Microbiome drives age-dependent shifts in brain transcriptomic programs at the single-cell level in Drosophila by Dianshu Zhao, Russel T. Shiga, Zhangrong Song, Runhang Shu, Lipin Loo, Adam Chun Nin Wong

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Emergence of Two Inertial Subranges in Solar Wind Turbulence: Dependence on Heliospheric Distance and Solar Activity by Shiladittya Mondal, Supratik Banerjee, Luca Sorriso-Valvo

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Pembrolizumab promotes degradation of cyclin dependent kinase 6 and suppresses ovarian cancer progression in vitro by Yi Wu, Ziyan Xu, Zuqiang Kou, Qiuling Ye, Liting Chen, Boyu Gou

“…Abstract Pembrolizumab is a novel humanized anti-PD-1 monoclonal antibody capable of enhancing T-cell mediated antitumor immunity. However, the function of pembrolizumab on tumor cells themselves and relative molecular mechanism in ovarian cancer remain unknown. …”
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Pitfalls of space-time trading when parametrizing a land use dependent hydrological model by Oudin, Ludovic, Lalonde, Morgane

“…Evaporation is a function of both climate conditions and other environmental conditions, including land use. …”
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Study of platelet activation, hypercoagulable state, and pulmonary hypertension in patients with transfusion-dependent beta-thalassemia by Lanja Othman Haji, Ranan Kardagh Polus, Nawsherwan Sadiq Mohammed

“…Complete blood counts, liver function tests, coagulation markers (P-selectin, protein C, antithrombin III, and fibrinogen), serum ferritin, and transthoracic echocardiography were performed, and blood transfusion/chelation history and splenectomy status were recorded. …”
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Gingival spatial analysis reveals geographic immunological variation in a microbiota-dependent and -independent manner by Yasmin Jaber, Avital Sarusi-Portuguez, Yasmin Netanely, Reem Naamneh, Shahd Yacoub, Or Saar, Nadeem Darawshi, Luba Eli-Berchoer, Hagit Shapiro, Eran Elinav, Asaf Wilensky, Avi-Hai Hovav

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A general assay platform to study protein pharmacology using ligand-dependent structural dynamics by Daniel A. Ciulla, Patricia K. Dranchak, Mahesh Aitha, Renier H. P. van Neer, Divia Shah, Ravi Tharakan, Kelli M. Wilson, Yuhong Wang, John C. Braisted, James Inglese

“…Here, NanoLuc luciferase, used as the intact protein or its α-complementation peptide, was fused to seven proteins from distinct enzyme superfamilies resulting in sensitive ligand-dependent bioluminescent outputs. This finding allows a general non-competitive, function-independent, quantitative, isothermal gain-of-signal ligand binding readout. …”
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Pressure-Dependent Thermal Network Model for Press-Pack Power Modules with Prognostics of Mechanical Status by Yao Chang, Yu Zhou, Ankang Zhu, Haoze Luo, Wuhua Li, Chushan Li, Francesco Iannuzzo, Xiangning He

“…By including the thermal contact resistance and thermal coupling resistance as the function of pressure, the proposed model ensures a more precise thermo-mechanical evaluation inside the press-pack power module. …”
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Macrophage Depletion Reduces Disease Pathology in Factor H-Dependent Immune Complex-Mediated Glomerulonephritis by Alexander Jacob, Michael Phelps, Shane Fraher, Marcos Lopez, Anthony Chang, Richard J. Quigg, Jessy J. Alexander

“…The administration of clodronate decreased monocytes and Mϕs in the kidneys by >80%. Kidney function assessed by BUN and albumin remained closer to normal on depletion of Mϕs. …”
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The pathogenic mechanism of the Mycobacterium ulcerans virulence factor, mycolactone, depends on blockade of protein translocation into the ER. by Belinda S Hall, Kirsti Hill, Michael McKenna, Joy Ogbechi, Stephen High, Anne E Willis, Rachel E Simmonds

“…Several lines of evidence support this transformative explanation of mycolactone function. First, cellular TNF and Cox-2 can be once more detected if the action of the 26S proteasome is inhibited concurrently. …”
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Activation of FADD-Dependent Neuronal Death Pathways as a Predictor of Pathogenicity for LRRK2 Mutations. by Katerina Melachroinou, Emmanouela Leandrou, Polytimi-Eleni Valkimadi, Anna Memou, Georgios Hadjigeorgiou, Leonidas Stefanis, Hardy J Rideout

