Association between cyclin-dependent kinase 4/6 inhibitors and nephrotoxicity in patients with breast cancer: A Systematic Review and meta-analysis by Jiayong Cui, Jinquan Sun, Xueying Zhou, Yi Li, Jiuda Zhao, Guoshuang Shen

“…Clinicians should remain vigilant in monitoring renal function indicators when prescribing CDK4/6 inhibitors.…”
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On-treatment blood pressure and dose-dependent effects of ARNI in heart failure with reduced ejection fraction: Insights from a multicenter registry. by Jiesuck Park, Chan Soon Park, Tae-Min Rhee, Hye Jung Choi, Hong-Mi Choi, Hyun-Jung Lee, Jun-Bean Park, Yeonyee E Yoon, Seung-Pyo Lee, Yong-Jin Kim, Goo-Yeong Cho, Hyung-Kwan Kim, In-Chang Hwang

“…This study evaluated dose-dependent effects of ARNI considering on-treatment blood pressure (BP).…”
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Radial-dependent Responsivity of Broad-line Regions in Active Galactic Nuclei: Observational Consequences for Reverberation Mapping and Black Hole Mass Measurements by Yan-Rong Li, Jian-Min Wang

“…However, key quantities in RM analysis such as emissivity, responsivity, transfer functions, and mean and rms spectra are fragmentally defined in the literature and largely lack a unified formulation. …”
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Organic cation transporter 3 on neuronal mitochondria mediates MPP+-induced mitochondrial dysfunction and neurotoxicity in a TIMM22-dependent manner by Ao Guan, Sida Han, Suzhen Liang, Weiwei Shen, Min Guo, Mei Cui

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From partial to complete: Wing- and tail-feather moult sequence and intensity depend on species, life-cycle stage, and moult completeness in passerines by Santi Guallar

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Temperature-dependent shifts in gut microbiota and metabolome of olive flounder (Paralichthys olivaceus): implications for cold-water aquaculture expansion and probiotic applicatio... by Che-Chun Chen, Yu-Ping Chen, Hsiao-Tsu Yang, Yu-Ling Chen, Chen-Wei Wu, Hong-Yi Gong, Yuan-Shing Ho, Ying-Ning Ho

“…Potential pathogens such as Vibrio and Photobacterium increased from 22 °C to 26 °C, while Pseudomonas declined, suggesting an elevated risk of pathogen infection at 26 °C. Functional predictions revealed that gut bacteria regulated host metabolism, particularly carbohydrate, amino acid, and lipid pathways. …”
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Dynamics of quality of life parameters and echocardiography depending on adherence to treatment in patients with chronic rheumatic heart disease at 5-year follow-up by V. S. Petrov

“…To assess the dynamics of quality of life indicators and echocardiography parameters depending on adherence to treatment in patients with chronic rheumatic heart disease at 5-year follow-up.Material and methods. …”
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Susceptibility to and severity of tuberculosis infection in mice depends upon MHC-II-determined level of activation-inhibition balance in CD4 T-cells by Nadezhda Logunova, Marina Kapina, Valeriia Kriukova, Olga Britanova, Olga Britanova, Olga Britanova, Konstantin Majorov, Irina Linge, Alexander Apt

“…Finally, in TB-susceptible mice, a higher proportion of CD4+ T-cells expressed both activation-associated and immune inhibition (checkpoint) markers, accompanied by functional CD4+ T-cell exhaustion at late stages of infection. …”
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Ub-POD: A Ubiquitin-Specific Proximity-Dependent Labeling Technique to Identify E3 Ubiquitin Ligase Substrates in Human Cells by Urbi Mukhopadhyay, Sophie Levantovsky, Christian Behrends, Sagar Bhogaraju

“…E3 ligases share a dual function of 1) transferring covalently attached ubiquitin from the catalytic cysteine of E2 (E2~Ub) to the substrate and 2) providing substrate specificity. …”
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Primary Tr1 cells from metastatic melanoma eliminate tumor-promoting macrophages through granzyme B- and perforin-dependent mechanisms by Hongxia Yan, Ping Zhang, Xue Kong, Xianglian Hou, Li Zhao, Tianhang Li, Xiaozhou Yuan, Hongjun Fu

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Anthropogenic mortality risk of lions depends on a combination of environmental, climatic, and cultural factors within a Sub-Saharan African ecosystem by Dipanjan Naha, J. Werner Kilian, Claire Goelst, Claudine Cloete, James C. Beasley

