Achieving significant mechanical improvement of chitosan aerogel with embedding or bridging structures mediated by size-dependent silk microfibers by Haiyu Liu, Fang He, Zhixiang Xu, Meng Zhang, Quan Wan, Yajun Shuai, Jie Wang, Mingying Yang, Zongpu Xu

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Probability of allogeneic hematopoietic stem cell transplant failure depending on the recipient's killer immunoglobulin-like receptor genotype by U. V. Maslikova, E. G. Khamaganova, M. Yu. Drokov, I. Yu. Urybin, E. D. Mikhaltsova, L. A. Kuzmina, E. N. Parovichnikova

“…Their role is to recognize "self" cells and block signals aimed at destroying their own cells. Knowledge of the functional activity of natural killers urged to studying the impact of mismatches between the inhibitory receptor gene and the ligand on the development of allogeneic hematopoietic stem cell transplant failure.The aim of research was to study the probability of the graft failure development in allogeneic hematopoietic stem cell transplantation depending on the recipient's killer immunoglobulin-like receptor genotype.Material and methods. …”
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Influence of Tariquidar, an ABC Transporter Inhibitor, on the Ca²⁺-Dependent Mitochondrial Permeability Transition Pore by Tatiana A. Fedotcheva, Alexey G. Kruglov, Nadezhda I. Fedotcheva

“…The effect of Tq on the opening of mPTP is strongly dependent on the concentrations of adenine nucleotides and, consequently, on the functional state of mitochondria. …”
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Loss of FGF-dependent mesoderm identity and rise of endogenous retinoid signalling determine cessation of body axis elongation. by Isabel Olivera-Martinez, Hidekiyo Harada, Pamela A Halley, Kate G Storey

“…Using gain and loss of function approaches in vitro and in vivo, we then show that attenuation of FGF/Erk signalling mediates this loss of Brachyury upstream of Wnt signalling, while high-level FGF maintains Brachyury and can induce ectopic CNH-like cell foci. …”
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Calcium-dependent protein kinases 2A involved in the growth of both asexual and sexual stages of Cryptosporidium parvum. by Fanfan Shu, Yujin Huang, Fuxian Yang, Yaqiong Guo, Rui Xu, Lihua Xiao, Yaoyu Feng, Na Li

“…Oocyst shedding, parasite load, villus length/crypt height ratio and survival of infected mice were used to evaluate the function of CpCDPK2A in vivo. The results revealed that CpCDPK2A was expressed in all the intracellular developmental stages, especially in the motile stages of sporozoites and merozoites. …”
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Activity-dependent degradation of Kv4.2 contributes to synaptic plasticity and behavior in Angelman syndrome model mice by Jia-Hua Hu, Cole Malloy, Ying Liu, Jung M. Park, Ashley Pratt, Meghyn Welch, Jonathan G. Murphy, Daniel Abebe, Rose-Marie Karlsson, Heather A. Cameron, Dax A. Hoffman

“…Summary: Angelman syndrome (AS) is a severe neurological disorder characterized by intellectual disability, absence of speech, spontaneous seizure, and motor dysfunction. The absence of functional maternally derived UBE3A protein is considered the primary cause of AS, yet the downstream signaling pathways remain elusive. …”
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METTL3-dependent DLG2 inhibits the malignant progression of cervical cancer by inactivating the Hippo/YAP signaling by Mei Pu, Xia Xiao, Shasha Lv, Daqing Ran, Qian Huang, Mingming Zhou, Qirong Lei, Lingshuang Kong, Qing Zhang

“…Colony formation assay, 5-Ethynyl-2’-deoxyuridine assay, flow cytometry, and transwell assays were conducted for cell functional analysis. A xenograft mouse model assay was performed to analyze tumor tumorigenesis in vivo. m6A RNA immunoprecipitation assay was used to analyze the association of METTL3 and DLG2. …”
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Actinomycetota From Macroalgae as Rich Source for Natural Products Discovery Revealed Through Culture‐Dependent and ‐Independent Approaches by Mariana Girão, Adriana Rego, Ana C. Fonseca, Weiwei Cao, Zhongjun Jia, Ralph Urbatzka, Pedro N. Leão, Maria F. Carvalho

“…The bioactive potential of the actinobacterial community from the same macroalgae specimens, which served as the source for the aforementioned Actinomycetota collection, was also explored through metagenomics analysis, allowing to obtain a broader picture of its functional diversity and novelty. A total of 133 biosynthetic gene clusters recovered from metagenomic contigs and metagenome assembled genomes (MAGs). …”
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Choice of specific and anticoagulant therapy in patients with newly diagnosed chronic thromboembolic pulmonary hypertension, depending on operability status by Z. S. Valieva, T. V. Martynyuk

