Chloride intracellular channel (CLIC) protein function in S1P-induced Rac1 activation requires membrane localization of the C-terminus, but not thiol-transferase nor ion channel ac... by De Yu Mao, Jordan J. Jesse, Jordan J. Jesse, Daniel D. Shaye, Daniel D. Shaye, Jan Kitajewski, Jan Kitajewski

“…Endothelial CLIC1 and CLIC4 are rapidly and transiently re-localized from the cytoplasm to the plasma membrane in response to the GPCR ligand sphingosine-1-phosphate (S1P), and both CLICs are required to activate Rac1 in response to S1P, but how they perform this function remains unknown. Biochemical studies suggest that CLICs act as non-specific ion channels and/or as glutathione-S-transferases, dependent on N-terminal features, in vitro. …”
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Anti-TNF-Alpha-Adalimumab Therapy Is Associated with Persistent Improvement of Endothelial Function without Progression of Carotid Intima-Media Wall Thickness in Patients with Rheu... by Carlos Gonzalez-Juanatey, Tomas R. Vazquez-Rodriguez, Jose A. Miranda-Filloy, Ines Gomez-Acebo, Ana Testa, Carlos Garcia-Porrua, Amalia Sanchez-Andrade, Javier Llorca, Miguel A. González-Gay

“…To determine whether treatment with the anti-TNF-alpha blocker adalimumab yields persistent improvement of endothelial function and prevents from morphological progression of subclinical atherosclerosis in patients with rheumatoid arthritis (RA) refractory to conventional therapy, a series of 34 consecutive RA patients, attending hospital outpatient clinics and who were switched from disease modifying antirheumatic drug therapy to anti-TNF-alpha-adalimumab treatment because of severe disease, were assessed by ultrasonography techniques before the onset of adalimumab therapy (at day 0) and then at day 14 and at month 12. …”
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First principles investigation of the structural, anisotropic mechanical, optical, thermodynamic, and thermoelectric properties of MF2 (M = Ca, Sr, Ba, Pb) fluorite minerals using... by V.A. Dabhi, H.S. Patel, A.M. Vora

“…Optical properties were thoroughly analyzed via frequency-dependent calculations of the complex dielectric function, refractive index, extinction coefficient, reflectivity, optical conductivity, absorption coefficient, and electron energy loss function. …”
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AKT1E17K‐Interacting lncRNA SVIL‐AS1 Promotes AKT1 Oncogenic Functions by Preferentially Blocking AKT1E17K Dephosphorylation by Jingyi Wang, Wenying Chen, Qianying Li, Ruiyi Yang, Xiaorong Lin, Ping Han, Xiaoming Huang, Hai Hu, Man‐Li Luo

“…Abstract AKT1E17K is a gain‐of‐function mutation that constitutively activates the PI3K‐AKT pathway. …”
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Profiling miRNA changes in Epstein-Barr virus lytic infection identifies a function for BZLF1 in upregulating miRNAs from the DLK1-DIO3 locus. by Ashley M Campbell, Victoria C Taylor, Beata Cohan, Lori Frappier

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Dietary tea tree (Melaleucae Aetheroleum) oil fortifies growth, biochemical, immune-antioxidant trait, gene function, tissue reaction, and Aeromonas sobria resistance in Nile tilap... by Mohamed Shaalan, Heba H. Mahboub, Ahmed Hosny Abdelgawad, Abdelwahab A. Abdelwarith, Elsayed M. Younis, Ahmed A. Elnegiry, Asmaa W. Basher, Walaa El-Houseiny, Sherif M. Shawky, Sahar H. Orabi, Simon J. Davies, Yasmina K. Mahmoud

“…Furthermore, TTO-enriched diets enhanced the relative percentage survival post-A. sobria challenge plus enhanced the clinical picture in a dose-dependent manner. Taken together, the findings revealed that long-term exposure to dietary TTO fortified the physiological performance, oxidant/anti-oxidant stability, immune function, gene expression, histological picture, and resistance of Nile tilapia against A. sobria.…”
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Temperature-dependent plasticity in organic synaptic transistors for adaptive learning and data encryption by Yu Gao, Xue-Er Han, Xu Gao, Fei-Le Xue, Jian-Ru Chen, Ya-Nan Zhong, Jian-Long Xu, Sui-Dong Wang

“…By leveraging these thermal responses, we establish a temperature-dependent physical unclonable function (PUF) capable of multi-level logic encoding and self-annihilating data storage. …”
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Delay-dependent robust control for uncertain Linear systems with distributed and multiple delays by Salman Baroumand, Bita Labibi

“…Solving the LMI problems, a robust memoryless state feedback control law is designed for all admissible uncertainties. The results depend on the size and varying rate of the delays.In this paper the presented model transformation and Lyapunov function can be applied further to H∞ control of linear uncertain systems with multiple state delays. …”
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Age-dependent integration of cortical progenitors transplanted at CSF-neurogenic niche interface by Gretchen Greene, Nikorn Pothayee, Jahandar Jahanipour, Hyesoo Jie, Jung-Hwa Tao-Cheng, Emily Petrus, Dragan Maric, Alan P. Koretsky

