Carcinoma initiation via RB tumor suppressor inactivation: a versatile approach to epithelial subtype-dependent cancer initiation in diverse tissues. by Yurong Song, Debra Gilbert, T Norene O'Sullivan, Chunyu Yang, Wenqi Pan, Alisan Fathalizadeh, Lucy Lu, Diana C Haines, Philip L Martin, Terry Van Dyke

“…The system allows independent assessment of epithelial subtypes that express either cytokeratins (K) 18 or 19. By Cre-dependent expression of a protein that dominantly inactivates RB and functionally redundant proteins p107 and p130, neoplasia could be initiated in either K18 or K19 expressing cells of numerous tissues. …”
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Nonlinear asymmetric thermomechanical buckling of shallow nanoscale arches having dissimilar end conditions embracing nonlocality and strain gradient size dependencies by Saeid Sahmani, Kamila Kotrasova, Mona Zareichian, Jian Sun, Babak Safaei

“…The arches, made from a functionally graded graphene nanofiller reinforced composite (FG-GNRC), are subjected to discretional radial concentrated loads along with converting of temperature. …”
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Local Strain Rate and Curvature Dependences of Scalar Dissipation Rate Transport in Turbulent Premixed Flames: A Direct Numerical Simulation Analysis by Y. Gao, N. Chakraborty, N. Swaminathan

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A phosphatidylinositol-3-kinase-dependent signal transition regulates ARF1 and ARF6 during Fcgamma receptor-mediated phagocytosis. by Peter Beemiller, Adam D Hoppe, Joel A Swanson

“…This indicates that a PI-3K-dependent signal transition defines the sequence of ARF GTPase activation during phagocytosis and that ARF6 and ARF1 coordinate different functions at the forming phagosome.…”
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Context‐Dependent Effects of Ivermectin Residues on Dung Insects: Interactions With Environmental Stressors, Size, and Sex in a Sepsid Fly (Sepsis neocynipsea) by Jill Walker, Benjamin J. Mathews, Patrick T. Rohner

“…Taken together, our findings highlight how the complex interactions between veterinary pharmaceuticals and abiotic stressors could drive changes in coprophagous insect populations and their ecological functions.…”
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Recombinant mouse PAP has pH-dependent ectonucleotidase activity and acts through A(1)-adenosine receptors to mediate antinociception. by Nathaniel A Sowa, Kunjumon I Vadakkan, Mark J Zylka

“…Prostatic acid phosphatase (PAP) is expressed in nociceptive neurons and functions as an ectonucleotidase. When injected intraspinally, the secretory isoforms of human and bovine PAP protein have potent and long-lasting antinociceptive effects that are dependent on A(1)-adenosine receptor (A(1)R) activation. …”
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Classical Layer-Resolving Scheme for a System of Two Singularly Perturbed Time-Dependent Problems with Discontinuous Source Terms and Spatial Delay by Joseph Paramasivam Mathiyazhagan, Ramiya Bharathi Karuppusamy, George E. Chatzarakis, S. L. Panetsos

“…In order to capture the abrupt change that occurs due to the behavior of these layers, the solution is further decomposed into smooth and singular components. Layer functions are also formulated in accordance with layer behavior. …”
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CD4+ T Cells Promote IgG Production in MHC-Independent and ICAM-1-Dependent Manners in Pristane-Induced Lupus Mice by Shuai Liu, Yu-mei Li, Jin-zhi Li, Shu-jun Wang, Ping Ji, Mei-yu Zhang, Ying Wang

“…While MHC was dispensable for IgG production, ICAM-1 likely functioned as an attenuating factor for IgG production. …”
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Valproic Acid Enhances the Anticancer Effect of L-Ascorbic Acid by Upregulating Sodium-Dependent Vitamin C Transporter 2 in Colorectal Cancer by Kawalin Kantawong, Hakim Meutia Diva, Phuong T. Ho, Ahlim Lee, Misae Kiba, Mi-Gi Lee, Hee Kang, Taek-Kyun Lee, Sukchan Lee

“…Vitamin C, also known as L-ascorbic acid (AA), functions as a pro-oxidant in cancer at high doses and exerts anticancer effects by generating reactive oxygen species (ROS) and selectively inducing damage to cancer cells. …”
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The Antarctic moss 2-oxoglutarate/Fe(II)-dependent dioxygenases (Pn2-ODD2) enhanced the tolerance to drought and oxidative stress by Huijuan Wang, Han Li, Chaochao Li, Shenghao Liu, Pengying Zhang

