A Method for Early Identification of Vessels Potentially Threatening Critical Maritime Infrastructure by Miroslaw Wielgosz, Marzena Malyszko

“…An integrated system is proposed, combining real-time electronic surveillance with continuous access to and analysis of data from both national and international databases. …”
Get full text

Gratitude, Self-Esteem and Optimism in People with Physical Disabilities by Rini LESTARI, Maharani FAJAR

“…Analysis of the data used multiple regression analysis. …”
Get full text

PHGDH activation fuels glioblastoma progression and radioresistance via serine synthesis pathway by Xiaojin Liu, Bangxin Liu, Junwen Wang, Hongbin Liu, Jiasheng Wu, Yiwei Qi, Yuan Liu, Hongtao Zhu, Chaoxi Li, Liu Yang, Jian Song, Guojie Yao, Weidong Tian, Kai Zhao, Lin Han, Kai Shu, Suojun Zhang, Jianghong Man, Chao You, Haohao Huang, Ran Li

“…However, its specific role in GBM, particularly in radioresistance, remains poorly understood. Methods In silico analysis of GBM patient data assessed SSP enrichment and PHGDH expression linked with tumor stemness. …”
Get full text

Identification of novel anti-ZIKV drugs from viral-infection temporal gene expression profiles by Nailou Zhang, Zhongyuan Tan, Jinbo Wei, Sai Zhang, Yan Liu, Yuanjiu Miao, Qingwen Ding, Wenfu Yi, Min Gan, Chunjie Li, Bin Liu, Hanzhong Wang, Zhenhua Zheng

“…Our strategies, which combine conventional and data-driven analysis, can be extended for other pathogens causing pandemics in the future.…”
Get full text

Predictors of in-hospital mortality in critically ill patients with COVID-19: a large dual tertiary centre study by Divaka Perera, Georgios Georgiopoulos, Hannah Sinclair, Matthew Ryan, Kevin O’Gallagher, Alexandros Papachristidis, Mark Monaghan, Ajay M Shah, Gerald Carr-White, Ozan M Demir, Mark Zuckerman, Andrew Osborne, Alina Hua, Richard Fisher, Peter Pearson, Kelly Victor, Vasileios Stylianidis, Eleanor Corcoran, Chiara Cirillo, Eleni Nakou, Christos Tountas, Apostolia Marvaki, Nishita Desai, Ana Pericao, Anender Dhariwal, Adam Abner Nabeebaccus, Tiago Fonseca, Eva Toth

“…Following multiple imputation of variables with more than 5% missing values, random forest analysis was applied to the imputed data. Right ventricular (RV) basal diameter (RVD1), RV mid-cavity diameter (RVD2), tricuspid annular plane systolic excursion, RV systolic pressure, hypertension, RV dysfunction, troponin level on admission, peak CRP, creatinine level on ICU admission, body mass index and age were found to have a high relative importance (> 0.7).Conclusions In patients with COVID-19 in the ICU, both severely impaired LV function and impaired RV function may have adverse prognostic implications, but older age and inflammatory markers appear to have a greater impact. …”
Get full text

Alimentation et gestion de l’eau sur la colline de Fourvière à Lyon : les aménagements hydrauliques, la ville et ses monuments by Aldo Borlenghi, Éric Leroy

“…The wells, both Republican and Augustan, are almost all concentrated in sectors above 280 m NGF. The analysis of the remains, and in particular the imposing size of some of the wells, allows us to deduce their public or semi-public function and, for the first time, the existence of hydraulic water drawing devices. …”
Get full text

Glucokinase Regulatory Protein as a Putative Target for Gestational Diabetes Mellitus and Related Complications: Evidence From the Mendelian Randomization Study by Weian Mao, Guiquan Wang, Xiao Wang, Yan Shen, Shuai Yuan, Lin Wang, Haiyan Yang, Yan Li, Kai Chen, Jun Liu, Xi Dong, Yue Zhao, Liangshan Mu

“…Methods We applied two‐sample Mendelian randomization (MR) and colocalization analysis using summary‐level data from genome‐wide association studies of GCKR and GDM. …”
Get full text

Natural product library screening identifies Darutigenol for the treatment of myocardial infarction and ischemia/reperfusion injury by Kun Liu, Li Zheng, Qian-Yu Huang, Hong-Ji Li, Cheng Li, Hui Zhao, Ze-Bing Ye, Hao Wang, Xu-Feng Qi, Meng Wang

“…In addition, in vivo administration of Dar was able to attenuate MI- and I/R-induced cardiac injury in adult mice by decreasing fibrosis and apoptosis, thereby improving cardiac function. Network pharmacology analysis and molecule docking assay showed that Dar has the highest binding affinity with AKT1 protein. …”
Get full text

Effectiveness of fermentation broth of Cordyceps sinensis for primary insomnia: a randomized clinical trial with digital health tool by Shuting Zhao, Ziqian Wang, Ziqian Wang, Xiaxia Fan, Xiaxia Fan, Xuanhao Shu, Xuanhao Shu, Qiao Chen, Yibo Zhou, Yongzhi Fu, Zheng Yu, Marcin Grzegorzek, Marcin Grzegorzek, Xinyu Huang, Chengwen Zheng, Chengwen Zheng, Yanxiong Gan, Chuanbiao Wen, Chuanbiao Wen

“…Significant group effects were also observed for most subcomponents, except for Sleep Disturbances and Daytime Function, indicating greater improvements in the FBCS group over time. …”
Get full text

Transcriptomic profiles of monocyte-derived macrophages exposed to SARS-CoV-2 VOCs reveal immune-evasion escape driven by delta by Alessia Gallo, Josè Camilla Sammartino, Roberta Vazzana, Roberto Giambruno, Claudia Carcione, Nicola Cuscino, Salvatore Castelbuono, Vitale Miceli, Matteo Bulati, Daniele Lilleri, Irene Cassaniti, Pier Giulio Conaldi, Fausto Baldanti

