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4261
Vitamin C Protected Human Retinal Pigmented Epithelium from Oxidant Injury Depending on Regulating SIRT1
Published 2014-01-01“…Consistently, nicotinamide (NA) relieved the protective functions of moderate Vit C. Interestingly, data also revealed the dysregulation of p53 and FOXO3 was dependent on the regulation of SIRT1 rather than Vit C. …”
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Hypoxia inducible factor signaling modulates susceptibility to mycobacterial infection via a nitric oxide dependent mechanism.
Published 2013-01-01“…We have previously shown that hypoxic signaling via stabilization of Hif-1α prolongs the functionality of leukocytes in the innate immune response to injury. …”
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4264
Evaluation of NFκB-dependent inflammatory responses induced by TNFα in 3D human microvessels
Published 2025-05-01Get full text
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4265
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4269
Balancing between cuproplasia and copper-dependent cell death: molecular basis and clinical implications of ATOX1 in cancer
Published 2025-07-01“…By interacting with other proteins involved in controlling the intracellular levels of cuprous ions (Cu+), ATOX1 contributes to the import, export, and subcellular distribution of Cu+ as it functions within the CTR1-ATOX1-ATP7A/ATP7B axis. For this reason, ATOX1 plays a key role in preventing copper toxicity. …”
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4270
Significant Inverse Correlation of Serum Levels of Osteoprotegerin (OPG) and Transferrin Saturation in Thalassemia Dependent Transfusion (TDT) Patients
Published 2024-04-01“…OPG is a glycoprotein that functions as a feedback receptor for the Receptor Activator of Nuclear Factor kappa B Ligand (RANKL), which is an alpha tumor necrosis factor receptor. …”
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4271
Multiplicity dependence of charged-particle intra-jet properties in pp collisions at $$\sqrt{{{\varvec{s}}}}$$ s = 13 TeV
Published 2024-10-01“…Abstract The first measurement of the multiplicity dependence of intra-jet properties of leading charged-particle jets in proton–proton (pp) collisions is reported. …”
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4272
Evidence of a relationship between circulating ghrelin and sleep quality in male alcohol-dependent patients after abstinence
Published 2025-07-01“…Abstract Objective Sleep disturbance is a commonly observed issue in individuals diagnosed with alcohol dependence (AD). Ghrelin, a peptide known for its role in stimulating appetite and maintaining energy balance, also plays a crucial role in regulating higher brain functions, such as the sleep-wake cycle. …”
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4273
A Reinforcement Learning-Based Generative Approach for Event Temporal Relation Extraction
Published 2025-03-01“…To achieve this, we reformulate the event temporal relation extraction task as a text generation problem, aiming to generate both event temporal relation labels and dependency path words based on the input sentence. To bridge the gap between the optimization objective and task performance metrics, we employ the REINFORCE algorithm to optimize our generative model, designing a novel reward function to simultaneously capture the accuracy of temporal prediction and the quality of generation. …”
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4274
Time-varying spectral power of resting-state fMRI networks reveal cross-frequency dependence in dynamic connectivity.
Published 2017-01-01“…Moreover, we introduce a new measure of dependence between pairs of rs-fMRI networks which reveals significant cross-frequency dependence between functional brain networks specifically default-mode, cerebellar and visual networks. …”
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Splice variants of Na(V)1.7 sodium channels have distinct β subunit-dependent biophysical properties.
Published 2012-01-01“…Because splicing is conserved, its unexpected role in regulating the functional impact of β subunits may apply to multiple voltage-gated sodium channels, and the full repertoire of β subunit function may depend on splicing in α subunits.…”
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Temperature-dependent regulation of bacterial cell division hydrolases by the coordinated action of a regulatory RNA and the ClpXP protease
Published 2025-06-01“…Notably, Rbc1 is capable of base pairing with RNAs encoding the CHAP domains of numerous cell wall hydrolases and we show that Rbc1 works in trans to upregulate the cell division hydrolase Sle1. Specifically, Rbc1 functions as a thermosensor allowing for upregulation of CxcA and Sle1 at low temperature where daughter cell separation is impeded. …”
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4280
On the question of applying discounts in the marketing process
Published 2023-11-01Get full text
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