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POWER, METALLURGICAL AND CHEMICAL MECHANICAL ENGINEERING DEVICE OF PIECEWISE-LINEAR APPROXIMATION OF TRANSIENT RESPONSE OF CONTROLLED ELECTRONIC COMPONENTS by T. A. Ismailov, Kh. M. Gajiyev, D. A. Chelushkin

“…The input measuring integrated circuit is capable of controlling the transient responses of both individual electronic components and their groups, consisting of various types of active and passive electronic components. The dependency between the systematic error in the piecewise-linear approximation of the transient response of the electronic components on functional cells and the time constant (T) of the input circuit of the measurement unit is established. …”
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MKS5 and CEP290 Dependent Assembly Pathway of the Ciliary Transition Zone. by Chunmei Li, Victor L Jensen, Kwangjin Park, Julie Kennedy, Francesc R Garcia-Gonzalo, Marta Romani, Roberta De Mori, Ange-Line Bruel, Dominique Gaillard, Bérénice Doray, Estelle Lopez, Jean-Baptiste Rivière, Laurence Faivre, Christel Thauvin-Robinet, Jeremy F Reiter, Oliver E Blacque, Enza Maria Valente, Michel R Leroux

“…Together, our findings expand the repertoire of MKS module-associated proteins--including the previously uncharacterised mammalian Tmem80--and suggest an MKS-5 and CEP-290-dependent assembly pathway for building a functional TZ.…”
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LIPID-LOWERING AND PLEIOTROPIC EFFECTS OF ATORVASTATIN IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE by SVETLANA A. Smakotina, SVETLANA A. Berns, EVGENIYA B. Gerasimova

“…To investigate how 6-month atorvastatin treatment affects serum lipid profile, pulmonary function, cytokine profile, and endothelial function in patients with chronic obstructive pulmonary disease (COPD) but without cardiovascular disease (CVD). …”
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Comparative transcriptomics reveal stage-dependent parasitic adaptations in the myxozoan Sphaerospora molnari by Monika M. Wiśniewska, Jiří Kyslík, Gema Alama-Bermejo, Alena Lövy, Martin Kolísko, Astrid S. Holzer, Anush Kosakyan

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Experimental Implementation of Automatic Control of Posture-Dependent Stimulation in an Implanted Standing Neuroprosthesis by Brooke M. Odle, Lisa M. Lombardo, Musa L. Audu, Ronald J. Triolo

“…To this end, a feedback controller, named the “Posture Follower Controller”, was developed to aid in task-dependent posture shifting by individuals with spinal cord injury standing with functional neuromuscular stimulation. …”
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MicroRNA-Dependent Transcriptional Silencing of Transposable Elements in Drosophila Follicle Cells. by Bruno Mugat, Abdou Akkouche, Vincent Serrano, Claudia Armenise, Blaise Li, Christine Brun, Tudor A Fulga, David Van Vactor, Alain Pélisson, Séverine Chambeyron

“…Here we show, for the first time, that a functional miRNA pathway is required for the piRNA-mediated transcriptional silencing of TEs in this tissue. …”
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Maximum likelihood estimation of spatially dependent interactions in large populations of cortical neurons by Camille Godin, J. P. Thivierge, J. P. Thivierge

“…Here, we present a maximum likelihood estimation (MLE) framework to quantify distance-dependent functional interactions directly from observed spiking activity. …”
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Stability Results of Thermal Control System with Time-Dependent Delays and Perturbations of Nonlinearity by Dagne Asefa Gemechu, K. Prabakaran, Lalithamani N, S. Nagarajan, S. Umamaheswaran, Umamageshwari. S, Meseret Leta Feyisa

“…To get less conservative stability requirements, a new LK functional was assumed in the stability analysis, and the time-dependent of the (LK) functional was taken via the reciprocal convex combination approach. …”
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Wavelets for Nonparametric Stochastic Regression with Pairwise Negative Quadrant Dependent Random Variables

“…We propose a wavelet based stochastic regression function estimator for the estimation of the regression function for a sequence of pairwise negative quadrant dependent random variables with a common one-dimensional probability density function. …”
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Calcium-dependent oligomerization of scavenger receptor CD163 facilitates the endocytosis of ligands by Hua Xu, Xiaohui Song, Xiao-dong Su

“…The most extensively studied function of CD163 is related to the elimination of hemoglobin-haptoglobin (Hb-Hp) complexes, to prevent potential oxidative toxicity of the iron-containing heme. …”
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Voltage-Dependent Anion Channels in Male Reproductive Cells: Players in Healthy Fertility? by Stefano Conti Nibali, Giuseppe Battiato, Xena Giada Pappalardo, Vito De Pinto

“…Spermatozoa rely on mitochondrial oxidative metabolism for motility and fertilization, with mitochondria playing a crucial role in sperm energy production, calcium regulation, and redox balance. Voltage-dependent anion channels (VDACs), located on the outer mitochondrial membrane, regulate energy and metabolite exchange, which are essential for sperm function. …”
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