Protocol for a multicentre, prospective observational cohort study in Japan: association among hospital-acquired disability, regular exercise and long-term care dependency in older... by Tetsuya Takahashi, Kentaro Iwata, Hidetaka Watanabe, Masayuki Tahara, Masakazu Saitoh, Tomoyuki Morisawa, Akihiro Sakuyama, Koji Sakurada, Yusuke Hanafusa, Yusuke Ochi, Go Takamura, Akira Minei

“…Therefore, prevention of functional decline and long-term care dependency after cardiac surgery are important; however, our current understanding of postoperative functional trajectory and effects of postoperative regular exercise on long-term functional decline and long-term care dependency is limited. …”
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Increased nuclear factor I-mediated chromatin access drives transition to androgen receptor splice variant dependence in prostate cancer by Larysa Poluben, Mannan Nouri, Jiaqian Liang, Shaoyong Chen, Andreas Varkaris, Betul Ersoy-Fazlioglu, Olga Voznesensky, Irene I. Lee, Xintao Qiu, Laura Cato, Ji-Heui Seo, Matthew L. Freedman, Adam G. Sowalsky, Nathan A. Lack, Eva Corey, Peter S. Nelson, Myles Brown, Henry W. Long, Joshua W. Russo, Steven P. Balk

“…AR and nuclear factor I (NFI) motifs are most enriched at more accessible sites, and NFIB/X knockdown greatly diminishes ARv7 function. These findings indicate that ARv7 can drive the AR program but that its activity is dependent on adaptations that increase chromatin accessibility to enhance its intrinsically weak chromatin binding.…”
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Avelumab induces greater Fc-Fc receptor-dependent natural killer cell activation and dendritic cell crosstalk compared to durvalumab by Nicole Osborne, Amit Rupani, Vladimir Makarov, Timothy A. Chan, Raghvendra M. Srivastava

“…We show a robust enhancement in NK-cell effector function, DC maturation, reciprocal NK:DC crosstalk and DC editing that is unique to avelumab treatment using multiple functional immune assays. …”
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Improved Results Synchronization on Secure Communication in Complex Dynamical Networks With Time-Varying Delay Using Delay-Dependent Feedback Control by Arthit Hongsri, Ovidiu Bagdasar, Narongsak Yotha

“…After fully accounting for the nonlinear function, a unique Lyapunov-Krasovskii functional (LKF) is developed. …”
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KIF5A regulates axonal repair and time-dependent axonal transport of SFPQ granules and mitochondria in human motor neurons by Irune Guerra San Juan, Jessie W. Brunner, Kevin Eggan, Ruud F. Toonen, Matthijs Verhage

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BCG Vaccination Potentially Modulates the Transcriptome of Infant CD4 T Cells in Addition to Age-Dependent Immune Ontogeny-Associated Changes by Vidya Vijayan Karuvan Kandiyil, Eunchong Kang, Emily Coates, Portia Kamthunzi, Gerald Tegha, Mina Hosseinipour, Di Wu, Fei Zou, Kristina De Paris

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Optimization on construction machinery considering sequence-dependent setup times and personnel fatigue based on the improved gray wolf and whale algorithm. by Dawei Wang, Bo Gao, Lei Zhang

“…An innovative algorithm, the improved hybrid gray wolf and whale algorithm fused with a penalty function for construction machinery optimization (IHWGWO), is introduced, incorporating a penalty function to handle constraints effectively. …”
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Trauma patients have reduced ex vivo flow-dependent platelet hemostatic capacity in a microfluidic model of vessel injury. by Kimberly A Thomas, Rassam M G Rassam, Ronit Kar, Devin M Dishong, Katelin C Rahn, Ricardo Fonseca, Melissa Canas, Jose Aldana, Hussain Afzal, Kelly Bochicchio, Matthew D Neal, Grant V Bochicchio, Philip C Spinella, Susan M Shea

“…We hypothesized that trauma patients would have flow-regime dependent alterations in platelet function. Blood was collected from trauma patients with level I activations (N = 34) within 60 min of hospital arrival, as well as healthy volunteer controls (N = 10). …”
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Nash Equilibrium Strategy for a DC Pension Plan with State-Dependent Risk Aversion: A Multiperiod Mean-Variance Framework by Liyuan Wang, Zhiping Chen

“…Different from most studies in the literature, where the investor’s risk aversion attitude is state-independent, we choose a state-dependent risk aversion parameter, which is a fractional function of the current wealth level. …”
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Computer modeling of a diffusion in a mixture of ideal gases given the dependence of the diffusion coefficient on the entropy of mixing in Wolfram Mathematica by P. K. Shalkevich, N. A. Shilov, N. N. Grinchik

“…Built-in function NDSolveValue in Wolfram Mathematica and the default solver were used for the numerical solution of the one-dimensional task; for the numerical solution of the two-dimensional task the same function was used, for which the Numerical Method of Lines was specified as the solver.Results. …”
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Upregulation of ALOX12−12-HETE pathway impairs AMPK-dependent modulation of vascular metabolism in ApoE/LDLR−/− mice by Mariola Olkowicz, Agnieszka Karas, Piotr Berkowicz, Patrycja Kaczara, Agnieszka Jasztal, Zuzanna Kurylowicz, Filip Fedak, Hernando Rosales-Solano, Kanchan Sinha Roy, Agnieszka Kij, Elzbieta Buczek, Janusz Pawliszyn, Stefan Chlopicki

