Cell cycle-dependent expression of Dub3, Nanog and the p160 family of nuclear receptor coactivators (NCoAs) in mouse embryonic stem cells. by Siem van der Laan, Eleonora Golfetto, Jean-Marc Vanacker, Domenico Maiorano

“…Curiously, while Esrrb showed only limited cell-cycle oscillations, transcript levels of the p160 family of nuclear receptor coactivators (NCoAs) displayed strong cell cycle-dependent fluctuations. Since NCoAs function in concert with Esrrb in transcriptional activation, we focussed on NCoA1 whose levels specifically increase prior onset of Dub3 transcription. …”
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Elevating CLIC4 in Multiple Cell Types Reveals a TGF- Dependent Induction of a Dominant Negative Smad7 Splice Variant. by Anjali Shukla, Yihan Yang, Sara Madanikia, Yan Ho, Mangmang Li, Vanesa Sanchez, Christophe Cataisson, Jing Huang, Stuart H Yuspa

“…We now report that elevated CLIC4 alters Smad7 function, a feedback inhibitor of the TGF-β pathway. …”
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Macrophage contact dependent and independent TLR4 mechanisms induce β-cell dysfunction and apoptosis in a mouse model of type 2 diabetes. by Helena Cucak, Christopher Mayer, Morten Tonnesen, Lise Høj Thomsen, Lars Groth Grunnet, Alexander Rosendahl

“…Therefore, we evaluated the expression and the function of the toll-like receptor 4 (TLR4) on pancreatic β-cells in primary mouse islets and on the murine β-cell line MIN6 in the presence or absence of macrophages. …”
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Prognostic value of NT-proANP levels on major cardiovascular outcomes in a 31-year follow-up study depends on baseline morbidity by Samuli Sakko, Juha Perkiömäki, Antti Ylitalo, Heikki Huikuri, Olavi Ukkola, Peppi Koivunen, Joona Tapio

“…In subjects with CVDs, the high NT-proANP tertile had decreased kidney function, higher prevalence of CVDs and adverse echocardiographic measures but also the lowest fasting insulin levels, and in longitudinal analysis had an increased risk for HF events and CVD mortality. …”
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Musashi-dependent mRNA translational activation is mediated through association with the Scd6/Like-sm family member, LSM14B by Katherine Bronson, Jewel Banik, Juchan Lim, Milla M. Reddick, Linda Hardy, Gwen V. Childs, Melanie C. MacNicol, Angus M. MacNicol

“…Abstract The Musashi family of sequence-specific RNA binding proteins (Musashi1 and Musashi2) serve a critical role in mediating both physiological and pathological stem cell function in many tissue types by repressing the translation of target mRNAs that encode proteins that promote cell cycle inhibition and cell differentiation. …”
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Proteolysis of mature HIV-1 p6 Gag protein by the insulin-degrading enzyme (IDE) regulates virus replication in an Env-dependent manner. by Friedrich Hahn, Adrian Schmalen, Christian Setz, Melanie Friedrich, Stefan Schlößer, Julia Kölle, Robert Spranger, Pia Rauch, Kirsten Fraedrich, Tatjana Reif, Julia Karius-Fischer, Ashok Balasubramanyam, Petra Henklein, Torgils Fossen, Ulrich Schubert

“…In this context, p6 promotes virus release by its two late (L-) domains, and facilitates the incorporation of the viral accessory protein Vpr. However, the function of p6 in its mature form, after proteolytic release from Gag, has not been investigated yet. …”
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The Potentials of Integration in the Historical Khan of Al-Exandria-Babylon by Shaker Fatima Sadiq, Musa Rashaa Malik

“…The theoretical framework Showed that urban integration depends on valuable indicators such as the availability of architectural symbols and connotations, availability of aesthetic characteristics, availability of current function, integrity of origin, originality of materials, etc. …”
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Exploratory study of associations between monetary reward anticipation brain responses and mu-opioid signalling in alcohol dependence, gambling disorder and healthy controls by Samuel Turton, Louise M. Paterson, James FM. Myers, Inge Mick, Chen-Chia Lan, John McGonigle, Henrietta Bowden-Jones, Luke Clark, David J. Nutt, Anne R. Lingford-Hughes

“…Alcohol dependence (AD) and gambling disorder (GD) are common addiction disorders with significant physical and mental health consequences. …”
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Efectos de un entrenamiento neuromuscular sobre el equilibrio postural dinámico y propiocepción en basquetbolistas juveniles con inestabilidad funcional de tobillo (Effects of neu... by Karina Vásquez-Orellana, Matías López-Vásquez, Guillermo Méndez-Rebolledo, Eduardo Guzman Muñoz

“…   Introducción: La prevención de lesiones depende de varios factores en el deportista, en donde un buen equilibrio postural y propiocepción son claves para lograrlo. …”
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Puerarin prevents cadmium-induced endoplasmic reticulum stress via SIRT1-dependent PERK-CHOP pathway in HepG2 cells by Huang Di, Qiu Mengqi, Luo Kuanhong, Zhu Yanzhe, Zhang Siyu, He Zhen, Hu Xiaobo, Cao Zhaohui

