PEG-functionalized UiO-66 MOFs for targeted vincristine delivery: enhanced cytotoxicity in breast and ovarian cancer cell lines by Zahra Sadeghi Jam, Farzaneh Tafvizi, Parvin Khodarahmi, Parvaneh Jafari, Fahimeh Baghbani-Arani

“…This study aimed to develop a polyethylene glycol (PEG)-functionalized UiO-66 metal–organic framework (MOF) as a targeted drug delivery system for VIN in MDA-MB-231 (breast cancer) and A2780 (ovarian cancer) cell lines. …”
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The multi-functional reovirus σ3 protein is a virulence factor that suppresses stress granule formation and is associated with myocardial injury. by Yingying Guo, Meleana M Hinchman, Mercedes Lewandrowski, Shaun T Cross, Danica M Sutherland, Olivia L Welsh, Terence S Dermody, John S L Parker

“…Overall, our results indicate that σ3 functions to suppress PKR activation and subsequent SG formation during viral infection and that these functions correlate with virulence in mice.…”
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The impact of Toll-like receptors on the immune system functioning and on the immunopathogenesis of chronic hepatitis C: a modern view (literature review) by L. M. Syzova, T. I. Koval, V. I. Ilchenko, I. M. Zviaholska, О. M. Iziumska

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Sequence and copy number analyses of HEXB gene in patients affected by Sandhoff disease: functional characterization of 9 novel sequence variants. by Stefania Zampieri, Silvia Cattarossi, Ana Maria Oller Ramirez, Camillo Rosano, Charles Marques Lourenco, Nadia Passon, Isabella Moroni, Graziella Uziel, Antonella Pettinari, Franco Stanzial, Raquel Dodelson de Kremer, Nydia Beatriz Azar, Filiz Hazan, Mirella Filocamo, Bruno Bembi, Andrea Dardis

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USE OF A NUMERICAL ANALYTICAL MODEL FOR ASSESSING THE FUNCTIONAL EFFECTIVENESS OF AN INFORMATION PROTECTION SYSTEM BY ANALYSING ITS PROBABILISTIC-TEMPORAL CHARACTERISTICS by V. P. Alferov, A. V. Butskikh, A. V. Krisilov, A. D. Popov, E. A. Rogozin

“…Aim Currently, the implementation of computational experiments to determine the probabilistic-temporal characteristics of protection functions for automated information systems is a complex and costly task. …”
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Classification of female MDD patients with and without suicidal ideation using resting-state functional magnetic resonance imaging and machine learning by Morteza Fattahi, Milad Esmaeil-Zadeh, Hamid Soltanian-Zadeh, Hamid Soltanian-Zadeh, Hamid Soltanian-Zadeh, Reza Rostami, Jamil Mansouri, Gholam-Ali Hossein-Zadeh, Gholam-Ali Hossein-Zadeh

“…Spontaneous blood oxygen level-dependent signals can be indirectly recorded in different brain regions with functional magnetic resonance imaging. …”
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IFN-α and vitamin B6-induced galectin-9 promotes the immunomodulatory function of human clonal mesenchymal stem cells by Jee-Hoon Nam, Jeong Hyun Moon, Byeol Choi, Geun-Hyung Kang, Yunok Park, Se-Yeon Park, Tae-Hyun Ko, Donghee Shin, YoungSu Jung, Si-Na Kim, Yun-Kyoung Cho, Myung-Shin Jeon

“…Abstract Background Mesenchymal stem cells (MSCs) possess a variety of immunomodulatory functions that can vary depending on the MSC line. …”
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Enhanced Quality in Bean Products Through Mixed Fermentation: A Comparative Analysis of Physicochemical, Structural, and Functional Properties of Soybean Products by Yalin Li, Wenwen Zhang, Yongqi Chen, Liu Liu, Xiaoxia Wu, Ying Luo, Yuhuan Zhang

“…These findings establish synergistic microbial–metabolic regulation as a strategy for developing functional bean products with enhanced nutritional and sensory properties.…”
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Repression of Connexin26 hemichannel activity protects the barrier function of respiratory airway epithelial cells against LPS-induced alteration by Tina Lehrich, Anne Dierks, Masina Plenge, Helena Obernolte, Klaudia Grieger, Katherina Sewald, Frederic Rodriguez, Lucie Malet, Peter Braubach, Florence Bedos-Belval, Anaclet Ngezahayo

“…The small molecule CVB4-57, newly published as a potential inhibitor of Cx26 hemichannels, mitigated the effects of LPS on the epithelial barrier function. Molecular docking studies revealed a potential interaction between CVB4-57 and Cx26 thereby reducing its hemichannel activity. …”
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Improving the shelf-life and functionality of an orange juice by the addition of polyphenol-enriched extracts obtained using natural deep eutectic solvents by Clara Gomez-Urios, Lorenzo Siroli, Davide Gottardi, Simona Benedetti, Rosalba Lanciotti, Ana Frigola, Susanna Buratti, Jesus Blesa, Mattia Di Nunzio, Francesca Patrignani, Maria J Esteve

“…Overall, this study demonstrates the feasibility of extending the shelf life and enhancing the functionality of orange juice using NADES extracts and without compromising its organoleptic properties.…”
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Effect of ACE-inhibition on coronary microvascular function and symptoms in normotensive women with microvascular angina: A randomized placebo-controlled trial. by Marie Mide Michelsen, Anna Bay Rask, Elena Suhrs, Kristoffer Flintholm Raft, Nis Høst, Eva Prescott

