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The reaction specificity of mammalian ALOX15B orthologs does not depend on the evolutionary ranking of the animals
Published 2025-04-01“…To address this question, we systematically searched the public databases for ALOX15B genes, expressed selected enzymes, and characterized their functional properties. We found that functional ALOX15B genes frequently occur in Prototheria and Eutheria but orthologous genes are rare in Metatheria. …”
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3703
Promoters of ASCL1‐ and NEUROD1‐dependent genes are specific targets of lurbinectedin in SCLC cells
Published 2022-03-01Get full text
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3704
Time-dependent phenotypical changes of microglia drive alterations in hippocampal synaptic transmission in acute slices
Published 2024-11-01“…It is widely acknowledged that microglia actively regulate synaptic function in the brain. Remarkably, much of our understanding regarding the role of microglia in synaptic regulation is derived from studies in acute brain slices. …”
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3705
The impact of juniper removal on shrubs and understory vegetation and its implications for sagebrush dependent vertebrate herbivores
Published 2024-12-01“…The expansion of trees into previously grass- and shrub- dominated ecosystems is a global phenomenon threatening ecosystem integrity and function in encroached systems, including the North American sagebrush biome. …”
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3706
Depth-dependent structural analysis of polyolefin multilayer films using microbeam X-ray diffraction
Published 2025-09-01“…The step-milled sculptures of multilayer films were exposed normal to microbeam x-rays in a transmission-mode, providing insights into the composition, nanoparticle dispersion, and crystal orientation as a function of film thickness. Our results highlight the analytical capability using an effective combination of FIB-SEM technique and M-WAXD, pointing out the importance of depth-dependent structural analysis for mono-material PO multilayer films.…”
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3707
Layer dependent thermal transport properties of one- to three-layer magnetic Fe:MoS2
Published 2025-01-01“…We also characterized Fe:MoS2’s thermal transport at high temperature, and calculated Fe:MoS2’s thermal transport by density theory function. These findings will shed light on the thermal management and thermoelectric designs for Fe:MoS2 based nano and quantum electronic devices.…”
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3708
Stress-dependent activation of the Listeria monocytogenes virulence program ensures bacterial resilience during infection
Published 2025-06-01“…To define pathways that lead to Sigma B-dependent prfA activation, we performed a genetic screen in L2 fibroblasts using ΔP1 Lm that only has the Sigma B-dependent promoter directly upstream of prfA. …”
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3710
Quality of life of gastric cancer patients after radical surgery depending on the status of the duodenal passage
Published 2025-03-01“…The dynamics of QOL recovery in patients with GC after surgical treatment depends on the status of the duodenal passage: in the group of patients with PDP, faster positive dynamics are observed on all scales of functioning and symptoms than in patients without duodenal passage. …”
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3711
A Directed Continuous Time Random Walk Model with Jump Length Depending on Waiting Time
Published 2014-01-01Get full text
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3712
The role of proteins Stim and Orai as molecular components of the store-dependent current Ca2+ in lymphocytes
Published 2018-03-01“…Thus, the relationship and coordination of Stim and Orai proteins provides store - dependent Ca2+ current and causes cellular functional responses. …”
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3713
Phosphorylation of Elp1 by Hrr25 is required for elongator-dependent tRNA modification in yeast.
Published 2015-01-01Get full text
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3714
Knockout of Sirtuin 3 in endothelial cells impairs endothelial‐dependent relaxation and myogenic response in mice
Published 2024-10-01“…Abstract Sirtuin 3 has been shown to regulate endothelial function and coronary flow reserve in mice. Knockout of SIRT3 reduced endothelial nitric oxide synthase expression in the mouse hearts. …”
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Simulation of sand and mud transport processes in currents and waves by time-dependent 2DV model
Published 2025-02-01“…To represent mud flocculation and hindered settling processes, the settling velocity can be set as constant or concentration-dependent (input). The bed boundary condition is modelled as a bed concentration as function of the bed-shear stress. …”
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3717
Simulation of endothelium-dependent vasodilation in young male persons based on the parameters of body weight components
Published 2021-11-01“…The data obtained allow us to note that the functional state of the endothelium and its activity depends on the content of body weight components in the organism.…”
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3718
SUV39H1-dependent methyl-degron is a critical regulator of skeletal homeostasis
Published 2025-07-01Get full text
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System-driven and oscillator-dependent circadian transcription in mice with a conditionally active liver clock.
Published 2007-02-01“…To discriminate between these mechanisms, we engineered a mouse strain with a conditionally active liver clock, in which REV-ERBalpha represses the transcription of the essential core clock gene Bmal1 in a doxycycline-dependent manner. We examined circadian liver gene expression genome-wide in mice in which hepatocyte oscillators were either running or arrested, and found that the rhythmic transcription of most genes depended on functional hepatocyte clocks. …”
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