“…Moreover, PUE pretreatment alleviates ER stress by inhibiting the PERK-eIF2α-ATF4-CHOP axis and subsequently partially restores ER function as revealed by decreased Ca²⁺ release from the ER. …”
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Efficacy and Safety of Visible and Near-Infrared Photobiomodulation Therapy on Astenospermic Human Sperm: Wavelength-Dependent Regulation of Nitric Oxide Levels and Mitochondrial E... by Matilde Balbi, Rachele Lai, Sara Stigliani, Claudia Massarotti, Matteo Bozzo, Paola Scaruffi, Silvia Ravera, Andrea Amaroli

“…At longer wavelengths (940 nm and 1064 nm), interactions with water and lipids may introduce additional variables that affect membrane fluidity and mitochondrial function differently from shorter wavelengths.…”
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Combination Therapy with Pyridoxine and Arginine Supplementations along with a Lysine-Restricted Diet in Individuals with Pyridoxine-Dependent Epilepsy: A Comprehensive Systematic... by Ali Jafari, Mohammad Mehdi Abbasi, Hamid Abbasi, Sama Rahnemayan, Farnush Bakhshimoghaddam, Saeid Doaei

“…Background: Pyridoxine-dependent epilepsy (PDE) is identified as a rare neurometabolic disease marked by biallelic pathogenic mutations of the ALDH7A1 gene. …”
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Dendritic Cells Loaded with Heat Shock-Conditioned Ovarian Epithelial Carcinoma Cell Lysates Elicit T Cell-Dependent Antitumor Immune Responses In Vitro by Iván Flores, Daniel Hevia, Andrés Tittarelli, Dafne Soto, Daniel Rojas-Sepúlveda, Cristián Pereda, Fabián Tempio, Camila Fuentes, Cristian Falcón-Beas, Jimena Gatica, Felipe Falcón-Beas, Mario Galindo, Flavio Salazar-Onfray, Fermín E. González, Mercedes N. López

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The effectiveness of cardiac resynchronization therapy in patients with chronic heart failure of various origin depending on the structural myocardial injury in cardiac magnetic re... by O. V. Stukalova, N. A. Mironova, M. D. Utsumueva, S. Yu. Kashtanova, E. A. Butorova, V. N. Shitov, G. S. Tarasovsky, S. P. Golitsyn, S. K. Ternovoy

“…CRT response in ischemic HF did not depend on size of myocardial structural injury, but depend on scar localization. …”
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A Copula-based Method for River Ecological Flow Quantification and Algal Bloom Risk Assessment in the Hanjiang River by NONG Xi-zhi, LAI Cheng, JING Zheng, YE Ye

“…[Conclusions] (1) The joint risk model based on Copula functions can quantitatively capture the complex dependency between hydrological and ecological factors, overcoming limitations of traditional methods that depend on long-term data and neglect multi-factor interactions. …”
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Beta-hydroxybutyrate (BHB) elicits concentration-dependent anti-inflammatory effects on microglial cells which are reversible by blocking its monocarboxylate (MCT) importer by Chase Garcia, Ariana Banerjee, Claire Montgomery, Lauren Adcock, Izumi Maezawa, Jon Ramsey, Ana Cristina G. Grodzki, Kyoungmi Kim, Gino Cortopassi

“…BHB crossed the blood–brain barrier and rescued memory, improved cognitive function, and increased neuronal plasticity in two different mouse models of Alzheimer’s disease (PS1/APP and 5XFAD). …”
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Features of cardiac remodeling and GDF 15 and NTproBNP levels in patients with heart failure and preserved ejection fraction depending on the history of myocardial infarction by Ya. V. Zemlianyi, N. A. Zemliana

“…The serum concentration of GDF 15 was significantly correlated with the deterioration of the left ventricular diastolic function, such as an increase in the E/e’ ratio and the left atrial volume index. …”
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A novel polypeptide encoded by circSPIRE1 promotes prostate cancer proliferation and migration by restraining the ubiquitin-dependent degradation of LRP5 by Jintao Hu, Juanyi Shi, Junjie Wang, Yunfei Xiao, Degeng Kong, Mingchao Gao, Tianlong Luo, Shizhong Xu, Zhihan Yuan, Xinyi Ma, Xueseng Dong, Jingang Huang, Cheng Liu, Kewei Xu

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Calcitriol and Tacalcitol Modulate Th17 Differentiation Through Osteopontin Receptors: Age-Dependent Insights from a Mouse Breast Cancer Model by Strzykalska-Augustyniak A, Psurski M, Zachary H, Filip-Psurska B, Kłopotowska D, Milczarek M, Świtalska M, Stachowicz-Suhs M, Łabędź N, Ziemblicka A, Gos M, Wietrzyk J

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Aging-dependent YAP1 reduction contributes to AD pathology by upregulating the Nr4a1-AKT/GSK-3β axis by Ling Lei, Yilei Cheng, Anqi Yin, Jian-Min Han, Gang Wu, Fumin Yang, Qi Wang, Jian-Zhi Wang, Rong Liu, Hong-Lian Li, Xiaochuan Wang

“…Yes-associated protein 1 (YAP1), an aging-dependent protein, is a key element in the classical Hippo-YAP1 pathway mediated by a kinase cascade. …”
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