Decoupled dynamics of absolute and relative lymphocyte counts and age−polarized CD4+/CD8+ ratio in infants versus older adults by Ting Ge, Ting Ge, Ting Ge, Guixin He, Guixin He, Guixin He, Qian Cui, Qian Cui, Qian Cui, Shuangcui Wang, Shuangcui Wang, Shuangcui Wang, Zekun Wang, Yingying Xie, Yingying Xie, Yingying Xie, Yuanyuan Tian, Yuanyuan Tian, Yuanyuan Tian, Juyue Zhou, Juyue Zhou, Juyue Zhou, Wentao Li, Wentao Li, Baohui Wang, Keming Zhang, Jianchun Yu, Jianchun Yu

“…However, we are unable to specifically analyze the underlying causes owing to a lack of data on lymphocyte absolute counts and functional markers from two extremes of age.MethodsA total of 111 infants (≤ 6 months) and 111 older adults (≥ 65 years) were enrolled to assess the percentages and absolute counts of peripheral blood lymphocyte (PBL) subsets. …”
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Progressive resistance training in young people with Prader-Willi syndrome: protocol for a randomised trial (PRESTO) by Kim L Bennell, Nicholas F Taylor, Nora Shields, David Levitt, Jennifer J Watts, Luke Prendergast, Joseph Proietto, Lauren J Rice, Zoë McCallum, Alesha Southby, Tania Markovic, Christine Bigby, Cara Schofield, Georgina Loughnan, Janet Franklin, Viral Chikani, Susan Blair

“…Secondary outcomes are muscle mass, functional strength, physical activity, community participation, health-related quality of life and behaviour. …”
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Proteomic profiling identifies a stromal TGF-β1/podoplanin axis as a driver of colorectal cancer progression by Silvia Di Agostino, Davide La Padula, Vittoria Rago, Caterina Gabriele, Francesco Conforti, Elio Aprigliano, Lidia Urlandini, Elvira Parrotta, Danilo Lofaro, Francesca Vescio, Andrea Sacconi, Valeria Cernaro, Giuseppe Currò, Angela Alibrandi, Girolamo Ranieri, Valeria Zuccalà, Antonio Ieni, Marco Gaspari, Giovanni Cuda, Michele Ammendola, Vittorio Abbonante

“…The clinical relevance of PDPN expression was evaluated in CRC samples from two independent cohorts using immunohistochemistry and immunofluorescence analysis. Publicly available data from the Gene Expression Omnibus (GEO) database were analyzed to assess the association between PDPN expression and patient survival. …”
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Non-invasive device to alleviate symptoms in people living with Parkinson’s: study protocol for a multicentre phase II double-blind randomised controlled trial by David Gallagher, Cristina Simonet, Alexandra Zirra, Alastair Noyce, Caroline Budu, Ellen Camboe, Viktoria Azoidou, Essa Bhadra, Kira Rowsell, Kamalesh Dey, Corrine Quah, Thomas Boyle

“…Effectiveness will be evaluated at the same time points using movement tests (MDS-UPDRS Part III, Functional Gait Assessment, Timed Up and Go in isolation and with dual tasking and two keyboard-based typing tests—Bradykinesia Akinesia Incoordination and Digital Finger Tapping), with video recordings. …”
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Prognostic importance of the Controlling Nutritional Status (CONUT) score in patients undergoing cardiac resynchronisation therapy by Yasuo Okumura, Yukitoshi Ikeya, Yuki Saito, Toshiko Nakai, Rikitake Kogawa, Naoto Otsuka, Yuji Wakamatsu, Sayaka Kurokawa, Kimie Ohkubo, Koichi Nagashima

“…The primary endpoint was all-cause mortality.Results The moderate or severe malnutrition group had a lower body mass index, more advanced New York Heart Association functional class, higher Clinical Frailty Scale score, lower levels of haemoglobin and higher levels of N-terminal probrain natriuretic peptide (all p<0.05). …”
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Identification of Deregulated miRNAs and mRNAs Involved in Tumorigenesis and Detection of Glioblastoma Patients Applying Next-Generation RNA Sequencing by Dóra Géczi, Álmos Klekner, István Balogh, András Penyige, Melinda Szilágyi, József Virga, Andrea Bakó, Bálint Nagy, Bernadett Torner, Zsuzsanna Birkó

“…Based on the PPI network, a functional enrichment analysis of the target proteins was also carried out. (4) <b>Conclusions:</b> We identified an miRNA panel and several deregulated mRNAs that could play an important role in tumor development and distinguish GBM patients from healthy controls with high sensitivity and specificity using total RNA isolated from tissue samples.…”
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Separation of Hydrogen Isotopes by Metal-Organic Framework Quantum Sieving Effect by Peng LIU, Jia-xian CHENG, Fu-qiu MA

“…Among them, the metal-organic framework has the advantages of designable structure, adjustable pore size, diverse functional groups, large specific surface area, and good stability. …”
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Peculiarities of endoscopic treatment of vesicoureteral reflux in children by V.V. Pohoriliy, V.S. Konoplitskyi, T.I. Mykhalchuk, Yu.A. Dymchyna, Yu.Ye. Korobko

“…Purpose – is to highlight the importance of the pathology of vesicoureteral reflux using data from the literature and own observations. …”
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Bioinformatics and Network Pharmacology Identify the Therapeutic Role of Guominkang in Allergic Asthma by Inhibiting PI3K/Akt Signaling by Zhang H, Zhang H, Wang L, Zhang Y, Hu L, Liu J, Zhou Y, Wang J

