Thermal Analysis of Whole Bacterial Cells Exposed to Potassium Permanganate Using Differential Scanning Calorimetry: a Biphasic Dose-Dependent Response to Stress by Marina K. Abuladze, Victor M. Sokhadze, Emma N. Namchevadze, E. Kiziria, Leila V. Tabatadze, Lia V. Lejava, Sh. Gogichaishvili, Nugzar B. Bakradze

“…Differential scanning calorimetry (DSC) was applied to estimate the impact of the toxic oxidant potassium permanganate (PM) on the intracellular structural and functional alterations at whole cell level using soil bacteria Arthrobacter oxydans as a model culture. …”
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Natural killer cell antibody‐dependent cellular cytotoxicity to Plasmodium falciparum is impacted by cellular phenotypes, erythrocyte polymorphisms, parasite diversity and intensit... by Stephen Tukwasibwe, Savannah Nicole Lewis, Yoweri Taremwa, Kattria van derPloeg, Kathleen D Press, Maureen Ty, Felistas Namirimu Nankya, Kenneth Musinguzi, Evelyn Nansubuga, Florian Bach, Martin Chamai, Martin Okitwi, Gerald Tumusiime, Annettee Nakimuli, Francesco Colucci, Moses R Kamya, Joaniter I Nankabirwa, Emmanuel Arinaitwe, Bryan Greenhouse, Grant Dorsey, Philip J Rosenthal, Isaac Ssewanyana, Prasanna Jagannathan

“…Methods We compared the functions and phenotypes of NK cells from malaria‐exposed and malaria‐naive donors, and then varied the erythrocyte genetic background, Plasmodium falciparum strain and opsonising plasma used in ADCC to observe their impacts on NK cell degranulation as measured by CD107a mobilisation. …”
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Titanium Ions Promote Exogenous Calcium-Dependent Calcium Influx in Activated Jurkat T Cells: A Possible Mechanism to Explain Its Immunostimulatory Properties by Jing Chen, Qiuying Li, Zhenhua Pang, Ming Gong, Li Tang

“…Calcium signaling has been confirmed to be involved in regulation of lymphocyte immune function. Therefore, we hypothesize that Ti(IV) ions modulated T cell function through the change of intracellular calcium concentrations. …”
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Dose-dependent therapeutic effects of gum acacia on kidney and metabolic dysfunction in adenine-induced chronic kidney disease in rats: involvement of antioxidant pathways by Hadeer Badry, Nadia M. El-Beih, Aya M. Hussein, Hanaa F. Abd El-Kareem, Wael M. El-Sayed

“…Results AD treatment led to significant reductions in body weight, increased relative kidney weight, and disrupted kidney and liver function markers, including elevated urea, creatinine, ALT, GGT, and glucose levels. …”
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A randomized, open-label study on the effect of nipocalimab on vaccine responses in healthy participants by Marta Cossu, Carolina Bobadilla Mendez, Amanda Jackson, Eugene Myshkin, Grace Liu, Edwin Lam, Ulf H. Beier, Kathleen Weisel, Brittney Scott, Jocelyn H. Leu, Sheng Gao, Dessislava Dimitrova

“…Nipocalimab, a human immunoglobulin G (IgG) 1 monoclonal antibody, selectively binds the IgG-binding site on the neonatal Fc receptor (FcRn) and blocks IgG recycling, reducing IgG levels without impacting antigen presentation or T-/B-cell functions. In this phase 1, open-label study, we assessed the effect of nipocalimab on IgG response in healthy adults receiving T-cell–dependent/–independent vaccines (ie, tetanus toxoid [TT], diphtheria, and acellular pertussis vaccine [Tdap] and 23-polysaccharide pneumococcal vaccine [PPSV®23], respectively). …”
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Drosophila CENP-A mutations cause a BubR1-dependent early mitotic delay without normal localization of kinetochore components. by Michael D Blower, Tanya Daigle, Thom Kaufman, Gary H Karpen

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Rapid Exercise-Induced Mobilization of Dendritic Cells Is Potentially Mediated by a Flt3L- and MMP-9-Dependent Process in Multiple Sclerosis by Nathalie Deckx, Inez Wens, Amber H. Nuyts, Wai-Ping Lee, Niel Hens, Gudrun Koppen, Herman Goossens, Pierre Van Damme, Zwi N. Berneman, Bert O. Eijnde, Nathalie Cools

“…In healthy individuals, one exercise bout induces a substantial increase in the number of circulating leukocytes, while their function is transiently suppressed. The effect of one exercise bout in multiple sclerosis (MS) is less studied. …”
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Temperature Dependent I-V Characteristics of Ag/P-Sn0.2Se0.8 Thin Film Schottky Barrier Diode by K.K. Patel, M. Patel, K.D. Patel, G.K. Solanki, V.M. Pathak, R. Srivastava

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Prevalence and Correlates of Dilated and Non-Dilated Left Ventricular Cardiomyopathy in Transfusion-Dependent Thalassemia: Data from a National, Multicenter, Observational Registry by Antonella Meloni, Laura Pistoia, Anna Spasiano, Francesco Sorrentino, Giuseppe Messina, Michele Santodirocco, Zelia Borsellino, Valerio Cecinati, Vincenzo Positano, Gennaro Restaino, Nicolò Schicchi, Emanuele Grassedonio, Antonino Vallone, Michele Emdin, Alberto Clemente, Andrea Barison

