First-line chemotherapy for head and neck squamous cell carcinoma. Optimal strategy by L. V. Bolotina, A. L. Kornietskaya, A. D. Kaprin, Е. Yu. Karpenko

“…Cetuximab-containing chemotherapy regimens are the most effective treatment option in head and neck squamous cell carcinoma They can be used in patients with different functional status depending on the clinical situation.…”
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Neutrophils negatively control IL-17A-producing γδ T cell frequencies in a contact-dependent manner under physiological conditions by Xinhua Yu, Xiaoyang Yue, Xiaoyang Yue, Junie D. Tchudjin Magatsin, Sebastian Marwitz, Sebastian Marwitz, Jochen Behrends, Torsten Goldmann, Torsten Goldmann, Joseph T. Opferman, Brigitte Kasper, Frank Petersen

“…Additionally, in vitro experiments demonstrated that neutrophils could inhibit the function of IL-17A producing γδ T cells by inducing cell death in a contact-dependent manner.ConclusionThis present study demonstrates that neutrophils negatively regulate IL-17 producing γδ T cells under physiological conditions. …”
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Calpain 2 promotes Lenvatinib resistance and cancer stem cell traits via both proteolysis-dependent and independent approach in hepatocellular carcinoma by Xiaolu Ma, Kaixia Zhou, Tianqing Yan, Ling Hu, Suhong Xie, Hui Zheng, Ying Tong, Heng Zhang, Yanchun Wang, Zhiyun Gong, Cuncun Chen, Yanan Tian, Lin Guo, Renquan Lu

“…Mechanistically, we strikingly discovered that CAPN2 exerted its function by both enzyme-dependent and enzyme-independent manner simultaneously: activating β-Catenin signaling through its enzyme activity, and preventing GLI1/GLI2 degradation through direct binding to YWHAE in an enzyme-independent manner, which disrupting the association between YWHAE and GLI1/GLI2 to inhibit YWHAE-induced degradation of GLIs. …”
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N6-methyladenosine RNA base modification regulates NKG2D-dependent and cytotoxic genes expression in natural killer cells by Raghda A. Elsabbagh, Ghada Abdelhady, Doris Urlaub, Mina Sandusky, Ola Khorshid, Mohamed Z. Gad, Khaled Abou-Aisha, Carsten Watzl, Mona Rady

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Lipoprotein N-terminal modification in Bacillus: a new paradigm for extracellular acetylation and species-dependent Toll-like receptor 2 immunomodulation by Gloria Komazin, Rachel M. Wigmore, Aditi M. Ranade, Amena A. Rizk, John H. Gardiner, Timothy C. Meredith

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Daurisoline Modulates the TBK1-Dependent Type I Interferon Pathway to Boost Anti-tumor Immunity via Targeting of LRP1 by Borui Tang, Yuting Wang, Liping Li, Cuicui Sun, Jingwen Dong, Ruoqi Li, Jianfeng Wang, Yu Long, Mingxiao Yin, Fei Xie, Dian Xiao, Xinbo Zhou, Na Zhang, Xiuli Zhao, Yanchun Feng, Hongbin Deng

“…Mechanistically, the binding of DS to LRP1 substantially disrupted lysosomal function, which subsequently triggered 5′-azacytidine-induced protein 2-mediated TBK1 activation and IFN-I production. …”
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TSLP pretreatment inhibits M1 macrophage polarization and attenuates LPS-induced iNKT cell-dependent acute lung injury by Ting Zhou, Ziyao Zhang, Yawen Zhan, Meiying Wang, Meiying Wang, Meiying Wang, Mi Wu, Xiufang Weng, Xiufang Weng, Xiufang Weng, Xiufang Weng, Younian Xu, Younian Xu, Younian Xu

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Prenatal exposure to PM2.5 disturbs the glucose metabolism of offspring fed with high-fat diet in a gender-dependent manner by Bin Pan, Yuanting Xie, Wenpu Shao, Xinyi Fang, Dongyang Han, Jingyu Li, Xiaoqing Hong, Wenyue Tu, Jiayi Shi, Mingjun Yang, Fang Tian, Minjie Xia, Jingying Hu, Jianke Ren, Haidong Kan, Yanyi Xu, Weihua Li

“…Specifically, hepatic insulin resistance as indicated by significantly decreased AKT phosphorylation (p-AKT) level, changed liver structure as indicated by increased ballooning and steatosis based on H&E staining images, and impaired liver function as indicated by up-regulated ALT activity were observed in HFD-fed female offspring from CAP-exposed mothers in comparison to those from FA-exposed ones. …”
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MOTS-c attenuates lung ischemia-reperfusion injury via MYH9-Dependent nuclear translocation and transcriptional activation of antioxidant genes by Xiangyu Li, Faliang Zhan, Guangfeng Qiu, Peng Lu, Zihao Shen, Yuanpu Qi, Minchao Wu, Mingyu Chu, Jia Feng, Ziang Wen, Xin Yao, Ao Wang, Wanjun Jin, Xiao Zhang, Junjie Liao, Jialin Zhang, Meijuan Song, Wei Wang, Xiaowei Wang

“…Our findings establish MOTS-c as a dual-function molecule—acting via ROS-CK2A-MYH9 signaling to activate nuclear antioxidant defenses and serving as a prognostic biomarker for CPB-related complications. …”
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ENERGIZE: A GLOBAL PHASE 3 STUDY OF MITAPIVAT DEMONSTRATING EFFICACY AND SAFETY IN ADULTS WITH ALPHA- OR BETA-NON–TRANSFUSION-DEPENDENT THALASSEMIA by AT Taher, H Al-Samkari, Y Aydinok, M Besser, G Luna, S Gheuens, A Glenthj, AS Goh, A Kattamis, SR Loggetto, KM Musallam, P Ricchi, E Salido-Fiérrez, S Sheth, V Viprakasit, MD Cappellini, KH Kuo