“…The success of each VOC, as well as the virus fitness, were enabled by altered intrinsic functional properties and, reasonably, to virus antigenicity changes, conferring the ability to evade a primed immune response. …”
Get full text

LncRNA targeted by coordinate zygotic genome activation during porcine embryonic development by Mengxin Liu, Enhong Li, Haiyuan Mu, Zimo Zhao, Xinze Chen, Jie Gao, Dengfeng Gao, Zhiyu Liu, Jianyong Han, Liang Zhong, Suying Cao

“…These results implied that the functional axis of TPRA1 - XLOC-040580 -downstream genes involved in ZGA-related functions also coordinated early embryonic development in porcine.…”
Get full text

The prevalence of erectile dysfunction and its associated factors among diabetic patients in the Southwestern Region of Saudi Arabia analytical cross-sectional study by Safar Saad Battar, Faisal Saeed Al-Qahtani, Mohammed Mansour M. Alqahtani, Rayyan Mohammed A. Alassiri, Abdulrhman Saeid Z. Alshahrani, Mohammed Ahmed M. Alhanash, Nawaf Faris A. Alnahdi, Saad Ali S. Alasiri, Abdulaziz Saud S. Alotaibi, Ali Mohammed AlAmri

“…The sample included 398 married male Saudi nationals aged 18 years and older, diagnosed with diabetes and attending PHCCs. Data collection involved a standardized questionnaire that included the International Index of Erectile Function (IIEF-5) to measure ED severity and explore related factors. …”
Get full text

Clinical profile of hypertension patients in primary health Care in Cirebon Regency, Indonesia by Tiar Masykuroh Pratamawati, Ahmad Fariz Malvi Zamzam Zein, Uswatun Khasanah, Donny Nauphar, Vincentius S.W. Budhyanto, Idrus Alwi, Asmarinah

“…Patients with secondary hypertension or hypertension in pregnancy were excluded. Data were collected through questionnaires, blood pressure measurements, and analysis of blood and urine samples. …”
Get full text

Lower dietary folate intake increases the risk of autoimmune thyroiditis by Lijun Chen, Changjian Yan, Yingxuan Lin, Liqun Huang, Chunling Huang, Zhida Wei, Hongli Lin, Xiaohong Wu, Ruhai Lin, Zhengrong Jiang, Huibin Huang

“…Univariate and multivariate logistic regression models were employed to examine the relationship between AIT risk and various factors, including demographics, complete blood count, blood biochemistry parameters, thyroid function test, urinary iodine concentration, as well as intakes of vitamin B12 and folate. …”
Get full text

Experimental Study on Hydraulic Characteristics of Fish-friendly Culverts with Baffles by MAO Jing-qiao, LU Peng, GONG Yi-qing, GAO Huan, DAI Jie

“…[Methods] Three-dimensional velocity data were collected using an Acoustic Doppler Velocimeter (ADV) to analyze the distribution patterns of turbulent kinetic energy and Reynolds stress. …”
Get full text

Multi-branch horizontal well hole docking pressure control extraction technology for close distance coal seam group by Liang CHEN, Zhiheng CHENG, Xin LUO, Hongyang YU, Zherui ZHANG, Peng WANG, Xiangdong WANG

“…Taking Shaqu well field in Lyuliang city, Shanxi province as an example, through theoretical analysis and data statistics, the geological structure of coalbed methane accumulation in the well field, the influence of hydrodynamic conditions, coalbed methane reservoir characteristics and gas-bearing distribution are obtained. …”
Get full text

Risk factors for postoperative complications in patients with pulmonary tuberculosis by Bing Wang, Li Yao, Jian Sheng, Xiaoyu Liu, Yuhui Jiang, Lei Shen, Feng Xu, Qibin Liu, Sheng Bao, Chao Gao, Xiyong Dai

“…Methods We conducted a retrospective analysis of baseline data—including sex, age, BMI, comorbidities, previous COVID-19 status, smoking history, respiratory function, ASA grade, affected lung lobe, and operative factors—in patients who underwent surgical treatment at Wuhan Pulmonary Hospital between January 2018 and September 2022. …”
Get full text

Feasibility and safety of regadenoson stress perfusion protocol in pediatric transplant patients under general anesthesia by Nikkan Das, Eric L. Vu, Andrada Popescu, Defne Magnetta, Cynthia K. Rigsby, Joshua D. Robinson, Simon Lee, Nazia Husain

“…Background: Cardiovascular magnetic resonance with myocardial stress perfusion (stress CMR) is a non-invasive technique that offers an assessment of myocardial function, perfusion, and viability. Regadenoson is a selective cardiac adenosine A2 receptor agonist with fewer side effects than adenosine and a favorable safety profile in older pediatric heart transplant recipients (PHTR). …”
Get full text

Patient Resilience, Is it Nature or Nurture? by Nathaniel Zona BA, Kenneth Hunt MD

“…Furthermore, patients with high preoperative BRS scores demonstrate significantly better improvements in function and pain compared to low resilience patients. …”
Get full text

Operationalizing the principles of patient engagement through a Patient Advisory Council: Lessons and recommendations by Ingrid Nielssen, Maria Santana, Surakshya Pokharel, Kimberly Strain, Veronika Kiryanova, Sandra Zelinsky, Zoha Khawaja, Prachi Khanna, Anni Rychtera, Anshula Ambasta

“…Patient research partners were active members of the PAC and informed the research project design, participant recruitment strategies, data collection and analysis, and will be involved in the implementation and dissemination of results. …”
Get full text