Syncytiotrophoblast extracellular vesicles impair rat uterine vascular function via the lectin-like oxidized LDL receptor-1. by Floor Spaans, Cindy K Kao, Jude S Morton, Anita L Quon, Tatsuya Sawamura, Dionne S Tannetta, Ian L Sargent, Sandra T Davidge

“…Uterine arteries were obtained in late gestation from Sprague-Dawley rats and incubated for 24h with or without human STBEVs (derived from a normal pregnant placenta) in the absence or presence of a LOX-1 blocking antibody. Vascular function was assessed using wire myography. Endothelium-dependent maximal vasodilation to methylcholine was impaired by STBEVs (MCh Emax: 57.7±5.9% in STBEV-incubated arteries vs. 77.8±2.9% in controls, p<0.05). …”
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Neuropilin-1/GIPC1 signaling regulates alpha5beta1 integrin traffic and function in endothelial cells. by Donatella Valdembri, Patrick T Caswell, Kurt I Anderson, Juliane P Schwarz, Ireen König, Elena Astanina, Francesca Caccavari, Jim C Norman, Martin J Humphries, Federico Bussolino, Guido Serini

“…In conclusion, we propose that Nrp1, in addition to and independently of its role as coreceptor for VEGF-A165 and SEMA3A, stimulates through its cytoplasmic domain the spreading of ECs on fibronectin by increasing the Rab5/GIPC1/Myo6-dependent internalization of active alpha5beta1. Nrp1 modulation of alpha5beta1 integrin function can play a causal role in the generation of angiogenesis defects observed in Nrp1 null mice.…”
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Effect of Spinal Versus General Anesthesia on Pulmonary Functions among Adults at Al-Sadder Medical City: Comparative Study by Mohammed A. Mustafa Al-Janabi

“…Conclusions: The study concluded that anesthesia has effect on pulmonary function. Recommendations: The study recommended that breathing techniques should use for patients before anesthesia and smoking cessation before 4-8 weeks of surgery Studies should evaluate the clinical effects of different anesthesia regimes in patients with compromised lung function, and Reduction in FVC after surgery should influence the clinician decision at this time when choosing between general and spinal anesthesia depends on the particular clinical situation, possible other disorders, and the surgical demands. …”
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In-depth analysis of cystic fibrosis cases caused by CFTR gene variation and research on the prediction and simulation of the impact on protein function by Yuxia Shan, Ziwei Zhu, Xiaomei Liu, Lei Chi, Jianqin Zhang, Li Cheng, Tianyi Liu

“…Five tools, namely Mutation Taster, PolyPhen-2, SIFT, FATHMM, and PROVEAN, were used to predict the impacts of mutations on protein function. AlphaFold was employed to predict protein structures, and GROMACS software was used to conduct stability analysis through molecular dynamics simulations.ResultsThe child was diagnosed with severe pneumonia, plastic bronchitis, and acute asthmatic bronchitis, with a high suspicion of CF. …”
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Climate is stronger than you think: Exploring functional planting and TRIAD zoning for increased forest resilience to extreme disturbances. by Clément Hardy, Christian Messier, Yan Boulanger, Dominic Cyr, Élise Filotas

“…In this perspective, we modified the TRIAD zoning approach to add a resilience component through functionally diverse plantations following harvesting in the extensive areas. …”
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Moving beyond species: fungal function in house dust provides novel targets for potential indicators of mold growth in homes by Neeraja Balasubrahmaniam, Jon C. King, Bridget Hegarty, Karen C. Dannemiller

“…We need new quantitative methods to identify homes with potentially harmful fungal growth that are not dependent upon species. The goal of this study was to identify genes consistently associated with fungal growth and associated function under damp conditions for use as potential indicators of mold in homes regardless of fungal species present. …”
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Plant Functional Traits and Soil Nutrients Drive Divergent Symbiotic Fungal Strategies in Three Urban Street Tree Species by Yifan Xue, Yao Wang, Jiang Shi, Jingyao Wei, Qiong Wang, Wenchen Song

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Human neural stem cells directly programmed from peripheral blood show functional integration into the adult mouse brain by Lea Jessica Berg, Chung Ku Lee, Hideaki Matsumura, Anke Leinhaas, Rachel Konang, Ali H. Shaib, Pedro Royero, Julia Schlee, Chao Sheng, Heinz Beck, Martin Karl Schwarz, Nils Brose, Jeong Seop Rhee, Oliver Brüstle

“…Engrafted cells gave rise to stable transplants composed of mature neurons displaying extensive neurite outgrowth and dendritic spine formation. Functional analyses of acute slices using patch clamp recordings revealed that already after 12 weeks of in vivo maturation, most of iNSC-derived cells possess unique properties exclusive to neurons and exhibit voltage-dependent ion channel currents as well as action potential firing. …”
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Analysis of structural and functional central nervous system abnormalities associated with prenatal exposure to ethanol in children of primary school age by E. V. Fadeeva, A. M. Lanovaya, A. Yu. Nenastieva, G. A. Korchagina

