The dose-dependent effect of caffeine supplementation on performance, reaction time and postural stability in CrossFit – a randomized placebo-controlled crossover trial by Natalia Główka, Jakub Malik, Tomasz Podgórski, Rafał Stemplewski, Janusz Maciaszek, Julia Ciążyńska, Emilia E. Zawieja, Agata Chmurzynska, Paulina M. Nowaczyk, Krzysztof Durkalec-Michalski

“…Nevertheless, the CAF-induced, dose-dependent effect on discipline-specific performance and cognitive functions in CrossFit/High-Intensity Functional Training (HIFT) has not been sufficiently investigated. …”
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Advanced Software Package for Estimatiom Boundary Trajectories of Electron Beams and Other Practical Applications by Igor Melnyk, Mykhailo Skrypka, Alina Pochynok, Olga Demyanchenko

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Spatiotemporal patterns and prediction of multi-region house prices via functional mixed effects model by Yilin Chen, Haitao Zheng

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Probable and confirmed sarcopenia are still better predictors of disability than sarcopenic obesity following ESPEN/EASO consensus steps by Sibel Cavdar, Fatma Ozge Kayhan Kocak, Sumru Savas

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Diabetes-associated sleep fragmentation impairs liver and heart function via SIRT1-dependent epigenetic modulation of NADPH oxidase 4 by Yuanfang Guo, Jie Wang, Dongmei Zhang, Yufeng Tang, Quanli Cheng, Jiahao Li, Ting Gao, Xiaohui Zhang, Guangping Lu, Mingrui Liu, Xun Guan, Xinyu Tang, Junlian Gu

“…Here, our findings revealed that sleep fragmentation (SF) displayed notable hepatic detrimental phenotypes, including steatosis and oxidative damage, along with significant abnormalities in cardiac structure and function. All these pathological changes persisted even after sleep recovery for 2 consecutive weeks or more, displaying memory properties. …”
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Size-Dependent Thermoelastic Behavior Analysis of Functionally Graded Magneto-Electro-Elastic Cylindrical Shells Based on Modified Couple Stress Theory by Sajad Golchin Khazari, Younes Mohammadi, Mohammad Mahdi Kheirikhah

“…In this article, the influence of important parameters on the size-dependent thermoelastic behavior of functionally graded magneto-electro-thermo-elastic microcylinders (FGMEE) is studied by means of modified stress couple theory and under the influence of combined mechanical-thermal-magnetic loads. …”
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Time-Dependent Nuclear Energy-Density Functional Theory Toolkit for Neutron Star Crust: Dynamics of a Nucleus in a Neutron Superfluid by Daniel Pęcak, Agata Zdanowicz, Nicolas Chamel, Piotr Magierski, Gabriel Wlazłowski

“…It is based on the time-dependent Hartree-Fock-Bogoliubov theory with generalized Skyrme nuclear energy-density functionals of the Brussels-Montreal family. …”
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Echocardiographic Measures of Diastolic Function Are Preload Dependent during Triggered Positive Pressure Ventilation: A Controlled Crossover Study in Healthy Subjects by Peter Juhl-Olsen, Christian Alcaraz Frederiksen, Johan Fridolf Hermansen, Carl-Johan Jakobsen, Erik Sloth

“…Studies on indices of diastolic function report conflicting results with regard to dependence on volume status. …”
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Predicting cellular adaptation proteins dependent on eIF2α regulation under stress conditions: Physiological and pathophysiological implications in neuronal function by Víctor Herrera-Fernández, Hugo Fanlo-Ucar, Patrick Gohl, Melisa Ece Zeylan, Simge Senyuz, Ozlem Keskin, Attila Gursoy, Rubén Vicente, Baldo Oliva, Francisco J. Muñoz

“…Gene Ontology (GO) enrichment analysis identified significant biological processes, molecular functions, and cellular components involved. An interactome analysis using STRING-db highlighted pathways related to synaptoplasticity (physiological stress) and Alzheimer’s disease (pathophysiological stress). …”
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A simple size-dependent isogeometric approach for bending analysis of functionally graded microplates using the modified strain gradient elasticity theory by Chien H. Thai, H. Nguyen-Xuan

“… In this study, a simple size-dependent isogeometric approach for bending analysis of functionally graded (FG) microplates using the modified strain gradient theory (MSGT), simple first-order shear deformation theory (sFSDT) and isogeometric analysis is presented for the first time. …”
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Genome-Wide Analysis of PAPS1-Dependent Polyadenylation Identifies Novel Roles for Functionally Specialized Poly(A) Polymerases in Arabidopsis thaliana. by Christian Kappel, Gerda Trost, Hjördis Czesnick, Anna Ramming, Benjamin Kolbe, Son Lang Vi, Cláudia Bispo, Jörg D Becker, Cornelia de Moor, Michael Lenhard