“…In bryophytes, the earliest land plant group, little is known about the biological functions of these enzymes. Results Here, we cloned a Pn2-ODD2 gene of flavonoid biosynthesis pathway from Antarctic moss Pohlia nutans, which was induced by exogenous NaCl, PEG and abscisic acid (ABA) treatment. …”
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Localization and Single Molecule Dynamics of <i>Bacillus subtilis</i> Penicillin-Binding Proteins Depend on Substrate Availability and Are Affected by Stress Conditions by Lisa Stuckenschneider, Peter L. Graumann

“…The data suggest that PBPs could take over functions in cell wall synthesis during different stress conditions, increasing the resilience of cell wall homeostasis in different environmental conditions. …”
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Integrating environmental and LULC drivers of groundwater droughts in groundwater-dependent ecosystems: a machine learning (XGBoost)-SEM analysis with ecosystem implications by Kawawa Banda, Christopher Shilengwe, Imasiku Nyambe

“…This understanding is not only critical for sustaining groundwater availability but also for preserving the integrity and functioning of groundwater-dependent ecosystems.…”
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The Role of Light-Harvesting Complex II Organization in the Efficiency of Light-Dependent Reactions in the Photosynthetic Apparatus of <i>Pisum sativum</i> L. by Georgi D. Rashkov, Martin A. Stefanov, Amarendra N. Misra, Emilia L. Apostolova

“…In this study, the functions of the photosynthetic machinery were evaluated using chlorophyll <i>a</i> fluorescence technique (PAM and JIP test) in pea plants (<i>Pisum sativum</i> L. cv Borec) and its LHC II oligomerization variants (mutants <i>Costata 2</i>/<i>133</i> and <i>Coeruleovireus 2</i>/<i>16</i>). …”
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STUDY OF CEREBROTROPIC DOSE-DEPENDENT EFFECT OF PYRIMIDINE DERIVATIVE UNDER PIR-9 CODE AGAINST THE BACKGROUND OF EXPERIMENTAL CEREBRAL ISCHEMIA IN RATS by A. V. Voronkov, N. B. Shabanova, M. P. Voronkova, T. A. Lysenko

“…One day later the survival, neurological deficiency, behavioral activity, changes in cognitive-mnestic functions, as well as some indicators of brain energy exchange were evaluated.Results. …”
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PLOD1 promotes the malignancy of hepatocellular carcinoma by facilitating the NF-κB/IL-6/STAT3-dependent TCA cycle by Chengfei Zhang, Yangchun Zhou, Minghua Hu, Yue Pan, Xin Chen, Qi Sun, Zhijie Ma, Cheng Wang, Yong Zha, Feng Zhu, Hongping Xia

“…Herein, we aimed to investigate the underlying biological functions and mechanisms of PLOD1 in HCC. Methods: The expression levels of PLOD1 in HCC were measured by qPCR, Western blot, and immunohistochemistry. …”
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The sensor histidine kinase PhcS participates in the regulation of quorum sensing-dependent virulence genes in Ralstonia pseudosolanacearum strain OE1-1 by Wakana Senuma, Masayuki Tsuzuki, Chika Takemura, Yuki Terazawa, Akinori Kiba, Kouhei Ohnishi, Kenji Kai, Yasufumi Hikichi

“…The activated PhcA controls the expression of QS-dependent genes responsible for QS-regulated phenotypes including virulence. …”
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Sensory profiles in older adults with orthopedic conditions during quiet stance: a cross-sectional study by Marine Brika, France Mourey, Alexandre Kubicki

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SYSTEMIC ENZYME THERAPY IN COMPLEX TREATMENT OF PATIENTS WITH SEVERE BRONCHIAL ASTHMA by E. V. Churyukina, L. P. Sizyakina

“…The paper presents the results of the study of the effectiveness and safety of the use of systemic enzyme therapy with Wobenzym in the complex treatment of patients with hormone-dependent severe bronchial asthma. It was found that the inclusion in the complex basic therapy of severe hormone-dependent bronchial asthma systemic enzyme Wobenzyme accompanied by improving the parameters of the functional state of the bronchi, reducing circulating immune complexes, a steady increase in cortisol levels. …”
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Inverse source problems for multi-parameter space-time fractional differential equations with bi-fractional Laplacian operators by M. J. Huntul

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The Prosecutor's Offices of the Russian Federation and the People’s Republic of China (a Comparative Legal Analysis) by N. R. Koreshnikova

“…The conditionality of the prosecutor's office to a particular branch of government, as well as the main functions of the Prosecutor’s Office of the People's Republic of China, the status of the prosecutor and the requirements for it are investigated. …”
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