The interaction of tPA with NMDAR1 drives neuroinflammation and neurodegeneration in α-synuclein-mediated neurotoxicity by Daniel Torrente, Enming J. Su, Alí Francisco Citalán-Madrid, Gerald P. Schielke, Daniel Magaoay, Mark Warnock, Tamara Stevenson, Kris Mann, Flavie Lesept, Nathalie Delétage, Manuel Blanc, Erin H. Norris, Denis Vivien, Daniel A. Lawrence

“…Abstract The thrombolytic protease tissue plasminogen activator (tPA) is expressed in the CNS, where it regulates diverse functions including neuronal plasticity, neuroinflammation, and blood-brain-barrier integrity. …”
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Quality management system in vocational education of the Republic of Belarus: Improvement strategy by V. N. Golubovsky

“…The contradiction between the declaration of goals in the field of quality of education in strategic programme documents and the attempt to achieve them exclusively through the control function determines the need to improve the quality management system of vocational education in the Republic of Belarus in modern conditions.Aim. …”
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Defining criteria for disease activity states in juvenile dermatomyositis based on the Juvenile Dermatomyositis Activity Index by Carine Wouters, Nicolino Ruperto, Maria Trachana, Angelo Ravelli, Veronika Vargová, Troels Herlin, Angela Pistorio, Pavla Dolezalova, Claudia Bracaglia, Alessandro Consolaro, Silvia Rosina, Ana Rebollo-Giménez, Ana Guilaisne Bernard-Medina, Laura Carenini

“…Objectives To develop and validate the cut-offs in the Juvenile DermatoMyositis Activity Index (JDMAI) to distinguish the states of inactive disease (ID), low disease activity (LDA), moderate disease activity (MDA) and high disease activity (HDA) in children with juvenile dermatomyositis (JDM).Methods For cut-off definition, data from 139 patients included in a randomised clinical trial were used. …”
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An Adiabatic-Expansion-Induced Perturbation Study on Gas–Aerosol Partitioning in Ambient Air—Formation of NH₄NO₃ and Microdroplet Nitrogen Fixation (2) by Yating Gao, Qinchu Fan, Yujiao Zhu, Hengqing Shen, Qi Yuan, Yang Gao, Huiwang Gao, Xiaohong Yao

“…However, the current observational data do not allow us to derive a functional relationship between the redox reaction rate and these parameters, nor to fully detail the underlying chemistry. …”
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Piezo1/ITGB1 Synergizes With Ca2+/YAP Signaling to Propel Bladder Carcinoma Progression via a Stiffness‐Dependent Positive Feedback Loop by Minghai Ma, Jianpeng Li, Xing Li, Minxuan Jing, Lu Wang, Yunzhong Jiang, Zezhong Yang, Jiale He, Min Wang, Hang Liu, Yutong Chen, Kaibo Mi, Lei Wang, Jinhai Fan, Hongxia Du

“…This study systematically investigates the functional synergy of Piezo1/ITGB1 in orchestrating ECM biomechanical remodeling to fuel BLCA progression. …”
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Menstrual blood and ritual beliefs: a qualitative study on menstrual health and hygiene practices among senior high school girls in Volta Region, Ghana by Sitsofe Gbogbo, Israel Wuresah, Wisdom Axame, Priscilla Klutse, Emmanuel Gbogbo, Robert Kokou Dowou, Sarah Odi Mantey, Sarah Abena Yeome Ayitey, Ishmael Boateng, Paramount Eli Nelson, Nuworza Kugbey, Victor Christian Korley Doku, Julie Hennegan, Frank E. Baiden, Fred N. Binka

“…Additionally, water and hygiene facilities were mostly inadequate, with many girls relying on poorly maintained pit latrines and non-functional flushing toilets. Conclusion The study found a mismatch between what girls say they do with menstrual waste and what actually happens in schools. …”
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Dissecting genomic regions and underlying candidate genes in groundnut MAGIC population for drought tolerance by Vinay Sharma, Supriya S. Mahadevaiah, Putta Latha, S. Anjan Gowda, Surendra S. Manohar, Kanchan Jadhav, Prasad Bajaj, Pushpesh Joshi, T. Anitha, Mangesh P. Jadhav, Shailendra Sharma, Pasupuleti Janila, Ramesh S. Bhat, Rajeev K. Varshney, Manish K. Pandey