“…Demographic, functional status, anticoagulant therapy and specific therapy regimens were analyzed.Results. …”
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CLINICAL AND HEMODYNAMIC PROFILE AND NEUROHORMONAL INDICATORS IN PATIENTS WITH IDIOPATHIC PULMONARY HYPERTENSION, DEPENDING ON VASOREACTIVITY RESERVE OF PULMONARY ARTERIES by V. M. Paramonov, T. V. Martynyuk, Z. H. Dadacheva, N. M. Danilov, V. P. Masenko, I. Ye. Chazova

“…Clinical and hemodynamic profile and neurohormonal indicators in patients with idiopathic pulmonary hypertension, depending on vasoreactivity reserve of pulmonary arteries. …”
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RNA-seq dataset of the estrogen-dependent regulation of the transcriptome in mouse mammary gland organoidsGene Expression Omnibus by Aurélie Lacouture, Mame Sokhna Sylla, Lucas Germain, Étienne Audet-Walsh

“…These data can be reanalyzed and combined with recent single-cell RNA-seq data to study the estrogen-dependent transcriptome at the cellular level and better understand the functional impact on the mammary gland in physiopathological conditions, such as during lactation, following endocrine-disrupting chemical exposure, or through the course of carcinogenesis.…”
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Involvement of WNT Signaling in the Regulation of Gestational Age-Dependent Umbilical Cord-Derived Mesenchymal Stem Cell Proliferation by Sota Iwatani, Akemi Shono, Makiko Yoshida, Keiji Yamana, Khin Kyae Mon Thwin, Jumpei Kuroda, Daisuke Kurokawa, Tsubasa Koda, Kosuke Nishida, Toshihiko Ikuta, Kazumichi Fujioka, Masami Mizobuchi, Mariko Taniguchi-Ikeda, Ichiro Morioka, Kazumoto Iijima, Noriyuki Nishimura

“…Although the cell proliferation and differentiation of BM-derived MSCs is known to decline with age, the functional difference between preterm and term UC-MSCs is poorly characterized. …”
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miPEP31 alleviates sepsis development by regulating Chi3l1-dependent macrophage polarization by Yu Zhou, Yuan Yuan, Xuanqi Yao, Lin Wang, Liangfang Yao, Daolin Tang, Feng Chen, Jinbao Li

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Carboxymethyl chitosan oligosaccharide prevents the progression of chronic kidney disease as a Nrf2-dependent apoptosis inhibitor by Xiaozheng Yuan, Huan He, Youtao Xu, Xinru Chen, Jiawen Wu, Xianpeng Zhong, Xiyu Li, Jing Qiao

“…This study reports that the renal protective effects of CMCOS are associated with anti-apoptosis in glomerular podocytes and renal tubular epithelial cells, which maintains the integrity of renal structure and function. Furthermore, CMCOS suppresses tissue oxidative stress and intracellular accumulation of reactive oxygen species both in vitro and in vivo, demonstrating positive correlations with its apoptosis inhibition. …”
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Modeling of power losses in contact systems of low-voltage switching devices by A. R. Petrov, E. I. Gracheva

“…Models of functional dependences of active power losses on nominal current for low-voltage switching devices of some manufacturers are developed. …”
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Affective state-dependent effects of prefrontal rTMS on the cognitive control of negative stimuli in healthy and depressed individuals by Jasmina Paneva, Teresa Schuhmann, Stefanie De Smet, Terence De Meza, Felix Duecker, Alexander T. Sack

“…As a function of BDI-II scores, we observed either increased or decreased response times on the task. …”
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Aminophylline suppresses chronic renal failure progression by activating SIRT1/AMPK/mTOR-dependent autophagy by Liao Xin, Lu Jieyi, Huang Zhifeng, Lin Jinai, Zhang Miao, Chen Huanru, Lin Xiaoqing, Gao Xia, Gong Sitang

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Recurrence of acute allergic asthma depends on the role of ILC2 driven by Il1rl1 signaling by Hui Gan, Zhifeng Huang, Qingjun Pan, Fei Ye, Zheng Zhu, Baoqing Sun

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Promoter- and enhancer-dependent cohesin loading initiates chromosome looping to fold Tcrb loci for long-range recombination by Brittney M. Allyn, Katharina E. Hayer, Clement Oyeniran, Vincent Nganga, Kyutae Lee, Ahmet Sacan, Eugene M. Oltz, Craig H. Bassing

“…Thus, Vb promoter- or enhancer-dependent cohesin loading initiates LE in opposite directions across the locus to assemble a broad Tcrb repertoire, a finding that has broad implications for genomic architecture and function.…”
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Optimizing carbon nanoparticle staining for sentinel lymph nodes in rabbit lower limb models: concentration and time dependence by Narbol Kylyshbek, Heng Wang, Shuning Feng, Yuxin Zhang, Dong Dong, Wangjaleoseop Han, Ayidana Ayoujiang, Liang Chen, Tianyi Liu

“…Long-term CNPs retention has no significant negative impact on the structure and function of lymph nodes. Conclusions CNPs are an effective and safe lymphatic tracer. …”
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