“…We investigated the prevalence, clinical characteristics, and prognostic role of dilated cardiomyopathy (DCM) and non-dilated left ventricular cardiomyopathy (NDLVC) in patients with transfusion-dependent β-thalassemia (β-TDT). We retrospectively included 415 β-TDT patients who underwent cardiovascular magnetic resonance to quantify myocardial iron overload (MIO) and biventricular function parameters and to detect replacement myocardial fibrosis. …”
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PPTC7 acts as an essential co-factor of the SCFFBXL4 ubiquitin ligase complex to restrict BNIP3/3L-dependent mitophagy by Xiayun Xu, Yingji Chen, Siqi Fei, Xinyue Jiang, Xiaoting Zhou, Yimeng Xue, Yao Li, Shi-Min Zhao, Yan Huang, Chenji Wang

“…The SCFFBXL4 E3 ubiquitin ligase complex suppresses basal mitophagy by targeting BNIP3 and BNIP3L, two key mitophagy cargo receptors, for ubiquitin-proteasomal degradation. FBXL4 loss-of-function mutations lead to excessive BNIP3/3L-dependent mitophagy, thereby causing a devastating multi-system disorder called mitochondrial DNA depletion syndrome, type 13 (MTDPS13). …”
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Identification of Y-box binding protein 1 as a core regulator of MEK/ERK pathway-dependent gene signatures in colorectal cancer cells. by Karsten Jürchott, Ralf-Jürgen Kuban, Till Krech, Nils Blüthgen, Ulrike Stein, Wolfgang Walther, Christian Friese, Szymon M Kiełbasa, Ute Ungethüm, Per Lund, Thomas Knösel, Wolfgang Kemmner, Markus Morkel, Johannes Fritzmann, Peter M Schlag, Walter Birchmeier, Tammo Krueger, Silke Sperling, Christine Sers, Hans-Dieter Royer, Hanspeter Herzel, Reinhold Schäfer

“…This suggests that MEK/ERK-dependent, YBX1-regulated target genes are involved in executing malignant properties.…”
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Transforming growth factor-β1 gene promoter -509C/T polymorphism in association with expression affects colorectal cancer development and depends on gender. by Spaska Stanilova, Noyko Stanilov, Alexander Julianov, Irena Manolova, Lyuba Miteva

“…In this context, the aim of the study was to explore the role of circulating TGF-β1 and the -509C/T functional promoter polymorphism (rs1800469) within the TGF-β1 gene (TGFB1) in the susceptibility, progression, and prognosis of CRC among Bulgarian male and female patients. …”
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Charcteristics of the Autonomic Nervous System in Patients with Liver Cirrhosis and its Dependence on the Severity of Portal Hypertension due to the Values of the Heart Rate Variab... by Abrahamovych M., Ferko M.

“…Wein, exploring the autonomic nervous system, primarily it is important to assess its functional status according to the results of functional and dynamic studies: tone, autonomic reactivity and vegetative support of the body, the first two of which characterize the homeostatic capabilities of the organism, and the last – adaptive. …”
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Age-Dependent Composition and Diversity of the Gut Microbiome in Endangered Gibbon (<i>Nomascus hainanus</i>) Based on 16S rDNA Sequencing Analysis by Jieli Fan, Yanan Yin, Yanhui Liu, Yuan Chen, Wenxing Long, Chenghong Liao

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Celecoxib disrupts temporal coordination of TGF-β/α-SMA signaling in skeletal muscle repair: a time-dependent study of fibrosis and inflammation by Jia Li, Huan Chen, Qianying Xiong, Jinzhong Ni, Fangyun Sun, Xin Gong, Huachun Miao

“…These findings advocate for time-restricted administration of celecoxib in muscle injury therapy, emphasizing the need to balance acute symptom management with long-term functional recovery.…”
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SIRT2-dependent DKK1 deacetylation aggravates polycystic ovary syndrome by targeting the TGF-β1/Smad3 signaling pathway by Lan Chen, Caixia Kong

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The RING-CH ligase K5 antagonizes restriction of KSHV and HIV-1 particle release by mediating ubiquitin-dependent endosomal degradation of tetherin. by Claire Pardieu, Raphaël Vigan, Sam J Wilson, Alessandra Calvi, Trinity Zang, Paul Bieniasz, Paul Kellam, Greg J Towers, Stuart J D Neil

“…Importantly, we also show that the ability of K5 to substitute for Vpu in HIV-1 release is entirely dependent on K18 and the RING-CH domain of K5. By contrast, while Vpu induces ubiquitination of tetherin cytoplasmic tail lysine residues, mutation of these positions has no effect on its antagonism of tetherin function, and residual tetherin is associated with the trans-Golgi network (TGN) in Vpu-expressing cells. …”
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Investigation of Dependence of Brightness-Structural Features of Images Generated by the Vision System on Navigation Parameters of Unmanned Aerial Vehicles and their Use for Select... by Sotnikov O., Vlasov I., Pavlov Ya., Morin O., Kizian R., Lukyanova V.

“…This goal is achieved by studying the dependence of brightness-structural features of images on the sighting geometry. …”
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Exploring the Temperature‐Dependent Structural Evolution of Mechanically Synthesized Na3PS4 Solid Electrolyte through In Situ X‐Ray Diffraction by Sergio Federico Mayer, Marta Mirolo, Alisson Andrea Iles Velez, Ove Korjus, Emmanuelle Suard, Laureline Lecarme, Jean‐Baptiste Ducros, Claire Villevieille

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Humic acids modify root architecture in Arabidopsis through H+-ATPase-dependent target of rapamycin activation in concert with Ca2+ and ROS signaling by Mirella Pupo Santos, Milan Zupunski, Hiarhi Monda, Jason Gralian, Aletia James, Guido Grossmann, Richard T. Lamar, Daniel Basílio Zandonadi

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