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53BP1 regulates p53-E2F7-dependent transcriptional gene repression and participates in the Fanconi anemia pathway
Published 2025-08-01“…Here, we demonstrate that 53BP1 depletion leads to a p53-dependent upregulation of E2F7. The direct interaction between 53BP1 and p53 is dispensable for this process, which is distinct from the established function of 53BP1-USP28-p53 complex. …”
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METHODS OF SOLVING THE PATTERN RECOGNITION PROBLEM USING RESIDUE NUMBER SYSTEM
Published 2022-09-01“…Application of non-modular operations, based on the Core Function imposes a limitation on the choice of Residue Number System moduli set, but allows to increase the parallelism of operations for each moduli. …”
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4685
Effect of Corrosion Products of Pure Iron on the Corrosion Behavior of Pure Iron and Its Mechanism
Published 2021-07-01“…The corrosion-promotion effect of corrosion products on pure iron depended on two factors: the relative magnitude of the work function of corrosion product and the work function of pure iron, and the oxygen reduction reaction activity of the corrosion product. …”
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4686
SARS-CoV-2 hijacks host CD55, CD59 and factor H to impair antibody-dependent complement-mediated lysis
Published 2024-12-01“…Blockage of the biological functions of virion-associated CD55 and CD59 and competition of FH recruitment with functionally inactive recombinant FH-derived short consensus repeats SCR18-20 restore SARS-CoV-2 complement sensitivity in a synergistic manner. …”
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4687
Pooling umbilical cord-mesenchymal stromal cells derived from selected multiple donors reduces donor-dependent variability and improves their immunomodulatory properties
Published 2025-05-01“…Results Our study highlights the donor-dependent heterogeneity of UC-MSCs immunomodulatory functions. …”
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4688
Cyclin-dependent kinases (CDKs) are key genes regulating early development of Neptunea arthritica cumingii: evidence from comparative transcriptome and proteome analyses
Published 2024-12-01“…Through techniques such as qRT-PCR, our data elucidate for the first time the regulatory functions of CDK family genes and establish CDKs as a pivotal gene cluster in the early embryonic development of N. cumingii. …”
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4689
The nitric oxide donor SNAP-induced amino acid neurotransmitter release in cortical neurons. Effects of blockers of voltage-dependent sodium and calcium channels.
Published 2014-01-01“…<h4>Background</h4>The discovery that nitric oxide (NO) functions as a signalling molecule in the nervous system has radically changed the concept of neuronal communication. …”
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TDP2-dependent non-homologous end-joining protects against topoisomerase II-induced DNA breaks and genome instability in cells and in vivo.
Published 2013-01-01“…Our results demonstrate that TDP2 functions in non-homologous end-joining (NHEJ) and liberates DSB termini that are competent for ligation. …”
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4694
Brachycephaly, Ear Anatomy, and Co—Does Size Matter? A Retrospective Study on the Influence of Size-Dependent Features Regarding Canine Otitis Externa
Published 2025-03-01“…This study, which involved 868 patients, focused on size-dependent features (body size, pinna formation, brachycephaly, overweight) and their associations with the occurrence of canine Otitis externa. …”
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4695
Piezo1 aggravates ischemia/reperfusion-induced acute kidney injury by Ca2+-dependent calpain/HIF-1α/Notch signaling
Published 2025-12-01“…In conclusion, our findings elucidate the biological functions of Piezo1 in renal macrophages, underscoring its role as a crucial mediator of acute kidney injury. …”
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Algorithmic Analysis of Queuing System with Varying Number of Servers, Phase-Type Service Time Distribution, and Changeable Arrival Process Depending on Random Environment
Published 2025-06-01“…An <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mi>M</mi><mi>A</mi><mi>P</mi><mo>/</mo><mi>P</mi><mi>H</mi><mo>/</mo><mi>N</mi></mrow></semantics></math></inline-formula>-type queuing system functioning within a finite-state Markovian random environment is studied. …”
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4697
In silico studies to understand the interactions of flavonoid inhibitor with nsp12-RNA dependent RNA polymerase of SARS-CoV-2 and its homologs
Published 2025-06-01“…Aim: COVID 19 continues to be a major health concern. RNA dependent RNA polymerase of SARS-CoV-2 which is crucial for replication is therefore a potential drug target. …”
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Predictors of Dependency in Instrumental Activities of Daily Living Among Community Dwelling Elderly in A Rural Field Practice Area of a Tertiary Care Hospital in Chengalpattu Dist...
Published 2025-01-01“… Background: Longer lifespans of elderly are associated with chronic illnesses that impair functioning, making it harder to carry out daily activities and making assistance necessary. …”
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Features of clinical manifestations of rheumatoid arthritis in patients after failure of conventional synthetic disease-modifying antirheumatic drugs therapy depending on the signs...
Published 2023-04-01“…The PainDETECT, FSS, FIRST, HAQ questionnaires were used for screening neuropathic pain symptoms (NPS), fatigue, fibromyalgia signs and functional impairment, respectively. The HADS questionnaire was recommended for early diagnosis anxiety and depression disorders.Results. …”
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Cytochrome P450 Epoxygenase-Dependent Activation of TRPV4 Channel Participates in Enhanced Serotonin-Induced Pulmonary Vasoconstriction in Chronic Hypoxic Pulmonary Hypertension
Published 2020-01-01“…Transient receptor potential vanilloid 4 (TRPV4) is a multi-functional non-selective channel expressed in pulmonary vasculatures. …”
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