“…In contrast, each of the variants tested induced apoptotic death of cultured neurons similar to pathogenic LRRK2 in a FADD-dependent manner.<h4>Conclusions</h4>Overall, despite differences in some properties of LRRK2 function such as kinase activity and its oligomerization, each of the LRRK2 variants examined induced neuronal death to a similar extent. …”
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Interleukin-6 as a prognostic marker in acute kidney injury and its klotho-dependent regulation by Laura González-Lafuente, Elisa Mercado-García, Sara Vázquez-Sánchez, Daniel González-Moreno, Lisardo Boscá, María Fernández-Velasco, Julián Segura, Makoto Kuro-O, Luis M. Ruilope, Fernando Liaño, Gema Ruiz-Hurtado

“…Material and methods: Plasma levels of IL-6, klotho and FGF23 were analysed in samples from 28 patients with AKI and related to renal function on hospital admission, and after 24 and 72 h. …”
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Electrostatics of salt-dependent reentrant phase behaviors highlights diverse roles of ATP in biomolecular condensates by Yi-Hsuan Lin, Tae Hun Kim, Suman Das, Tanmoy Pal, Jonas Wessén, Atul Kaushik Rangadurai, Lewis E Kay, Julie D Forman-Kay, Hue Sun Chan

“…The electrostatic nature of these features complements ATP’s involvement in π-related interactions and as an amphiphilic hydrotrope, underscoring a general role of biomolecular condensates in modulating ion concentrations and its functional ramifications.…”
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Characterization and kinetic analysis of Vc1509, a NAD+ dependent deacetylase from Vibrio cholerae by Arindam Jana, Pragyan Mishra, Ritu Ghosh, Ajit Kumar Dhal, Shibangini Beura, Amrita Mishra, Rahul Modak

“…Among deacetylases, sirtuin-type NAD+ dependent deacetylases, CobB, play central role in bacterial homeostasis. …”
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Early and delayed STAT1-dependent responses drive local trained immunity of macrophages in the spleen by Aryeh Solomon, Noa Bossel Ben-Moshe, Dotan Hoffman, Sébastien Trzebanski, Dror Yehezkel, Leia Vainman, Mihai G Netea, Roi Avraham

“…Trained immunity (TI) is the process wherein innate immune cells gain functional memory upon exposure to specific ligands or pathogens, leading to augmented inflammatory responses and pathogen clearance upon secondary exposure. …”
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Wnt-dependent mechanism of the apical constriction of roof plate cells in developing mouse spinal cord by Takuma Shinozuka, Takuma Shinozuka, Takuma Shinozuka, Tadashi Okubo, Noriaki Sasai, Shinji Takada, Shinji Takada, Shinji Takada

“…Analysis of Wntless conditional knock-out (cKO) embryos, in which Wnt secretion from Wnt1-expressing roof plate cells is impaired, revealed that RP-derived Wnt ligands are required for phosphorylation of myosin light chain (MLC) and apical constriction of RP cells. Loss- or gain-of-function analysis of β-catenin reveals that this apical constriction is regulated in a β-catenin-dependent manner. …”
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Baicalin improves isoproterenol-induced cardiac remodeling by regulating the Nrf2-dependent signaling pathway by Kai Qian, Li Song, Jia-Min Guo, Dan Fu, Jia Shi, Yu Ma, Zi-Jie Ge, Lei Li, Su-qin Zhang

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Endotheliopathy in systemic sclerosis: from endothelium-dependent vasodilation to the dysfunction of the vascular reserve, is the paradise lost? by Giulia Bandini, Silvia Bellando Randone, Mirko Manetti, Lorenzo Dagna, Marco Matucci Cerinic, Alberto Moggi Pignone

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Mechanistic Insights into Autophagy-Dependent Cell Death (ADCD): A Novel Avenue for Cancer Therapy by Md Ataur Rahman, Maroua Jalouli, Mohammed Al-Zharani, Ehsanul Hoque Apu, Abdel Halim Harrath

“…Autophagy regulates cellular breakdown and stress responses, serving a dual function—either inhibiting tumorigenesis or facilitating the survival of cancer cells in advanced stages. …”
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Latitudinal Dependence of the Solar Wind During Periods of High and Low Activity Through Interplanetary Scintillation by A. Waszewski, J. S. Morgan, R. Ekers, M. Johnston‐Hollitt, M. C. M. Cheung, N. D. R. Bhat, R. Chhetri, S. C. Fu

“…On the other hand, with a reduction in solar activity we find the solar wind density inherits a latitudinal dependence. As is consistent with prior studies, an elliptical function better represents the transition from poles to equator, although we find a more exaggerated sigmoid shaped curve is required to represent the low‐to mid‐latitude transition region during the minimum of solar cycle 24. …”
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