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Retention Characteristics Dependent on High-κ Gate-Insulator Stack in Hf-ZnO Synaptic Thin-Film Transistors by Gyoungyeop do, Danyoung Cha, Kunhee Tae, Nayeong Lee, Seokhyun Byun, Jeongseok Pi, Sungsik Lee

“…A memory function of Syn-TFTs can be implemented in a gate insulator, where electrons are trapped with applying positive programming pulses to a gate terminal. …”
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Subthreshold Effects of Low-Frequency Alternating Current on Nerve Conduction Delay by Michael Ryne Horn, Nathaniel Liam Lazorchak, Usama Kalim Khan, Ken Yoshida

“…<b>Conclusions:</b> These findings suggest that LFACb could serve as a neuromodulation tool for selectively blocking larger fibers while preserving smaller fiber function. This has potential applications in functional electrical stimulation (FES) and temporary, non-destructive nerve blocks for clinical and research applications.…”
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Study anti-viral drugs for their efficiency against multiple SARS CoV-2 drug targets within molecular docking, molecular quantum similarity, and chemical reactivity indices framewo... by Jesús Sánchez-Márquez, Savaş Kaya, Alejandro Morales-Bayuelo, Ricardo Vivas-Reyes

“…For the local reactivity descriptors, the Fukui Functions were used. Fukui functions, representing electrophilic and nucleophilic sites, were calculated for selected ligands (Valacyclovir and Penciclovir). …”
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Efficacy and safety of high-dose and personalized TBS on post-stroke cognitive impairment: A randomized controlled trial by Jianxun Ren, Wenlong Su, Ying Zhou, Kaiyue Han, Ruiqi Pan, Xinyu Duan, Jiajie Liu, Haitao Lu, Ping Zhang, Wei Zhang, Jian Sun, Mengying Ding, Yafei Zhu, Wuxiang Xie, Jianting Huang, Hao Zhang, Hesheng Liu

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Unveiling the physiological impact of ESCRT-dependent autophagosome closure by targeting the VPS37A ubiquitin E2 variant-like domain by Kouta Hamamoto, Xinwen Liang, Ayako Ito, Matthew Lanza, Van Bui, Jiawen Zhang, David M. Opozda, Tatsuya Hattori, Longgui Chen, David Haddock, Fumiaki Imamura, Hong-Gang Wang, Yoshinori Takahashi

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Organisation of consumer accounting as a promising direction of accounting and analytical support for strategic management by G. A. Adamova

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Probing DCV5T-Me for Organic Photovoltaics: A Comprehensive DFT and NEGF Study by Souraya Goumri-Said, Rachida Rahmani, Abdelkader Chouaih, Mohammed Benali Kanoun

“…Electronic structure calculations reveal a HOMO-LUMO energy gap of ∼1.89 eV, aligning with strong absorption in the visible and near-infrared regions, with a maximum absorption wavelength around 650 nm. Time-dependent density functional theory (TD-DFT) confirms significant intramolecular charge transfer excitations, characterized by high oscillator strengths and transition dipole moments. …”
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Angiotensin receptor neprilysin inhibition versus individualized RAAS blockade: design and rationale of the PARALLAX trial by Rolf Wachter, Sanjiv J. Shah, Martin R. Cowie, Peter Szecsödy, Victor Shi, Ghionul Ibram, Ziqiang Zhao, Jianjian Gong, Sven Klebs, Burkert Pieske

“…Abstract Aims Although the effect of the angiotensin receptor blocker neprilysin inhibitor (ARNI) sacubitril/valsartan on heart failure (HF) hospitalizations and cardiovascular death has been evaluated, its effects on functional capacity in patients with HF and ejection fraction (EF) >40% has yet to be determined. …”
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Gestational saccharin consumption disrupts gut-brain axis glucose homeostasis control in adolescent offspring rats in a sex-dependent manner by Beatriz Pacheco-Sánchez, Sonia Melgar-Locatelli, Raquel López-Merchán, María José Benítez-Marín, Marta Blasco-Alonso, Ernesto González-Mesa, Rubén Tovar, Pablo Rubio, Juan Suárez, Carlos Sanjuan, Fernando Rodríguez de Fonseca, Francisco Alén, Marialuisa de Ceglia, Patricia Rivera

“…Abstract Background Certain events that occur in early life, such as changes in nutrition, can promote structural and functional modifications in brain development, projecting to either short, medium, and/or long terms, resulting in metabolic programming. …”
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