Structural and functional studies of rabbit SAMD9 reveal a distinct tRNase module that underlies the antiviral activity. by Juhi Chaturvedi, Fushun Zhang, Chen Zhang, Sonal Badhe, Yan Xiang, Junpeng Deng

“…These findings demonstrate that lagomorph SAMD9 preserves core tRNA-targeting and antiviral functions despite a key residue variation and the need for an extended tRNase module.…”
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The crucial function of IDO1 in pulmonary fibrosis: From the perspective of mitochondrial fusion in lung fibroblasts and targeted molecular inhibition by Lei Wang, Shanchun Ge, Ye Zhang, Deqin Feng, Ting Zhu, Louqian Zhang, Chaofeng Zhang

“…Indoleamine 2,3-dioxygenase 1 (IDO1) is expressed in lung fibroblasts and epithelial cells, but its functions in lung homeostasis and diseases remain elusive. …”
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Chemosensory protein 16 has an immune function and participates in host-pathogen interaction in Galleria mellonella infected with Pseudomonas entomophila by Jakub Kordaczuk, Michał Sułek, Paweł Mak, Alicja Frączek, Iwona Wojda

“…Taking into account its immune properties and putative ability to bind bacteria-derived compounds, the possible function of CSP16 in the host-pathogen interaction is discussed.…”
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Acceleration of Functional Maturation and Differentiation of Neonatal Porcine Islet Cell Monolayers Shortly In Vitro Cocultured with Microencapsulated Sertoli Cells by Francesca Mancuso, Mario Calvitti, Giovanni Luca, Claudio Nastruzzi, Tiziano Baroni, Stefania Mazzitelli, Ennio Becchetti, Iva Arato, Carlo Boselli, Monique D. Ngo Nselel, Riccardo Calafiore

“…The insulin/c-kit positive cells might represent a new, still unknown functionally immature β-cell like element in the porcine pancreas. …”
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Differences in bird and bat traits, seed-dispersal interactions and functions between tropical montane forest and bracken-dominated areas by Cesar Mayta, Cesar Mayta, Cesar Mayta, Matthias Schleuning, Cecilia L. López, Cecilia L. López, Cecilia L. López, Mariana Villegas, Mariana Villegas, Isabell Hensen, Isabell Hensen, Silvia C. Gallegos, Silvia C. Gallegos, Silvia C. Gallegos

“…In this study, we analyze the differences on the composition of functional traits and on seed-dispersal interactions and functions by birds and bats between forest and deforested areas dominated by bracken fern. …”
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Functional Characterization of <i>TNFα</i> in the Starry Flounder (<i>Platichthys stellatus</i>) and Its Potential as an Immunostimulant by Min-Young Sohn, Gyoungsik Kang, Kyung-Ho Kim, Ha-Jeong Son, Chan-Il Park

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The role of regulatory CD4+CD25+high T-lymphocytes and their functional activity in the development of type 1 diabetes mellitus by Tatiana Vasil'evna Nikonova, Pavel Vasil'evich Apanovich, Elena Vladimirovna Pekareva, Vera Anatol'evna Gorelysheva, Sergey Alexandrovich Prokof'ev, Alexander Vasil'evich Karpukhin, Ivan Ivanovich Dedov

“…Detection of quantitative and functional alterations at the level of regulation of immunity in subjects at risk of DM1 and patients with different duration of DM1. …”
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Estimation and diagnostic for single-index partially functional linear regression model with $ p $-order autoregressive skew-normal errors by Lijie Zhou, Liucang Wu, Bin Yang

“…This work bridged significant gaps in functional data analysis by simultaneously addressing dimension reduction, temporal dependence, and distributional asymmetry, which are crucial challenges in modern energy analytics and biomedical studies.…”
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A Helicobacter pylori flagellar motor accessory is needed to maintain the barrier function of the outer membrane during flagellar rotation. by Kyle Rosinke, Shoichi Tachiyama, Jan Mrásek, Jun Liu, Timothy R Hoover

“…Our data suggest that the FapH ring helps to preserve outer membrane barrier function during flagellar rotation. Given that FapH homologs are present in many members of the phylum Campylobacterota, they may have similar roles in protecting the outer membrane from damage due to flagellar rotation in these bacteria.…”
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Trends in indirect liver function marker testing in Wales from 2000 to 2017 and their association with age and sex: an observational study by Joe West, Joanne R Morling, Trevor Alexander Hill, Colin John Crooks

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Remote Sensing of Multitemporal Functional Lake‐To‐Channel Connectivity and Implications for Water Movement Through the Mackenzie River Delta, Canada by W. Dolan, T. M. Pavelsky, A. Piliouras