“…In conclusion, excessive activation of the ALOX12–12-HETE pathway in vascular inflammation in early atherosclerosis inhibits AMPK-dependent regulation of vascular metabolism. Consequently, ALOX12 may represent a novel target to boost impaired vascular mitochondrial function in pro-atherosclerotic vascular inflammation.…”
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Item condition of the autonomic nervous system in patients with hypertension stage II low additional cardiovascular risk depending on the status of smokers by E. A. Poznanskaya, V. V. Syvolap

“…Research devoted to the study of influence of risk factors , including smoking, on the structural and geometric and functional changes of the heart is not enough. Aim. …”
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The exocytosis regulator complexin controls spontaneous synaptic vesicle release in a CAPS-dependent manner at C. elegans excitatory synapses. by Ya Wang, Chun Hin Chow, Yu Zhang, Mengjia Huang, Randa Higazy, Neeraja Ramakrishnan, Lili Chen, Xuhui Chen, Yixiang Deng, Sheng Wang, Cuntai Zhang, Cong Ma, Shuzo Sugita, Shangbang Gao

“…Notably, we found that CPX-1's clamping function is dependent on UNC-31 and is sensitive to external Ca2+. …”
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Atp7b-dependent choroid plexus dysfunction causes transient copper deficit and metabolic changes in the developing mouse brain. by Clorissa L Washington-Hughes, Shubhrajit Roy, Herana Kamal Seneviratne, Senthilkumar S Karuppagounder, Yulemni Morel, Jace W Jones, Alex Zak, Tong Xiao, Tatiana N Boronina, Robert N Cole, Namandjé N Bumpus, Christopher J Chang, Ted M Dawson, Svetlana Lutsenko

“…Copper (Cu) has a multifaceted role in brain development, function, and metabolism. Two homologous Cu transporters, Atp7a (Menkes disease protein) and Atp7b (Wilson disease protein), maintain Cu homeostasis in the tissue. …”
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BLISTER-regulated vegetative growth is dependent on the protein kinase domain of ER stress modulator IRE1A in Arabidopsis thaliana. by Zheng-Hui Hong, Tao Qing, Daniel Schubert, Julia Anna Kleinmanns, Jian-Xiang Liu

“…Hence, our results reveal the important role of IRE1A in plant growth and development, and BLI negatively controls IRE1A's function under normal growth condition in plants.…”
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RIS Assisted UAV for Weather-Dependent Satellite Terrestrial Integrated Network With Hybrid FSO/RF Systems by Xin Li, Yongjun Li, Xinkang Song, Long Shao, Hai Li

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Greening concept in inventory system for deteriorating items with preservation investment and price and stock dependent demand via marine predators algorithm by Hachen Ali, Gobinda Chandra Panda, Adel Fahad Alrasheedi, Ali Akbar Shaikh, Jeonghwan Gwak

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Interferon Regulatory Factor 4 dose-dependently controls peripheral Treg cell differentiation and homeostasis by modulating chromatin accessibility in mice by Leonie Caroline Voß, Constantin Schmidt, Constantin Schmidt, Aenne Harberts, Aenne Harberts, Aenne Harberts, Michael Spohn, Michael Spohn, Michael Spohn, Peter Bradtke, Alina Borchers, Alina Borchers, Alina Borchers, Stefanie Fertig, Joanna Schmid, Friedrich Koch-Nolte, Christian F. Krebs, Christian F. Krebs, Christian F. Krebs, Friederike Raczkowski, Hans-Willi Mittrücker, Hans-Willi Mittrücker

“…The transcription factor Interferon Regulatory Factor 4 (IRF4) controls differentiation and function of T cells. In Treg cells, IRF4 is required for peripheral activation and maturation to effector Treg (eTreg) cells with enhanced suppressive function. …”
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The nuclear immune receptor RPS4 is required for RRS1SLH1-dependent constitutive defense activation in Arabidopsis thaliana. by Kee Hoon Sohn, Cécile Segonzac, Ghanasyam Rallapalli, Panagiotis F Sarris, Joo Yong Woo, Simon J Williams, Toby E Newman, Kyung Hee Paek, Bostjan Kobe, Jonathan D G Jones

“…NB-LRR proteins structurally and functionally resemble mammalian Nod-like receptors (NLRs). …”
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Maximum likelihood self-calibration for direction-dependent gain-phase errors with carry-on instrumental sensors:case of deterministic signal model by WANG Ding1, PAN Miao2, WU Ying1

“…Aim at the self-calibration of direction-dependent gain-phase errors in case of deterministic signal model,the maximum likelihood method（MLM） for calibrating the direction-dependent gain-phase errors with carry-on instrumental sensors was presented.In order to maximize the high-dimensional nonlinear cost function appearing in the MLM,an improved alternative projection iteration algorithm,which could optimize the azimuths and direction-dependent gain-phase errors was proposed.The closed-form expressions of the Cramér-Rao bound（CRB） for azimuths and gain-phase errors were derived.Simulation experiments show the effectiveness and advantage of the novel method.…”
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