“…The aim of this study was to explored the mechanism of action through which GMK combats AA.Methods: Potential target genes for the compounds were identified from the database and subjected to functional enrichment analysis. Subsequently, a protein-protein interaction (PPI) network was constructed in order to screen the core target and confirmed by molecular docking. …”
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Preoperative imaging and intraoperative navigation of the parathyroid glands neoplasms in primary hyperparathyroidism by K. Yu. Slashchuk, M. V. Degtyarev, P. O. Rumyantsev, A. K. Eremkina, N. V. Tarbaeva, D. G. Beltsevich, I. V. Kim, G. A. Melnicthhenko, N. G. Mokrysheva

“…A single-stage, open-label comparative study was carried out, including clinical, laboratory and instrumental data of patients. The follow-up period after surgery for primary hyperparathyroidism was at least 6 months.Results. …”
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Predicting hypoglycemia in elderly inpatients with type 2 diabetes: the ADOCHBIU model by Rui-Ting Zhang, Yu Liu, Chao Sun, Quan-Ying Wu, Hong Guo, Gong-Ming Wang, Ke-Ke Lin, Jing Wang, Xiao-Yan Bai

“…BackgroundHypoglycemic episodes cause varying degrees of damage in the functional system of elderly inpatients with type 2 diabetes mellitus (T2DM). …”
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Encuesta Nacional de Tendencias Fitness para México en 2024 (National Survey of Fitness Trends in Mexico for 2024) by Lino Francisco Jacobo Gómez Chávez, Jorge López-Haro, Adrián Ricardo Pelayo-Zavalza, Luis Eduardo Aguirre Rodríguez

“…An adaptation of the Worldwide Survey of Fitness Trends to the Mexican context was used for the data collection. Results: the main fitness trends in Mexico for 2024 are exercise and weight loss programs, personal training, traditional strength training, training and feeding programs, as well as functional training. 14 trends remain from 2023 to 2024 and seven of the main Mexican trends coincide with those of the United States of America. …”
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Adsorption, Modeling, Thermodynamic, and Kinetic Studies of Methyl Red Removal from Textile-Polluted Water Using Natural and Purified Organic Matter Rich Clays as Low-Cost Adsorben... by Dalila Fkih Romdhane, Yosra Satlaoui, Rawya Nasraoui, Abdelkrim Charef, Rim Azouzi

“…X-Ray diffraction, Fourier transform infrared (FTIR) spectroscopy, and scanning electron microscopy (SEM) analysis confirmed that functional groups of clay adsorbed the dye. …”
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Modified single-incision MIS-TLIF with expandable tubular assistance for degenerative lumbar spine diseases by Wenlong Hu, Wenlong Hu, Fei He, Fei He, Kai Sun, Kai Sun, Haiwu Wan, Sijun Ruan, Bo Huang

“…We collected basic demographic data including age, gender, BMI, and surgical level. …”
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Life beyond 5 Years after TAVI: Patients’ Perceived Health Status and Long-Term Outcome after Transcatheter Aortic Valve Implantation by Marie-Isabel K. Murray, Eileen Hofmann, Roberta De Rosa, Silvia Mas-Peiro, Philipp Seppelt, Thomas Walther, Andreas M. Zeiher, Stephan Fichtlscherer, Mariuca Vasa-Nicotera

“…Demographic and procedure data were obtained from all patients treated with TAVI at our institution from 2006 to 2012. …”
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The association between frailty index and abdominal aortic calcification in the middle-aged and older US adults: NHANES 2013–2014 by ZhengJun Zhang, Peng Wu, Shaobin Yang, Baozhen Zhu, Dapeng Chen, Xiaocheng Li, Yarong Wang, Ning Yan

“…Frailty, a global clinical and public health challenge, is associated with increased risks of mortality, functional decline, and loss of independence. However, the relationship between the Frailty Index (FI) and AAC among middle-aged and older adults has yet to be explored.MethodsThis study analyzed data from 2013 to 2014 National Health and Nutrition Examination Survey (NHANES) cohort, focusing on individuals aged ≥ 40 years. …”
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Predictive potential of cardiovascular risk factors and their associations with arterial stiffness in people of European and Korean ethnic groups by T. A. Brodskaya, V. A. Nevzorova, K. I. Shakhgeldyan, B. I. Geltser, D. A. Vrazhnov, Yu. V. Kistenev

“…Its predictive potential was realized only in combination with functional and metabolic status parameters of patients. …”
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Micro-scale genetic structure and genetic variation of Neotricula aperta (Gastropoda: Pomatiopsidae), the intermediate host of Schistosoma mekongi (Digenea: Schistosomatidae) in Ch... by Naruemon Bunchom, Weerachai Saijuntha, Chairat Tantrawatpan, Wanchai Maleewong, Joseph Valencia, Takeshi Agatsuma, Virasack Bounavong, Philippe Buchy, Moritoshi Iwagami

“…Further ecological and functional investigations will be needed to determine whether adaptive processes are influencing population structure. …”
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C→U transition biases in SARS-CoV-2: still rampant 4 years from the start of the COVID-19 pandemic by Peter Simmonds

“…The genome of SARS-CoV-2 is also increasingly scarred by the effects of multiple C→U mutations from host genome editing as a cellular defense mechanism akin to restriction factors for retroviruses. Through the analysis of large data sets of SARS-CoV-2 isolate sequences collected throughout the pandemic period and beyond, we show that C→U transitions have driven a base compositional change over time amounting to a net loss of C bases and accumulation of U’s at a rate of approximately 0.2%–0.25%/decade. …”
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Numerical Solution to the Problem of Thermal Conductivity in a Porous Plate with a Topology of Triply Periodic Minimal Surfaces by K. V. Gubareva, A. V. Eremin

“…Since these materials have unique structural and functional characteristics, understanding the relationship between their geometry and thermal parameters plays a key role in optimizing their use. …”
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