“…A serious functional disorder of the CNS, manifested by mild and moderate mental retardation, was found in 23 children (30%). …”
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Interactions of the anti-FcRn monoclonal antibody, rozanolixizumab, with Fcγ receptors and functional impact on immune cells in vitro by Omar S. Qureshi, Emma J. Sutton, Rosemary F. Bithell, Shauna M. West, Rona M. Cutler, Gillian McCluskey, Graham Craggs, Asher Maroof, Nicholas M. Barnes, David P. Humphreys, Stephen Rapecki, Bryan J. Smith, Anthony Shock

“…Furthermore, data from in vitro experiments using relevant human cell types that express both FcRn and FcγRI indicated no evidence for functional sequelae in relation to cellular activation events (e.g., intracellular signaling, cytokine production) upon either FcRn or FcγR binding of rozanolixizumab. …”
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Cetylpyridinium chloride disrupts maternal-to-zygotic transition during early embryonic development by impairing mitochondrial function and histone modification by Caiyun Wu, Zhiming Ding, Xuanxi Li, Yan Xu, Huilei Chen, Hongzhen Ruan, Ping Zhou, Zuying Xu, Huifen Xiang

“…Functional enrichment analysis further revealed that DEGs were significantly involved in pathways and processes related to mitochondrial function, ROS, and gene transcription. …”
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Functionalization of surfactant templated magnetite by chitosan and PEGylated/Chitosan – In vitro studies on drug loading, release and anti-proliferative activity by Nasima Arshad, Maliha Khan, Muhammad Waseem, Mohd Afzal, Abdullah Alarifi, Rahman Shah Zaib Saleem

“…Magnetite iron oxide nanoparticles (MNPs) were synthesized using micro emulsion assisted co-precipitation method. The surface functionalization of MNPs was done with chitosan and PEGylated/chitosan and three samples of each were prepared. …”
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COMPREHENSIVE THERAPY OF ENDO-PERIODONTAL LESIONS: MOVING STEP BY STEP TOWARDS COMPLETE FUNCTIONAL REHABILITATION OF PATIENTS WITH COMBINED PATHOLOGY by Yu.O. Kinash, L.V. Kinash

“…The comprehensive therapy included endodontic treatment of the affected teeth (both conservative and surgical interventions), bone augmentation (depending on the extent of the lesion), and occlusal rehabilitation with the restoration of group function on the laterotrusion side performed by all working side teeth using CAD/CAM technology. …”
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Characterizing Neurocardiovascular Responses to an Active Stand Test in Older Women: A Pilot Study Using Functional Data Analysis by Feng Xue, Roman Romero-Ortuno

“…This observational pilot study investigated neurocardiovascular responses to an active stand test using continuous physiological monitoring and functional data analysis (FDA) in older women. A sample of 25 community-dwelling female adults aged 59–78 years (mean age: 70.3 years) participated. …”
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INFLUENCE OF CHROMIUM PICOLINATE ON THE FUNCTIONING OF THE NITRIC OXIDE CYCLE IN THE BICEPS FEMORIS MUSCLE OF RATS UNDER CONDITIONS OF METABOLIC SYNDROME by O.Ye. Akimov, A.O. Mykytenko, V.O. Kostenko

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Milkweed (Asclepias syriaca) invasion, forest-steppe fragment size and isolation jointly constrain arthropod communities and their functional traits by Róbert Gallé, Ágota Réka Szabó, Edina Török, Tamás Lakatos, Dávid Korányi, Attila Torma, Nikolett Gallé-Szpisjak, Péter Batáry

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How Do Occupational Sedentary Behavior and Occupational Cognitive Complexity Relate to Cognitive Function? A Cross‐Sectional Study by Nabeela Rizvi, Honghuang Lin, Alexa S. Beiser, Nicole L. Spartano

“…Analysis of covariance (ANCOVA) models were used to evaluate the association of occupational sedentary time (independent variable) with cognitive function (dependent variable), including models adjusting for age, sex, leisure time physical activity (LTPA), education, and OCC. …”
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Age- and gender-related differences in explosive leg muscle function with respect to jump tests used: a comparative study by Erika Zemková, Gabriela Kotyrová Štefániková

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Effects of Different Treatments on the Structure and in Vitro Hypolipidemic Function of Soluble Dietary Fiber from Rosa roxburghii Tratt Pomace by Renwei ZHU, Sha TAN, Qingqing LIU, Jia SHI, Xiaonian WU

“…The yield, structure, and in vitro hypolipidemic function of the four dietary fibers were investigated. …”
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Executive function at baseline and follow-up in opioid maintenance patients and its relation to psychiatric comorbidity and substance use patterns by John Hanson Högberg, Björn Philips, Jonas Nielsen, Stina Richter Simsek, Kristina Berglund

“…Abstract Background Research investigating executive functions in opioid-dependent patients undergoing opioid maintenance treatment (OMT) is scarce. …”
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