“…In this study, a multi-parent advanced generation inter-cross (MAGIC) population was developed and evaluated for five seasons at two locations for three consecutive years (2018–19, 2019–20 and 2020–21) under drought stress and normal environments. Results Phenotyping data of drought tolerance related traits, combined with the high-quality 10,556 polymorphic SNPs, were used to perform multi-locus model genome-wide association study (GWAS) analysis. …”
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Proteomic profiling improves prognostic risk stratification of the Sarculator nomogram in soft tissue sarcomas of the extremities and trunk wall by Madhumeeta Chadha, Sara Iadecola, Andrew Jenks, Valeriya Pankova, Yuen Bun Tam, Jessica Burns, Amani Arthur, Christopher P. Wilding, Liang Chen, Priya Chudasama, Dario Callegaro, Dirk C. Strauss, Khin Thway, Alessandro Gronchi, Robin L. Jones, Rosalba Miceli, Sandro Pasquali, Paul H. Huang

“…Results DNA replication and cell cycle proteins were upregulated in high‐risk versus very low‐risk patients. Evaluation of the functional effects of CRISPR‐Cas9 gene knockdown of proteins enriched in high‐risk patients using the cancer cell line encyclopaedia database identified candidate drug targets. …”
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Diffusion imaging changes in the treated tract following focused ultrasound thalamotomy for tremor by Erin L. Mazerolle, Robyn Warwaruk-Rogers, Paul Romo, Tejas Sankar, Sarah Scott, Conrad P. Rockel, Samuel Pichardo, Davide Martino, Zelma H.T. Kiss, G. Bruce Pike

“…No significant correlations were detected between diffusion measures and clinical effects, suggesting that microstructural changes in the treated portion of the DRTT alone do not fully explain tremor reduction and motivating additional research using higher spatial resolution diffusion imaging and multimodal approaches such as integrating diffusion and functional magnetic resonance imaging data. Our individualized approach, in which patient-specific lesions are incorporated into the tractography analysis, provided novel insight into both immediate and longer term MRgFUS-related microstructural brain changes.…”
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Enhancing Process Efficiency in Industry Through Statistical Process Control: Study of Aspartyl Phenylalanine Methyl Ester by Mostafa Essam Eissa

“…Data corresponding to selected inspection attributes were imported into Minitab version 17.1.0 for subsequent statistical analysis. …”
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Impact of HbA1c variability and time‐in‐range fluctuations on large and small nerve fiber dysfunction in well‐controlled type 2 diabetes: A prospective cohort observational study... by Yun‐Ru Lai, Wen‐Chan Chiu, Ben‐Chung Cheng, I‐Hsun Yu, Ting‐Yin Lin, Hui‐Ching Chiang, Chun‐En Aurea Kuo, Cheng‐Hsien Lu

“…Results Linear regression analysis adjusted for age, diabetes duration, and renal function revealed strong correlations between HbA1c ARV, TIR ARV, and diabetes duration. …”
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Recognition of HER2 expression in hepatocellular carcinoma and its significance in postoperative tumor recurrence by Ji‐Hua Shi, Wen‐Zhi Guo, Yang Jin, Hua-Peng Zhang, Chun Pang, Jie Li, Pål‐Dag Line, Shui‐Jun Zhang

“…Trastuzumab intravenous injection inhibited in vivo tumor size and metastases (P < 0.05). Signal analysis revealed that HER2 functioned through upregulation of β‐catenin and inhibition of SMAD3. …”
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WABAH CORONA DAN UNGGAHAN DI INSTAGRAM: ANALISIS KOMPONEN TINDAK TUTUR by Anak Agung Ayu Dian Andriyani, I Gusti Agung Sri Rwa Jayantini