“…As shown by their different mutant phenotypes, these three isoforms are functionally specialized, with PAPS1 modifying organ growth and suppressing a constitutive immune response. …”
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A Cross-sectional Study to Assess the Association between the Cognitive Function with Severity of Dependence and Motivation to Quit in Patients with Substance Use Disorder by Shivani Dua, Ramchandra Das, Sudipta Kumar Das

“…The severity of dependence on the substance was not significantly associated with either cognitive function or frontal lobe functioning. …”
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Identification and Functional Characterisation of CRK12:CYC9, a Novel Cyclin-Dependent Kinase (CDK)-Cyclin Complex in Trypanosoma brucei. by Séverine Monnerat, Cristina I Almeida Costa, Andrea C Forkert, Corinna Benz, Alana Hamilton, Laurence Tetley, Richard Burchmore, Carlos Novo, Jeremy C Mottram, Tansy C Hammarton

“…To date, relatively little is known about the function of many of the CRKs and cyclins, and only CRK3 has previously been shown to be cyclin-dependent in vivo. …”
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Astroglial modulation of synaptic function in the non-demyelinated cerebellar cortex is dependent on MyD88 signaling in a model of toxic demyelination by Melanie Lohrberg, Lena Sünke Mortensen, Carolina Thomas, Franziska Fries, Franziska van der Meer, Alexander Götz, Carolin Landt, Hong Jun Rhee, JeongSeop Rhee, David Gómez-Varela, Manuela Schmidt, Wiebke Möbius, Torben Ruhwedel, Luis A. Pardo, Linus Remling, Nadine Kramann, Claudia Wrzos, Erik Bahn, Christine Stadelmann, Alonso Barrantes-Freer

“…Proteomic analysis of the cerebellar cortex revealed differential regulation of synaptic and glutamate transport proteins in the absence of evident structural synaptic pathology or local gray matter demyelination. At the functional level, synaptic changes manifested as a reduction in frequency-dependent facilitation at the parallel fiber– Purkinje cell synapse. …”
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Dose-dependent changes in global brain activity and functional connectivity following exposure to psilocybin: a BOLD MRI study in awake rats by Evan Fuini, Arnold Chang, Richard J. Ortiz, Richard J. Ortiz, Taufiq Nasseef, Josh Edwards, Marc Latta, Elias Gonzalez, Taylor J. Woodward, Bryce Axe, Ashwath Maheswari, Noah Cavallaro, Heather B. Bradshaw, Praveen P. Kulkarni, Craig F. Ferris, Craig F. Ferris

“…There was a significant dose-dependent global increase in functional connectivity, highlighted by hyperconnectivity to the cerebellum. …”
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The Effects of Soil Cover Thickness on Leaf Functional Traits of Vine Plants in Mining Areas Depend on Soil Enzyme Activities and Nutrient Cycling by Ren Liu, Yun Sun, Zongming Cai, Ping He, Yunxia Song, Longhua Yu, Huacong Zhang, Yueqiao Li

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Anthocyanin attenuates pulmonary arterial hypertension and associated heart failure via improving mitochondrial function through Nrf2-dependent mechanism by Xiao Liu, Xiaoli Tan, Yidan Su, Luohao Zou, Wenhui Yuan, Changqing Yu

“…Finally, in Nrf2 deficient mice, the protective effects of anthocyanin on PAH were largely vanished.Conclusions Collectively, we showed that anthocyanin attenuated PAH and associated right heart failure via improving mitochondrial function through Nrf2-dependent mechanism, suggesting that anthocyanin may represent a novel therapeutic potential for PAH.…”
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Disease-Associated Dopamine Receptor D2 Variants Exhibit Functional Consequences Depending on Different Heterotrimeric G-Protein Subunit Combinations by Nele Niebrügge, Olga Trovato, Roman Praschberger, Andreas Lieb

“…<b>Conclusions:</b> Although our results indicate that the interaction of the two variants with the most highly expressed heterotrimeric G-protein complex subunit combinations also results in a gain-of-function phenotype, they also clearly demonstrate that the phenotype can be significantly altered, dependent on heterotrimeric G-protein complex expression.…”
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TMEM206 Contributes to Cancer Hallmark Functions in Colorectal Cancer Cells and Is Regulated by p53 in a p21-Dependent Manner by Korollus Melek, Barbara Hauert, Sven Kappel

“…Our results show that in colorectal cancer cells, TMEM206 expression is elevated, contributes to cancer hallmark functions, and its regulation is dependent on p53 through a p21-dependent mechanism.…”
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Angiotensin (1–7) Improves Pancreatic Islet Function via Upregulating PDX-1 and GCK: A Dose-Dependent Study in Mice by Ziwei Lin, Jiaqi Lin, Anqi Huang, Zixu Zhang, Xinyi Wu, Guoshu Yin, Chiju Wei, Wencan Xu

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