catherine Chassagne‐Clément, Gilles Salles, Karin Tarte, Patrick Mehlen, Marie Castets

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Temperature Dependences of the Electron Energy in AlxGa1 – xAs / GaAs / AlxGa1 – xAs Nanofilms of Different Thickness and Composition of the Barrier Material by D.V. Kondryuk, V.M. Kramar

“…Calculations were performed by using the Green functions method, approximation of the effective masses for the electronic system and model of the dielectric continuum – for phonons. …”
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Sex-dependent epigenetic disruption of YY1 binding by prenatal BPA exposure downregulates Matr3 and alters Agap1 splicing in the offspring hippocampus by Pattanachat Lertpeerapan, Songphon Kanlayaprasit, Surangrat Thongkorn, Kasidit Kasitipradit, Pawinee Panjabud, Kwanjira Songsritaya, Thanawin Jantheang, Masanobu Morita, Takaaki Akaike, Valerie W. Hu, Depicha Jindatip, Thanit Saeliw, Tewarit Sarachana

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Early-Life Respiratory Syncytial Virus (RSV) Infection Triggers Immunological Changes in Gut-Associated Lymphoid Tissues in a Sex-Dependent Manner in Adulthood by Stella Liong, Felicia Liong, Mitra Mohsenipour, Elisa L. Hill-Yardin, Mark A. Miles, Stavros Selemidis

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Time-Dependent Effect of Oral Morphine Consumption on the Development of Cytotrophoblast and Syncytiotrophoblast Cells of the Placental Layers during the Three Different Periods of... by Leila Dehghani, Hedayat Sahraei, Rokhsareh Meamar, Masoomeh Kazemi

“…In general, the time-dependent effects of oral morphine consumption can inhibit the development and natural functioning of cytotrophoblast and syncytiotrophoblast cells of the placental layers.…”
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Heme bound to the bacterial transcription factor SqrR/YgaV catalyzes oxygen-dependent conversion of hydrogen sulfide to polysulfide for regulated gene expression by Ryoma Iwata, Shinji Masuda

“…This study investigates the molecular mechanisms underlying the sulfur sensing and regulatory functions of two homologous transcription factors, SqrR from Rhodobacter capsulatus and YgaV from Escherichia coli. …”
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Forest transformation effects on the soil water-holding capacity depend on the forest characteristics and soil properties: A case study in the subtropical regions of southeast Chin... by Jiantao Zhou, Qiao Yang, Xin Peng, Qiqian Wu, Yan Peng, Yutong Zhang, Hualing Jiang, Fuzhong Wu, Kai Yue

“…Our findings will help to better understand the functions of forests in water source conservation under the pressures of human disturbances and environmental changes.…”
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Molecular mechanisms of dose-dependent regulation of hepatic lipid metabolism by BaP through modulation of AhR binding to XRE1 or XRE3 by Mengdi Zhang, Mengdi Zhang, Xiaoli Lv, Xiaoli Lv, Chaojie Wang, Chaojie Wang, Lei Wang, Lei Wang, Han Wang, Han Wang, Xue Wang, Xue Wang, Yulu Du, Yulu Du, Jun Li, Jun Li, Jun Li, Xiuli Han, Xiuli Han, Xiuli Han, Lei Fan, Lei Fan, Yuxia Hu, Yuxia Hu, Yuxia Hu, Tuya Bai, Tuya Bai, Weizhong Huangfu, Fuhou Chang, Fuhou Chang

“…Benzo[a]pyrene (BaP), a polycyclic aromatic hydrocarbon and a potent environmental pollutant, has been implicated in the dysregulation of lipid metabolism and metabolic diseases, warranting investigation into its effects on liver functions, particularly regarding fibroblast growth factor 21 (FGF21) mediated pathways. …”
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