“…In-depth interviews were also conducted involving 20 Instagram users to be utilized as supporting data for more comprehensive analysis. The data were analyzed using domain analysis, taxonomy, componential analysis, and cultural theme observation by taking into account the context of situation. …”
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Effect of the gut core microbiota Cetobacterium on the growth, physiology, and nutritional metabolism of Nile tilapia (Oreochromis niloticus) by Miao Wang, Chenglin Tang, Ziyue Zhang, Zijian Fan, Lijin Jiang, Zhigang Liu, Jianmeng Cao, Zhang Wang, Maixin Lu, Mengmeng Yi, Xiaoli Ke

“…Our results showed that dietary supplementation with NK01 significantly improved carcass ratio, increased levels of insulin and amino acids in the serum, and reduced serum glucose and TG levels as well as gut carbohydrate content. Furthermore, analysis of the liver transcriptome and RT-qPCR data indicated a decrease of genes expression of fatty acid synthesis (SREB 1c, ACCα, and FAS) with NK01 supplementation feeding group. …”
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Leksikon unsur-unsur struktur bangunan rumah adat Joglo Surakarta: Kajian etnolinguistik by Mido Mashela Jaya, Aliifa Khoiru Rajwa, Alexander Fanky Carelino, Mei Lestari Mardiyani, Miftah Nugroho

“…The use of data provision techniques through recording and analysis shows that there is a cultural meaning of the elements of the building structure of the Surakarta Joglo traditional house as shown by the data from the object of research which presents both meaning and definition in each structure of the Surakarta Joglo traditional house. …”
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Vitamin D in the prevention of exacerbations of asthma in preschoolers (DIVA): protocol for a multicentre randomised placebo-controlled triple-blind trial by Mohsen Sadatsafavi, Megan E Jensen, Francine M Ducharme, Nathalie Alos, Geneviève Mailhot, Benoît Mâsse, John H White, Ali Khamessan, Sze Man Tse, Reza Alizadehfar, Dirk E Bock, Patrick Daigneault, Chantal Lemire, Connie Yang, Dhenuka Radhakrishnan

“…Although evidence suggests that vitamin D supplements significantly decrease URTIs and asthma exacerbations requiring OCS, there is insufficient data in preschoolers. This study aims to determine the impact of vitamin D3 supplementation on exacerbations requiring OCS, in preschoolers with recurrent URTI-induced asthma exacerbations.Methods and analysis This is a phase III, randomised, triple-blind, placebo-controlled, parallel-group multicentre trial of vitamin D3 supplementation in children aged 1–5 years, with asthma triggered by URTIs and a recent history of frequent URTIs and OCS use. …”
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Fungal Footprints: Soil Fungal Communities in Black Walnut and Red Oak Forests by Shaneka S. Lawson, Juan P. Frene, Niall D. Lue Sue

“…Soil fungal communities are critical for forest ecosystem functions in the Central Hardwood Region (CHR) of the USA. …”
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Possible causes, ways of development and stages of formation of atopic dermatitis in children by O.V. Gryn, O.M. Okhotnikova

“…The purpose was to analyze and systematize current data on the etiology, pathogenesis, and stages of atopic dermatitis development in children. …”
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Designing a Multi-Objective Stable Mathematical Model for Routing Municipal Waste Collection Vehicles by Afrouz Rahmandoust, Ashkan Hafezalkotob, Bijan Rahmani Parchikolaei, َAmir Azizi

“…Multi-objective meta-heuristic algorithms were applied to solve the model in scenarios with larger dimensions. A comparative analysis was subsequently conducted, evaluating solution methods based on both the values of the objective function and the solution time.   …”
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Hematological toxicity of [225Ac]Ac-PSMA-617 and [177Lu]Lu-PSMA-617 in RM1-PGLS syngeneic mouse model by Meryl Maria Vilangattil, Abir Swaidan, Jonathan Godinez, Marco F. Taddio, Johannes Czernin, Christine E. Mona, Giuseppe Carlucci

“…Liver and kidney functions remained unaffected, and no significant renal or hepatic toxicity was observed. …”
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