“…No changes were detected in parameters of systolic and diastolic function. No serious adverse reactions were reported.…”
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The C2238/αANP variant is a negative modulator of both viability and function of coronary artery smooth muscle cells. by Speranza Rubattu, Speranza Rubattu, Simona Marchitti, Franca Bianchi, Sara Di Castro, Rosita Stanzione, Maria Cotugno, Cristina Bozzao, Sebastiano Sciarretta, Massimo Volpe

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Natural SEL1L variants rescue a model of NGLY1 deficiency and modify ERAD function and proteasome sensitivity. by Travis K Tu'ifua, Clement Y Chow

“…We found that the SEL1LS780P and SEL1LΔ806-809 variants improve resistance to ER stress, with enhanced ERAD function as a likely contributing mechanism. This effect depends on NGLY1 activity, further implicating NGLY1 in general ERAD function. …”
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Impact of Fear and Habitat Complexity in a Predator-Prey System with Two Different Shaped Functional Responses: A Comparative Study by Debgopal Sahoo, Guruprasad Samanta, Manuel De la Sen

“…In this study, we investigate the interplay between the level of fear and the degree of habitat complexity in a predator-prey model with two different shaped functional responses. We, therefore, develop the functional response using the timescale separation method, and the shape of the resulting functional response depends upon the monotonous property of catch rate, gN where N is the prey biomass. …”
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The Toll-like receptor 4 polymorphism Asp299Gly but not Thr399Ile influences TLR4 signaling and function. by Huaicong Long, Brian P O'Connor, Rachel L Zemans, Xiaofang Zhou, Ivana V Yang, David A Schwartz

“…The purpose of this study was to identify the relative contributions of the Asp299Gly and the Thr399Ile variants in inhibiting the function of TLR4. 293/hMD2-CD14 cell line was transfected with lentiviral constructs containing human wild type (WT) TLR4-EGFP or TLR4-EGFP with Asp299Gly, Thr399Ile or Asp299Gly/Thr399Ile complementary DNA (cDNA). …”
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Characterizing the Endophytic Microbiome and Microbial Functional Assemblages Associated with Fengtang Plum (<i>Prunus salicina</i> Lindl.) Development and Resistance by Jiqing Lei, Yinna Shi, Hong Li, Rui Wang

“…This study elucidates microbial community succession patterns during Fengtang plum development; notably, functional predictions were inferred from 16S/ITS sequencing data rather than direct metagenomic or metatranscriptomic analyses, thus limiting mechanistic interpretations, though future work integrating multi-omics approaches would strengthen functional insights.…”
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Stimulation of regulatory dendritic cells suppresses cytotoxic T cell function and alleviates DEN-induced liver injury, fibrosis and hepatocellular carcinoma by Junjie Wang, Pixu Gong, Qingqing Liu, Menglei Wang, Dengfang Wu, Mengyu Li, Shujie Zheng, Han Wang, Han Wang, Qiaoming Long

“…The observed functional changes of T cells correlated well with the presence of a hepatic DC subset displaying a regulatory or tolerogenic transcriptional signature.ConclusionOverall, these data suggest that stimulation of regulatory dendritic cells (rDCs) in the liver by LAP suppresses cytotoxic T-cell function and alleviates DEN-induced liver damage, fibrosis and tumorigenesis.…”
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Comparison of anterior and posterior approaches for functional improvement in cervical myelopathy: A systematic review and meta-analysis of 33,025 patients by Abdulsalam Aleid, MD, Saud Aldanyowi, MD, Hasan Alaidarous, MD, Zainab Aleid, MD, Abdulaziz Alharthi, MD, Abbas Al Mutair, MD

“…Conclusions: Studies suggest that an anterior approach for cervical myelopathy may improve nerve function, correct spinal curvature more effectively, and lead to fewer complications, less pain, reduced blood loss, and a shorter hospital stay compared to a posterior approach.…”
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HAX1, gene responsible for Kostmann syndrome, regulates gingival epithelial barrier function via intracellular trafficking of JAM1 by Keita Tanigaki, Tsukasa Tamamori, Naoko Sasaki, Risako Matsumura, Shunsuke Yamaga, Akito Sakanaka, Atsuo Amano, Michiya Matsusaki, Hiroki Takeuchi, Masae Kuboniwa

“…In the present study, the effects of HAX1 on gingival barrier function were investigated.ResultsExaminations of immortalized human gingival epithelial (IHGE) cells showed HAX1 localization in mitochondria. …”
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E2F2 Reprograms Macrophage Function By Modulating Material and Energy Metabolism in the Progression of Metabolic Dysfunction‐Associated Steatohepatitis by Zheng Liu, Hao Wang, Yuan Liang, Mu Liu, Qiyuan Huang, Mingming Wang, Jinren Zhou, Qingfa Bu, Haoming Zhou, Ling Lu

“…E2F2 deficiency upregulates the expression of SLC7A5 to mediate amino acids flux, resulting in enhanced glycolysis, impaired mitochondrial function, and increased macrophages proinflammatory response in a Leu‐mTORC1‐dependent manner. …”
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