“…Key secondary endpoints were changes from BL in average Hb concentration and Functional Assessment of Chronic Illness Therapy–Fatigue Scale (FACIT-Fatigue) score over Wks 12–24. …”
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Small nucleolar RNA SNORD13H suppresses tumor progression via FBL-dependent 2′-O-methylation in hepatocellular carcinoma by Minglu Zhang, Minglu Zhang, Minglu Zhang, Minglu Zhang, Jianbo He, Jianbo He, Jianbo He, Jianbo He, Rao Fu, Rao Fu, Rao Fu, Rao Fu, Guojian Bao, Guojian Bao, Guojian Bao, Yijun Lu, Yijun Lu, Yijun Lu, Zechuan Zhang, Zechuan Zhang, Zechuan Zhang, Jiawu Yan, Jiawu Yan, Jiawu Yan, Jialu Ding, Jialu Ding, Jialu Ding, Fei Yang, Fei Yang, Fei Yang, Fei Yang, Beicheng Sun, Beicheng Sun, Beicheng Sun, Beicheng Sun

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Calculation of state equation isobars of carbon dioxide and methane in pressure interval from 2 to 20 MPa by R.A. Magomedov, E.V. Akhmedov

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Design and Manufacturing of Polymer Composite Materials Using Quality Management Methods by Berladir K., Mitalova Z., Pavlenko I., Trojanowska J., Ivanov V., Rudenko P.

“…Based on the expert assessment results and quality function deployment analysis, the most critical factors affecting wear resistance were obtained: polymer brand, filler shape and size, technological parameters of mixing, pressing, sintering, and mechanical processing. …”
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Phytotherapeutic potential of herbal extracts on male reproductive organs in rat models by A.A. Ammari, A.R. Alhimaidi, R.A. Amran, A. Rady, H. aljawdah

“…Herbal extracts, recognized for their bioactive properties such as antioxidation and hormone modulation, were evaluated for their effects on testicular function, spermatogenesis, and reproductive hormone levels. …”
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Do Exogenous Shocks in Macroeconomic Variables Respond to Changes in Stock Prices? by H. Srivastava, P. Solomon, S. P. Singh

“…The study applies two econometric models such as «Variance Decomposition» (VDC) and «Impulse Response Function» (IRF) for examining the exogenous shocks in macroeconomic variables respond to changes in stock prices. …”
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ACCOUNTING FOR SYSTEM-WIDE REGULARITIES IN THE MODELING OF COMPLEX SYSTEMS BY MEANS OF THE SYSTEM-OBJECT APPROACH by Sergey Igorevich Matorin, Sergey Pavlovich Belov, Alexander Gennadievich Zhikharev

“…Results of the study and their discussion: the presented formalisms were used to take into account system-wide regularities in the construction of graphoanalytical models of organizational-business and industrial-technological processes in terms of "Node-Function-Object". The described approach makes it possible to distribute known system-wide regularities into three groups: related to the structural properties of systems related to their functional properties and to substantial properties, which justi-ies the hierarchical dependence between them. …”
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Integrating mRNA and miRNA Weighted Gene Co-Expression Networks with eQTLs in the Nucleus Accumbens of Subjects with Alcohol Dependence. by Mohammed Mamdani, Vernell Williamson, Gowon O McMichael, Tana Blevins, Fazil Aliev, Amy Adkins, Laura Hack, Tim Bigdeli, Andrew D van der Vaart, Bradley Todd Web, Silviu-Alin Bacanu, Gursharan Kalsi, COGA Consortium, Kenneth S Kendler, Michael F Miles, Danielle Dick, Brien P Riley, Catherine Dumur, Vladimir I Vladimirov

“…Glial-specific modules were predominantly enriched for genes involved in processes related to immune functions, i.e. cytokine signaling (all adj. p≤ 0.05). …”
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Spinal Tolerance and Dependence: Some Observations on the Role of Spinal N-Methyl-D-Aspartate Receptors and Phosphorylation in the Loss of Opioid Analgesic Responses by Tony L Yaksh, Xiao-Ying Hua

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Growth cone MKK7 mRNA targeting regulates MAP1b-dependent microtubule bundling to control neurite elongation. by Daniel Feltrin, Ludovico Fusco, Harald Witte, Francesca Moretti, Katrin Martin, Michel Letzelter, Erika Fluri, Peter Scheiffele, Olivier Pertz

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ARC/ARG3.1 binds the nuclear polyadenylate-binding protein RRM and regulates neuronal activity-dependent formation of nuclear speckles by Tambudzai Kanhema, Kamil Parobczak, Sudarshan Patil, Dagmara Holm-Kaczmarek, Erik I. Hallin, Jan Ludwiczak, Andrzej Antoni Szczepankiewicz, Francois Philippe Pauzin, Aamra Mahboob, Adrian Szum, Yuta Ishizuka, Stanisław Dunin-Horkawicz, Petri Kursula, Grzegorz Wilczynski, Adriana Magalska, Clive R. Bramham

“…ARC localizes to synapses and the nucleus, but its nuclear functions are little known. Following in vivo long-term potentiation (LTP) induction in the dentate gyrus, we show that ARC accumulates in the nucleosol fraction and interchromatin space of granule cells. …”
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