THE METHOD OF DETERMINATION OF ERROR IN THE REFERENCE VALUE OF THE DOSE DURING THE LINEAR ACCELERATOR RADIATION OUTPUT CALIBRATION PROCEDURE. Part 3. The dependence of the radiatio... by E. V. Titovich, I. G. Tarutin, M. G. Kiselev

“…To ensure the radiation protection of oncology patients is needed to provide the constancy of functional characteristics of the medical linear accelerators, which affect the accuracy of dose delivery. …”
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A549 in-silico 1.0: A first computational model to simulate cell cycle dependent ion current modulation in the human lung adenocarcinoma. by Sonja Langthaler, Theresa Rienmüller, Susanne Scheruebel, Brigitte Pelzmann, Niroj Shrestha, Klaus Zorn-Pauly, Wolfgang Schreibmayer, Andrew Koff, Christian Baumgartner

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Long-Term Efficacy of an AI-Based Health Coaching Mobile App in Slowing the Progression of Nondialysis-Dependent Chronic Kidney Disease: Retrospective Cohort Study by Jianwei Ma, Jiangyuan Wang, Jiapei Ying, Shasha Xie, Qin Su, Tianmeng Zhou, Fuman Han, Jiayan Xu, Siyi Zhu, Chenyi Yuan, Ziyuan Huang, Jingfang Xu, Xuyong Chen, Xueyan Bian

“…Subgroup analysis revealed that the effect of the KidneyOnline care group was more significant in male patients, patients older than 45 years, and patients with worse baseline kidney function, higher blood pressure, and heavier proteinuria. …”
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A cobalt concentration sensitive Btu-like system facilitates cobalamin uptake in Anabaena sp. PCC 7120 by Julia Graf, Leonard Fresenborg, Hans-Michael Seitz, Rafael Pernil, Enrico Schleiff

“…Anabaena contains at least three cobalamin riboswitches in its genome, for one of which the functionality is confirmed here. Moreover, two outer membrane-localized cobalamin TonB-dependent transporters, namely BtuB1 and BtuB2, were identified. …”
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Three positively charged binding sites on the eastern equine encephalitis virus E2 glycoprotein coordinate heparan sulfate- and protein receptor-dependent infection by Maria D. H. Alcorn, Chengqun Sun, Theron C. Gilliland, Tetyana Lukash, Christine M. Crasto, Saravanan Raju, Michael S. Diamond, Scott C. Weaver, William B. Klimstra

“…The proteins apolipoprotein E receptor 2 (ApoER2) isoforms 1 and 2, and LDLR have also been shown to function as EEEV receptors. Herein, we investigate the individual contribution of each HS interaction site to EEEV HS- and protein receptor-dependent infection in vitro and EEEV replication in animals. …”
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Cell-Autonomous and Non-Cell-Autonomous Regulation of a Feeding State-Dependent Chemoreceptor Gene via MEF-2 and bHLH Transcription Factors. by Matthew Gruner, Jeremy Grubbs, Aja McDonagh, Dominic Valdes, Ari Winbush, Alexander M van der Linden

“…We further demonstrate that the expression levels of srh-234 in ADL neurons are regulated remotely by MXL-3 (Max-like 3 homolog) and HLH-30 (TFEB ortholog) acting in the intestine, which is dependent on insulin signaling functioning specifically in ADL neurons. …”
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Production, Purification, and Biochemical Characterization of a Novel ATP-Dependent Caseinolytic Protease from the Marine Bacterium <i>Cobetia amphilecti</i> KMM 296 by Yulia Noskova, Olga Nedashkovskaya, Larissa Balabanova

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Psychometric properties of the Indonesian version of the Quality of Life Index (QLI-I) among family caregivers of dependent older persons with type 2 diabetes mellitus by Rinco Siregar, Charuwan Kritpracha, Tippamas Chinnawong, Jos M. Latour

“…Background: The quality of life (QoL) of family caregivers supporting older persons with functional dependence due to Type 2 Diabetes Mellitus (T2DM) is a growing concern. …”
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Amyloid-β and proinflammatory cytokines utilize a prion protein-dependent pathway to activate NADPH oxidase and induce cofilin-actin rods in hippocampal neurons. by Keifer P Walsh, Laurie S Minamide, Sarah J Kane, Alisa E Shaw, David R Brown, Bruce Pulford, Mark D Zabel, J David Lambeth, Thomas B Kuhn, James R Bamburg

“…Neurites of neurons under acute or chronic stress form bundles of filaments (rods) containing 1∶1 cofilin∶actin, which impair transport and synaptic function. Rods contain disulfide cross-linked cofilin and are induced by treatments resulting in oxidative stress. …”
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Channel-Dependent Multilayer EEG Time-Frequency Representations Combined with Transfer Learning-Based Deep CNN Framework for Few-Channel MI EEG Classification by Ziang Liu, Kang Fan, Qin Gu, Yaduan Ruan