“…The degree to which this filtering takes place depends on the ease with which sediment‐laden water is transported from distributary channels into deltaic lakes, referred to as functional lake‐to‐channel connectivity, which varies both spatially and temporally. …”
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Extrafollicular CD4 T cell-derived IL-10 functions rapidly and transiently to support anti-Plasmodium humoral immunity. by Fionna A Surette, Jenna J Guthmiller, Lei Li, Alexandria J Sturtz, Rahul Vijay, Rosemary L Pope, Brandon L McClellan, Angela D Pack, Ryan A Zander, Peng Shao, Linda Yu-Ling Lan, Daniel Fernandez-Ruiz, William R Heath, Patrick C Wilson, Noah S Butler

“…Immunity against malaria depends on germinal center (GC)-derived antibody responses that are orchestrated by T follicular helper (TFH) cells. …”
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Small heat shock protein B8: from cell functions to its involvement in diseases and potential therapeutic applications by Marta Chierichetti, Riccardo Cristofani, Valeria Crippa, Veronica Ferrari, Marta Cozzi, Elena Casarotto, Paola Pramaggiore, Laura Cornaggia, Guglielmo Patelli, Ali Mohamed, Margherita Piccolella, Mariarita Galbiati, Paola Rusmini, Barbara Tedesco, Angelo Poletti

“…This review aims to summarize the diverse and multiple functions of HSPB8 in different pathological conditions, focusing on the beneficial effects of its modulation. …”
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Hsp70 cochaperones HspBP1 and BAG-1M differentially regulate steroid hormone receptor function. by Regina T Knapp, Michael J H Wong, Lorenz K Kollmannsberger, Nils C Gassen, Anja Kretzschmar, Jürgen Zschocke, Kathrin Hafner, Jason C Young, Theo Rein

“…Hsp70 binding protein 1 (HspBP1) and Bcl2-associated athanogene 1 (BAG-1), the functional orthologous nucleotide exchange factors of the heat shock protein 70 kilodalton (Hsc70/Hsp70) chaperones, catalyze the release of ADP from Hsp70 while inducing different conformational changes of the ATPase domain of Hsp70. …”
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Oncolytic adeno-immunotherapy improves allogeneic adoptive HER2.CAR-NK function against pancreatic ductal adenocarcinoma by Greyson Biegert, Amanda Rosewell Shaw, Daisuke Morita, Caroline Porter, Ryu Matsumoto, Lisa Jatta, Noah Crooks, Mae Woods, Qizhi Cathy Yao, Robin Parihar, Masataka Suzuki

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Quercetin-Loaded Ginkgo Starch Nanoparticles: A Promising Strategy to Improve Bioactive Delivery and Cellular Homeostasis in Functional Foods by Yanyu Sun, Kaiping Cong, Tao Wang, Xiaojing Li, Tingting Li, Gongjian Fan, Dandan Zhou, Caie Wu

“…This study reveals the potential of the SNPs/Qc system as a biocompatible and efficient delivery platform for natural bioactive compounds, particularly in health promotion and functional food applications.…”
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Functional organotypic human lymph node model with native immune cells benefits from fibroblastic reticular cell enrichment by Andrew I. Morrison, Jesse E. Kuipers, Henk P. Roest, Luc J. W. van der Laan, Charlotte M. de Winde, Jasper J. Koning, Susan Gibbs, Reina E. Mebius

“…Abstract Lymphoid organ function depends on fibroblastic reticular cells (FRCs), the non-hematopoietic mesenchymal stromal cells that crucially support immune activity in human lymph nodes (LNs). …”
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Effect of extraction processes on the physicochemical and functional properties of protein-rich extracts from the red seaweed Pyropia Seriata (Nori) by Bohan Zhang, Yaoyao Peng, Pattarasuda Rawiwan, Tom Wheeler, Joshua Fitzgerald, Lee Huffman, Siew Young Quek

“…This study examined the physicochemical and techno-functional properties of protein extracts from the red seaweed (Pyropia seriata). …”
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Markers of Gut Health in Small Animals: Focus on Fatty Acids and Amino Acids as Indicators of Intestinal Functionality and Microbiome Activity by Ana I. Rey, Cristina Higueras, Patricia Olmeda, Angel Sainz, Beatriz G. Gálvez, Mar Larrosa

“…Chronic inflammatory enteropathies (CIEs) in companion animals represent a group of idiopathic, immune-mediated gastrointestinal disorders in which the intestinal epithelium can be altered, affecting intestinal functionality, nutrient absorption, and microbiota composition. …”
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Coupling of mitochondrial function and skeletal muscle fiber type by a miR‐499/Fnip1/AMPK circuit by Jing Liu, Xijun Liang, Danxia Zhou, Ling Lai, Liwei Xiao, Lin Liu, Tingting Fu, Yan Kong, Qian Zhou, Rick B Vega, Min‐Sheng Zhu, Daniel P Kelly, Xiang Gao, Zhenji Gan

“…Here, we show that the expression of the genes encoding type I myosins, Myh7/Myh7b and their intronic miR‐208b/miR‐499, parallels mitochondrial function during fiber type transitions. Using in vivo approaches in mice, we found that miR‐499 drives a PGC‐1α‐dependent mitochondrial oxidative metabolism program to match shifts in slow‐twitch muscle fiber composition. …”
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