“…The study of electroencephalogram (EEG) signals is crucial for understanding brain function and has extensive applications in clinical diagnosis, neuroscience, and brain–computer interface technology. …”
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Hypoxia-Inducible Factor-1α Regulates High Phosphate-Induced Vascular Calcification via Type III Sodium-Dependent Phosphate Cotransporter 1 by Chengkun Guo, Zhengli Quan, Jingjing Ke, Hualong Zang, Qiuping Teng, Xin Li, Dan Peng, Ping Wang

“…Phosphonoformic acid was employed to restrain the function of type III sodium-dependent phosphate cotransporter 1 (Pit-1). …”
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Sevoflurane-induced cognitive dysfunction in aged mice mediated by HDAC8-dependent suppression of adult hippocampal neurogenesis via the pCREB/BDNF pathway by Yingxue He, Yanjing Guo, Xiaowei Li, Jiangnan Wu, Zunsai Feng, Gongming Wang, Mengyuan Zhang

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Histidine triad nucleotide-binding protein 2 attenuates metabolic dysfunction-associated steatotic liver disease through NAD+-dependent sirtuin-3 activation by Qinqiu Wang, Yanjun Guo, Shenghui Chen, Zhening Liu, Xinyu Wang, Hangkai Huang, Qi-en Shen, Ling Yang, Meng Li, Youming Li, Chaohui Yu, Chengfu Xu

“…HINT2 inhibits free fatty acid-induced lipid accumulation and impairs mitochondrial function in hepatocytes. Hint2 knockout exacerbates diet-induced hepatic steatosis, inflammation, fibrosis and mitochondrial damage in mice. …”
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Persistence of solvability in quantum systems deformed by Dunkl operators by Axel Schulze-Halberg

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Global Simulations of Gravitational Instability in Protostellar Disks with Full Radiation Transport. I. Stochastic Fragmentation with Optical-depth-dependent Rate and Universal Fra... by Wenrui Xu, Yan-Fei Jiang, Matthew W. Kunz, James M. Stone

“…Compared to a prescribed constant β , radiative cooling in the optically thin/thick regime makes p _frag decrease slower/faster in β ; the critical β corresponding to ∼1 fragment per orbit is ≈3, 5, and 2 for constant β , optically thin, and optically thick cooling, respectively. The distribution function of the initial fragment mass is remarkably insensitive to disk thermodynamics. …”
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WTAP mediates IL-1β-induced chondrocyte injury by enhancing CA12 mRNA stability depending on m6A modification by Gang Deng, Yizhou Xu, Zhengnan Li, Guangxuan Zeng

“…Yet, CA12 overexpression exerted an opposing function. WTAP reinforced the stability of CA12 mRNA depending on the m6A modification. …”
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Baicalin targets YTHDC2 and alleviates male reproductive toxicity caused by co-exposure to nanoplastics and manganese through m6A-dependent pathway by Yi Wen, Tingwei Pan, Lu Liu, Jinning Wang, Kexin Yang, Zhushan Fu, Wenhao Li, XinMiao Wang, Zhiru Shen, Yan Li, Yinke Du, Yu Deng

“…This study establishes in vivo and in vitro models to assess the effects of single and co-exposure to polystyrene nanoplastics (PS-NPs, 0.1 μm) and manganese (Mn) on male reproductive function. Our results reveal that co-exposure leads to a synergistic toxic effect, aggravating testicular damage, sperm abnormalities, and hormone disruption. …”
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ALKBH5 suppresses gastric cancer tumorigenesis and metastasis by inhibiting the translation of uncapped WRAP53 RNA isoforms in an m6A-dependent manner by Ziqi Zheng, Feizhi Lin, Baiwei Zhao, Guoming Chen, Chengzhi Wei, Xiaojiang Chen, Runcong Nie, Ruopeng Zhang, Zhoukai Zhao, Zhiwei Zhou, Yuanfang Li, Weigang Dai, Yijia Lin, Yongming Chen

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Evolutionary unique N-glycan-dependent protein quality control system plays pivotal roles in cellular fitness and extracellular vesicle transport in Cryptococcus neoformans by Catia Mota, Kiseung Kim, Ye Ji Son, Eun Jung Thak, Su-Bin Lee, Ju-El Kim, Jeong-Kee Yoon, Min-Ho Kang, Heeyoun Hwang, Yong-Sun Bahn, J Andrew Alspaugh, Hyun Ah Kang

“…A conserved N-glycan-dependent endoplasmic reticulum protein quality control (ERQC) system has evolved in eukaryotes to ensure accuracy during glycoprotein folding. …”
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Harm reduction measures in a recreational gym user with anabolic androgenic steroid dependence: a case report in the context of current best clinical practice by Raphael Magnolini, Sofia Laura Bottoni, Helena Hammer, Joël Capraro, Philip Bruggmann, Oliver Senn

“…Despite more than a year of abstinence from non-medical androgen use and normalization of cardiac function, the patient died from a cardiovascular event, highlighting the possibly persistent risks of prior androgen use. …”
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